Best Unrestricted Grants for Nonprofits in Texas

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing research on immune tolerance through its Collaborative Network. This program aims to clarify the mechanisms of immune tolerance and develop interventions for related diseases, including transplant rejection and autoimmune disorders. Key objectives include conducting clinical trials on tolerogenic strategies and refining immune assays. This initiative is supported by regulations under the Public Health Service Act, ensuring a structured approach to improving patient outcomes.

The Translational Transplantation Tolerance Cooperative Study Group, supported by the National Institute of Allergy and Infectious Diseases, aims to advance transplant tolerance strategies that promote long-term graft survival without lifelong immunosuppression. This initiative focuses on developing, optimizing, and evaluating methods to induce immune tolerance in allogeneic transplants through collaborative efforts across multiple centers, utilizing translationally relevant models to ensure effective outcomes.

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Arthur and Lois Jean Stuenkel Scholarship

This scholarship provides financial support to a graduating senior seeking to further his or her education beyond high school. The recipient must be in the top 25% of his or her graduating class and demonstrate financial need. This scholarship is for a worthy student who has participated in sports or extracurricular activities. 

The scholarship is renewable.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

The National Scleroderma Foundation's New Investigator Grant aims to support emerging researchers dedicated to scleroderma studies. This three-year grant, totaling $200,000, encourages applicants with doctoral degrees and postdoctoral experience. Eligible candidates are invited to submit proposals that may lead to further research funding. The grant emphasizes innovative research approaches while providing essential financial support for early-career investigators. Note that the grant does not cover certain costs, ensuring focused investment in research advancement.

The Parkinson's Foundation offers Community Grants to support impactful programs for people with Parkinson's disease across the U.S. With over $5 million awarded in the last three years, the Foundation aims to enhance health, wellness, and education. Eligible applicants include local non-profits and healthcare facilities focusing on mental health, care partner support, and exercise programs tailored for PD. This initiative promotes diversity, equity, and inclusion in service delivery.

GBA1 Parkinson's Disease Research Catalyst Program

The GBA1-PD Research Catalyst Program seeks to build a deeper, globally integrated understanding of GBA1-associated Parkinson’s disease by aligning efforts across geographies and maximizing the value of shared datasets and research assets. Funding will support hypothesis- driven projects with an emphasis on integrative, cross-cohort analyses and the systematic characterization and standardization of models to enable broad use by the research community.

Funding

Duration: 12 to 24 months

Award Amount: Up to $300,000. Requested support should be commensurate with work proposed.

These budgets include direct and indirect costs. For academic and for-profit institutions, no more than 15% or 10%, respectively, may go to indirect costs. 

Accelerating the Development of Combined CGM–Pump Devices

A combined continuous glucose monitor (CGM) and insulin pump device represents an innovative approach to simplifying diabetes management by integrating two essential technologies into a single device. This approach has the potential to improve quality of life for people with type 1 diabetes (T1D) by reducing the burden associated with wearing and managing multiple devices.

Despite this promise, the development of combined CGM–pump devices presents technical and commercialization challenges. These include the need for further advances in device compatibility and lifespan, system reliability, and scalable manufacturing, while maintaining affordability and broadaccessibility. In addition, a potential insulin dilution effect may require adjustment of the CGM algorithm.

Breakthrough T1D invites applications for research and development projects that address key technical, clinical, and translational challenges related to combined CGM–pump devices, with the goal of accelerating their development and improving outcomes for people living with T1D.

In response to this announcement, applications may request up to a total of $900,000 USD for up to three years. 

AD Osherman Scholarship

Benefiting first-generation students in Texas.

Funding

Four (4) scholarships awarded out:

• $3,500 for students pursuing a 4-year degree
• $2,500 for students pursuing a 2-year degree

One-time award. Previous recipients may reapply as long as all eligibility requirements are met.

Camillo Family Scholarship 

Benefiting dependents of Camillo Properties, Camcorp Entities, or LCI Services employees.

The Camillo Family Scholarship was created to provide dependents of employees of Camillo Companies (Camillo Holdings, LCI Services, Legend Homes, Millmark Capital, and SimplyHome) with scholarships to further their education.

This is a renewable scholarship, meaning recipients can renew the award and claim up to 4 years of funding if they meet the GPA and enrollment requirements and complete the renewal application for each academic year they plan to be enrolled.

Multiple scholarships awarded for the 2026-27 academic year. Award amount varies by college/degree type:

• 4-Year College/University - The scholarship is comprised of up to four annual awards of $5,000, for a total award of up to $20,000. The four annual awards may be received over a period of up to five years.
• 2-Year College/Trade School - The scholarship award is comprised of up to two annual awards of $2,500, for a total award of up to $5,000. The two annual awards may be received over a period of up to three years.

What can the scholarship be used for?

The scholarship will be mailed directly to the student's college to be used towards tuition, required academic fees, and/or book expenses. 

Scholarship funding cannot be distributed directly to the student. 

Joseph P. Siegferth Sr. and Family Fund

Established by Joseph P. Siegferth Jr. in memory of his father to provide scholarships to graduating high school seniors majoring in elementary education, K-12 physical education, sports management or logistics.

Amount:

• $1,000

Number of awards:

• Varies

Renewal:

• No

The Russell Hill Rogers Fund for the Arts Grant supports the creative and performing arts in the San Antonio area, honoring Rogers' legacy. Grants are focused on specific projects, performances, and productions aligned with the arts, including music, literature, and visual arts. Only 501(c)(3) organizations primarily serving the San Antonio metropolitan area are eligible. The Fund emphasizes thoughtful consideration of funding requests while adhering to its budget limitations, ensuring a lasting impact on the local arts community.

Jazz Road Tours Grants provide financial support for emerging and mid-career jazz artists to develop tours across communities in the U.S. Grants up to $15,000 facilitate three-to-six site tours, focusing on underserved areas. This program, funded by the Doris Duke Charitable Foundation and the Mellon Foundation, aims to enhance artists' income opportunities while promoting jazz in diverse venues. Applications are encouraged from individual artists, with deadlines throughout 2024 and 2025 for various tour periods.

The Simply Organic Giving Fund Grant aims to combat food insecurity in the U.S. and Canada by providing access to nutrient-dense organic food for those in need. Since its inception, the fund has supported various initiatives, including training centers for organic agriculture and community food projects. With a focus on sustainable practices, the grant program seeks to empower communities and improve food access for vulnerable populations, ensuring that healthy, organic options are available to all.

MetroWest Health Foundation

The MetroWest Health Foundation is an independent health philanthropy whose mission is to improve the health status of the community, its individuals, and families through informed and innovative leadership.

The foundation meets the health needs of our region's residents by supporting community-based and community driven programs. We encourage and foster leadership on critical health issues. We are a grantmaker, convener and facilitator, working to provide resources, information, ideas and advocacy for community change. Since its inception in 1999, the foundation has provided more than $50 million in financial support that helps residents and their families lead healthier lives.

MetroWest Health Foundation: Nursing Scholarship

Scholarships are provided to students who are residents of one of the 25 towns in our MetroWest service area. Students must be accepted into an eligible nursing program at an accredited academic institution.

Tuition scholarships are awarded for a maximum of up to $4,000 per academic year. Students can receive a maximum of 4 scholarships. Applicants are eligible to reapply on an annual basis.

The REACHing Communities (REACH) Consortium (U01) Clinical Trials Optional grant aims to advance health equity among racial and ethnic minorities through cooperative agreements. It focuses on research, outreach, and mentoring diverse students and researchers. Although the grant information has not been updated in over six months, it remains under observation for potential updates. The initiative is part of the FDA Office of Minority Health and Health Equity's commitment to improving minority health.

The REI Cooperative Action Fund Grant supports U.S.-based organizations that align with its mission to serve communities, particularly those connecting historically excluded individuals to the outdoors. The fund prioritizes initiatives that promote equitable access to outdoor spaces, enhance community health through nature, and create inclusive outdoor experiences. Eligible applicants must have a 501(c)(3) status and demonstrate a commitment to these values. However, individuals and certain organizations are not eligible for funding.

The AAD Shade Structure Grant Program provides funding up to $8,000 for non-profit organizations and public schools to install shade structures, promoting sun safety for children and teenagers. Applicants must demonstrate a commitment to sun safety, including a year-long awareness program, and submit a letter of recommendation from an AAD dermatologist. The program aims to enhance outdoor safety, supported by donations from members and organizations.

Joseph L. Ruby Student Scholarship Fund

Established in honor of former Direction Home Akron Canton President and CEO Joseph Ruby to award scholarships to students enrolled in gerontology, social work, nursing or a related health care program.

Amount:

• $5,000 or more

Number of awards:

• Varies

Renewal:

• Must reapply annually by submission of a new application.

The Pastures for Upland Birds Grant Program (PUB) supports private landowners in restoring native grass and forb vegetation on pastures dominated by exotic grasses. This initiative enhances grassland bird conservation, increases biodiversity, and provides crucial habitats for various bird populations. With funding from the Texas Parks and Wildlife Department, landowners receive technical guidance, herbicides, and native seed mixtures to implement effective management practices, ensuring sustainable livestock forage and ecological restoration in east-central Texas.

The Health Equity Innovation Award (U01) aims to support innovative research that enhances minority health and health equity. Key areas include promoting diversity in clinical trials, improving data visibility for underrepresented groups, and amplifying diverse patient perspectives. This initiative, funded by the US Department of Health and Human Services' FDA, seeks to ensure equitable health outcomes and address unmet needs within varied populations.

The AISES National Conference Travel Scholarship provides financial support for full-time students in STEM fields to attend the annual conference. Covering registration, airfare, and lodging, recipients must commit to attending all events and uphold the AISES Code of Conduct. Selection is based on the quality of essays, letters of recommendation, and academic performance. Announcements for awarded scholarships will be made in late August/early September 2025, facilitating networking and professional development for indigenous students.

Judith A. Resnik Memorial Fund and Judith A. Resnik Scholarship Fund of the Women's Network

Established in memory of Judith A. Resnik to award scholarships to seniors at Akron Public Schools who plan to pursue a career in science, technology, engineering, mathematics (STEM) or allied fields.

Amount:

• $1,000

Number of awards:

• 2

Renewal:

• Renewable for three additional years. Must maintain a minimum 2.5 GPA, full-time student status, and continue to major in science, technology, engineering, mathematics (STEM) or allied fields.

The Ittleson Foundation Environmental Program Grants support innovative projects that enhance environmental activism through education and grassroots efforts. In 2025, grants will focus on initiatives that strengthen environmental movements and engage new constituencies, particularly in environmental equity. The Foundation has provided resources since 1932 to improve public policy and community welfare, alternating its grantmaking focus annually between mental health and environmental initiatives.

Communities Foundation of Oklahoma

The Communities Foundation of Oklahoma stems from the vision of Tom McCasland Jr., and Gene Rainbolt. Two decades ago, these gentlemen formed a shared vision to create a single philanthropic organization to serve the charitable needs to rural communities across the great state of Oklahoma. Today, CFO has grown to assist hundreds of efforts in more than 45 counties.

At the Communities Foundation of Oklahoma, we believe in the power of connecting individuals, nonprofits, businesses, and communities. Because when passionate people are paired with purposes they care about most, the communities in Oklahoma will prosper. We aim to strategically distribute charitable funds, maximize our donors’ impact, and strengthen their communities through stewardship and commitment to sustainable change.

2027 Cherokee Nation Nursing Scholarship

The purpose of this scholarship is to provide financial assistance to Cherokee Nation students pursuing college degrees in nursing no matter the residence of the student. You must currently be enrolled in a bachelor's or master's program (no prerequisites). Payback period required upon program completion, in the Cherokee Nation Reservation. This application is for members of the Cherokee Nation ONLY.

The Athene Charitable Foundation focuses on corporate social responsibility through community involvement, aiming to create positive social impacts in education, health, human services, and the environment. Their initiatives include partnerships, employee volunteering, and donations aligned with their mission. They prioritize organizations that support diversity and inclusion while ensuring compliance with their non-discrimination policies. Eligible entities must be registered 501(c)(3) organizations or equivalent, enhancing community welfare where Athene employees live and work.

The Majestic Realty Foundation, established in 2002, champions active philanthropy by addressing critical community needs across eight regions in the U.S. Focused on youth, education, health, family support, and violence prevention, the Foundation fosters sustainable community development. Through initiatives like the Los Angeles Youth Leadership Council, it empowers young leaders while encouraging employee volunteerism. By partnering with local nonprofits, the Foundation strengthens community ties, ensuring lasting impact against challenges such as homelessness and youth violence.