Best Unrestricted Grants for Nonprofits

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Eosinophilic esophagitis

Help with healthcare costs for eosinophilic esophagitis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Eosinophilic Esophagitis (EoE) is a disorder of the esophagus and is increasingly recognized as a major cause of swallowing difficulties in children and adults. It is a chronic disease of the immune system and can be triggered by a food allergy, acid reflux, or an airborne allergy. An allergic trigger causes the immune system to overact which causes many white blood cells, or eosinophils, to collect in the esophagus. This causes the esophagus to become inflamed and not contract properly. The esophagus can also narrow and develop rings or abscesses. This condition can become worse over time.

The ATV/UTV Safety Enhancement Funding, provided by the Wisconsin Department of Natural Resources, supports nonprofit organizations in promoting safe and responsible use of all-terrain and utility-terrain vehicles. This biennial funding, with a minimum of $297,000, is aimed at enhancing education and safety measures related to ATV/UTV operations. Eligible organizations must focus on environmental stewardship, comply with relevant laws, and actively support ATV/UTV clubs, thereby fostering community involvement and responsible recreation.

Boone County Community Foundation

The Boone County Community Foundation was formed in 2005 to coordinate and provide philanthropic support for community betterment projects in Boone County. The foundation is made up of community minded individuals who have the ability to assess community needs, implement asset development, evaluate area grant applications, encourage partnerships and initiate activities to enhance Boone County.

Mission: The Boone County Community Foundation is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our communities that lasts forever.

Grants

Each year the foundation makes grant awards to worthwhile projects located in the county that are identified through a community grants application process. Our foundation’s areas of emphasis include: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.

Three types of grants based on grant amount: Simple Grant; Standard Grant and Impact Grant

Impact Grant

$15,001 and up

Boone County Community Foundation

The Boone County Community Foundation was formed in 2005 to coordinate and provide philanthropic support for community betterment projects in Boone County. The foundation is made up of community minded individuals who have the ability to assess community needs, implement asset development, evaluate area grant applications, encourage partnerships and initiate activities to enhance Boone County.

Mission: The Boone County Community Foundation is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our communities that lasts forever.

Grants

Each year the foundation makes grant awards to worthwhile projects located in the county that are identified through a community grants application process. Our foundation’s areas of emphasis include: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.

Three types of grants based on grant amount: Simple Grant; Standard Grant and Impact Grant

Standard Grant

$3,001 - $15,000

Boone County Community Foundation

The Boone County Community Foundation was formed in 2005 to coordinate and provide philanthropic support for community betterment projects in Boone County. The foundation is made up of community minded individuals who have the ability to assess community needs, implement asset development, evaluate area grant applications, encourage partnerships and initiate activities to enhance Boone County.

Mission: The Boone County Community Foundation is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our communities that lasts forever.

Grants

Each year the foundation makes grant awards to worthwhile projects located in the county that are identified through a community grants application process. Our foundation’s areas of emphasis include: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.

Three types of grants based on grant amount: Simple Grant; Standard Grant and Impact Grant

Simple Grant

$3,000 and under

Hogg Foundation for Mental Health

The Hogg Foundation for Mental Health was established in 1940 at The University of Texas at Austin by the children of Texas Governor James Hogg. For over a quarter of a century, the Hogg Foundation was guided by the passion and insight of the Governor’s daughter, Miss Ima Hogg, who actively promoted the foundation and encouraged its staff to pursue a bold, new vision. Today the Hogg Foundation is based at The University of Texas at Austin Steve Hicks School of Social Work and is funded through an endowment created by gifts from the Hogg family and managed by The University of Texas/Texas A&M Investment Management Company.

The Hogg Foundation is inspired by Ima Hogg’s vision for a Texas that supports and promotes mental health, resilience, and well-being. Miss Ima was ahead of her time in believing that mental health was just as important as physical health. She believed all people should have access to community-based resources to support mental well-being and live fulfilling lives, and she championed supports in everyday environments like schools, workplaces, places of worship, and homes.

Rio Grande Valley Policy Initiative

The Hogg Foundation for Mental Health invites eligible organizations in South Texas, especially those in the Rio Grande Valley (Cameron, Hidalgo, Starr, or Willacy Counties), to submit a proposal to support organizations engaged in local policy work, and to build local organizational capacity to enable sustained, strategic engagement in policy processes that advance mental wellness and address non-medical drivers of health. Each grantee partner will receive a three-year grant, with an award amount of up to $70,000 per year divided equally across the grant term. Each selected organization will have access to additional capacity building support through the University of Texas Rio Grande Valley’s Nonprofit Resource Center.

Initiative Goals

The VPI aims to achieve the following:

• To support forward-looking strategies that empower local leaders
• To expand participation in policymaking
• To advance sustainable, community-driven solutions for the RGV and surrounding South Texas counties

The WDNR offers grants totaling $250,000 annually to friends groups and nonprofit conservation organizations to enhance facilities, develop recreation projects, and restore habitats on state properties. Eligible applicants must be nonprofit entities committed to conservation and have a written agreement with the DNR. Projects should focus on nature-based outdoor recreation and address specific unmet needs in alignment with DNR management plans. Grants can cover up to 50% of project costs, promoting sustainable environmental practices.

The Community Charter Network Scholarship, provided by the Central Indiana Community Foundation, assists students from Fall Creek Academy or University Heights Preparatory Academy in covering post-secondary educational expenses. This scholarship aims to support those who demonstrate financial need and excel academically. Eligible applicants include former students of these institutions or residents within the IPS district. Awards vary based on available funds and may cover tuition, fees, and other educational costs.

Lawson Family Foundation

The Lawson Family Foundation was established by Phil Lawson in 2020 to serve as a catalyst for the development of a more healthy, prosperous, and inclusive Knoxville community. As a private grantmaking foundation, the Lawson Family Foundation focuses support on organizations involved in the areas of Justice & Economic Mobility, Education & Youth Development, Prevention of Exploitation & Violence, and Community Health & Food Security. 

Driven by the belief that every life has equal value, the Lawson Family Foundation exists to support efforts that promote justice and opportunity in all aspects of society, primarily in Knoxville, Tennessee. In doing so, it seeks to achieve a positive impact in marginalized communities that will last for generations.

Lawson Family Foundation Community Health & Food Security Grant

Access to basic healthcare and nutritious food is essential for individual well-being and community resilience. However, many families in the Knoxville area lack access to healthy food, preventative care, and wellness resources—contributing to persistent physical and mental health disparities, particularly in historically underserved communities.

The Foundation supports programs that expand access to nutritious food, promote healthy lifestyles, and strengthen community-based health resources. 

The Associated General Contractors of Indiana (AGCI) Scholarship, established by AGC/I, aims to support construction students in Indiana by covering educational expenses. Eligible applicants must be Indiana residents, enrolled in construction-related programs, and have completed at least 60 credit hours. The scholarship encourages students to pursue careers in the construction industry within Indiana, emphasizing leadership and professional experience. Awards can be used for tuition, fees, and other educational costs.

Lawson Family Foundation

The Lawson Family Foundation was established by Phil Lawson in 2020 to serve as a catalyst for the development of a more healthy, prosperous, and inclusive Knoxville community. As a private grantmaking foundation, the Lawson Family Foundation focuses support on organizations involved in the areas of Justice & Economic Mobility, Education & Youth Development, Prevention of Exploitation & Violence, and Community Health & Food Security. 

Driven by the belief that every life has equal value, the Lawson Family Foundation exists to support efforts that promote justice and opportunity in all aspects of society, primarily in Knoxville, Tennessee. In doing so, it seeks to achieve a positive impact in marginalized communities that will last for generations.

Lawson Family Foundation Education & Youth Development Grant

Education is foundational to long-term success and thriving communities. Yet many children in the Knoxville area face disparities in access to quality education, supportive environments, and essential resources—including children with physical, mental, intellectual, and learning disabilities, as well as those from historically underserved communities.

The Foundation invests in efforts that strengthen early childhood development, improve literacy, and expand pathways to college and career. We support programs such as after-school enrichment, mentorship, and family-centered initiatives, with an emphasis on inclusive approaches that ensure all children—regardless of ability or background—have access to the tools, support, and opportunities needed to reach their full potential.

Keokuk County Community Endowment Foundation

The KCCEF was formed in 2005 as an affiliate of the Community Foundation of Greater Des Moines. The founding members of the organization had a vision to ensure that our county’s charitable programs were supported now, and in the future. We work together with many individuals, families, businesses and organizations to establish endowment funds that will provide grant awards for years to come.

What We Offer

The Keokuk County Community Endowment Foundation is here to assist our county’s organizations contribute to the local quality of life, and one of the ways that is done is through grant funding. KCCEF accepts grant applications to enable projects and programs impacting a wide range of needs in the community. In the past, grants have been awarded for projects involving arts and culture, health & human services, community betterment, historic preservation, and more. Proof of non-profit status, or sponsorship by a government entity is required. 

Major Grant

What We Support

The Keokuk County Community Endowment Foundation will provide grants to improve life in Keokuk County, Iowa by supporting projects relating to: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.

Community Care Centers of Excellence (INFR8) 

The Community Care Centers of Excellence (CCCE) is a funding program by the California Institute for Regenerative Medicine (CIRM) that aims to expand access to innovative clinical trials and regenerative medicine treatments throughout designated counties in Northern California.

CCCEs will enhance patient access to regenerative medicine treatments by:

• Expanding the geographic reach of centers capable of conducting clinical trials and delivering approved therapies, and
• Developing a skilled workforce to support the delivery of regenerative medicine treatments and ensure broad accessibility to California patients.

This initiative addresses a key mandate of the California Stem Cell Research, Treatments, and Cures Initiative of 2020 (Proposition 14), emphasizing the importance of providing access to clinical trials and approved therapies resulting from CIRM-funded research.

Award Details

• Maximum Award Amount $9,000,000
• Maximum Award Duration Five years

The Woman's Club of Pewaukee Grant supports community initiatives that enhance the quality of life in Pewaukee. This service organization dedicates itself to fundraising and volunteer efforts, benefiting around twenty local groups. These groups focus on arts, education, health, and civic engagement, helping individuals and families in need. By fostering collaboration and outreach, the Woman's Club plays a vital role in nurturing a thriving community.

The Nationwide Insurance Foundation Grant aims to enhance community quality of life by providing support to nonprofits in areas where many Nationwide members reside. Since 2000, the foundation has donated over $700 million to various organizations, focusing on food security, crisis stabilization, economic empowerment, and children's wellbeing. Grants are available for general operating support, project/program support, and capital support, with a commitment to matching associate contributions.

The Kansas City Chiefs Charity Game Grant offers a unique opportunity for a 501(c)(3) organization in the greater Kansas City area to partner with the Chiefs for a major fundraising event. The selected organization will receive 90% of the game proceeds, with a commitment to support children and families in crisis. This partnership includes game tickets, promotional support, and the chance to expand fundraising capacity through a well-defined plan, ensuring a significant community impact.

The COPIC Medical Foundation Grants aim to improve healthcare outcomes by funding programs that enhance patient safety and reduce medical errors. With over $10 million awarded since its inception in 1991, the foundation focuses on scalable solutions to address healthcare fragmentation. This final grant cycle emphasizes innovative approaches that can be replicated across the healthcare community. Organizations must be 501(c)(3) certified or have a fiduciary partner to qualify for funding.

The Judy Ziels Memorial Scholarship, offered by the Chuckanut Health Foundation, honors a remarkable leader in public health. This scholarship supports master's-prepared nurse leaders who understand the importance of addressing interconnected health systems. By investing in education and mentorship, the program fosters future leaders who will drive meaningful change in their communities. This initiative reflects Judy's legacy of compassion and commitment to empowering others, ensuring that her influence continues to inspire new generations.

The Ohio Developmental Disabilities Council aims to enhance transportation opportunities for individuals with developmental disabilities through funded projects. By expanding access to transportation, the council seeks to empower individuals with I/IDD to achieve independence and improve their quality of life. Two projects may receive $50,000 annually for five years, supporting diverse entities in Ohio. This initiative aligns with the council's mission to foster inclusion and community involvement for people with disabilities.

The Ko'olau Pilina Fund Grant, supported by the Harold K.L. Castle Foundation, aims to enhance community resilience in the Ko'olau region of Oʻahu. This grant prioritizes projects that align with community values and support for organizations serving Hawaii. Eligible applicants include nonprofits and public schools, with funding ranging from $3,000 to $15,000. The grant fosters grassroots initiatives through an open application process, empowering local communities to innovate and develop sustainable solutions.

The Early College High School (ECHS) initiative by the Texas Education Agency (TEA) offers an innovative program that allows students to earn up to two years of college credit at no cost. Targeting historically underserved and at-risk students, ECHS promotes higher education access and success. Research indicates that ECHS participants are nearly three times more likely to earn college degrees compared to their peers, demonstrating its effectiveness in bridging educational gaps.

The Agriculture Innovation Center Grant Program aims to support Agriculture Innovation Centers by providing grants that facilitate technical assistance to agricultural producers. This initiative focuses on enhancing the marketing of value-added agricultural products, ultimately fostering growth in the agricultural sector. Funded by the USDA's Rural Business-Cooperative Service, this program is designed to empower producers and promote innovation in agricultural practices.

The Merrimack County Savings Bank Foundation, established in 1997 with a $1 million endowment, focuses on improving community life in its service areas in New Hampshire. It allocates 5% of its endowment annually to support non-profit organizations, particularly in civic, arts, social services, and health sectors. The Foundation prioritizes local needs and considers requests from 501(c)(3) organizations, while excluding individuals and lobbying entities from funding.

Pershing Square Lotus Award for Ovarian Cancer Research

The Pershing Square Foundation (PSF) has worked across sectors to catalyze innovative approaches to the most difficult problems. Talented individuals have always been at the center of our approach. We aim to support leaders who transform systems, embrace new paradigms, and have an innate drive to make an impact.

PSF has funded pioneering cancer researchers through the Pershing Square Sohn Cancer Research Alliance for over a decade and supported women’s health initiatives in New York City. Through this Request for Proposals (RFP), PSF aims to combine these two priority areas of women’s health and cancer to shine a light on one of the most understudied and underfunded cancers—ovarian cancer. Ovarian cancer is the deadliest gynecologic cancer, with 80% of women diagnosed at an advanced stage. Only 27% of women diagnosed during an advanced stage survive for five years. Ovarian cancer remains a disease with a poor prognosis due to limited early detection and treatment options.

PSF supports research efforts by 

• deploying capital quickly, 
• funding high-risk, high-reward ideas, 
• bringing new perspectives into a field, 
• encouraging collaboration, and 
• leveraging our vast network. We challenge our scientific partners to think creatively and across silos, to spur innovation to fight ovarian cancer.

Through the Pershing Square Lotus Award for Ovarian Cancer Research, PSF is looking for investigators who are either already working on a promising project in ovarian cancer or in another type of cancer that could have an impact on ovarian cancer. Grantees each receive $250,000 a year for three years, totaling $750,000.

Researchers who are not studying ovarian cancer are encouraged to apply and required to find a collaborator with experience in ovarian cancer research.

This award aims to 

• inspire investigators with unique expertise to apply their knowledge to ovarian cancer and 
• empower ovarian cancer researchers to pursue their boldest, most innovative ideas. Facing a disease where too few have survived to-date, PSF ultimately aims to create a culture around ovarian cancer that offers women hope, akin to the breast cancer community. PSF is passionate about changing outcomes for tens of thousands of women a year and is hopeful that future scientific discoveries will allow for more survivors who can share their stories for years to come.

The Winthrop Family Fund Grant, hosted by the Coastal Community Foundation of South Carolina, offers financial support to nonprofit organizations in Allendale and Hampton counties. Applications are accepted through an online portal, with deadlines set for February 1st each year. This grant prioritizes initiatives in education, health, and environmental conservation, empowering local nonprofits to address diverse charitable needs within their communities.

The Business Attraction Prime Sites program, administered by the Illinois Department of Commerce and Economic Opportunity, aims to foster economic growth by supporting large-scale capital investments. This initiative targets companies relocating or expanding in Illinois, promoting job creation through diverse projects, including infrastructure development. Eligible applicants must commit to significant investments and job creation, contributing to a robust economic landscape in the state. The program aligns with strategic industry focuses outlined in the Illinois Economic Plan.

The Windham Foundation Grants Program offers financial support to organizations enhancing the quality of life in Vermont. Grants, averaging $2,500 to $5,000, focus on agriculture, arts, community development, and wellness initiatives. Eligible applicants include non-profits and public entities located in Vermont, with a preference for collaborative projects. The Foundation encourages applications that demonstrate financial stability and a clear impact on community resilience, while limiting funding to no more than 50% of the total project cost.