Best Large Grants for Nonprofit Organizations in South Carolina

The Columbus Foundation

In 1943, during the darkness of World War II, a group of passionate citizens, led by Columbus businessman Harrison M. Sayre, envisioned a way to improve the well-being of the community and the quality of life in central Ohio. With little more than this sound idea and faith, The Columbus Foundation was established.

Our Mission

To assist donors and others in strengthening and improving our community for the benefit of all its residents.

Mary Siberell Rader Scholarship

This scholarship was established to provide awards to deserving students from Ross County, Ohio, or surrounding counties, who are pursuing post-secondary academic or vocational training to allow themselves to become self-sustaining.

The Renee Starks Steed Memorial Scholarship, offered by the United Negro College Fund, supports HBCU students majoring in fashion-related fields. Aimed at sophomores, juniors, and seniors, it emphasizes academic excellence with a minimum GPA of 3.0. This need-based scholarship fosters diversity, prioritizing students of color, and is part of UNCF's broader mission to enhance educational opportunities for underrepresented communities. Applications for the 2025-2026 academic year are now open.

The OREF Multimodal Musculoskeletal Perioperative Pain Management Grant invites research proposals aimed at enhancing perioperative pain management strategies. This funding opportunity emphasizes opioid-sparing techniques and effective regional anesthesia methods to improve patient outcomes in orthopedic surgeries. Eligible applicants include Certified Registered Nurse Anesthetists (CRNAs) in collaboration with PhDs or MDs, fostering a diverse range of expertise in pain management research.

The SVS Student Research Fellowship, offered by the Society for Vascular Surgery Foundation, supports undergraduate and medical students in the U.S. and Canada conducting vascular research. The fellowship emphasizes hypothesis-driven projects, providing a $3,000 award and a complimentary Journal of Vascular Surgery subscription. It aims to enhance students' education while fostering innovative solutions in vascular health, ensuring inclusivity and diversity in applicant eligibility.

KKR Charitable Donations supports impactful collaborations and programs addressing current needs while paving the way for future progress. Through their Corporate Citizenship program, KKR focuses on philanthropy, employee engagement, and sustainable community initiatives. The KKR Cares initiative enables employees to engage with communities worldwide via matching gifts, board service, and volunteer opportunities, aiming to enhance economic opportunity and security for underserved populations.

The Ronald Dean Estes Scholarship, established in 2011, honors the legacy of Ronald Dean Estes, a dedicated resident and lawyer of Wenatchee. This scholarship supports graduating seniors from Chelan or Douglas counties, or Ritzville High School, who exhibit strong leadership and a passion for learning. Eligible applicants must have a minimum GPA of 2.5, demonstrate financial need, and show involvement in community activities. Preference is given to first-generation college students.

The Prisma Health-Upstate Foundation Micro-Grant Program, established in 2023, aims to enhance the patient experience and quality of care by providing clinical care teams with resources. Individual awards can reach up to $5,000, with funds available to selected applicants in February, to be utilized by the end of the fiscal year. Award recipients are expected to report on the impact of their funding, contributing to a legacy of compassionate care in the Upstate community.

The National Register Internship Travel Scholarship, funded by the American Psychological Foundation, offers financial assistance to psychology doctoral students for relocation to their predoctoral internship sites. This scholarship supports diverse applicants who are in good standing in accredited programs and have secured internships recognized by the APA or CPA. By alleviating relocation costs, the scholarship aims to facilitate the professional development of future psychologists.

The Paul E. Henkin School Psychology Travel Grant, offered by the American Psychological Foundation, provides up to $1,500 for student members of APA Division 16. This funding helps cover registration, lodging, and travel expenses for attending the APA Annual Convention. It encourages applicants from diverse backgrounds and requires a commitment to a career in school psychology. Eligible applicants must be current student members of APA Division 16 and cannot use the funds for food or materials not included in registration.

The Division 39 Marsha D. McCary Fund Grant for Psychoanalysis aims to enhance public understanding of psychoanalysis and its applications in various fields. This grant supports initiatives that promote psychoanalytic education, research, and services, especially benefiting early career professionals and underserved populations. The American Psychological Foundation encourages applicants from diverse backgrounds to apply, ensuring a broad representation within the field. This initiative fosters the ongoing development of psychoanalysis as a vital discipline in psychology.

The National Institute on Aging (NIA) is set to release a Notice of Funding Opportunity (NOFO) aimed at advancing the discovery of in vivo chemical probes for brain targets. Collaborating institutes include the National Eye Institute (NEI), National Institute on Drug Abuse (NIDA), and National Institute of Mental Health (NIMH). The initiative seeks to foster research into small molecules and novel biological targets related to brain diseases, encouraging innovative projects and collaborations.

The 2026 Radiation Oncology Institute- Innovation Awards aim to advance cancer treatment by integrating radiation therapy with immunotherapy. Researchers are invited to submit proposals that explore optimal combinations of these modalities to enhance patient outcomes. Funding of up to $100,000 over two years will support projects focused on identifying effective treatment strategies, understanding mechanisms of synergy, and improving access to care. This initiative represents a significant opportunity for innovative research in oncology.

The Improving Shared Decision Making in Hemophilia Visiting Professorship Program, sponsored by Pfizer and HTRS, aims to enhance educational resources for organizations with limited access to hemophilia expertise. This initiative invites clinicians and multidisciplinary teams to host a distinguished Visiting Professor who will address unmet educational needs in shared decision making and emerging therapies. Grants of up to $7,500 will support local program costs, with a focus on enhancing care for patients with hemostatic disorders.

The Paul and Barbara Yamber Memorial STEM Scholarship, administered by the Quad Cities Community Foundation, provides need-based financial support for students pursuing STEM fields. Annually, up to $10,000 is awarded, renewable for up to four years. Applicants must demonstrate financial need and a commitment to STEM education, ensuring that this scholarship significantly impacts their ability to attend college. Preference is given to undergraduates, making this a vital resource for aspiring STEM professionals.

The Dr. Doris R. Corbett-Johnson Leaders for Our Future Award, presented by SHAPE America, honors young professionals under 36 who exhibit exceptional promise in scholarship, teaching, and leadership. This prestigious award is available in two categories: college/university and non-college/university, with a maximum of two recipients per category each year. By recognizing emerging leaders, SHAPE America aims to inspire a new generation dedicated to advancing health and physical education.

The First Book Grant for Scholars of Color (FBG) offers up to $55,000 to support early-career, pre-tenured scholars of color in completing significant research projects related to Christian faith and life, religious trends, and social issues. This grant aims to facilitate the publication of their first book, enhancing the connection between academic scholarship and the church in North America, while prioritizing projects that are already underway.

The Wharton Nursing Leaders Program Scholarship, offered by the Oncology Nursing Foundation, supports nurse-managers aspiring to become chief nursing officers. This program, taking place from December 15-19, 2025, in Philadelphia, focuses on enhancing leadership skills through interactive sessions. Applicants must first be accepted into the program and meet specific eligibility criteria, ensuring that the scholarship aids those committed to advancing their careers in oncology nursing.

Pfizer is offering a grant opportunity for independent medical education initiatives focused on Muscle Invasive Bladder Cancer (MIBC). This program aims to address the current knowledge gaps among healthcare professionals regarding emerging treatment data and its potential impact on clinical practices. By collaborating with Astellas, Pfizer seeks proposals that enhance awareness and understanding of the evolving MIBC landscape, ultimately improving patient outcomes in this critical area of unmet medical need.

The PIDS Foundation's Apprenticeship Program fosters early-career pediatric infectious diseases physicians, enhancing their skills in academic publishing. Named in honor of Ralph D. Feigin, the program offers junior faculty members the opportunity to engage with the editorial process of the Journal of the Pediatric Infectious Diseases Society. Recipients will contribute to manuscript discussions and special projects, committing approximately four hours weekly. The award will be presented during the PIDS Annual Membership Meeting at IDWeek 2025, with the term spanning October 2025 to October 2026.

The CPIC Scholars Program, part of the Rare Diseases Clinical Research Network (RDCRN), offers education and career development opportunities for early-stage faculty and fellows. This initiative aims to foster the research careers of the next generation, focusing on congenital cytomegalovirus, neonatal herpes simplex virus, and enterovirus sepsis. Scholars engage in research projects and participate in CPIC Scholar Circles, enhancing their professional skills and knowledge in rare disease research.

The UNCF General Scholarship, offered by the United Negro College Fund, provides essential financial support to students enrolled full-time at one of 37 UNCF Member Institutions for the 2024-2025 academic year. This scholarship aims to enhance access to higher education for minority students, helping them thrive and graduate. The application process is designed to create a pool of eligible candidates for various scholarship opportunities, emphasizing the importance of education and community engagement.

The Wm. Wrigley's Foundation Scholarship, offered by the United Negro College Fund, supports undergraduate students enrolled in UNCF member schools for the 2025-2026 academic year. This scholarship provides up to $5,000 based on verified financial need. Eligible candidates must be majoring in specific fields such as engineering, business, or computer science, and maintain a minimum GPA of 2.5. This initiative reinforces the commitment to enhancing minority education and fostering future leaders.

The AO Spine NA Fellowship Award aims to fund post-graduate fellowship programs at institutions in North America, covering expenses such as stipends, research, and education. This award is limited in number and contingent upon available funding as determined by the AO Spine NA Board. Applications undergo a rigorous review based on established criteria, while the engagement of faculty and compliance with eligibility requirements are critical for the selection process.

The Dr. Anita L. Pinc Memorial Scholarship, administered by the Quad Cities Community Foundation, provides financial assistance up to $1,000 to female students pursuing a medical degree in the U.S. Applicants must be enrolled in a medical school and have ties to Scott County, Iowa, or Rock Island County, Illinois. This renewable scholarship supports students committed to practicing medicine in the Quad Cities region, helping to foster local healthcare professionals.

The ASTRO-ACS Clinician Scientist Development Award aims to support full-time faculty members in radiation oncology who aspire to become independent investigators. Co-funded by the American Cancer Society and the American Society for Radiation Oncology, this grant provides $135,000 per year for 3 to 5 years, along with 8% allowable indirect costs. It encourages applications from underrepresented groups and those with disabilities, fostering diversity in cancer research.

The Japanese-Language Learners Event Grant, offered by the Japan Foundation, Los Angeles, provides financial support of up to $1,000 for events that promote Japanese language education across various educational levels. This grant aims to motivate learners through contests and presentations, encouraging participation from multiple schools in the region. Eligible expenses include judge fees, venue costs, and production materials, while closed events for single schools are not supported.

The ACS-ASTRO Felix Feng, MD Clinician Scientist Development Award supports practicing radiation oncologists engaged in research that enhances health across the cancer continuum. Funded by the American Cancer Society and ASTRO, this award provides $730,000 over three to five years, aiming to advance the field of radiation oncology and improve patient care through innovative research and collaboration.