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Best St. Clair County Grants for Nonprofits in Missouri

Looking for grants for 501(c)(3) nonprofit organizations working in St. Clair County, Missouri? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

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$3.38B

Total funding

$5K

Median grant

9,000+ grants
$3.38B total
$5K median

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9,158 Results based on applied filters

Hand in Hand Research Grant

The American Occupational Therapy Foundation Inc
Private
United States
US $50,000

About AOTF

Established in 1965, AOTF is an independent 501(c)(3) charitable, scientific, and educational organization. We serve as the premier resource for occupational therapy research and scholarship, working alongside researchers, educators, practitioners, community partners, and students to build evidence-based practice that improves lives.

As the only foundation dedicated exclusively to advancing occupational therapy science, we bridge the critical gap between innovative research and real-world practice. Our work ensures that occupational therapy interventions are grounded in rigorous scientific evidence, ultimately improving outcomes for millions of people worldwide.

Hand in Hand Research Grant

Background

To address the urgent need for more practice evidence in hand and occupational therapy, the American Occupational Therapy Foundation (AOTF), American Society of Hand Therapists (ASHT), and the American Hand Therapy Foundation (AHTF) have joined forces to launch the Hand in Hand Research Grant- a proof-of-concept initiative designed to close the gap between research and real-world practice.

Program Mission

The Hand in Hand Research Grant aims to spark innovative, early-stage research that is deeply rooted in community engagement. This grant is designed to help lay necessary groundwork for future large-scale studies by supporting foundational work that advances real-world impact in hand and upper extremity therapy.

This grant seeks to catalyze partnerships among researchers, clinicians, and community stakeholders, fostering collaboration at every stage of the research process. By prioritizing research that is grounded in the lived experiences and practical realities of diverse communities, this initiative aims to ensure that findings are not only evidence-informed but also actionable in everyday practice settings.

Grant Details

Grant Amount: $50,000

Duration: 1 year

Priority areas for research include, but are not limited to:

  • Health Disparities
  • Comparative Effectiveness
  • Clinical Practice and Outcome Validation
  • Orthosis Use and Biophysical Agents
Health Disparities & Social Determinants of Health Occupational Therapy

Hand Foundation's Student Grant Program

The Hand Foundation Incorporated
Private
United States
Unspecified amount

Our mission

Advancing the Glades area community and beyond through improving access to education and fostering enrichment initiatives.

The Foundation supports those willing to build a better future for themselves and their community through hard work, academic excellence, and a commitment to sharing success with others. 

Hand Foundation's Student Grant Program

Through The Hand Foundation's Student Grant Program, we provide scholarship grants to full-time aspiring students attending or preparing to attend an accredited college, university, or trade school. In evaluating candidates, the Foundation considers financial need and merit as part of a holistic review of each applicant.

Grant assistance is considered for up to 4 years (max. 8 semesters). Funding goes towards core costs of tuition, books, and fees +. The awarded grant amount varies depending on financial need, merit, school attending, among other factors. The Foundation funds fall and spring semesters only. 

Prospective students shall complete a Letter of Interest prior to submitting an application (which can be started here on the site via submit). The letter should include two elements - first, a personal bio with high school history (achievements, activities, skills, interests, etc.) and second, college objectives and goals (institution planning to attend, area of focus, projected start and end date, career goals). The student candidate will provide their contact information - mailing address, phone number, email.   

The Foundation will review the letter based on merit and budget, then, will send an application to the student candidate to complete. 

Education - Higher Education Vocational & Trade Education

Hand Foundation's Organization Grant Program

The Hand Foundation Incorporated
Private
United States
Up to US $100,000

Our mission

Advancing the Glades area community and beyond through improving access to education and fostering enrichment initiatives.

The Foundation supports those willing to build a better future for themselves and their community through hard work, academic excellence, and a commitment to sharing success with others. 

Hand Foundation's Organization Grant Program

Through The Hand Foundation’s Organizational Grant Program, we provide grants to professionally managed and sustainable nonprofit organizations with financial need to amplify a purpose or mission. Grants are considered for charitable and impactful programming as well as capital endeavors that assist in supporting a nonprofit organization’s core mission.

Emerging Program and Capital Grants support high-impact, sustainable, and responsive nonprofit organizations in delivering their core missions through thoughtful and time-bound projects. These grants help address an immediate need that is critical to the organization’s work. Grant amounts are up to $100,000, most often paid over one year.

Transformational Capital Grants provide major funding for nonprofit organizations to permanently and profoundly improve their mission delivery by supporting the development of physical spaces and/or assets that create a meaningful difference in enhancing the ability to provide high-quality, impactful programs and services to those served. Grant amounts are over $100,000, often payable over multiple years.

Organizations that have not been previously funded by the Foundation are encouraged to apply for Emerging Program and Capital Grants to familiarize the Foundation with its work before submitting an application and proposal for a Transformational Capital Grant. 

Grant requests are highly competitive. The most compelling proposals will demonstrate a complete analysis that validates the program or project's impact, need, and viability.

Economic Services & Development Community Development & Revitalization Nonprofit Growth & Development

Artist Professional Development Grant

Iowa Economic Development Authority
State/Local Government
Iowa, United States
US $500 - US $5,000

Iowa Economic Development Authority

Mission

Strengthen economic and community vitality by building partnerships and leveraging resources to make Iowa the choice for people and business. Through two main divisions – business development and community development – IEDA administers several state and federal programs to meet its goals of assisting individuals, communities and businesses. IEDA works to achieve its mission and goals to benefit Iowans while maintaining a high level of transparency. 

Artist Professional Development Grant

The Artist Professional Development Grant provides support to Iowa’s artists to undertake activities that advance their artistic practices and elevate the creative industry in Iowa. The program supports learning, mentorship, and business development opportunities to enable artists of all disciplines to catalyze momentum in their artistic practices and increase their professional skills and capacity.

Artist Training & Development Arts / Culture Access & Participation Tutoring & Mentoring +1 more

ROSES 2025: D.10 Astrophysics Theory

National Aeronautics and Space Administration (NASA)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Astrophysics Theory Program (ATP) supports the development of fundamental theories for NASA's space astrophysics initiatives. It seeks proposals that enhance the understanding of astrophysical data or predict outcomes that can be empirically tested. Investigations can last from one to four years, with a typical duration of three years. Each proposal must be led by a single Principal Investigator, ensuring focused leadership for each project.
Mathematics Science Physics +2 more

National Animal Disease Preparedness and Response Program (NADPRP) FY 2027 State Preparedness Funding Opportunity

USDA: Animal and Plant Health Inspection Service (APHIS)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $2,000,000
The USDA Animal and Plant Health Inspection Service (APHIS) is providing up to $40 million through the NADPRP FY 2027 State Preparedness Funding Opportunity. This initiative aims to enhance state and regional capabilities to combat foreign and emerging animal diseases, including highly pathogenic avian influenza and African swine fever. The program supports critical projects that mitigate disease risks, ensuring the safety of U.S. agriculture. More information can be found on the USDA APHIS NADPRP website.
Agriculture Livestock & Ranching Veterinary Science & Services +2 more

National Animal Disease Preparedness and Response Program (NADPRP) FY 2027 Industry Preparedness Funding Opportunity

USDA: Animal and Plant Health Inspection Service (APHIS)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $4,000,000
The USDA Animal and Plant Health Inspection Service (APHIS) has announced a funding opportunity of up to $40 million for the National Animal Disease Preparedness and Response Program (NADPRP) FY 2027. This initiative aims to bolster readiness against foreign animal disease outbreaks by supporting high-value projects that enhance prevention, preparedness, response, and recovery capabilities in the agricultural sector. Eligible organizations include livestock producer and veterinary groups, with further details available on the USDA APHIS NADPRP website.
Agriculture Livestock & Ranching Veterinary Science & Services +2 more

OVW Fiscal Year 2026 Grants to Tribal Domestic Violence and Sexual Assault Coalitions Program

US DOJ: Office on Violence Against Women (OVW)
Federal Government
American Samoa, Guam +4 more
Up to US $342,358
The OVW Fiscal Year 2026 Grants to Tribal Domestic Violence and Sexual Assault Coalitions Program aims to support nonprofit, nongovernmental Tribal coalitions focused on domestic violence and sexual assault. Eligible applicants are recognized coalitions invited by OVW to apply. Each coalition will receive a base funding amount, with additional funds available for projects emphasizing sexual assault. This initiative seeks to strengthen resources for Indian Tribes and Native Hawaiian communities in addressing these critical issues.
Domestic Violence Sexual Assault / Abuse Human Trafficking +2 more

Flexible Funding Model - Advancing Domestic Mutual Reliance Through Strengthened Infrastructure Development and Maintenance for Manufactured Food Regulatory Programs

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
Puerto Rico, United States
Up to US $450,000
The Flexible Funding Model aims to enhance manufactured food regulatory infrastructure and foster mutual reliance in food safety. This initiative will support both new and existing programs in achieving compliance with the Manufactured Food Regulatory Program Standards (MFRPS). By promoting collaboration between manufactured food programs and the FDA, the initiative seeks to improve regulatory efficiency and effectiveness through shared data and coordinated enforcement efforts, ultimately ensuring high-quality food safety oversight.
Epidemiology & Public Health Community / Public Safety Food Safety +2 more

Project Rental Assistance Program of Section 811 Supportive Housing for Persons with Disabilities FY 2027

US HUD: Office of Housing-Federal Housing Commissioner
Federal Government
American Samoa, Guam +4 more
Up to US $7,094,211
The Project Rental Assistance Program of Section 811 supports innovative strategies to enhance access to affordable supportive housing for individuals with disabilities. This initiative fosters collaborations between State Housing Agencies and Health Services, aiming to increase the availability of supportive services. By empowering states to manage funds flexibly, the program addresses the critical shortage of integrated housing options, ensuring that eligible individuals receive necessary rental assistance effectively.
Disability Care & Services Community Development & Revitalization Real Estate & Housing +2 more

BJA FY26 State Criminal Alien Assistance Program (SCAAP)

US Department of Justice: Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Up to US $59,000,000
The BJA FY26 State Criminal Alien Assistance Program (SCAAP) aims to support eligible state and local governments by providing funding for costs incurred from the incarceration of undocumented criminal aliens. This initiative, led by the U.S. Department of Justice's Bureau of Justice Assistance, seeks to enhance public safety and uphold civil rights by addressing the challenges posed by undocumented criminal activity. Applications for funding are welcomed for the reporting period from July 1, 2024, to June 30, 2025.
Crime & Justice Community / Public Safety Police & Law Enforcement +2 more

FY2027 Grants to Highest State Courts to Improve Guardianship

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $200,000 - US $500,000
The FY2027 Grants to Highest State Courts aim to enhance guardianship systems by evaluating and improving the fairness and effectiveness of adult guardianship proceedings. This initiative, funded by the US HHS Administration for Community Living, seeks to implement necessary changes based on assessments, streamline filing processes, and better detect fraud, ultimately ensuring the safety and integrity of protected individuals.
Public Policy Senior Services Crime & Justice +1 more

National Center on Elder Abuse Resource Center (364112)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $856,250 - US $1,000,000
The National Center on Elder Abuse Resource Center aims to enhance the readiness of communities to combat elder abuse, neglect, and exploitation. By offering resources, training, and information, the center empowers professionals and the public to effectively prevent and respond to elder maltreatment, ensuring that older Americans can live with dignity and independence. This initiative, supported by the US HHS Administration for Community Living, emphasizes best practices and awareness to mitigate risks associated with elder fraud and scams.
Senior Services Human & Social Services Violence Prevention

Alzheimer's Disease Programs Initiative (ADPI) - States and Community Grants (364113)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $850,000 - US $1,000,000
The Alzheimer's Disease Programs Initiative (ADPI) offers State and Community Grants to enhance dementia-capable home and community-based service systems. Option A targets state agencies to develop sustainable HCBS systems, while Option B focuses on community-based organizations to fill service gaps for individuals with dementia. Both options aim to provide quality support for those living with dementia and their caregivers, fostering independence and safety in their communities.
Disability Care & Services Senior Services Neurological Diseases & Disorders +2 more

Elder Justice Innovation Grants FY2027

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $250,000 - US $500,000
The Elder Justice Innovation Grants for FY2027 aim to foster innovative solutions to elder justice issues, enhancing prevention and intervention strategies against elder abuse. Projects funded under this program will focus on developing and disseminating effective materials and programs, contributing to a robust evidence base in the field. This initiative by the US HHS: Administration for Community Living supports efforts that can be replicated across communities, promoting greater awareness and support for elder individuals.
Senior Services Human & Social Services Crime Victim Services +1 more

Alzheimer's Disease Programs Initiative (ADPI) - Dementia Capability in Indian Country (364115)

US HHS: Administration for Community Living (ACL)
Federal Government
United States
US $200,000 - US $300,000
The Alzheimer's Disease Programs Initiative (ADPI) aims to develop dementia-capable home and community-based service systems in Indian Country over a 36-month period. This initiative is designed for federally recognized tribes and organizations, promoting person-centered services that support individuals with dementia and their caregivers. Applicants can choose between two options: enhancing existing programs or establishing new dementia services, ensuring tribal leadership support and community engagement throughout the process.
Senior Services Neurological Diseases & Disorders Health Care Access & Delivery +2 more

Alheimer's Disease Programs Initiative (ADPI) - State Programs for Dementia Specific Respite (364114)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $4,000,000
The Alzheimer's Disease Programs Initiative (ADPI) aims to enhance support for unpaid family caregivers by expanding access to high-quality, dementia-specific respite services. This initiative, funded by the US HHS Administration for Community Living, focuses on reducing caregiver burden and delaying institutionalization for individuals with Alzheimer's disease or related dementias. By partnering with aging service providers, the program ensures caregivers receive necessary training and support, fostering a sustainable and responsive respite care system.
Senior Services Neurological Diseases & Disorders Family Services +2 more

No Wrong Door System Modernization: Connecting People to Services

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
Up to US $450,000
The No Wrong Door System Modernization funding aims to enhance access to services for older adults, people with disabilities, and caregivers. By modernizing NWD systems, states can improve service navigation through innovative strategies and technology, including AI. This initiative supports the Administration for Community Living's efforts to connect individuals to vital resources and build evidence on effective service access methods, ensuring a person-centered approach to community living.
Disability Care & Services Senior Services Health Care Access & Delivery +2 more

Evaluating Innovative Community Based Nutrition Models that Improve Health Outcomes for Older Adults in Senior Nutrition Programs

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $400,000 - US $439,520
This funding opportunity from the US HHS Administration for Community Living aims to support innovative community-based nutrition models that enhance health outcomes for older adults participating in Senior Nutrition Programs. Projects should focus on improving access to healthy foods, promoting healthy aging, and developing sustainable practices. By fostering community partnerships, the initiative seeks to replicate successful strategies across the Aging Network, ultimately improving the quality of life for seniors nationwide.
Disability Care & Services Senior Services Health Care Access & Delivery +2 more

Wine Marketing & Research Program Funding

Pennsylvania Department of Agriculture (PDA)
State/Local Government
Pennsylvania, United States
Unspecified amount

Pennsylvania Department of Agriculture

The Pennsylvania Department of Agriculture encourages, protects and promotes agriculture and related industries throughout the commonwealth while providing consumer protection through inspection services that impact the health and financial security of Pennsylvania's citizens.

Wine Marketing & Research Program

Introduction

The Pennsylvania Wine Marketing and Research Program Board (Board) annually, or more frequently as the availability of the fund permits, solicits applications for grants to conduct promotion, marketing and research projects to increase the quality, profitability, production and sale of wines, enhance the wine industry and benefit wine producers of this Commonwealth.

Research includes, but is not limited to:

  • Characterization of Accentuated Cut Edges (ACE)
  • Impacts of Spotted Lanternfly
  • Impact of Under-trellis Groundcover
  • Marketing Education and Professional Development for the PA Wine Industry
  • Pennsylvania Wine Land Statewide Marketing & Promotions
  • Spotted Wing Drosophila in Pennsylvania
  • Grapevine Leafroll Viruses
  • Tannin Extraction
Viticulture

Young Faculty Award (YFA) 2027

US DOD: Advanced Research Projects Agency
Federal Government
American Samoa, Guam +4 more
Up to US $500,000
The Young Faculty Award (YFA) 2027, sponsored by the Defense Advanced Research Projects Agency (DARPA), seeks to support emerging researchers in academia and non-profit research institutions. This program focuses on those without previous DARPA funding, aiming to align innovative research with national security needs. By providing significant funding, the YFA encourages the development of transformative capabilities for the Department of War, fostering the next generation of researchers dedicated to addressing critical national security challenges.
Engineering Education - Higher Education Science +1 more

FY 2027 - 2029 Broad Agency Announcement (BAA), Oceanic and Atmospheric Research (OAR)

National Oceanic and Atmospheric Administration (NOAA)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The FY 2027 - 2029 Broad Agency Announcement by NOAA seeks proposals for innovative research and projects through the Cooperative Ecosystem Studies Unit (CESU) program. This initiative connects federal agencies with diverse partners to address ecological challenges. It encourages efforts that enhance understanding of weather and environmental systems while ensuring the conservation of marine resources. Funding is contingent on appropriations, and applications are subject to an administrative review process.
Natural Resources Atmospheric Sciences Marine / Ocean Conservation +1 more

Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource-Constrained Settings--Implementation Science Network (PATC3H-IN)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The PATC3H-IN initiative focuses on improving HIV care for adolescents in resource-constrained settings while generating evidence that can enhance care models in the United States. By developing scalable care delivery strategies and studying their impact, the project aims to address barriers faced by young people, such as stigma and access issues. This research is crucial for achieving effective interventions, ultimately helping to reduce new HIV infections and improve health outcomes for adolescents both domestically and globally.
Epidemiology & Public Health Infectious & Parasitic Diseases HIV / AIDS +1 more

Discovery Gateway to Reproductive Health Innovation

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Discovery Gateway to Reproductive Health Innovation, established by the NICHD, aims to create a comprehensive knowledgebase to advance research on various reproductive health conditions like preeclampsia and infertility. This initiative will integrate clinical and multi-omic data to bridge critical knowledge gaps, enabling scientists to generate insights that could lead to new treatments and commercial products, thereby accelerating public-private partnerships and improving health outcomes.
Health & Medicine Genetics & Genomics Women's Health +1 more

Learning Disabilities Research Centers

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Learning Disabilities Research Centers program, supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, aims to enhance outcomes for children with learning disabilities such as dyslexia and dyscalculia. This initiative promotes collaborative research to improve SLD identification, understanding genetic factors, and testing innovative interventions. By fostering mentorship and collaboration, the program seeks to empower the next generation of researchers and enhance educational strategies for affected youth.
Disability Care & Services Genetics & Genomics Education - K through 12

CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect aims to address the critical public health issue of child sexual abuse (CSA). This initiative focuses on overcoming research challenges and enhancing data infrastructure to support innovative studies on CSA interventions and long-term health outcomes. By emphasizing prevention and translational research, the Centers seek to create measurable impacts on public health, thus contributing to the well-being of affected children and communities.
Epidemiology & Public Health Crime Victim Services Violence Prevention

Sawyer Foundation Grant

Sawyer Foundation Charitable Tr
Private
United States
US $1,000 - US $25,000

About Sawyer Foundation Charitable Trust Our mission is to support partner organizations that share the gift of clean drinking water to under-resourced communities. Our vision is to see all of our global community have access to clean, safe drinking water.Through our partnership with Sawyer, our nonprofit partners have access to affordable, point-of-use filters designed to provide reliable access to clean water for 10+ years.‍

Sawyer partners with over 140 non-profits in more than 100 countries, providing clean water to families lacking access to clean water – for long-term relief and in disaster situations.About Sawyer Foundation Grant We prioritize projects that demonstrate a strong commitment to:

  • Long-term sustainability in water filtration and access.
  • Training, follow-up, and local engagement that strengthen best practices.
  • Data collection or research that improves project implementation and outcomes.
  • Unique expertise, partnerships, or approaches that enhance global impact.
Sanitation & Clean Drinking Water

St. Clair County Grants for Nonprofits Highlights

Looking for St. Clair County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all St. Clair County grants recommended for your specific programs in Missouri.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Grant Funding Trends in Missouri

Average Grant Size

What's the typical amount funded for Missouri?

Grants are most commonly $101,542.

$101,542

Total Number of Grants

What's the total number of grants in St. Clair County Grants for Nonprofits year over year?

In 2024, funders in Missouri awarded a total of 44,064 grants.

2022 39,922

2023 39,688

2024 44,064

Top Grant Focus Areas

Among all the St. Clair County Grants for Nonprofits given out in Missouri, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for St. Clair County Grants for Nonprofits changing over time?

Funding has increased by -15.61%.

2022 $4,698,402,122

2023 $5,287,874,816
12.55%

2024 $4,462,369,205
-15.61%

Missouri Counties That Receive the Most Funding

How does grant funding vary by county?

St Louis County, Jackson County, and St Louis City receive the most funding.

County Total Grant Funding in 2024
St Louis County $2,185,711,864
Jackson County $1,234,679,326
St Louis City $1,054,441,922
Greene County $223,079,775
Clay County $178,423,081

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