Best Berkeley County Grants for Nonprofits in South Carolina

Kickstart Your Project with a Mini-Grant

At H2O for Life, we never want finances to be a barrier to participating in a service project. The H2O for Life Mini-Grants are meant to be a supportive resource for teachers and students who want to kick-start their projects with us. Mini-grants of up to $500 will be awarded to support teachers and students with the necessary funds for their service-learning programs.

Our Mission

H2O for Life offers a service-learning opportunity designed to engage, educate and inspire youth to take action to solve the global water crisis by raising awareness and funds to support implementation of water, sanitation and hygiene education projects for global partner schools.

Since 2007, nearly 1 million students from H2O for Life schools have supported water, sanitation, and hygiene education projects for partner schools in the developing world.

What is H2O for Life doing to address the global water crisis?

H2O for Life’s service-learning opportunities are designed to engage, educate, and inspire youth to become global citizens. Our innovative school-to-school approach helps young people develop a concern for others by taking a major global crisis and scaling it down to a manageable size — one water project in the developing world.

Through the service-learning opportunity we provide, students learn that they can make a tangible difference for the students in their partner school.

The Community Seed Donations program by Seed Savers Exchange provides seeds to schools, community gardens, and nonprofits, ensuring that these resources are freely available to those in need. In addition, they offer disaster relief seed donations for organizations affected by recent natural disasters. To qualify, applicants must be nonprofits with U.S. shipping addresses. This initiative not only supports community growth but also promotes sustainability and resilience in the face of challenges.

The Science of Science: Discovery, Communication, and Impact (SoS:DCI) program fosters research that enhances the public value of scientific endeavors. It invites proposals that explore mechanisms of scientific discovery, improve understanding of communication outcomes, and assess societal benefits of science. Emphasizing interdisciplinary approaches, the program prioritizes proposals that broaden participation in science, engage diverse teams, and support America's leadership in global scientific innovation. The goal is to create impactful, evidence-based policies and advance the science of science.

The Mark Wahlberg Youth Foundation, established in 2001 by Mark and Jim Wahlberg, aims to support youth service programs that eliminate barriers to success for inner city youth. By providing financial and community support, the foundation empowers young individuals to achieve their potential and dreams, fostering a nurturing environment reminiscent of the Boys and Girls Clubs of America, where Mark spent his formative years.

The Dennis Schuman Charitable Foundation Grant supports qualified Jewish organizations and charities in the United States, focusing on arts, education, health, human services, public benefit, and religion. Established by Dennis Schuman, the foundation continues his philanthropic legacy, providing funding exclusively for charitable, religious, scientific, literary, or educational purposes. Organizations must be exempt under Section 501(c)(3) of the Internal Revenue Code to qualify for funding.

The Father's Table Foundation Grant aims to glorify God by addressing the immediate and future needs of women and children globally. This selective grant process emphasizes building self-sufficiency and resilience among beneficiaries, focusing on proven partners capable of expanding their impact. The foundation supports a diverse range of projects, including employment assistance, education, humanitarian aid, and health care, ensuring that aid not only meets urgent needs but also fosters long-term sustainability.

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

The Litter Enforcement Grant, funded by PalmettoPride, has been pivotal in South Carolina for 20 years, providing up to $5,000 for equipment and resources to support litter control efforts. This competitive grant encourages law enforcement and code enforcement agencies to actively engage in litter prevention initiatives, bolstered by community support. Priority is given to groups without recent funding and those collaborating with volunteer organizations focused on litter reduction and beautification.

Takeda Oncology offers grant funding opportunities aimed at addressing unmet educational and research needs in the medical community. They prioritize support for programs in hematology, thoracic, and gastrointestinal cancers, including lymphoma, leukemia, and previously treated metastatic colorectal cancer. Takeda encourages partnerships that enhance patient outcomes and provide tangible benefits through donations, grants, and sponsorships. Applications must be submitted at least 60 days prior to the program start date for timely review.

The Overwatch Alliance Grants support non-profit organizations with annual revenues of $500,000 or less that aid military members, veterans, and their families. Grants of up to $15,000 are available for impactful projects such as emergency financial assistance, transitional housing, and employment support. Eligible organizations must be IRS-designated 501(c)(3) entities. The Alliance encourages applications from those addressing crucial veteran community needs while reinforcing the importance of community backing for capital projects.

The Myelodysplastic Syndromes (MDS) Research Fund Grant, established by the Vera and Joseph Dresner Foundation, aims to enhance research and treatment of MDS and related blood disorders. This fund supports innovative projects addressing etiology, biology, genetics, prognosis, treatment, symptom management, and quality of life. It offers up to $125,000 for Early Career Awards and $250,000 for Established Investigator Awards, facilitating significant advancements in the field.

The SC Ministry Foundation provides annual grants aimed at supporting nonprofit organizations aligned with the mission of the Sisters of Charity of Cincinnati. These grants can be used for core programs, planning, and program expansion. Eligible organizations must demonstrate financial sustainability and avoid duplication of services. The application process starts with a pre-application survey, and funding decisions are typically made by June 30. Priority is given to projects in education, healthcare, and social services.

Stealth Biotherapeutics offers grants and sponsorships aimed at enhancing healthcare education for providers and patient communities. These funding opportunities focus on innovative programs that address rare genetic disorders, neurodegenerative conditions, and ophthalmic disorders. To apply, requests must be submitted 60 days prior to the funding start date, ensuring alignment with the therapeutic interests of the organization while providing valuable insights for healthcare professionals.

Stealth Biotherapeutics is dedicated to supporting innovative programs that enhance disease awareness and therapeutic management. Their charitable contributions focus on accredited institutions, promoting educational initiatives for health care providers and patient communities. Funding is prioritized for unique and cost-effective projects that align with their therapeutic interests, including rare genetic disorders, neurodegenerative diseases, and ophthalmic conditions. By fostering community awareness, they aim to make a significant impact in the healthcare landscape.

Who We Are

The Unitarian Universalist Funding Program (UUFP) is a denominational grantmaking program of the Unitarian Universalist Association. Inspired by the richness and diversity of our liberal religious tradition, the mission of the UUFP is to promote the influence of Unitarian Universalist principles through grantmaking.

With funds generously provided by the Unitarian Universalist Veatch Program at Shelter Rock, the UUFP awards grants to Unitarian Universalist (UU) and non-UU projects and organizations. Grants are made that:

• Support the work of social justice.
• Strengthen Unitarian Universalist institutions.
• Transform gratitude for being into generosity of living.

Get Out The Vote - 2026

The Fund for UU Social Responsibility has increased funding for grants to UU congregations and organizations working to Get Out The Vote in 2026. Grants of up to $1,000 will be made on a rolling basis until funds are depleted.  

Please note that funds must go to a UU congregation or organization for the work by UUs of the organization. The funds may not be passed through to another organization. Collaboration and partnerships are encouraged.

UU congregations and organizations frequently support the democratic process in an election cycle in a non-partisan* manner by participating in voter registration drives, organizing to stop voter suppression, providing non-partisan educational materials or forums for voters, or by volunteering to help registered voters get to the polls on election day.

The Officers’ Research Grants on Reducing Inequality support studies aimed at understanding and addressing inequalities affecting youth ages 5-25 in the U.S. This initiative funds descriptive, intervention, and measurement development studies focused on academic, social, behavioral, and economic outcomes. The William T. Grant Foundation encourages research that identifies specific inequalities and explores effective programs or policies to mitigate these disparities while addressing systemic issues such as racism and structural inequality.

The McKnight Endowment Fund for Neuroscience offers Scholar Awards to early-career neuroscientists focusing on learning and memory disorders. The awards provide up to $225,000 over three years, emphasizing research that could lead to significant clinical advancements. Eligible candidates must work as independent investigators at U.S. non-profit institutions, hold an Assistant Professor position for less than four years, and demonstrate their research program's potential. The program aims to foster innovative solutions in neuroscience.

The JA Community Foundation focuses on funding solutions that address the needs of the Japanese American and broader Asian American communities. They prioritize programs that enhance senior health, promote history, arts, culture, and support youth. Eligible applicants must be registered 501c3 organizations and can apply from all 50 states. However, organizations with open grants cannot submit new applications until their current grants are closed.

Grants

Through our grantmaking, we support nonprofits that serve South Carolina at local, regional and state levels to address root causes of poverty while honoring the dignity of every South Carolinian.

Starting in 2026, our grants focus primarily on systems change in the areas of

• economic mobility,
• housing security and
• health care (with health care systems change grants by invitation only).

By focusing our efforts and going deeper on these three issues, we aim to have an even greater impact on the nonprofits and communities we serve.

Systems Change Grants

Systems Change Grants fund organizations and coalitions that are working to change the policies, power structures and mindsets that cause and reinforce poverty in South Carolina. These grants specifically fund systems change that supports economic mobility and housing security.

Through these grants, we aim to generate a larger impact through more intentional funding, highly focused work and alignment across our Foundation’s activities.

What Systems Change Grants Support

• Organizations that are actively working on systems change that impacts people experiencing poverty and addresses economic mobility or housing security. To see how the Foundation defines these terms, visit our Strategic Plan webpage.
• Organizations that are seeking to change systems at the local, regional or state level. Systems Change Grants provide up to $75,000 annually for local or regional work.
  • State-level grants have a $100,000 maximum each year. 
• Organizations addressing systems change in at least one of the following ways:
  • Participating in advocacy and lobbying
    • Focus on changing policies, practices, processes, rules or laws
    • Impacting resource flows (i.e., reallocated and/or new funding streams)
    • Holding systems accountable to their intended purpose through the above as well as through litigation
  • Addressing unequal power
    • Focus on changing the distribution and dynamics of privilege, relationships and tradition
    • Organizing and building connections and coalitions that center community voices and perspectives
    • Civic engagement
  • Affirming the dignity of people experiencing poverty
    • Focus on changing the narrative around poverty
    • Focus on changing attitudes, mindsets, values, belief systems, norms, mental models and paradigms
  • Implementing big impact, scalable, or innovative solutions
    • Focus on changing results, especially for groups experiencing inequitable outcomes as a result of historic and current marginalization

All grants are for one year, with the possibility of renewal up to three years based on meeting reporting requirements and the availability of funding.

The Emerging Scholars in Family Planning Grant, offered by the Society of Family Planning, aims to support early-career researchers in developing a family planning research portfolio. This grant provides funding for publishable scholarly research projects, including thesis or dissertation work, fostering the next generation of scholars in abortion and contraception research. By promoting diversity and inclusion, the grant seeks to build a multidisciplinary community dedicated to advancing family planning science.

The Zero Hunger | Zero Waste Foundation Grant supports nonprofit organizations focused on ending hunger and reducing food waste. Since its inception, the foundation has allocated over $59 million to enhance food security through innovative programs and community engagement. Eligible applicants include 501(c)(3) nonprofits addressing critical needs such as food access, nutrition education, and support for vulnerable populations. This initiative aims to create equitable food systems and ensure that no one goes hungry.

The Francis R. Dewing Foundation Grant provides seed money to support innovative projects in early childhood education, benefiting children up to sixth grade. Founded by Frances R. Dewing in 1963, the foundation aims to stimulate intellectual growth in young children through unique educational methods. Grants typically range from $1,000 to $25,000, with a focus on projects that demonstrate a broad impact on the educational community. Applications are accepted from 501(c)(3) nonprofit organizations and government entities across the United States.

The IECA Foundation Grant offers up to $5,000 to nonprofit organizations in the U.S. that assist underserved youth and young adults in achieving their educational goals. The Foundation prioritizes projects that demonstrate measurable impact and align with its mission of fostering positive outcomes through personalized support and community engagement. Eligible organizations must be 501(c)(3) nonprofits with an annual budget of $1 million or less, focusing on innovative, project-based initiatives.

The AWS Imagine Grant Program aims to empower U.S.-based nonprofit organizations by prioritizing technology in their projects. This initiative offers three award categories: The Pathfinder Award for innovative generative AI projects, the Go Further, Faster Award for cloud-based solutions, and the Momentum to Modernize Award for foundational tech projects. Each category provides significant financial support, AWS promotional credits, and implementation guidance to help nonprofits achieve their mission-driven goals.

Nikon USA is dedicated to supporting innovative initiatives that align with its marketing strategies and community impact. They seek sponsorship proposals that demonstrate unique ideas, enhancing brand engagement and consumer reach. However, applicants must be over 18 and submit requests at least six months prior to their program. Nikon prioritizes USA-based entities and cannot support individual projects or certain causes. For more details, please submit your request through their designated online form.

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

The Covenant Foundation's Signature & Ignition Grants celebrate excellence in Jewish education by funding innovative projects that enhance educational practices. The Foundation supports diverse institutions across North America, inviting applications for creative programs that can adapt and disseminate effective practices. While Signature Grants may reach up to $150,000 over three years, Ignition Grants focus on untested ideas with funding up to $20,000 for one year. One application per cycle is permitted.