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Best St. Clair County Grants for Nonprofits in Missouri

Looking for grants for 501(c)(3) nonprofit organizations working in St. Clair County, Missouri? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

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$3.38B

Total funding

$5K

Median grant

9,000+ grants
$3.38B total
$5K median

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9,182 Results based on applied filters

Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed) (363858)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to uncover biological processes and disease mechanisms influenced by somatic mutations. Since its inception in 2023, it has produced valuable multi-omic datasets from diverse human tissues. The upcoming Stage 2 Genome Characterization Centers will focus on understanding the impact of these mutations in both healthy and clinically significant samples, enhancing our knowledge of somatic mosaicism's role in human health and disease.
Biology Genetics & Genomics

A Year of STEM

American Library Association (ALA)
Association/Society
United States
US $5,000

In collaboration with Cummins Inc., the American Library Association (ALA) invites applications from U.S. public libraries to participate in A Year of STEM, 12 months of curated STEM programming to foster curiosity and STEM-mindedness in early childhood learners across the country. 

Twenty-five libraries will be chosen to participate in A Year of STEM, receiving professional development to prepare them for the project, copies of a newly created A Year of STEM programming guide developed by librarian advisors, a $5,000 programming stipend, four STEM kits (to be delivered quarterly), and support from ALA’s Public Programs Office staff throughout the project implementation period.

STEM / STEAM Education Library Services

The Penn Play Award

LR Penn
Corporate
United States
Unspecified amount

LRPenn.com is home to the novels, plays, and screenplays of LR Penn. His books specializes in Thrillers, Dramatic Comedies, and Film Noir. Thanks to the generous support of our sponsors, grants may be available to nonprofit theater companies in the United States with 501(c)(3) status that are staging productions of plays written by LR Penn.  

Theater

Technology Development Program

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Technology Development Program by the US Department of Health & Human Services focuses on advancing technology research from proof-of-concept to prototype development. This initiative prioritizes innovation to enhance biomedical research, emphasizing technological improvements without the inclusion of biological hypothesis testing. Eligible projects should aim at significant technological advancements to maximize impact in the field.
Engineering Science Emerging Technology Development

Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $190,000 - US $500,000
The R21 Clinical Trial Not Allowed funding opportunity invites innovative research to develop and enhance research models and biological materials vital for studying human health and diseases. It emphasizes the need for new approach methodologies (NAMs) to improve the identification of confounding factors in biomedical research. Projects should have broad applicability across multiple NIH Institutes, focusing on various body systems and disease categories, ensuring relevance to a wide range of health issues.
Biology Health & Medicine Emerging Technology Development

FY2026/2027 Community Compass Technical Assistance and Capacity Building Program Notice of Funding Opportunity

US HUD: Office of Community Planning and Development (CPD)
Federal Government
American Samoa, Guam +4 more
US $250,000 - US $35,000,000
The FY2026/2027 Community Compass Technical Assistance and Capacity Building Program provides competitive grants to organizations capable of delivering technical assistance (TA) to communities served by HUD. With up to $86 million available, recipients are expected to develop educational tools, collaborate with HUD, and show a strong record of performance. This initiative aims to enhance community systems, support high-priority projects, and ensure effective training delivery, fostering impactful outcomes across the nation.
Community Services Nonprofit Growth & Development

Landmarks of History and Culture and Summer Institutes

National Endowment for the Humanities
Federal Government
American Samoa, Guam +4 more
Up to US $460,000
The National Endowment for the Humanities invites K-12 teachers and higher education faculty to apply for the Landmarks of American History and Culture and Summer Institutes program. This initiative aims to enhance humanities education through professional development opportunities, fostering a deeper understanding of historical and cultural landmarks. Participants will engage in enriching experiences designed to improve teaching practices and student learning outcomes in the humanities.
Humanities & Social Science Community Culture & Heritage Teacher Development & Training

Connecting All Missourians

Missouri Department of Economic Development
State/Local Government
Missouri
Up to US $5,000,000

About

The Missouri Department of Economic Development (DED) works to create an environment that encourages economic growth by supporting Missouri’s businesses and diverse industries, strengthening our communities, developing a talented and skilled workforce, and maintaining a high quality of life. As one team built around the customer and driven by data, DED aspires to be the best economic development department in the Midwest. DED is helping create opportunities for Missourians to prosper through the various initiatives of its six divisions: Administration, Business and Community Solutions, Missouri One Start, Regional Engagement, Strategy and Performance, and Tourism.

The Office of Broadband Development (OBD) is focused on addressing broadband availability and non-infrastructure barriers to full participation in the digital economy in Missouri by working with providers, communities, and stakeholders to expand and accelerate broadband deployment across the state. There is critical need for broadband availability in Missouri. The Office of Broadband Development (OBD) is focused on addressing this issue by in five core areas including

  • Increase broadband data collection and utilization
  • Accelerate deployment of broadband infrastructure
  • Leverage partnerships to accelerate broadband efforts.
  • Increase broadband adoption & awareness
  • Promote efficiencies in broadband development

Connecting All Missourians (BEAD)

The Missouri Broadband Equity, Access, and Deployment (BEAD) Program aids entities to deploy broadband service to unserved and underserved areas of the state, and to Community Anchor Institutions (CAIs) through competitive grants.

The BEAD Program is funded by the Infrastructure Investment and Jobs Act of 2021, also known as the Bipartisan Infrastructure Law, and is administered by the U.S. Department of Commerce’s National Telecommunications and Information Administration (NTIA).

Data Science & Digital Information Systems Technology Access & Digital Literacy

Ski Racing Safety Equipment Grant

Kelly S Brush Foundation
Private
United States
Unspecified amount

KBF Ski Racing Safety

The KBF helps alpine ski clubs around the country purchase safety equipment like netting and padding, and also contributes to venue improvement initiatives. Funding requests are reviewed through an annual grant cycle with an application process. Over the past decade, the Kelly Brush Foundation has purchased thousands of rolls of b-netting, supported trail widening projects, and helped with the purchase of other safety equipment. 

KBF Ski Racing Safety Equipment Grants are all matching grants–meaning that any grant awarded by the Kelly Brush Foundation will need to be matched by the ski club. We expect that clubs will join us in making safety a priority by fundraising or finding room in their budget for safety.

Snow Sports

Fiscal Year (FY) 2027 Department of War (DoW) Multidisciplinary Research Program of the University Research Initiative (MURI)

US DOD: Dept. of the Air Force, Materiel Command
Federal Government
American Samoa, Guam +4 more
Up to US $15,000,000
The FY 2027 Department of War Multidisciplinary Research Program of the University Research Initiative (MURI) aims to fund U.S. academic teams conducting innovative research to tackle complex challenges for the Department of War. Established in 1985, MURI promotes collaboration among diverse scientific disciplines, enhancing the defense workforce and addressing critical areas of interest through multidisciplinary research efforts at U.S. universities.
Engineering Education - Higher Education Science +1 more

Fiscal Year (FY) 2027 Department of War (DoW) Multidisciplinary Research Program of the University Research Initiative (MURI) (363905)

US DOD: U.S. Army Materiel Command
Federal Government
American Samoa, Guam +4 more
Up to US $7,500,000
The FY 2027 Department of War Multidisciplinary Research Program (MURI) funds U.S. academic teams engaged in innovative basic research addressing future defense challenges. Established in 1985, MURI emphasizes collaboration across multiple scientific disciplines to tackle complex, DoW-relevant issues. By fostering partnerships among faculty, postdoctoral researchers, and students, the program aims to advance the U.S. defense industrial base and nurture a skilled scientific workforce, contributing to significant breakthroughs in military technology and economic growth.
Engineering Science Workforce Preparation & Job Readiness +1 more

Fiscal Year (FY) 2027 Department of War Multidisciplinary Research Program of the University Research Initiative (MURI)

US DOD: Dept. of the Navy, Office of the Chief of Naval Research
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Fiscal Year 2027 Department of War Multidisciplinary Research Program aims to fund innovative research teams from U.S. universities. Established in 1985, this initiative addresses complex challenges faced by the Department of War, fostering collaboration across various scientific disciplines. By integrating world-class faculty and graduate students, the program seeks to cultivate a skilled workforce poised to enhance the U.S. defense capabilities and contribute to the advancement of the defense industrial base.
Engineering Education - Higher Education Science +1 more

State Biomonitoring Cooperative Agreement

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $750,000 - US $900,000
The State Biomonitoring Cooperative Agreement aims to enhance public health laboratories' ability to conduct biomonitoring and assess human exposure to environmental chemicals. This funding opportunity emphasizes community investigations, state-level studies, and emerging chemicals not covered in the National Exposure Report. By improving laboratory capacity and fostering collaboration, the initiative seeks to identify harmful exposures and evaluate intervention effectiveness over a three-year period.
Epidemiology & Public Health Environmental Contamination & Pollution Environmental Health

Research to Improve Rigor, Replicability, and Reproducibility in Biomedical and Behavioral Sciences

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Neurological Disorders and Stroke (NINDS) is collaborating with other NIH institutes to enhance rigor and replicability in biomedical and behavioral research. This initiative aims to support projects focused on assessing the impact of improved research practices, developing frameworks for study selection, and measuring the generalizability of findings. Currently, applications are not being solicited, allowing researchers time to prepare collaborative proposals.
Neurological Diseases & Disorders

John H. Prescott Marine Mammal Rescue Assistance Grant (363929)

DOC NOAA - ERA Production
Federal Government
American Samoa, Guam +4 more
Up to US $150,000
The John H. Prescott Marine Mammal Rescue Assistance Grant supports the recovery and care of sick or injured marine mammals through federal assistance to the U.S. National Marine Mammal Stranding and Entanglement Response Networks. Eligible applicants must provide a Prescott Letter of Eligibility, confirming their participation in the network. This program aims to enhance marine mammal health monitoring and response capabilities across the country, ensuring timely and effective interventions for stranded marine life.
Wildlife Management Marine / Ocean Conservation Environmental Health

R3PEATS Multi-Team Triangulation: Collaborative Cross-Method Approaches to Scientific Discovery (RM1)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The R3PEATS Multi-Team Triangulation initiative supports collaborative research teams to explore a central biomedical question using diverse methods and model systems. It emphasizes the importance of identifying biological variability and ensuring the robustness of findings through replication strategies. This program is part of the NIH Common Fund's Rigor, Replicability, & Reproducibility to Promote Excellence in Science, aiming to enhance the accuracy and translation of scientific discoveries.
Science

R3PEATS Rigor Scholar Cohort Awards (K12)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The R3PEATS Rigor Scholar Cohort Awards (K12) are designed to empower early-career researchers by enhancing their skills in rigorous scientific practices. This initiative promotes collaboration across institutions to develop best practices in research methodologies, including preregistration and randomization. Participants will gain essential training to ensure excellence and transparency in scientific research, aligning with the NIH's commitment to improve replicability and reproducibility in the field.
Education - Higher Education Medical Education & Professional Training

Nehemiah Atkinson Humanitarian Grant

Dennis Van der Meer Tennis Foundation
Association/Society
United States
Up to US $5,000

Dennis Van der Meer Tennis Foundation

A 2021 International Tennis Hall of Famer, Dennis was the founder of the Professional Tennis Registry Foundation (PTR Foundation), now called Dennis Van der Meer Tennis Foundation, Professional Tennis Registry (PTR), and the Van Der Meer Tennis University.

Dennis Van der Meer Tennis Foundation is a nonprofit organization exempt from federal income tax under Section 501(c)(3) of the Internal Revenue Code. The Dennis Van der Meer Tennis Foundation provides support to deserving individuals and organizations globally. The foundation is also focused on bringing tennis within reach to countless people worldwide.

Nehemiah Atkinson Humanitarian Grant

This grant reflects the Foundation’s dedication to giving and serving others. It is awarded to individuals who have shown an extraordinary commitment to enhancing the lives of those around them.

The Foundation supports projects that promote and preserve the legacy, vision, and spirit of our founder, Dennis Van der Meer. We will only consider funding for educational, life enrichment, mentoring, and tennis programs.

Academic Success & Enrichment Tutoring & Mentoring Tennis

Natural Disaster Relief Request

Dennis Van der Meer Tennis Foundation
Association/Society
United States
Unspecified amount

Dennis Van der Meer Tennis Foundation

A 2021 International Tennis Hall of Famer, Dennis was the founder of the Professional Tennis Registry Foundation (PTR Foundation), now called Dennis Van der Meer Tennis Foundation, Professional Tennis Registry (PTR), and the Van Der Meer Tennis University.

Dennis Van der Meer Tennis Foundation is a nonprofit organization exempt from federal income tax under Section 501(c)(3) of the Internal Revenue Code. The Dennis Van der Meer Tennis Foundation provides support to deserving individuals and organizations globally. The foundation is also focused on bringing tennis within reach to countless people worldwide.

Natural Disaster Relief Request

The Foundation stands with tennis professionals affected by the devastating hurricanes and other natural disasters in the U.S. in 2024. If you are a tennis pro facing hardships due to recent storms, we are here to help you get back on your feet. Our assistance program provides relief and resources specifically for tennis professionals affected by these events. Together, we can rebuild stronger.

Tennis Disaster Relief / Humanitarian Aid

Patient Travel Grant Program

Mesothelioma Applied Research Foundation Inc
Private
United States
Up to US $6,000

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

  • funding research to improve treatment options;
  • providing treatment support and education for patients and their families;
  • and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Patient Travel Grant Program

A mesothelioma diagnosis and treatment often require the patient and their family to incur numerous expenses as part of their treatment. Travel to treatment, alone, can cause a significant financial burden on the patient, which might even cause the patient to not seek treatment away from home, even it’s their best option. To ensure that all patients have the ability to seek specialized help and treatments, the Mesothelioma Applied Research Foundation administers its Travel Grant Program.

The Meso Foundation’s Patient Travel Grant Program, founded by Mary and Bob Cosentino, provides travel grants to patients and one caregiver traveling for an initial consult and/or for clinical trial treatments.

  • The type of eligible travel must fall into at least one of these two categories:
    • One trip for one initial consultation with a mesothelioma specialist.
    • Multiple trips to participate in an interventional clinical trial (found on clinicaltrials.gov).
Cancer / Oncology Patient Care & Services Adventure Travel & Expeditions

Bret A. Rosenthal Patient Assistance Fund

Mesothelioma Applied Research Foundation Inc
Private
United States
Up to US $2,000

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

  • funding research to improve treatment options;
  • providing treatment support and education for patients and their families;
  • and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Bret A. Rosenthal Patient Assistance Fund

Patients diagnosed with cancer at a younger age often face greater financial burdens. This is a time in a patient’s life when they are raising a family, starting a career, or have not accumulated savings. For patients 49 and under, the Foundation administers the Bret A. Rosenthal Patient Assistance Fund grant program. This program is made possible by the generosity of the Rosenthal family.

Cancer / Oncology Patient Care & Services

Utilizing the Full Power of Empire AI Request for Applications

Simons Foundation Inc.
Private
United States
Unspecified amount

Utilizing the Full Power of Empire AI Request for Applications

The Simons Foundation (SF) intends to support cutting-edge mathematics and basic science research, drawing on the advanced computational power of the Empire AI.

Toward this goal, SF plans to initiate a new program to fund six to 12 proposals through a competitive open call to the Empire AI research community.

A successful proposal will outline an ambitious two-year research program in one of the following fields, or at their intersections: computational astrophysics and physics, computational biology, mathematics, neuroscience and computational physical chemistry. Each proposal will necessarily rely on the development and utilization of foundational machine learning models, aimed at solving problems of fundamental importance in the above-listed disciplines.

Computational biophysics, neuroscience, ecology and evolution, plant biology, optimal transport, multiscale physics, fluid dynamics and numerical general relativity are representative examples of fields that could use multinode clusters of GPUs of Empire AI, which is a requirement of the program. All submitted proposals should detail how their work will use multinode clusters of GPUs in Empire AI. Proposals focused on data curation and creation of datasets can be considered in exceptional cases, as long as the attained data will be used by the proposers for solving scientific problems as part of the same proposal.

The program’s total budget is expected to be $6 million USD over a two-year period.

Funding

Award Amount: There is no maximum budget total for an individual award. The total amount requested should reflect the proposed research. All award amounts are inclusive of indirect costs (see our grant policies). Please note that we anticipate funding six to 12 applications. The total program’s budget of $6 million USD over two years will be spread across all awards.

Award Duration: June 1, 2027, through May 31, 2029.

Number of Awards: We expect to select six to 12 applications for funding.

Artificial Intelligence (AI)

Affordable Rural Cooperative (ARC) Energy Program

Rural Utilities Service
Federal Government
American Samoa, Guam +4 more
US $100,000 - US $20,000,000
The Affordable Rural Cooperative (ARC) Energy Program, initiated by the Rural Utilities Service (RUS), aims to enhance rural electric systems through substantial funding of approximately $175 million. This initiative focuses on increasing emission-free nuclear power and improving transmission infrastructure efficiency, promoting long-term reliability and affordability. Eligible entities include electric cooperatives serving rural areas and their subsidiaries. The program aligns with the Inflation Reduction Act (IRA) to achieve significant reductions in greenhouse gas emissions, thus fostering a sustainable energy future.
Energy Rural Development Public Infrastructure +1 more

Greenawalt Foundation Community Grant

Greenawalt Foundation
Private
United States
Unspecified amount

Greenawalt Foundation

Our Mission

The Greenawalt Foundation advances opportunities in the skilled trades through funding for accredited pre-apprenticeship and apprenticeship programs, workforce training initiatives, and youth career exploration experiences. These programs promote technical readiness and connect STEM education to modern trades careers, building a stronger, more sustainable workforce. Foundation support focuses on expanding access and creating equitable pathways to prosperity for individuals pursuing skilled trades careers. Through these efforts, the Foundation helps develop the next generation of skilled professionals who will shape the future of our communities.

Community Grant

The Greenawalt Foundation extends its commitment to opportunity and well-being through community grants that support nonprofit organizations serving women, children, and vulnerable populations. These grants focus on programs that promote safety, stability, and self-sufficiency, including initiatives supporting domestic violence recovery, foster care, the working poor, and animal welfare. Foundation support strengthens the social fabric of communities and expands access to essential resources for those in need. Through these efforts, the Foundation helps build stronger, more compassionate communities where individuals and families can thrive.

Areas of Support

We focus our community grants on initiatives that align with our mission of compassion, opportunity, and empowerment. Areas of support may include:

  • Domestic violence prevention and survivor support
  • Programs for women and children
  • Family assistance and poverty relief initiatives
  • Foster care, youth development, and educational support
  • Animal welfare and community-based rescue programs
Women & Girl Services Family Services Child Welfare Services +6 more

Greenawalt Foundation Skilled Trades Program Grant

Greenawalt Foundation
Private
United States
Unspecified amount

Greenawalt Foundation

Building Stronger Communities

At The Greenawalt Foundation, we believe that opportunity is the foundation of prosperity. By supporting organizations that educate, train, and empower people in the trades, we’re helping to build a stronger, more sustainable future for all.

Skilled Trades Grant Opportunities

The Greenawalt Foundation advances opportunities in the skilled trades through funding for accredited pre-apprenticeship and apprenticeship programs, workforce training initiatives, and youth career exploration experiences. These programs promote technical readiness and connect STEM education to modern trades careers, building a stronger, more sustainable workforce. Foundation support focuses on expanding access and creating equitable pathways to prosperity for individuals pursuing skilled trades careers. Through these efforts, the Foundation helps develop the next generation of skilled professionals who will shape the future of our communities.

Eligible Grant Categories

  • Skilled Trades Training Support
  • Pre-Apprenticeship or Apprenticeship Programs
  • Youth Career Exploration Camps
Vocational & Trade Education Apprenticeship & Internship Programs Youth Development & Leadership +1 more

St. Clair County Grants for Nonprofits Highlights

Looking for St. Clair County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all St. Clair County grants recommended for your specific programs in Missouri.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Grant Funding Trends in Missouri

Average Grant Size

What's the typical amount funded for Missouri?

Grants are most commonly $101,542.

$101,542

Total Number of Grants

What's the total number of grants in St. Clair County Grants for Nonprofits year over year?

In 2024, funders in Missouri awarded a total of 44,064 grants.

2022 39,922

2023 39,688

2024 44,064

Top Grant Focus Areas

Among all the St. Clair County Grants for Nonprofits given out in Missouri, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for St. Clair County Grants for Nonprofits changing over time?

Funding has increased by -15.61%.

2022 $4,698,402,122

2023 $5,287,874,816
12.55%

2024 $4,462,369,205
-15.61%

Missouri Counties That Receive the Most Funding

How does grant funding vary by county?

St Louis County, Jackson County, and St Louis City receive the most funding.

County Total Grant Funding in 2024
St Louis County $2,185,711,864
Jackson County $1,234,679,326
St Louis City $1,054,441,922
Greene County $223,079,775
Clay County $178,423,081

Related Grants in Missouri

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