Upcoming Webinar
How Funders Feel About AI, and What Keeps Them Saying Yes.
Wed, Oct 14 @ 2PM ET

Skip to main content
Main content

Best Lexington County Grants for Nonprofits in South Carolina

Discover active funding opportunities in Lexington County Grants for Nonprofits. 37,000+ grants are available for a wide range of missions and programs with additional grants in Richland County, Charleston County, and Greenville County.

9,000+

Available grants

$2.61B

Total funding

$5K

Median grant

9,000+ grants
$2.61B total
$5K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

9,255 Results based on applied filters

High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed) (356883)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $5,000,000
The High-End Instrumentation (HEI) Grant Program, offered by the NIH, invites applications for purchasing or upgrading high-end, specialized instruments, with a minimum award of $750,001 and a maximum of $2,000,000. This program supports NIH investigators aiming to enhance their research capabilities through advanced technologies such as mass spectrometers and electron microscopes. Applications must be submitted by 5:00 pm local time of the applicant organization.
Medical Technology, Devices, and Equipment Health & Medicine Biotechnology +1 more

Computational Approaches to Curation at Scale for Biomedical Research Assets (R01 Clinical Trial Not Allowed) (356888)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.
Biomedical informatics Epidemiology & Public Health Health Information Technology

Reboot Representation Grant

Reboot Representation Tech Coalition
Association/Society
United States
Unspecified amount
The Reboot Representation Tech Coalition aims to significantly increase the number of Black, Latina, and Native American women earning computing bachelor’s degrees. They invite qualified organizations to submit grant inquiries focused on recruiting and retaining these women in tech. Programs that leverage existing resources and operate across multiple regions will be prioritized, and the Coalition seeks initiatives backed by substantial research and community trust.
Computer Science & Engineering Diversity, Equity & Inclusion Women's Rights & Equality +4 more

Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
The Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program, funded by the NIH, aims to enhance the biomedical research landscape by supporting resource-limited organizations. It targets domestic institutions with limited research resources and few doctoral students in biomedical fields, promoting broader participation in research and boosting administrative capacities for sponsored programs. Applications are due by 5:00 PM local time of the applicant organization, ensuring timely submissions.
Biology Health & Medicine

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) (356925)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
This grant opportunity from the NIH aims to enhance mechanistic research on precision probiotic therapies through a biphasic R61/R33 award mechanism. It encourages innovative studies to identify specific biological factors influencing probiotic responses, thereby improving clinical outcomes. The program supports up to five years of research, with the initial phase focused on discovering unique host characteristics and the second phase assessing improvements in probiotic efficacy through rigorous studies.
Integrative & Alternative Health Microbiomes

Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) (356927)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,400,000
This funding opportunity aims to advance mechanistic research for precision probiotic therapies. It invites R33 applications focused on characterizing individual differences in probiotic responses, identifying responder subgroups, and enhancing clinical outcomes. The goal is to develop strategies addressing barriers to effective probiotic use, accounting for human variability. Proposals should include innovative studies using animal models or human subjects, supported by preliminary data to test biological patterns and their effects on health outcomes.
Biology Microbiology Microbiomes

Extramural Discovery Science Accelerator Award

American Cancer Society
Association/Society
United States
Up to US $75,000
The Extramural Discovery Science Accelerator Award supports the commercialization of ongoing cancer research projects, focusing on experiments that facilitate technology validation and de-risking. Applications are accepted on a rolling basis, with a budget of up to $75,000 for one year. This award encourages independent investigators at any career stage to advance their technologies, with a strong emphasis on commercial viability and collaboration within a learning community.
Cancer / Oncology Medical Technology, Devices, and Equipment

WNDB: Internship Grant Program

We Need Diverse Books
Private
United States
US $3,000
The WNDB Internship Grant Program aims to support diverse students pursuing careers in publishing by offering 16 grants of $3,000 each. Given the high living costs in major publishing hubs, this program helps alleviate financial barriers, enabling interns to gain vital industry experience. Grantees are required to attend various events during the summer, including training and networking opportunities. By fostering diversity, WNDB contributes to a more inclusive publishing landscape, having supported over 140 students since its inception.
Writing & Literature Apprenticeship & Internship Programs Diversity, Equity & Inclusion

WNDB: Walter Dean Myers Grant Program

We Need Diverse Books
Private
United States
US $2,000
The Walter Dean Myers Grant Program, established by We Need Diverse Books, offers $2,000 grants to promising unpublished diverse writers and illustrators. Aimed at enhancing their craft and supporting traditional publication pursuits, this initiative has awarded over 70 grants since 2015, resulting in nearly 60 published books and numerous literary accolades. Applicants must identify as diverse and be U.S. residents, working towards a career in children's literature.
Writing & Literature Diversity, Equity & Inclusion

Watson-Brown Foundation Grant

Watson Brown Foundation Inc
Private
Alabama, Arkansas +8 more
US $33,000
The Watson-Brown Foundation Grant supports organizations dedicated to preserving the history and culture of the South. It offers various types of grants, including for educational programming and historic preservation, with a focus on southern studies. Eligible recipients include public charities in the southeastern United States. The Foundation's Junior Board of Trustees also awards grants to preservation projects in east central Georgia, emphasizing youth engagement in cultural heritage.
Law History Writing & Literature +2 more

Watson-Brown Foundation Scholarship

Watson Brown Foundation Inc
Private
United States
Up to US $3,000
The Watson-Brown Foundation Scholarship offers need and merit-based financial assistance to students from Georgia and South Carolina attending accredited four-year colleges. Established in 1970, the foundation aims to enhance educational opportunities for underprivileged youth, awarding over $2.4 million annually. Eligible students can receive up to $3,000 per semester to cover educational expenses, supporting their academic journey while encouraging responsible scholarship and historic preservation.
Education - Higher Education

National Scleroderma Foundation: New Investigator Grant

National Scleroderma Foundation
Private
United States
Up to US $200,000
The National Scleroderma Foundation's New Investigator Grant aims to support emerging researchers dedicated to scleroderma studies. This three-year grant, totaling $200,000, encourages applicants with doctoral degrees and postdoctoral experience. Eligible candidates are invited to submit proposals that may lead to further research funding. The grant emphasizes innovative research approaches while providing essential financial support for early-career investigators. Note that the grant does not cover certain costs, ensuring focused investment in research advancement.
Immune System Diseases Rare Diseases

Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant

National Scleroderma Foundation
Private
United States
US $200,000
The Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant, provided by the National Scleroderma Foundation, aims to support research in scleroderma-related lung disease. With a funding amount of $200,000, the grant encourages established investigators to explore innovative solutions and enhance understanding of this condition, ultimately working towards improving the quality of life for affected individuals and advancing medical knowledge in the field.
Rare Diseases Immune System Diseases Interstitial Lung Disease

National Scleroderma Foundation: Pediatric Scleroderma

National Scleroderma Foundation
Private
United States
Up to US $500,000
The National Scleroderma Foundation supports pediatric scleroderma research with up to $500,000 in funding for new and established investigators. Their mission focuses on advancing medical research and promoting awareness of scleroderma, with the vision of improving the lives of those affected. This initiative aims to encourage innovative research that could lead to better treatments and a potential cure for pediatric scleroderma, enhancing support for affected families.
Rare Diseases Immune System Diseases Children’s Health & Pediatrics

Blue Meridian Partners Grant

Blue Meridian Partners Inc
Private
United States
Unspecified amount
Blue Meridian Partners Grant aims to transform lives of young people and families in poverty by investing in scalable strategies that enhance economic and social mobility. The organization seeks stand-alone nonprofits with a proven track record, a compelling vision, and strong leadership. With a commitment to performance-based investing, Blue Meridian provides significant capital, often exceeding $100 million, to foster impactful solutions and address pressing social challenges effectively.
Economic Services & Development Poverty Alleviation & Services Youth Services +3 more

EmpowHer Grants

Boundless Futures Foundation
Private
United States
Up to US $50,000
EmpowHer Grants, offered by the Boundless Futures Foundation, provide essential financial support and resources to female entrepreneurs in the U.S. who are committed to creating social impact through their businesses. Grants, which can go up to $25,000, are available to those with businesses that are less than three years old and demonstrate revenue generation. This initiative aims to empower women by reducing barriers and fostering a supportive entrepreneurial community.
Entrepreneurship Business Development

Corporate Giving Program: Health Equity in Cardiovascular Disease Grant

Cytokinetics
Association/Society
United States
Up to US $20,000
The Corporate Giving Program by Cytokinetics focuses on health equity in cardiovascular disease, targeting underserved communities. It seeks to fund initiatives that address disparities in healthcare access, including public health campaigns, community support programs, and innovative solutions. Eligible organizations must be 501(c)(3) nonprofits in the U.S. that align with these goals, ensuring that no direct healthcare practice involvement occurs. This initiative aims to foster equitable health outcomes and enhance community well-being.
Cardiovascular Diseases & Systems Epidemiology & Public Health

Emily Stover Memorial Scholarship

Community Foundation for Nantucket
Private
United States
US $1,000 - US $10,000
The Emily Stover Memorial Scholarship offers $2,000 annually to support outstanding members of the Nantucket community. This scholarship is aimed at individuals who are dedicated to helping others and are pursuing careers that reflect this commitment. Eligible applicants must be Nantucket residents attending accredited colleges or universities, demonstrating a passion for community service and a desire to make a positive impact.
Academic Scholarship Programs

HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $375,000
The HEAL Initiative: Pain Research Enhancement Program (PREP) supports R15-eligible Principal Investigators in conducting innovative pain research. This program encourages interdisciplinary partnerships and aims to enhance the research environment for health professional trainees. Key application deadlines include November 19, 2024, and October 28, 2025, with specific dates for AIDS-related applications. By fostering collaboration, the initiative seeks to advance understanding and treatment of pain.
Chronic / Acute Pain Drug Use Disorder Anesthesia and Pain Medicine

Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program (UE5/T32)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program aims to foster the development of American Indian and Alaska Native scientists by funding eligible Tribal Entities. This initiative focuses on creating effective training and mentoring activities for individuals pursuing doctoral degrees in biomedical research. Ultimately, it seeks to enhance the capability of researchers to address health disparities within AI/AN communities, ensuring culturally appropriate and ethically responsible research practices.
Indigenous Health Systems Native American Services Medical Education & Professional Training +1 more

Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program (UE5/T34)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program aims to support federally recognized AI/AN Tribes and organizations in developing a workforce of researchers focused on AI/AN health disparities. This initiative, funded by the NIH, provides phased support for training and mentoring activities that equip individuals with the necessary skills to conduct culturally responsible biomedical research, ultimately guiding them towards successful careers in the biomedical research field.
Indigenous Health Systems Native American Services Biology +2 more

Wexner Field Fellowship

Wexner Family Charitable Fund
Private
North America
Unspecified amount
The Wexner Field Fellowship is a three-year program aimed at enhancing the leadership skills of Jewish professionals in North America. Participants engage in leadership institutes, receive personalized coaching, and gain access to professional development funds. This fellowship fosters a robust network of leaders committed to serving the Jewish community, encouraging a deeper understanding of its diversity and strengthening essential leadership competencies. Eligible candidates must be full-time employees at Jewish organizations with at least five years of relevant experience.
Jewish Culture Civic Leadership Development

Wexner Davidson Fellowship

Wexner Family Charitable Fund
Private
Canada, Mexico +1 more
Unspecified amount
The Wexner Davidson Fellowship (WDF) is a transformative leadership development program designed for Jewish communal professionals in North America aged 26-36. Over three years, Fellows engage in cohort-based learning at biannual institutes, receive coaching, and deepen their Jewish knowledge while building a strong professional network. This initiative fosters personal and professional growth, equipping the next generation of leaders to serve their communities effectively and connect with a global alumni network.
Jewish Culture Judaism

NCB - Botany Research Scholarship Program

Northern California Botanists
Association/Society
United States
US $1,500
The NCB - Botany Research Scholarship Program, offered by Northern California Botanists, targets undergraduate and graduate students pursuing research in botany and plant ecology. Scholarships of $1,500 support independent study, thesis, or dissertation projects within a specific geographic area of Northern California. Eligible applicants may reapply for funding for up to four years. This initiative aims to foster academic careers in botany and promote valuable ecological research.
Plant Science Ecology Botanical Conservation

Clinical and Translational Science Award (UM1 Clinical Trial Optional) (356316)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $6,500,000
The Clinical and Translational Science Award (CTSA) Program invites applications to enhance clinical and translational science through innovative partnerships and research programs. This initiative aims to accelerate the delivery of treatments to diverse populations by improving clinical research efficiency, creating national resources for public health responses, and providing training for clinical research professionals. Applications are due by 5:00 PM local time, with optional Letters of Intent recommended 30 days prior to the full proposal deadline.
Science Health & Medicine Epidemiology & Public Health +1 more

MOORE Equity in Mental Health Community Grants Program

American Psychiatric Association Foundation
Private
United States
US $10,000
The MOORE Equity in Mental Health Community Grants Program, initiated by the American Psychiatric Association Foundation, aims to enhance mental health services for young people of color. With grants up to $10,000 over two years, it supports community organizations addressing mental health and substance use inequities. Eligible applicants include non-profits with a focus on culturally relevant care and sustainable solutions. The program fosters collaboration and awareness through innovative initiatives aimed at improving access to essential mental health services.
Mental Health & Psychiatric Diseases Addiction & Substance Use Disorders Health Care Access & Delivery

Warren Alpert Foundation: Grants Program Funding Over $25,000

Warren Alpert Foundation
Private
United States
More than US $25,000
The Warren Alpert Foundation supports initiatives aimed at enhancing public health through grants exceeding $25,000 for medical research, education, and basic human services. Applications are reviewed quarterly, with deadlines preceding board meetings. The foundation's mission encompasses advancing medical treatments and cures through rigorous research and health education. This commitment empowers various projects that align with their vision of improving community health and fostering innovation in medical practices.
Education Health & Medicine Human & Social Services +1 more

Lexington County Grants for Nonprofits Highlights

Looking for Lexington County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all Lexington County grants recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grant Funding Trends in South Carolina

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Lexington County Grants for Nonprofits year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Lexington County Grants for Nonprofits given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Lexington County Grants for Nonprofits changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081