Best Horry County Grants for Nonprofits in South Carolina

The Field Initiated Projects Program aims to foster new research and develop solutions that enhance the inclusion and independence of individuals with disabilities. This initiative focuses on generating scientific knowledge and understanding critical issues faced by these populations, particularly those with significant support needs. With a total of 16 grants available over a 36-month period, this program encourages innovative approaches that support employment, living arrangements, and caregiver involvement.

The Rehabilitation Research and Training Center (RRTC) focuses on enhancing the lives of parents with disabilities through research, training, and technical assistance. This initiative aims to develop evidence-based services and supports that empower parents in their caregiving roles. Funded by the US HHS: Administration for Community Living (ACL), the project spans 60 months with a commitment to fostering inclusive environments for families. The RRTC will explore innovative interventions and technologies to better support these parents in their daily challenges.

The Rehabilitation Engineering Research Center aims to enhance services for individuals who are blind or have low vision through innovative technology development. This initiative focuses on overcoming rehabilitation challenges and environmental barriers, promoting independence and community living. A grant of five years will support ongoing research efforts, ensuring advancements in assistive technologies that empower the target population. The project aligns with the Rehabilitation Act's goals, emphasizing the importance of accessibility and inclusion.

The Center on Knowledge Translation for Disability and Rehabilitation Research (KTDRR Center) aims to enhance the use of relevant disability and rehabilitation research through effective knowledge translation. Serving as a key resource for NIDILRR grantees and the general public, the KTDRR Center's initiatives will support high-quality research dissemination. The project spans 60 months, including five 12-month budget periods, ensuring ongoing support for researchers and stakeholders in the field.

The NIH Stroke Clinical Trials Network (StrokeNet) aims to enhance stroke treatment through regional clinical enrollment coordinating centers (RCCs). Supported by the National Institute of Neurological Disorders and Stroke (NINDS), this initiative promotes collaboration for clinical trials that focus on acute stroke treatment, prevention, and rehabilitation. While applications are not currently being solicited, this notice serves to prepare potential applicants for future opportunities in advancing stroke care.

The Undiagnosed Diseases Network (UDN) aims to enhance diagnostic excellence through multiple clinical Networks of Diagnostic Excellence (NODEs). These NODEs will operate as regional networks, leveraging partnerships with various healthcare facilities to provide participant-centered evaluations for complex conditions. They will also engage in research and training to improve diagnostic tools and strategies. This initiative encourages collaboration and aims to improve the overall experience and access for participants in need of specialized care.

The National Institutes of Health (NIH) is continuing its support for the NeuroNEXT initiative, which focuses on conducting clinical trials and biomarker validation studies for neurological disorders. This infrastructure aims to foster innovation and enhance the development of effective neurotherapeutics for both adult and pediatric populations. While applications for network clinical research sites are not currently being solicited, this notice allows potential applicants to prepare collaborative and responsive applications.

The Homeless Veterans' Reintegration Program (HVRP) aims to assist veterans experiencing homelessness by providing tailored employment services. This federal initiative focuses on helping veterans transition to stable employment through job training, case management, and connections to local supportive services. HVRP aligns with national priorities to enhance career outcomes for veterans, ensuring they receive the necessary tools and resources for sustainable employment and integration into the workforce.

The Native Public Health Resilience (NPHR) program is a new funding opportunity aimed at supporting Tribes and Tribal Organizations in delivering essential public health services. Sponsored by the Indian Health Service, this initiative seeks to bolster public health infrastructure and resilience within tribal communities, ensuring they have the necessary resources to address health challenges effectively. Eligible applicants will receive financial assistance to enhance their public health capabilities and improve community health outcomes.

The NIH Stroke Clinical Trials Network (StrokeNet) aims to enhance stroke treatment and recovery through a robust national infrastructure. Funded by the National Institutes of Health, this initiative focuses on clinical trials that evaluate innovative therapies for stroke patients and those at risk. The program is currently not soliciting applications but encourages the development of collaborations to support the national coordinating center and data management efforts, ultimately improving outcomes for individuals affected by stroke.

The NIDA Avenir Program aims to cultivate innovative leaders in addiction science by funding exceptional early stage investigators (ESIs) embarking on pioneering research. Launched in 2015, this initiative encourages high-risk, high-reward mechanistic studies related to Substance Use Disorders (SUDs) across diverse scientific domains. Applications from new investigators and those outside addiction research are welcomed, fostering interdisciplinary approaches that enhance understanding of SUD mechanisms. The program supports ESIs who may lack preliminary data but demonstrate potential for impactful contributions.

The BRAIN Initiative aims to advance innovative neurotechnologies by funding early-stage clinical studies for devices that record or stimulate the human central nervous system. This initiative encourages collaborations between clinical researchers and device manufacturers to facilitate groundbreaking studies. By addressing the challenges of obtaining safety and utility data, this program supports both non-invasive and significant risk devices, providing essential insights into their functionality and design. Applications are currently not being solicited, allowing time for meaningful project development.

The BRAIN Initiative, led by the NIH, aims to advance neurotechnologies at institutions with limited NIH funding. This funding opportunity encourages collaboration and knowledge transfer to integrate innovative neurotechnologies into research and training programs. While applications are currently not being solicited, potential applicants should start developing partnerships and projects in preparation for future submissions. This initiative will enhance the dissemination of BRAIN technologies and support novel research practices.

Stars, Stripes & Skilled Trades

General Motors invites eligible 501(c)(3) nonprofit organizations to submit proposals for Stars, Stripes & Skilled Trades, a workforce development initiative designed to support veterans, transitioning service members, and military-connected family members—including spouses—in building lasting careers in manufacturing, automotive, and skilled trades. GM is seeking scalable, results-driven programs that create clear pathways to quality careers while recognizing the experience and leadership that veterans and military families bring to American industry. 

We're looking for existing initiatives that:

• Serve career-transitioning service members, veterans, and military-connected family members
• Provide industry-recognized training, certifications, or credentials
• Connect participants to mentorships, quality jobs, and long-term career pathways in manufacturing, automotive technician roles, or skilled trades.

Grant Range

• $100,000 | $250,000 | $500,000

Mellon Foundation

The Andrew W. Mellon Foundation was established in 1969 to strengthen, promote, and defend the arts and humanities as essential to democratic societies. Throughout our history, Mellon has held true to our founding commitments, secure in our conviction that the arts and humanities are essential to the health of a multivocal and democratic society. From our earliest days, we have aspired to build partnerships with our grantees, offering expertise and counsel in addition to funding

In recent years, Mellon has expanded on these core principles by actively prioritizing social justice across all of our grantmaking. This strategic shift builds on our long history of advocating for and investing in expanded access to higher education, humanities, and the arts, and addressing historical inequities in these fields. Our vision for Mellon’s future includes a focus on justice for all in all that we do—rooted in the Foundation’s long-held historic belief in the impact and power of the arts and humanities. At Mellon, we make grants to actively support communities and ideas that unlock the power in the arts and humanities that helps connect us all.

Humanities in Place Grant Program

The Andrew W. Mellon Foundation actively works with our grantee partners and we are deeply immersed in the fields in which we invest. Our grants are designed to activate the spirit of learning through the creation and sharing of bold new ideas and the inspiration felt in art, expression, spaces, and scholarship. 

From Alaska to Guam and the Borderlands to the Midwest, America is a constellation of unique heritages, traditions, and stories. In communities of all sizes, people are striving to expand the ways we can understand and authentically engage with the history that is all around us. Our Humanities in Place grants fund place keepers, artists, institutions, and storytellers who shine a spotlight on historically overlooked sites, and the communities and stories that surround them. In doing so, they help broaden our shared understanding and open new paths to discover what unites us, what makes us unique, and what we can learn from one another.

Melton Foundation

The Melton Foundation is an international 501(c)(3) non-profit organization registered in the USA, and a leading proponent of Global Citizenship education and practice worldwide. Established nearly thirty years ago with the credence that collaborations across boundaries can forge sustainable solutions to the world’s most pressing challenges, today, our programs reach millions of young leaders, having crystallized into a network of over 750 life-long Melton Fellows spread across 40+ countries. Our primary operations are in Chile, China, Germany, Ghana, India, and the United States of America, with legal subsidiaries in Bangalore, India; Jena, Germany; Temuco, Chile; and Accra, Ghana. 

Through our fellowship and collaborative programs we promote and enable global citizenship as a way for individuals and organizations to work together across boundaries of place and identity to solve challenges in an interconnected world.

Melton Foundation Action Grants

The Melton Foundation offers grants year-round to support Melton Fellows in developing skills, perspective and wider networks to further their capacity as global citizens and contribute towards building an equitable, sustainable, and peaceful world.

In almost 10 years of granting, more than 100 Fellows’ initiatives have been awarded with a Melton Foundation grant to

• Build awareness and/or further awareness raising around global issues and the Sustainable Development Goals (SDGs),
• Develop individual and collective responsibility for sustained, collaborative action,
• Grow capacity to collaboratively drive and sustain social impact at the local and/or global level,
• Further the design, implementation and evaluation of collaborative actions that embody the spirit of global citizenship practice and further social impact, or
• Support coordinated social-impact efforts in a particular or across (emerging) Melton Foundation Hub regions to promote global citizenship practice (s) and the organization’s mission.

The Climate Program Office (CPO) FY2026 Earth System Science and Services Partnership (ESSSP) aims to enhance NOAA's mission through collaborative research and activities. It focuses on understanding changes in Earth's systems and their impacts on ecosystems and communities. Eligible applicants include academic institutions offering doctoral degrees in NOAA-related sciences. The total funding available is approximately $10 million, supporting initiatives that encompass research, data evaluations, and stakeholder engagement.

The project titled 'Aquatic Fauna Response to Ecosystem Restoration in Southwest Florida' aims to assess the effects of the Comprehensive Everglades Restoration Plan (CERP) on aquatic fauna. It will utilize a Monitoring and Assessment Plan (MAP) to evaluate responses of aquatic communities and inform future restoration efforts. This initiative is crucial for documenting CERP benefits and guiding further ecosystem restoration, ultimately benefiting the public by tracking progress in ecological recovery.

The R3PEATS Grassroots Rigor Projects, funded by the NIH, aim to enhance research practices through two project types: Metascience and Laboratory Capacity-Building. Metascience projects focus on creating tools and metrics to promote high-quality research, while Laboratory Capacity-Building projects help labs adopt new techniques and share data that influence research outcomes. This initiative is part of a broader effort to improve rigor, replicability, and reproducibility in scientific research.

The R3PEATS Multi-Team Triangulation initiative supports collaborative research teams to explore a central biomedical question using diverse methods and model systems. It emphasizes the importance of identifying biological variability and ensuring the robustness of findings through replication strategies. This program is part of the NIH Common Fund's Rigor, Replicability, & Reproducibility to Promote Excellence in Science, aiming to enhance the accuracy and translation of scientific discoveries.

The R3PEATS Rigor Scholar Cohort Awards (K12) are designed to empower early-career researchers by enhancing their skills in rigorous scientific practices. This initiative promotes collaboration across institutions to develop best practices in research methodologies, including preregistration and randomization. Participants will gain essential training to ensure excellence and transparency in scientific research, aligning with the NIH's commitment to improve replicability and reproducibility in the field.

Dennis Van der Meer Tennis Foundation

A 2021 International Tennis Hall of Famer, Dennis was the founder of the Professional Tennis Registry Foundation (PTR Foundation), now called Dennis Van der Meer Tennis Foundation, Professional Tennis Registry (PTR), and the Van Der Meer Tennis University.

Dennis Van der Meer Tennis Foundation is a nonprofit organization exempt from federal income tax under Section 501(c)(3) of the Internal Revenue Code. The Dennis Van der Meer Tennis Foundation provides support to deserving individuals and organizations globally. The foundation is also focused on bringing tennis within reach to countless people worldwide.

Nehemiah Atkinson Humanitarian Grant

This grant reflects the Foundation’s dedication to giving and serving others. It is awarded to individuals who have shown an extraordinary commitment to enhancing the lives of those around them.

The Foundation supports projects that promote and preserve the legacy, vision, and spirit of our founder, Dennis Van der Meer. We will only consider funding for educational, life enrichment, mentoring, and tennis programs.

The Accelerating Impact for Hard-to-Treat Cancers Award, offered by the Children's Cancer Research Fund, focuses on pre-clinical research to enhance treatment outcomes for pediatric cancers that are difficult to treat. The award supports innovative studies, including pilot projects and the development of new technologies. As a nonprofit, CCRF has invested over $235 million in initiatives since 1981, aiming to improve therapies and support for children battling cancer, thereby fostering safer and more effective treatment options.

Barbara McDowell Social Justice Center Inc.

The Barbara McDowell Social Justice Center litigates, educates, advocates, and provides grants to nonprofits to eradicate social injustices. 

We pursue litigation through our own efforts as well as funding others in the following fifteen issue areas: Access to Benefits, Children’s Rights, Disability Rights, Discrimination, Domestic Violence, Due Process, Environmental Justice, Healthcare, Homelessness, Housing, Native American Rights, Prisoners’ Rights, Refugee and Immigration Rights, Voting Rights, and Veterans’ Rights.

Barbara McDowell Social Justice Center Grant

We make grants to organizations that undertake systemic social justice litigation across fifteen issue areas. The Center funds litigation matters that are consistent with our namesake Barbara McDowell’s past legal efforts and her beliefs regarding social justice.

Applications must be for a specific social justice legal case, including the filing of an appeal. Grant funds are to be used only for attorney time charges and litigation expenses related to the specific case for which an organization is applying to be funded. 

The A Woman’s Work Founders Scholarship, provided by the Longmont Community Foundation, supports women in the Longmont and St. Vrain Valley area who demonstrate financial need and a commitment to their education. With awards ranging from $500 to $5,000, this scholarship prioritizes applicants who have shown resilience in overcoming challenges. By empowering women, the scholarship aims to foster individual achievement and strengthen the community, creating pathways to sustainable futures.

The Braly Trade / Vocational Scholarship, offered by the Longmont Community Foundation, supports individuals over 21 pursuing a trade or vocational education. This one-time award of $5,000 is allocated for tuition, fees, books, and other educational expenses. The scholarship honors the Braly family’s legacy in trades and aims to empower recipients to positively impact their communities. Applicants must be high school graduates or hold a GED and plan to attend an accredited institution in the U.S.

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Homeless To Housing Program - Household Comfort Support

DVNF is dedicated to assisting disabled and at-risk veterans in their transition from homelessness to permanent housing. Recognizing that securing a home is a significant milestone, DVNF understands that true stability is achieved when a house becomes a home, furnished with essential items that provide comfort and functionality. We help cover essential costs related to securing and creating comfortable housing for at-risk veterans.

The H2H Program offers comprehensive support to veterans by providing: Household Comfort Support of up to $2,000 worth of essential household items to ensure veterans have a stable, safe, and comfortable living environment.

For Financial Assistance: Payments are processed through two payment cycles each month, around the 15th and 30th. For Furniture Assistance: Once the List of Items form is completed, DVNF staff will purchase the requested items, which should arrive within 7-10 business days.