Best Greenville Grants for Nonprofits in South Carolina

The National Institute of Allergy and Infectious Diseases (NIAID) is funding research to enhance drug susceptibility testing (DST) for mycobacteria. This initiative aims to improve testing for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections, which are on the rise. Current methods are slow and ineffective against drug-resistant strains, making rapid DSTs essential for effective treatment and reducing transmission rates. Innovative approaches, including rapid genotypic and phenotypic methods, will be supported to address these challenges.

The Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) aims to enhance asthma prevention and treatment in economically disadvantaged pediatric populations. Funded by the NIH, CAUSE supports multi-site clinical studies to identify innovative strategies and treatment targets for asthma. Utilizing systems biology, the network seeks to discover specific disease endotypes suitable for new therapeutic approaches, addressing the high burden of asthma in urban settings.

The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.

The National Institute of Mental Health is inviting research applications for the AIDS Research Center program, which includes Developmental Centers and full Research Centers. This initiative aims to enhance interdisciplinary HIV/AIDS research through collaboration and innovative approaches across various scientific domains. The program emphasizes alignment with national strategies and encourages applications from teams skilled in fostering partnerships with diverse stakeholders. Although applications are currently not being solicited, this notice allows potential applicants time to prepare strong proposals.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing research on immune tolerance through its Collaborative Network. This program aims to clarify the mechanisms of immune tolerance and develop interventions for related diseases, including transplant rejection and autoimmune disorders. Key objectives include conducting clinical trials on tolerogenic strategies and refining immune assays. This initiative is supported by regulations under the Public Health Service Act, ensuring a structured approach to improving patient outcomes.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

The Translational Transplantation Tolerance Cooperative Study Group, supported by the National Institute of Allergy and Infectious Diseases, aims to advance transplant tolerance strategies that promote long-term graft survival without lifelong immunosuppression. This initiative focuses on developing, optimizing, and evaluating methods to induce immune tolerance in allogeneic transplants through collaborative efforts across multiple centers, utilizing translationally relevant models to ensure effective outcomes.

The NIAID aims to enhance our understanding of the interplay between chronic and infectious diseases through innovative precision systems biology research. By utilizing advanced technologies such as multi-omics and artificial intelligence, the initiative focuses on uncovering critical pathways that connect infections to chronic health issues. This multidisciplinary approach leverages longitudinal patient data to inform and improve prevention and treatment strategies, ultimately seeking to provide insights into disease progression and host-pathogen interactions.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

Small Rental Development Program (SRDP)

The Small Rental Development Program (SRDP) offers both federal and state funding sources for the development of new construction and rehabilitation of projects with small numbers of affordable housing units (4-39). Funding available for the 2026 Small Rental Development Program (SRDP) will be approximately $40,483,611.93 through a competitive application cycle beginning in April. 

Approximately $40,483,611.93 of funding will be available. Applications will be placed in one of the three (3) set-asides:

• General New Construction/ Conversion– $20,241,805.97 50% of available funds. This set-aside will include new construction applications that contain 5-39 units.
• Micro Developments – $10,120,902.98, 25% of available funds. Thisset-aside will include new construction and rehabilitation applicationsthat contain 4 units.
• Rehabilitation – $10,120,902.98, 25% of available funds. This set-aside will include rehabilitation applications that contain 5-39 units.

ASPCA Reimagining Racers: Grants for Adopting Out Retired Racehorses Grant

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and organizations actively participating in the warm-up ring (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) are invited to apply for a grant to support an increase in capacity and/or efficiency of programs aimed at adopting out retired Thoroughbred racehorses. 

Funding requests for this grant initiative should focus on:

Activities that increase capacity, decrease length of stay, reduce cost of care or increase efficiencies, and/or improve humane outcomes in other ways. Examples:

• Training programs
• Programs that engage new adopters and grow the market share for adoption
• Medical make-ready or rehabilitation with a focus on innovation and/or sustainability
• Collaborations with other equine industry organizations to increase support for retired racehorses

Proposals will be evaluated on their potential (within the 12-month grant term) to: 

• Increase capacity (the number of horses that can be rehabilitated, trained, and placed)
• Decrease length of stay
• Decrease cost of care
• Reduce risk, harm or suffering for retired racehorses

Requests may be for the creation of new programs or the expansion of existing programs. Programs that test innovative ideas are welcome.

Grant Amounts

Grants will generally range from $10,000-$40,000, with a maximum individual grant amount of $60,000. The total funding amount available for this grant opportunity is $200,000. 

Eligibility

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and active Warm-Up Ring participants (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) whose mission or operations focus significantly on serving retired Thoroughbred racehorses are eligible to apply for this grant opportunity. Adoption organizations must be up to date on reporting data biannually to the Equine Welfare Data Collective (EWDC). If you’re unsure about your eligibility, you may contact therighthorse@aspca.org to confirm before applying.   

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) was founded on the belief that animals are entitled to kind and respectful treatment by humans. We invite all voices to join us in working together to improve the lives of animals in need.

The ASPCA Right Horse Grants aim to enhance equine adoptions and support community equines by funding programs that boost shelter capacity or assist in keeping owned equines in their homes. Grants between $5,000 and $50,000 are available, with a total funding pool of up to $750,000. Eligible applicants include ASPCA Right Horse Adoption Partners and organizations committed to the welfare of retired Thoroughbred racehorses. Proposals should clearly outline the objectives and expected impacts.

SC Historic Preservation State Grant Fund 

The purpose of the State Grant Fund is to support historic preservation projects that benefit local communities and the public through the physical repair and rehabilitation of South Carolina’s historic buildings. 

Historic buildings, for the purposes of the grant, are buildings that are listed as a contributing resource in a National Register of Historic Places district, or listed individually in the National Register, or determined by the SHPO to be individually eligible for listing in the National Register. The historic building must be located in South Carolina.

Planning Grants

Planning Grants are awarded to assist applicants in the development of conditions assessments and/or “bid-ready” plans and specifications that meet the Secretary of the Interior's Standards for Rehabilitation. Reimbursable planning grants up to $50,000 will be awarded. No cash match is required. 

Awarded funds are provided only as a reimbursement. SCDAH contributes its share and repays the grant recipient for eligible expenses through a reimbursement process. Applicants must document that they have a minimum of 50% of the Total Project Costs on hand designated specifically for the project and should be prepared to make whatever financial arrangements are necessary to ensure that project work is not delayed during the reimbursement process, which may take six (6) weeks. No work completed prior to the execution of the grant funding agreement will be eligible for reimbursement.

SC Federal Historic Preservation Grants

Historic Preservation Grants are federal funds from the US Department of the Interior, National Park Service, and administered by the South Carolina Department of Archives and History, State Historic Preservation Office (SHPO). Funds for the grant program are derived from Outer Continental Shelf mineral receipts. Each year the NPS allocates funds to the SHPO to help cover the cost of its operations, salaries and grants. Ten percent of those grant funds awarded to the SHPO must be passed through to Certified Local Governments (CLGs) per federal regulations.

Amounts available

Grant awards usually range from $5,000 to $35,000. The maximum amount awarded is $40,000. The SHPO anticipates that approximately $200,000 will be available for all grants. 

Stabilization Grants are awarded for “bid-ready projects” for the stabilization and weatherization of historic buildings. Stabilization and weatherization, as a treatment, is the act or process of applying measures designed to reestablish the structural stability of an unsafe or deteriorated property and a weather resistant enclosure while maintaining the essential form as it exists at present. The stabilization and weatherization must meet the Secretary of the Interior’s Standards for Rehabilitation. 

South Carolina Department of Parks, Recreation & Tourism

SCPRT operates state parks, markets the state as a tourist destination and provides grants for parks, recreation and tourism development.

Land and Water Conservation Fund

The Land and Water Conservation Fund (LWCF) is a Federal program that provides matching grants for the acquisition or development of outdoor recreation areas and facilities. This is a reimbursable grant program requiring a 50% match. Only state agencies and local governments may apply.

South Carolina has invested more than $67 million of Land & Water Conservation Funds in approximately 1,200 land acquisition and recreation facilities projects since the program began in 1965. The LWCF program has always required that any property acquired or developed with its funds be maintained in perpetuity as an active and viable outdoor recreation venue.

As in previous years, revitalizing existing LWCF properties will remain a topline priority; however, the 2026 round will also be open to new park projects, especially those that address capacity issues. For a new project to qualify for funding, the local government will have to prove, during an on-site inspection, that all of their existing LWCF properties are in good shape and are being used appropriately. If there are issues with any LWCF properties, we will request that you apply instead for LWCF to correct those problems.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

Junior League of the Great Lakes Bay Region Scholarship

Junior League of the Great Lakes Bay Region is an organization of women committed to promoting volunteerism, developing the potential of women and improving the community through the effective action and leadership of trained volunteers. Its purpose is exclusively educational and charitable. The Junior League of the Great Lakes Bay Region is an organization that welcomes for membership all women regardless of age, race, creed, religion or national origin, who demonstrate an interest in and commitment to volunteerism.

The league has had many fundraising events in its history, always with the purpose of returning monies to the community through varied and needed projects. The Junior League of the Great Lakes Bay Region Scholarship is one of those projects.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

JustJane Art Scholarship Fund for Women

Truly unique humans like Jane Marie Ewing do not populate the universe very often, and the JustJane Art Scholarship for Women was created to honor her remarkable spirit.

Jane was an artist at heart, finding joy in countless creative pursuits – whether baking delectable treats, capturing life’s beauty through photography, or expressing her imagination in fashion and digital illustration. Her zest for life was infectious, often bringing laughter through her playful “Jane Pranks”, which will forever live in the hearts of family and friends. Jane shared an inseparable bond with Kyle, each the center of the other’s universe. Tragically, Jane was taken from this world unexpectedly in 2025.

Her vibrant artistic soul touched every aspect of her life – from painting and interior design to crafting costumes for parties and pranks. Though her passion for art wasn’t fully nurtured early on, once she embraced it later in life, creativity flowed freely, illuminating the lives of everyone around her. Jane saw beauty everywhere, and her art became a reflection of that vision.

This scholarship carries forward Jane’s legacy, helping future generations cultivate their own artistic passions. It is a reminder to future generations that art has the power to transform lives.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

Kappa Alpha Psi Fraternity – Saginaw Alumni Scholarship

Kappa Alpha Psi, an international college fraternity, was founded in 1911 and has more than 600 functioning undergraduate and alumni chapters. The motto of the fraternity is “achievement in every field of human endeavor.” Fashioning achievement as its purpose, Kappa Alpha Psi continues to unite college men of patriotism and honor in a bond of fraternity.

The Kappa Instructional Leadership League is a male youth group consisting of area high school students. The youth group is sponsored by the Saginaw Alumni Chapter in accordance with the fraternity’s National Guide Right Program.

The Saginaw Alumni Chapter has established a scholarship program in recognition and memory of the following men who were devoted and dedicated members of Kappa Alpha Psi Fraternity: Lee Arthur, Sr., John Gibson Jr., Dr. Vernal Cambridge and George Carter, Sr.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

Lisa Krukowski-Whalen Nursing Scholarship

The Lisa Krukowski-Whalen Nursing Scholarship was established to provide financial assistance to a graduating senior or college student from Saginaw County who plans to pursue a nursing career.

Mrs. Lisa A. Krukowski-Whalen graduated with honors from Bridgeport High School in 1983 and with honors from the University of Michigan School of Nursing in 1987. Lisa loved her career in nursing. She worked at St. Luke’s Hospital in the Pediatrics Intensive Care Unit. While working at St. Luke’s Hospital, Lisa also taught nursing (clinical) at Saginaw Valley State University.

Despite health complications, Lisa remained an energetic and loving person until her passing at the age of 41. It is in her spirit that family and friends have created a nursing scholarship for any deserving student in the Saginaw County.

Kenny Simon Scholarship

Kenny Simon, a member of the class 1988, met an untimely death in the summer of 1985. Kenny’s parents and friends established a scholarship fund in his honor.

The interest from this fund is to be used annually to provide a scholarship for a deserving member of the graduating class. In the event the scholarship if not applied for by students, the money will be contributed to the Special Olympics Program.

Mark Gradeless Welding Scholarship

This award was created in 2021 to honor the life of Mark “Grady” Gradeless. A 1977 graduate of Columbia City Joint High School, he worked at Dana Corporation, where he tirelessly serviced machines from the age of 18 until his retirement. “Grady” was a member of the United Auto Workers, Steelworkers Union and could often be found in his barn fixing something or tinkering. He was known for his daredevil shenanigans, practical jokes, patience, hard work, common sense advice and ability to uplift those around him. “Grady” was an amazing Dad, Grandfather, Great-Grandfather and friend to all who knew and loved him. This award is for a student attending Ivy Tech Community College for the pursuit of a welding certificate.

Jerry Walker Memorial Scholarship

The Jerry Walker Memorial Scholarship Fund was established in Jerry’s honor, to partner with Whitley County young people whom Jerry cared deeply about. Jerry served on The Center’s Board of Directors for more than 6 years, and was a passionate volunteer, donor, and advocate for helping young people find hope and equipping them to thrive in life.

This scholarship is available to any person that has have been an active After-School SERVE participant for 2 or more semesters and will be attending any post-secondary schooling.

This Scholarship is due March 1st of each year.

Lester & Joy Worrick Memorial Scholarship Fund

This scholarship was created in memory of Lester and Joy Worrick. It will be awarded to a Whitley County 4H participant that plans to pursue a degree in agriculture.

Horizon of Hope Scholarship

Balancing the responsibilities of family and work can be challenging for anyone, but for single parents who want to improve their lives by continuing their education, juggling the added responsibilities can seem downright overwhelming.

The Horizons of Hope Fund was established to recognize and encourage single parents who have returned to school. Created to help lighten the load, Horizons of Hope assistance can be used for tuition expenses, books, supplies, transportation, childcare, or other living expenses.

Up to $500 per semester is available to single parents.