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Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease
The Challenge
Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).
The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.
This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.
Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease
The Challenge
Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).
The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.
This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.
Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows
Catalyzing Innovation through Partnerships
At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.
About this Challenge
This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).
Award Structure and Funding Level
To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:
For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.
Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows
Catalyzing Innovation through Partnerships
At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.
About this Challenge
This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).
Award Structure and Funding Level
To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:
For concepts with preliminary feasibility evidence that are ready to advance from prototype toward an integrated workflow—optimizing performance, broadening assay or pathogen coverage, and generating more robust cost-reduction and performance data.
Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows
Catalyzing Innovation through Partnerships
At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.
About this Challenge
This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).
Award Structure and Funding Level
To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:
For more mature concepts aimed at workflow refinement, performance optimization, and generation of proof-of-concept and validation data in relevant public-health use cases in LMICs.
About The American Chestnut Foundation:
Our mission is to return the iconic American chestnut to its native range.
Our vision is a robust eastern forest returned to its splendor.
Small Grants Program
Are you looking for funding to support your American chestnut research? External small grants offer recipients a variety of benefits such as professional development and an expanded network. Grant activities contribute to the continuous renewal and development of faculty and staff, to the education and motivation of students, and achievement of our mutual interest — restoration of the American chestnut. This is a small grants program. TACF does not ordinarily fund projects in excess of $10,000.
Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre
Our Mission and Goals
The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).
ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:
Grants for Educators & Theatre Programs
A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.
For EdTA Members
Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.
Production Grants
Show-specific financial assistance for educational theatre programs
The Wilder Estate: The Long Christmas Dinner Festival Grant
In 1931, Thornton Wilder wrote The Long Christmas Dinner, a moving, funny, and ingeniously theatrical one-act play created specifically for student theater groups. In just 40 minutes, a single holiday meal becomes a 90-year journey through four generations of a family, exploring time, tradition, family, and the stories we tell about our lives.
In 2026, the Wilder Estate is launching The Long Christmas Dinner Festival, a national holiday celebration bringing schools, cultural organizations, and audiences together around this remarkable play.
Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre
Our Mission and Goals
The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).
ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:
Grants for Educators & Theatre Programs
A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.
For EdTA Members
Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.
Production Grants
Show-specific financial assistance for educational theatre programs
Music Theatre International: Heart of Rock and Roll "The Power of Love" Grant
Heart of Rock and Roll features a book by Jonathan Abrams and music and lyrics by Huey Lewis and his pop-rock band, Huey Lewis and the News, with new orchestrations of their music by Brian Usifer.
Selected schools will host intergenerational community events or outreach programs of their own design — because just as Huey Lewis’s music has always brought people together, school theatre has the power to do the same.
Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre
Our Mission and Goals
The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).
ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:
Grants for Educators & Theatre Programs
A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.
For EdTA Members
Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.
Production Grants
Show-specific financial assistance for educational theatre programs
Disney on Broadway: School of Excellence Grant
In collaboration with the Educational Theatre Foundation and Music Theatre International, Disney Theatrical Group will award complimentary licenses of select Disney musicals to middle and high schools throughout the United States to be performed each school year.
This nationwide program celebrates schools that display both outstanding artistic achievement and student-led engagement in theatrical disciplines such as stagecraft, theatrical design, choreography, direction, or performance. Together, these schools will honor the timeless magic of Disney musicals on stage and represent the future of theatrical storytelling for the next generation.
Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre
Our Mission and Goals
The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).
ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:
Grants for Educators & Theatre Programs
A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.
For EdTA Members
Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.
Production Grants
Show-specific financial assistance for educational theatre programs
Austen's Pride: A New Musical of Pride and Prejudice Grant
The Authors of Austen’s Pride: A New Musical of Pride & Prejudice are thrilled to announce a collaboration with ETF to grant five (5) high schools free performance rights and materials to produce this beautiful new musical during the 2026-27 school year. Access a free digital perusal of the script.
Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre
Our Mission and Goals
The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).
ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:
Grants for Educators & Theatre Programs
A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.
For EdTA Members
Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.
Production Grants
Show-specific financial assistance for educational theatre programs
Fiddler on the Roof Grant
The Fiddler on the Roof Grant covers performance royalties and support resources for middle or high school Thespian troupes to perform Fiddler on the Roof or Fiddler on the Roof JR. through Music Theatre International. Funders Helene and Edward Cole created the grant to help educate students and communities about Jewish heritage and culture.
Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre
Our Mission and Goals
The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).
ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:
Grants for Educators & Theatre Programs
A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.
For EdTA Members
Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.
Production Grants
Show-specific financial assistance for educational theatre programs
Ain't Too Proud Grant
ETF, in partnership with Music Theatre International, is offering three no-cost licenses for Ain’t Too Proud for 2027. This electrifying jukebox musical follows the rise of The Temptations from Detroit to the Rock & Roll Hall of Fame, featuring beloved hits like “My Girl” and “Papa Was a Rollin’ Stone,” with a Tony-nominated book by Dominique Morisseau. It’s an exciting opportunity for high school theatre programs seeking a dynamic production with strong vocals, choreography, and storytelling.
Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre
Our Mission and Goals
The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).
ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:
Grants for Educators & Theatre Programs
A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.
EdTA Membership Grant
Theatre matters.
It belongs in our classrooms and communities – now more than ever. Yet the role of the theatre educator has become increasingly complex, and financial support is often uncertain or even eliminated.
To help meet this moment, the Educational Theatre Foundation is proud to introduce the EdTA Membership Grant.
Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre
Our Mission and Goals
The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).
ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:
Educator & Program Grants
Giving school theatre programs a boost
The Thespian Growth & Excellence Fund is committed to supporting the ongoing development of theatre programs and the pursuit of excellence for educators, students, schools, and communities by offering a number of grants that assist in EdTA membership, teacher support, and programmatic resources for theatre in schools.
By the end of 2024, the Thespian Growth and Excellence Fund has awarded 349 grants to 276 schools, totaling $286,167 in assistance provided to school theatre programs, many at schools with Title 1 designations.
Educator Support ($500)
Can be used for professional development for theatre educators that would benefit their students, including coursework, EdTA’s Theatre Education Conference registration fees, and related travel expenses.
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