Best Health and Medical Grants in California

Nonprofit Sustainability Initiative San Diego

Investing in Nonprofit Impact

The Nonprofit Sustainability Initiative (NSI) San Diego is a pooled fund fiscally sponsored by Catalyst of San Diego & Imperial Counties inviting applications from September 1, 2026 onward to support non-profit organizations pursuing formal sustained collaboration partnerships that increase mission impact, organizational effectiveness, and long-term sustainability.

Strengthening Nonprofits Through Collaboration

Collaboration is one of the most powerful paths towards sustained impact, and yet it is often one of the most under-resourced. Many nonprofits lack access to the flexible, discretionary funding required to navigate complex transitions while continuing to deliver on their missions.

NSI San Diego helps close that gap by supporting a range of collaboration models, including:

• Jointly managed programs
• Back-office consolidations
• Shared ventures
• Full-scale mergers.

With the right support in place, organizations can reduce duplicative work, strengthen internal operations, and focus more of their time and energy where it matters most: serving their communities.

Responding to a Changing Nonprofit Landscape

Nonprofits today are facing increasingly destabilizing conditions that threaten their long-term viability. Federal funding cuts, heightened scrutiny, and shifting policy environments have changed what risk looks like and how quickly it can compound. The pace of these challenges means organizations are losing capacity faster than it can be rebuilt.

NSI San Diego responds to these challenges by investing in the kinds of structural supports that help nonprofits adapt, stabilize, and continue serving communities.

Implementation Grants support two or more organizations that have reached an agreement to pursue a formal collaboration following an exploratory process.

Examples of eligible costs include:

• Financial and accounting services
• Technology and systems integration
• Human resources integration
• Communications and branding
• Board development and governance transition
• Asset consolidation
• Lease termination costs
• Staff transition and severance expenses
• Legal fees (when pro bono resources are unavailable)

Implementation Grants typically range from $20,000–$50,000.

Grant funds are intended to support one-time implementation and transition costs. While implementation funding is primarily intended for external costs, organizations may request support for limited staff-related expenses if they can demonstrate a unique, time-bound role that is essential to successful implementation.

CommonSpirit Health offers the Community Health Improvement Grant to enhance health equity and service systems for underserved populations. Through collaborative efforts with 501(c)(3) organizations, this initiative provides financial support for essential health projects. Grant amounts range from $19,500 for small grants to $150,000 for standard grants, varying by hospital. Participating hospitals include those under Catholic Health Initiatives and Dignity Health, aimed at addressing significant community health needs.

The Healthcare Expansion Loan Program II (HELP II) offers low-interest loans to California's non-profit small or rural health facilities. With loan amounts ranging from $25,000 to $1.5 million, borrowers can utilize funds for property purchases, equipment, and renovation projects. To qualify, applicants must meet specific eligibility criteria, including being a licensed health facility and demonstrating fiscal soundness. This program aims to enhance healthcare access and services across the state, providing crucial financial support to eligible organizations.

The McBeth Foundation Grant supports meaningful initiatives in animal welfare, environmental conservation, the arts, children's programs, health sciences, and communications. Founded by Barbara McBeth Woodruff, the foundation aims to create measurable improvements in local communities. Grants are intended for projects that can benefit multiple individuals, fostering growth like a seed that matures into a tree, offering shade and fruit. Eligible applicants must hold a 501(c)(3) tax-exempt status.

The John W. Porter Trust Grant, established in 1947, aims to enhance the lives of Long Beach, California residents by supporting non-profit organizations. The foundation focuses on arts, education, health, and other community benefits. Eligible organizations must be 501(c)(3) exempt and operate within California, with a preference for those serving the Long Beach area. Grants foster positive community impact, reflecting Mr. Porter's vision for a better society.

The Charles and Ruth Billingsley Foundation Grant supports a variety of charitable causes primarily in San Diego County, California. Established in 1988, this private foundation aims to enhance community welfare through funding in areas such as arts, education, health, and human services. Organizations eligible for support must qualify as 501(c)(3) exempt entities. Applications are accepted year-round with a deadline of June 30 for review in July.

The Harold McAlister Charitable Foundation Grant supports public charities focused on healthcare, education, social services, animal welfare, arts and culture, and environmental initiatives. Organizations should submit formal grant requests detailing their mission, funding needs, and intended use of funds. The Foundation prioritizes proposals that align with its funding areas and demonstrate measurable impact. Applications are due by February 15, with decisions made in March and funding released in April.

The Robert L. and Margaret K. Balmes Family Trust Grant aims to support organizations that assist individuals who have lost limbs during military service, as well as those improving Southern California. Established in 2004, the foundation honors Mr. Balmes, a pioneer in Homeowner Association Management. While there are no geographic restrictions, priority is given to 501(c)(3) organizations based in California. This grant reflects a commitment to community welfare and veteran support.

The Del E. Webb Foundation Grant offers financial support ranging from $5,000 to $3,000,000 for nonprofit organizations operating in Arizona, California, or Nevada. The foundation prioritizes projects that enhance self-sufficiency and have long-term benefits, particularly in child and health initiatives. Eligible organizations must be 501(c)(3) public charities and demonstrate a commitment to community service. The application process involves submitting a Letter of Intent, followed by a formal application if invited.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation supports nonprofit organizations that enhance community welfare. Focus areas include agriculture, education, fighting hunger, and public safety. Eligible applicants must have IRS 501(c)(3) status and a Taxpayer Identification number. Requests are prioritized for programs directly benefiting communities near Perdue facilities across various states. The foundation emphasizes responsible stewardship and community engagement in all funding decisions.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation focuses on supporting nonprofit organizations within specific states. They prioritize initiatives that enhance community welfare, especially in agriculture, education, health, and environmental sustainability. Organizations must have 501(c)(3) status to apply, and preference is given to those involving Perdue associates. Ineligible requests include those from religious, political, or individual-focused groups. This program emphasizes broad community benefits over organizational affiliations.

Nonprofit Sustainability Initiative San Diego

Investing in Nonprofit Impact

The Nonprofit Sustainability Initiative (NSI) San Diego is a pooled fund fiscally sponsored by Catalyst of San Diego & Imperial Counties inviting applications from September 1, 2026 onward to support non-profit organizations pursuing formal sustained collaboration partnerships that increase mission impact, organizational effectiveness, and long-term sustainability.

Strengthening Nonprofits Through Collaboration

Collaboration is one of the most powerful paths towards sustained impact, and yet it is often one of the most under-resourced. Many nonprofits lack access to the flexible, discretionary funding required to navigate complex transitions while continuing to deliver on their missions.

NSI San Diego helps close that gap by supporting a range of collaboration models, including:

• Jointly managed programs
• Back-office consolidations
• Shared ventures
• Full-scale mergers.

With the right support in place, organizations can reduce duplicative work, strengthen internal operations, and focus more of their time and energy where it matters most: serving their communities.

Responding to a Changing Nonprofit Landscape

Nonprofits today are facing increasingly destabilizing conditions that threaten their long-term viability. Federal funding cuts, heightened scrutiny, and shifting policy environments have changed what risk looks like and how quickly it can compound. The pace of these challenges means organizations are losing capacity faster than it can be rebuilt.

NSI San Diego responds to these challenges by investing in the kinds of structural supports that help nonprofits adapt, stabilize, and continue serving communities.

Exploratory Grants support two or more organizations that are ready to engage in structured discussions regarding a potential strategic partnership.

Organizations receiving Exploratory Grant funding are not committing to a specific outcome. Rather, they are committing to participate in a good-faith process of exploration, due diligence, and negotiation to determine whether a partnership would advance their missions and better serve their communities.

• Potential activities may include:
• Strategic assessment and readiness discussions
• Facilitation and negotiation support
• Organizational due diligence
• Governance and leadership conversations
• Financial and operational analysis
• Exploration of partnership models

Exploratory Grants typically range from $20,000–$40,000.

Funds are intended primarily for third-party consultants and technical assistance providers supporting the exploratory process.