Best Large Grants for Nonprofit Organizations in South Carolina

The Deaconess Foundation offers Nursing Scholarship Grants aimed at supporting local students pursuing nursing degrees with demonstrated financial need. This program reflects the foundation's mission to enhance community health in Eastern Missouri and Southern Illinois. Grants are administered in partnership with the Scholarship Foundation of St. Louis and the St. Louis American Foundation. Eligible students must be working towards an accredited nursing degree and demonstrate significant financial need, among other criteria.

The National Film Preservation Foundation (NFPF) offers Matching Grants to support the preservation of significant American films. Nonprofit and public institutions can apply for projects involving complex preservation efforts, with cash stipends ranging from $20,001 to $75,000. Grants require a matching contribution of one-fifth of the project costs. Since its inception, the NFPF has aided numerous organizations in preserving culturally important films, ensuring their accessibility for future generations.

The National Film Preservation Foundation offers Basic Preservation Grants to nonprofit and public institutions for preserving culturally significant American films. Since 1998, they have provided resources to 337 organizations across the U.S. Grants range from $1,000 to $20,000, facilitating the creation of new film preservation elements and public access copies. With an annual award of 30 to 40 grants, this initiative plays a crucial role in ensuring the survival of films that are at risk of being lost.

The FWW Research Awards support short-term studies focused on critical women’s health issues such as cardiovascular disease, female cancers, and hormonal influences on health. Eligible applicants include MDs or PhDs affiliated with accredited institutions. Research proposals must align with FWW's priority areas, and financial support must be confirmed to ensure project completion. Note that sociological studies are not funded, and only one application per Principal Investigator is allowed.

The FWW Fellowship Award supports emerging physicians and scientists dedicated to advancing women’s health research. Awardees, pursuing MD or PhD programs at U.S. institutions, explore critical health topics such as cardiovascular disease, leading female cancers, and the role of hormones. This initiative encourages diverse applicants and promotes innovative proposals that address health concerns disproportionately affecting women. With a commitment to fostering research excellence, the FWW Fellowship Award empowers the next generation of health leaders.

The AHA Predoctoral Fellowship aims to enhance research and clinical training for pre-doctoral students pursuing careers in cardiovascular health. Applicants must be enrolled in a relevant doctoral program and demonstrate collaboration with a mentor. The fellowship provides an annual stipend of $28,224, plus health insurance support and project funding. Eligible candidates are full-time students who have completed initial coursework and can commit to research efforts. This opportunity fosters the development of independent researchers in the field.

The FINRA Investor Education Foundation's General Grant Program funds educational and research projects aimed at enhancing financial literacy among underserved populations. Grants ranging from $50,000 to $100,000 support initiatives that promote financial inclusion and address systemic inequities. The foundation prioritizes projects that utilize existing data to improve understanding of financial capability and well-being. Applications are accepted anytime, with a focus on sustainability beyond the grant period.

The Established Investigator Award from the American Heart Association supports established investigators at the associate professor level, emphasizing innovative research in cardiovascular and cerebrovascular sciences. With a budget of $80,000 per year and a maximum award of $400,000 over five years, it aims to enhance the careers of candidates demonstrating significant accomplishments and promising research directions. Eligibility requires a doctoral degree and a full-time faculty position, with specific criteria for appointment levels and funding history.

The Stickley Scholarship Fund, established by L. & J. G. Stickley, Inc., offers four annual scholarships for graduating high school students who are children of full-time employees with over two years of service. This initiative promotes educational equity by making higher education more accessible, emphasizing the importance of financial need, community service, and academic achievement. Awarded in honor of Edward J. Audi, this scholarship aims to empower students to pursue their academic goals.

The Peter N. Whitcher Scholarship Fund provides financial assistance to eligible children of current or deceased members of the Iron Workers District Council of Western New York. This scholarship aims to support students pursuing high school graduation, higher education, or professional development, thus enhancing their educational opportunities and fostering equity in the community. Established by a key figure in the American labor movement, it reflects a commitment to uplift future generations through accessible education.

The Women's Fund Scholarship Award, established in 2014 by the Ashland County Community Foundation, provides financial assistance to female residents of Ashland County. It aims to empower women by supporting their education and job training goals, thereby improving their lives and their families' futures. This scholarship is available to high school seniors, college students, and non-traditional students, offering crucial resources for career advancement.

The BECU Foundation Scholarship aims to support educational endeavors while promoting community service. This scholarship, valued at up to $5,000 over two years, is designed for BECU members who exemplify the philosophy of 'people helping people.' Eligible applicants include high school seniors and current college students with a minimum GPA of 2.5, who are committed to full-time education and community involvement. Apply to join a legacy of giving back while pursuing your academic goals.

The Edward and Hannah Wingaris Scholarship, administered by the Center for Scholarship Administration, supports students who have resided in Schuylkill County, Pennsylvania, for at least one year. Eligible applicants must demonstrate financial need, maintain a minimum GPA of 2.0, and plan to attend an accredited institution full-time. This scholarship is renewable for up to four years, allowing recipients to continue their educational journey with financial assistance.

The Oldham Little Church Foundation Grant, established in 1949, has awarded over $53.56 million in facility completion grants to small evangelical Protestant churches across the U.S. The foundation aims to support church renovations and new construction projects, enhancing their ability to serve their communities. Grants typically range from $10,000 to $15,000 and are considered quarterly. Eligible churches must meet specific criteria, including membership size and financial stewardship, to qualify for funding.

The NewSchools: Teaching Reimagined Grant offers a unique funding opportunity of $150,000 to $250,000 for innovative ideas aimed at reimagining the role of educators and enhancing student outcomes. With a focus on leveraging generative AI, the grant supports early-stage organizations and initiatives that prioritize diverse teaching strategies and community involvement. The application deadline is January 8, 2026, with a priority deadline of December 1, 2025, for updates on eligibility.

The Affiliate Grants - Guest Speaker Fund, provided by the American Musicological Society, offers financial assistance to AMS committees and study groups inviting external speakers to the Annual Meeting. Grants up to $1,500 cover travel expenses and honoraria for invited guests, promoting interdisciplinary collaboration within musicology. Applications must be submitted by group representatives, and the deadline precedes the standard proposal deadlines for committee activities. This program encourages enriching discussions by including diverse voices from outside the field.

The Drops of Hope Giving Program, initiated by Vapur, aims to enhance environmental sustainability by reducing single-use plastics. This initiative collaborates with organizations to donate thousands of reusable bottles globally, promoting access to clean water. Eligible applicants include registered 501(c)3 nonprofit organizations or those offering marketing opportunities in exchange for contributions. The program reflects Vapur's commitment to innovative, portable products that inspire active lifestyles, fostering a healthier planet.

The Presbyterian Committee on the Self-Development of People Grant Program supports projects led by economically disadvantaged communities to combat poverty and injustice. By promoting justice, building stronger communities, and advocating for economic equity, this program empowers individuals and groups to address the root causes of their struggles. The initiative seeks sustainable solutions that respect the environment and reject violence, fostering long-term positive change in society.

The E. Rhodes and Leona B. Carpenter Foundation, established in 1975, supports public charities with a focus on Asian art, performing arts in Richmond, VA, and graduate theological education. The Foundation prioritizes requests from organizations with historical ties to the Carpenters and those promoting LGBTQ+ inclusion and community health. It aims to enhance cultural exchange through art exhibitions, particularly in the US and China, while excluding support for private education and large public charities.

The John William Pope Foundation offers annual grants to support public policy research promoting a free-market economy and individual liberty under the rule of law. Emphasizing the importance of property rights and personal initiative, the foundation welcomes proposals from tax-exempt organizations, particularly those impacting public policy in North Carolina. By focusing on long-term solutions rather than short-term aid, the foundation aims to empower communities and foster sustainable economic growth.

The J. C. and Alberta Long Fund, established by the Long family, supports high school seniors from Berkeley, Charleston, and Dorchester counties with scholarships. This fund honors the legacy of Mr. J.C. Long and Mrs. Alberta Long, aiming to empower youth in their educational pursuits while fostering community growth. With a commitment to addressing local needs, the Coastal Community Foundation ensures that qualified applicants receive financial assistance to achieve their academic goals, contributing to a brighter future for the region.

The Americana Foundation's American Heritage Grant aims to support projects that broaden inclusivity in early American art and narratives, especially for underrepresented groups. Recognizing the historical significance of Americana, the foundation prioritizes initiatives that promote understanding and appreciation of America's diverse heritage. Eligible applicants include nonprofit organizations and municipal entities. The foundation encourages innovative projects that reinterpret early American material culture, fostering a deeper connection to the past for future generations.

The LAMC Community Mitigation Scholarship Endowment, established in 2016 by the Coastal Community Foundation of South Carolina, aims to support students in underserved neighborhoods of North Charleston, SC. This fund provides scholarships for tuition and living expenses, addressing educational disparities and fostering community growth. By investing in local youth, the foundation helps empower future leaders and strengthens community resilience, ensuring equitable access to educational opportunities in the region.

The PreventSA Incubator aims to reduce sexual assault rates in the U.S. by 70% by 2050 through innovative solutions. This six-month program offers $50,000 in funding, mentorship, and community support for technology or social media ideas targeting high-school-aged youth (ages 14-18). It seeks projects that prevent peer-on-peer sexual assault and can launch by April 2026. Applicants must focus on direct engagement with high-risk youth and adapt successful interventions from other countries.

The Guitar Center Music Foundation is an independent 501c3 organization. Through instrument grants and donations, we help ensure schools and music education programs get the resources they need to keep music alive and accessible. We believe in a world in which music is cherished and respected for the immense value it brings to humanity, where every person who seeks to pursue music has the means to do so.

Our mission is to give everyone the power to create and express themselves through music. Since 2005, we have supported hundreds of music education and therapy programs and reached over 300,000 people. With your generous support, we aim to assist many more.

Guitar Center Music Foundation Grants

The Guitar Center Music Foundation awards musical instruments and equipment in-kind to public schools and music programs in need. 

Instrument grants range from up to $1,000 to $5,000 based upon need.

The Harry A. Saunders III Memorial Fund, established in 2025 by the Hawai‘i Community Foundation, supports Hawaii high school graduates pursuing higher education. This fund aims to empower students demonstrating financial need and maintaining a minimum GPA of 2.0. Preference is given to recipients who were awarded in the previous year, provided they continue to meet eligibility requirements. The fund embodies a commitment to fostering educational opportunities and enriching the lives of young Hawaiians.

The Joan Robinson Scholarship, offered by the Community Foundation of the Ozarks, provides a $1,900 scholarship to graduating high school seniors from Perry County, MO. Applicants must submit a transcript, an essay detailing community service and work experience, and a letter of recommendation. Preference is given to those pursuing degrees in Environmental Science. This initiative aims to enhance the quality of life through education, aligning with the foundation's core values of integrity, respect, and leadership.