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Best Darlington County Grants for Nonprofits in South Carolina

Looking for grants for 501(c)(3) nonprofit organizations working in Darlington County? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

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$2.61B

Total funding

$5K

Median grant

9,000+ grants
$2.61B total
$5K median

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9,244 Results based on applied filters

Agog Open Call: Climate Futures + Immersive Media

Agog: The Immersive Media Institute
Corporate
United States
US $25,000 - US $200,000

Agog Open Call: Climate Futures + Immersive Media

This open call supports immersive media projects that help people better understand and respond to climate challenges and imagine what a better world could be.

We are looking for projects that use immersive technologies—including smart glasses, augmented reality, spatial sound, and mixed reality—to create more engaging, experiential forms of climate storytelling and civic participation.

The open call will support projects across a range of stages and formats, from early ideas to more developed work. What matters most is a compelling story or experience, a clear sense of purpose, and a thoughtful approach to bringing the work to life.

Grants may be awarded in denominations ranging from $25,000 to $200,000. In addition to funding, selected projects may receive mentorship, advisor support, and opportunities for partnership and distribution.

Climate Change Resilience & Equity Virtual / Augmented Reality (VR / AR)

Gladys Phillips Memorial Scholarship

Grays Harbor Community Foundation
Private
United States
Unspecified amount

Gladys Phillips Memorial Scholarship

Gladys Phillips, the second of four daughters of former Aberdeen Mayor and Superior Court Judge J. M. Phillips, began practicing law in Aberdeen in 1937, the same year she joined three other women in graduating from the University of Washington Law School.

Gladys quickly earned a reputation – a reputation she maintained for over 60 years – as one of Grays Harbor’s most intelligent and formidable lawyers. With both an “encyclopedic knowledge of the law” and a love of roses, ballet and beautiful words, she was to her clients not only a trusted advisor but also a cherished friend.

As a community activist, she helped establish and lead the Bishop Foundation, served as a state representative, worked to erect the Aberdeen YMCA, and guided the creation of the Grays Harbor Community Foundation. The Gladys Phillips Memorial Scholarship is open to all applicants who satisfy the general eligibility requirements of the Scholarship Program.

Education - Higher Education Career / College Preparation

William and Bess Osheroff Memorial Scholarship

Grays Harbor Community Foundation
Private
United States
Unspecified amount

William and Bess Osheroff Memorial Scholarship

William Osheroff was born in Omaha and grew up in Erickson, Nebraska. He earned his Bachelor of Science and his Masters and Doctor of Medicine degrees from the University of Nebraska.

A member of the Grays Harbor Medical Association and the American Medical Association, Dr. Osheroff became known on the Harbor as an excellent physician who cared deeply about the community. A general practitioner, he trained to work as a cardiologist and introduced cardiac care services to the Harbor after recognizing that such services were badly needed in the community. Before the technology became commercially available, Dr. Osheroff developed a device for sending EKG tracings over the phone, allowing him to keep better track of his patients’ heart conditions. In 1972, he became a member of the American College of Cardiology.

Like her husband, Bess Osheroff cared deeply about the communities of Grays Harbor and worked to improve the quality of life and health of her neighbors. Born in Jessup, Pennsylvania and raised in Emporia, Virginia, Bess Osheroff became a Registered Nurse through New York City’s Cumberland Hospital School of Nursing.

Together, Bess and her husband helped organize the first Red Cross Blood Drive on Grays Harbor. Bess continued to organize blood drives for twenty years. William and Bess had a daughter and four sons, one of whom died in 1977. Bess died in November 1996, a month after seeing her son Doug, a Stanford physics professor, win the Nobel Prize in Physics.

While preference will be given to applicants interested in studying science or medicine, the William and Bess Osheroff Memorial Scholarship is open to all applicants who satisfy the general eligibility requirements of the Scholarship Program.

Education - Higher Education Career / College Preparation

Pre-clinical Investigation of anti-TFPI-mediated Rebalancing Mechanisms in Non-Hemophilic Bleeding Disorders RFP

Pfizer, Inc.
Corporate
Brazil, China +7 more
Up to US $50,000

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Pre-clinical Investigation of anti-TFPI-mediated Rebalancing Mechanisms in Non-Hemophilic Bleeding Disorders

There remains a scientific gap in understanding of the role of anti-TFPImediated hemostatic rebalancing in the context of inherited or non-hemophilic bleeding disorders. This competitive grant program encourages competitive submissions focsed on generating preclinical/foundational data exploring the therapeutic potential and mechanisms of TFPI modulation in bleeding disorders other than hemophilia.

Project Types and Area of Interest

Potential applicants are encouraged to identify and address preclinical/basic science data generation for TFPI modulation/rebalancing in their local setting. This may include:

  • Rare bleeding disorders which arise from deficiencies in different clotting factors or pathway components but converge on a common functional endpoint which is an impaired thrombin generation (e.g., Factor II, Factor V, Factor VII, Factor X and Factor XI deficiencies, as well as von Willebrand disease).
  • Other diseases such as Glanzmann's thrombasthenia (GT) that have a distinct pathophysiological mechanism.
  • Other rare bleeding disorders whose mechanisms are not well understood (e.g., Bleeding Disorder of Unknown Cause, BDUC).
Hematological Systems Rare Diseases

The Novak Family Scholarship

Grays Harbor Community Foundation
Private
United States
Unspecified amount

The Novak Family Scholarship

Walter M. Novak was born on April 19, 1921, the second son of Michael and Apolonia, Polish immigrants who had arrived in America just after the turn of the century. They were determined that their two sons receive a college education and through years of hard work in Hoquiam mills, survival through the Great Depression, and with help from their large vegetable garden, fishing, and clamming they were able to send both sons to the University of Washington where they each received Mechanical Engineering degrees.

Walter has inspired many people throughout his life with his dedicated work ethic, intelligence, honesty, concern and care for his employees and friends and his love for his family. He is the true product of the “American Dream” and these scholarships given in his name are meant to help others achieve their goals.

Education - Higher Education Career / College Preparation

Dr. John D. “Jack” Ehrhart Memorial Scholarship

Grays Harbor Community Foundation
Private
United States
Unspecified amount

Dr. John D. “Jack” Ehrhart Memorial Scholarship

Dr. John D. Ehrhart was a standout athlete in tennis, football, and basketball who graduated from Hoquiam High School in 1935 and went on to study at Stanford University and earn his M.D. degree from Stanford Medical School.

In high school, Jack won the Pacific Northwest Junior Tennis Championship, and in later years he was instrumental in helping young people learn to play tennis. He remained an avid sports fan all his life. He practiced medicine in Aberdeen for nearly 30 years before his life was cut tragically short in 1974 when the plane he was piloting through dense fog crashed in the hills of East Aberdeen.

The Dr. John D. “Jack” Ehrhart Memorial Scholarship is open to all applicants who satisfy the general eligibility requirements of the Scholarship Program

Education - Higher Education Career / College Preparation

Dr. George H. Hitchings Memorial Scholarship

Grays Harbor Community Foundation
Private
United States
Unspecified amount

Dr. George H. Hitchings Memorial Scholarship

Born in Hoquiam in 1905, George H. Hitchings grew up in a family of shipbuilders. Hitchings’ father, George, Sr., worked at and eventually managed the Hoquiam shipyard that his father-in-law, Peter Matthews, established in 1897. 

From the late 1960s until his death in 1998, Dr. Hitchings became increasingly involved with philanthropy. He served as President of the Burroughs Wellcome Fund, a nonprofit foundation which supports biomedical research, and he led several charities in the Research Triangle Park area of North Carolina, where Burroughs Wellcome had relocated in 1968. In 1983, Dr. Hitchings founded the Greater Triangle Community Foundation, which serves the Triangle area.

While preference will be given to applicants interested in studying science or medicine, the George H. Hitchings Memorial Scholarship is open to all applicants who satisfy the general eligibility requirements of the Scholarship Program.

Education - Higher Education Career / College Preparation

Dave Dupont Memorial Scholarship

Grays Harbor Community Foundation
Private
United States
Unspecified amount

Dave Dupont Memorial Scholarship

The family remembers Dave as a very kind hearted, loving husband, father, and friend. He and his wife Sandi were married 35 years, and had 2 children Kyle and Danielle DuPont.

Dave loved to give back to his community, and attend as many fundraisers as he could. Dave would be proud to be able to give back to the kids in his community.

Education - Higher Education Vocational & Trade Education

Biochemical and Molecular Characterization of Marstacimab and TFPI Pathways RFP

Pfizer, Inc.
Corporate
Brazil, China +10 more
Up to US $50,000

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Biochemical and Molecular Characterization of Marstacimab and TFPI Pathways 

This competitive grant encompasses research aimed at elucidating molecular and cellular mechanisms underlying marstacimab-TFPI interactions, including but not limited to differential expression of tissue factor and TFPI in various tissues, binding kinetics, and other biochemical properties. Projects should seek to advance foundational understanding of these interactions through innovative approaches in biochemistry, molecular biology, and related disciplines.

Project Types and Area of Interest

Projects that will be considered for Pfizer support will focus on basic science and fundamental biological understanding of Tissue Factor Pathway Inhibitor (TFPI), anti-TFPI Monoclonal Antibodies, and marstacimab. The areas of interest may include (but are not limited to):

  • Basic biology of TFPI including interactions among key regulatory proteins in the intrinsic and/or extrinsic clotting cascades (e.g. Protein S being a co-factor for both Protein C and TFPI).
  • Impact of differential TFPI expression within tissues and the role of various TFPI pools/isoforms in the regulation of coagulation.
  • Pharmacology resulting from concomitant therapies added to anti-TFPI
Rare Diseases Hematological Systems

South Carolina Commodity Supplemental Food Program (CSFP)

South Carolina Department of Agriculture
State/Local Government
South Carolina
Unspecified amount
The South Carolina Commodity Supplemental Food Program (CSFP) aims to enhance the health of individuals aged 60 and above by providing nutritious USDA food packages. Administered by the South Carolina Department of Agriculture, the program helps eligible participants with limited income access essential nutrients. Local agencies distribute food and offer nutrition education while connecting them to additional support services like SNAP and Medicaid. This initiative addresses dietary deficiencies in the senior population of South Carolina.
Food Access & Hunger Food Delivery & Distribution Services Senior Services

DoW Bone Marrow Failure, Investigator-Initiated Research Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $1,250,000
The DoW Bone Marrow Failure Investigator-Initiated Research Award supports innovative research aimed at advancing the understanding and treatment of bone marrow failure. This funding opportunity encourages applications for translational and clinical studies, requiring preliminary data to strengthen proposals. Unique features include the ability for a partnering Principal Investigator to contribute to the research, thereby fostering collaboration while maintaining a focus on significant advancements in patient care.
Skeletal Diseases Myeloma

DoW Rare Cancers Idea Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $490,000
The DoW Rare Cancers Idea Development Award promotes innovative research ideas for rare cancers, encouraging applicants to provide preliminary data and exploratory aims. This funding opportunity, offered by the US DOD: U.S. Army Medical Command, seeks projects with the potential for high-impact findings that can significantly benefit the patient community. It aims to foster new avenues of investigation and support discovery-driven research in the field of rare cancers.
Cancer / Oncology

DoW Rare Cancers Resource and Community Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $1,120,000
The 2026 Rare Cancers Research Program Resource and Community Development Award aims to enhance rare cancer research through improved resources and datasets. It addresses critical gaps in research resources, communication strategies, and data sharing infrastructures. Key features include engaging patient advocates throughout the research process and ensuring sustainability of community platforms. This funding opportunity emphasizes community building and the dissemination of findings to benefit scientific and patient communities alike.
Cancer / Oncology

DoW Joint Warfighter Medical, Military Medical Research and Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
US $1,400,000 - US $3,000,000
The FY26 Joint Warfighter Medical Research Program's Military Medical Research and Development Award aims to fund the continuation of previous Department of War-funded research addressing high-priority medical needs for Service Members and Military Health System beneficiaries. It supports various projects, including late-stage preclinical studies and clinical research. Eligibility requires prior DOD funding, and a Clinical Research Option is available for studies involving human subjects or biological samples.
Military Operations

DoW Bone Marrow Failure, Resource Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $1,250,000
The FY26 Bone Marrow Failure Research Program's Resource Development Award aims to create a multiomic atlas from human bone marrow failure samples. This resource will be open-access, providing essential data for researchers and clinicians to enhance their understanding of bone marrow failure diseases. A comprehensive Data Resource Sharing Plan is required to ensure timely availability of the developed resource, fostering collaboration within the scientific community.
Skeletal Diseases Myeloma

DoW Parkinson’s, Investigator-Initiated Research Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The FY26 Parkinson’s Research Program Investigator-Initiated Research Award supports innovative, multidisciplinary research projects aimed at advancing the understanding and treatment of Parkinson’s disease. The award encourages collaboration among multiple principal investigators, requiring preliminary data and allowing clinical trials to enhance research outcomes. This initiative is vital for fostering impactful discoveries within the four specified focus areas of the program, ultimately improving patient care and management.
Parkinson’s Disease

Fiscal Year (FY) 2027 Department of the Navy (DoN) Historically Black Colleges and Universities/Minority Institutions (HBCU/MI) Program

US DOD: Dept. of the Navy, Office of the Chief of Naval Research
Federal Government
United States
US $450,000 - US $525,000
The FY 2027 DoN HBCU/MI Program aims to enhance the research capabilities of Historically Black Colleges and Universities and Minority Institutions. This initiative promotes innovative solutions to naval science challenges while engaging students and faculty in STEM fields. Key objectives include strengthening research infrastructure and fostering collaborative efforts across institutions. White papers are due by September 18, 2026, and should clearly outline the proposed advancements in naval-relevant science and technology.
Engineering Education - Higher Education Science +1 more

DoW Parkinson’s, Early Investigator Research Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $1,000,000
The FY26 Parkinson’s Research Program (PRP) Early Investigator Research Award supports early-career researchers in Parkinson’s disease (PD) research. It offers two funding levels: Level 1 for fellows requiring a Mentor and Level 2 for independent investigators. The PI must show potential in PD research, with Level 1 emphasizing mentorship and Level 2 needing preliminary data. Research must align with one of the four FY26 PRP Focus Areas, excluding clinical trials.
Parkinson’s Disease

Fair Housing Initiatives Program - Education and Outreach Initiative (362880)

US HUD: Office of Fair Housing and Equal Opportunity (FHEO)
Federal Government
American Samoa, Guam +4 more
US $175,000 - US $2,500,000
The Fair Housing Initiatives Program (FHIP), established by Congress in 1988, aims to fund organizations to combat discriminatory housing practices. The Education and Outreach Initiative (EOI) educates stakeholders about their rights under fair housing laws. Key components include the National Media Campaign, which promotes fair housing awareness nationally, and local programs that support community-based outreach. HUD oversees the process, ensuring compliance and monitoring of funded initiatives to enhance fair housing practices.
Basic Human Needs Real Estate & Housing Equitable & Affordable Housing +1 more

George and Viola Hoffman Award

American Association of Geographers
Association/Society
United States
Up to US $500

An award from the George and Viola Hoffman Fund may be made annually for student research toward a master’s thesis or doctoral dissertation on a geographical subject in Eastern Europe. Eastern Europe includes the countries of East Central and Southeast Europe from Poland south to Romania, Bulgaria, and the successor states of the former Yugoslavia. Topics may be historical or contemporary, systematic or regional, limited to a small area or comparative.

Geography

F26AS00104 State ANS Management Plan 2026

US Department of the Interior: Fish and Wildlife Service (FWS)
Federal Government
United States
US $5,000 - US $150,000
The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.
Ichthyology (Fish) Limnology Fisheries +1 more

Child Protection Compact Annual Program Statement (362907)

US Department of State: Office to Monitor and Combat Trafficking in Persons
Federal Government
American Samoa, Guam +4 more
US $5,000,000 - US $10,000,000
The Child Protection Compact Annual Program Statement invites proposals aimed at combating child trafficking through collaborative efforts between the United States and other countries. This initiative focuses on enhancing the capacity to prosecute traffickers, providing care for victims, and implementing preventive measures. Organizations interested in applying must align with the objectives of the CPC to ensure comprehensive support and effective intervention against all forms of child trafficking.
Child Welfare Services Human Trafficking

TIP Office International Programs to Combat Human Trafficking Annual Program Statement (362906)

US Department of State: Office to Monitor and Combat Trafficking in Persons
Federal Government
American Samoa, Guam +4 more
US $1,000,000 - US $10,000,000
The TIP Office of the US Department of State invites applications for projects aimed at combating human trafficking, adhering to the Trafficking Victims Protection Act. This initiative prioritizes prosecuting traffickers, protecting victims, and preventing trafficking through strategies outlined in the National Security Strategy, executive orders, and the annual Trafficking in Persons Report, while aligning with America First Foreign Policy priorities.
Human Trafficking

Veterans' Homelessness and Transition Grant

South Carolina Department of Veterans' Affairs
State/Local Government
South Carolina
US $50,000 - US $250,000

Secretary's Intent

The Department's Purpose

The South Carolina Department of Veterans' Affairs exists to serve this state's Veterans, service members, and their families and to promote the value Veterans bring to their communities and their fellow citizens.

Veterans' Homelessness and Transition Grant

The Veterans’ Homelessness and Transition Grant was established on October 16, 2023, to provide funding to organizations that serve homeless Veterans or Veterans at imminent risk of being homeless with resources to obtain permanent housing. The Veterans Homelessness and Transition Grant Program is funded through an appropriation by the South Carolina General Assembly and managed by the South Carolina Department of Veterans’ Affairs (SCDVA).

The grant aims to enhance nonprofit organizations and state agencies' housing assistance programs for Veterans. The South Carolina Department of Veterans' Affairs will award a grant to nonprofit groups and state governmental agencies that assist eligible South Carolina Veterans with housing assistance, utility assistance, rental assistance, or drug addiction treatment and transitional housing programs.

The minimum grant award is $50,000, and the maximum grant award amount is $250,000 per grant cycle. Veteran eligibility is defined by Title 38 of the Code of Federal Regulations, as “a person who served in the active military, naval, or air service and who was discharged or released under conditions other than dishonorable.”

Military & Veterans Services Homelessness Services

Senior Centers and Permanent Improvement Project Grant

South Carolina Department on Aging
State/Local Government
South Carolina
Up to US $350,000

Senior Centers and Permanent Improvement Project Grant

The Older Americans Act identifies the South Carolina Department on Aging (SCDOA) as a leader in the development of multipurpose senior centers. Currently, the state has three nationally certified senior centers. Several additional centers are fully operational but have not yet achieved certification, while others operate solely as group dining sites.

Senior Center Permanent Improvement Project (PIP) Grant Program

 It is the intent of the South Carolina Department on Aging for all multipurpose senior centers to be focal points in their respective communities. The Older Americans Act (OAA) defines a focal point as a facility established to encourage the maximum collocation and coordination of services for older individuals.

A focal point is a facility established to provide local leadership on aging issues, to provide older adults access to services at a central location with customer-oriented staff, and to assist those in the community who have an interest in, or need for, information, resources, or services. All Permanent Improvement Program (PIP) funded Multipurpose Senior Centers shall be focal points of their respective communities.

In 1991, the South Carolina State Legislature established the Senior Center Permanent Improvement Project (PIP) grant program and appropriated $948,000 per year from State Bingo tax ($79,000 monthly) and licensing fee revenues to fund a list of 74 specifically identified capital improvement projects. The total amount of funding required to complete these projects was reached in the year 2000.

The original legislation was amended by the General Assembly in 1997 to continue the program beyond the original list and the State Unit on Aging (hereafter called the SC Department on Aging or SCDOA), was given responsibility for developing an ongoing process to select and fund applications for senior center capital improvement projects. The resulting procedures created a competitive grant process for securing Senior Center PIP funds.

Senior Services Aging / Gerontology Public Infrastructure

DOW Combat Readiness – Medical Research Program Translational Research Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $1,450,000
The DOW Combat Readiness – Medical Research Program's FY26 Translational Research Award supports innovative research aimed at improving trauma care outcomes. This program emphasizes hypothesis-driven studies that can transition promising technologies into practical solutions for enhancing casualty survivability. Applicants must provide preliminary data and utilize validated animal models, with a focus on projects that meet a minimum technology readiness level of 4, ensuring a mature translational research effort.
Crisis Intervention Post-Traumatic Stress Disorder

Improved Drug Susceptibility Testing (DST) for Mycobacteria

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is funding research to enhance drug susceptibility testing (DST) for mycobacteria. This initiative aims to improve testing for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections, which are on the rise. Current methods are slow and ineffective against drug-resistant strains, making rapid DSTs essential for effective treatment and reducing transmission rates. Innovative approaches, including rapid genotypic and phenotypic methods, will be supported to address these challenges.
Infectious & Parasitic Diseases Tuberculosis Drug-Resistant Bacteria

Darlington County Grants for Nonprofits Highlights

Looking for Darlington County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all Darlington County grants recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grant Funding Trends in South Carolina

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Darlington County Grants for Nonprofits year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Darlington County Grants for Nonprofits given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Darlington County Grants for Nonprofits changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081