Best Mariposa County Grants for Nonprofits in California

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Jenice Schlein Denning Scholarship

This scholarship is to provide assistance with educational expenses for students who cannot otherwise afford attendance at an institution of higher learning. The applicant must be matriculating to a bachelor degree graduate institution, shown academic potential, and be pursuing a 4 year degree at an accredited two-year or four-year college or university. Financial need should be a major consideration for this award.

The scholarship is renewable.

About Community Foundation of Henderson County

• Mission: Helping people who care make lasting contributions to causes that matter.
• Vision: Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Elizabeth DeVilling Environmental Odyssey Scholarship

This scholarship provides support to graduating seniors or graduates of any Henderson County public, private or parochial high school seeking to further their education beyond high school. Recipients of this scholarship must be accepted to an accredited degree granting college or university and be actively pursuing an undergraduate degree in the field of environmental science or a related field. Preference will be given to those who have expressed a desire to pursue work which relates to environmental preservation and/or conservation and have financial need for assistance. Extra-curricular and extra participation in activity relevant to earth sciences/environmental sciences will be given added priority.

The EdTA Thespian Growth & Excellence Grants support theatre programs by providing financial assistance for troupe expenses, including travel to professional productions and participation in state conferences. Founded by the Educational Theatre Foundation, these grants aim to enhance educational theatre access and representation. By the end of 2024, 349 grants totaling over $286,000 will have been awarded, benefiting schools with Title 1 designations and empowering students and educators in their creative pursuits.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Educator & Program Grants

Giving school theatre programs a boost

The Thespian Growth & Excellence Fund is committed to supporting the ongoing development of theatre programs and the pursuit of excellence for educators, students, schools, and communities by offering a number of grants that assist in EdTA membership, teacher support, and programmatic resources for theatre in schools.

By the end of 2024, the Thespian Growth and Excellence Fund has awarded 349 grants to 276 schools, totaling $286,167 in assistance provided to school theatre programs, many at schools with Title 1 designations.

Equipment Upgrade (up to $5,000)

Can be awarded to help school theatre programs with large technical purchases that upgrade the resources available for theatrical use, such as lighting and sound equipment.

Dick & Judy Hoyt Inclusion Grant

The Doug Flutie, Jr. Foundation for Autism is excited to collaborate with the Hoyt Foundation for the Dick and Judy Hoyt Grant for Inclusion. Our joint effort is driven by a shared vision of fostering a society where individuals with autism and other disabilities are embraced and valued within their communities. In tribute to the pioneering spirit of Dick and Judy Hoyt, we will be distributing $50,000 through this community grant to support people with autism and other disabilities. Successful ways grant funds can be used: 

• Side-by-side participation with non-disabled peers in a swim program, the grant provides a private lifeguard to allow individualized support to ensure an inclusive experience.
• Grant provides the purchase of a racing chair to allow an individual with a disability to run in races with non-disabled peers.
• Competitive horseback riding supported by the grant to purchase specialized equipment to allow a rider to compete against non-disabled peers.
• Grant provides the purchase of an adaptive ski prosthetic to allow an individual to participate side by side with non-disabled peers on their high school ski teams.
• Participation in dance training and competitions to allow a student with a disability to compete in a dance competition with non-disabled peers, grant lessons, and staff to assist in dance training.
• Grant provides a mobile stand to allow a student with a disability to participate side by side with non-disabled peers in the college marching band. 

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Resident Research Award

Provides residents and fellows an opportunity to attend and present their scientific research at the SIR Annual Scientific Meeting. The intent is to expose young researchers who wish to further their careers in interventional radiology.

Award

Up to two recipients will receive complimentary registration and a travel stipend of $1,000.

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Research Scientist Award

Recognizes the contributions and accomplishments of PhD scientists and engineers at all levels of training for their basic and preclinical research on the topic of interventional radiology.

Award

Up to two recipients will receive complimentary registration and a travel stipend of $1,000.

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Dr. Gary J. Becker Young Investigator Award

Promotes excellence in academic research for members early in their careers. This award honors the founding editor of the Journal of Vascular and Interventional Radiology (JVIR) and recognizes the importance of the young investigator in developing interventional solutions for the future.

About

In 1990, SIR Foundation established the Dr. Gary J. Becker Young Investigator Award as a way to recognize promising young practitioners of interventional radiology early in their careers and encourage their pursuit of academic careers. Each year, the author of the most outstanding clinical science research paper submitted receives this distinguished award.

Award

$3,000 honorarium along with complimentary registration to the SIR Annual Scientific Meeting.

The award will be presented during the SIR Foundation Awards Ceremony at the SIR Annual Scientific Meeting.

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Dr. Constantin Cope Medical Student Research Award

Introduces interested medical students to the greater interventional radiology community at the SIR Annual Scientific Meeting. Recognizes the student author of an accepted abstract that best honors the spirit of inventiveness and scientific purity.

Award

Up to two recipients will receive complimentary registration and a travel award of up to $1,000.

Dr. Barry T. Katzen Master Clinician Award

Honors an interventional radiologist who exemplifies dedication to clinical practice, patient care, diligence in their work and continuous improvement within the field and who has also made a demonstrable impact at their institution or practice as a result.

About

The Dr. Barry T. Katzen Master Clinician Award seeks to honor an interventional radiologist who exemplifies dedication to clinical practice, patient care, diligence in their work and continuous improvement within the field as well as who has made a demonstrable impact at their institution or practice as a result. This award recognizes individuals who have made significant contributions to enhancing patient outcomes and advancing the reputation and practice of interventional radiology through their hard work, commitment and, most importantly, clinical practice. The award is being given in the name of Barry T. Katzen, MD, FSIR, who pioneered clinical practice for IR in 1976 and became a vocal advocate, champion and example for colleagues of the importance of IR being a clinical discipline for advancement of the specialty.

The recipient will receive:

• Complimentary annual meeting registration
• Recognition during the SIR Annual Scientific Meeting

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Excellence in Innovation Award

Fund compelling, novel ideas that lead to improved health outcomes in IR.

About

Interventional radiologists create and introduce novel, minimally invasive procedures and devices that help solve some of our toughest medical challenges. To continue this rich history of innovation in IR, the purpose of this award is to fund compelling, novel ideas that lead to improved health outcomes in IR.

Innovation, for this purpose, is broadly defined as any use of emerging methods, new devices, new procedures or new technologies, such as artificial intelligence and nanotechnology, that display an exceptional degree of potential for transforming and advancing the specialty of interventional radiology.

The Annual Meeting Research Award Committee selects one recipient for this award each year.

The recipient will receive:

• Complimentary annual meeting registration
• Travel stipend up to $1,000
• The opportunity to present their research as well as meet peers, network with senior scientists and participate in learning opportunities at the SIR Annual Scientific Meeting
• Recognition during the SIR Annual Scientific Meeting

About the ASHFoundation

ASHFoundation supports innovators and sparks innovation in communication sciences. We give early support to promising students, researchers, and clinicians exploring bold ideas to transform the field and improve people's lives.

Artificial Intelligence in Communication Sciences and Disorders Research Grant

About

The American Speech-Language-Hearing Foundation (ASHFoundation) invites investigators to submit proposals for up to four research grants ranging from $25,000 to $50,000. The Artificial Intelligence in Communication Sciences and Disorders Research Grant (AI in CSD Research Grant) supports interdisciplinary studies that advance the ethical, clinically and scientifically grounded application and integration of artificial intelligence (AI) into communication sciences and disorders (CSD) practice and service delivery. Funding may be applied to one- or two-year studies.

Specific Objectives of the Funding Opportunity

As part of this initiative, the ASHFoundation invites proposals that implement AI technologies to transform clinical practice, education, and research in CSD. Proposals that are submitted under this funding opportunity must meet the following:

• Include interdisciplinary research teams that integrate clinicians and AI researchers,
• Address clinically relevant questions or have a clear translational potential, and
• Cover one or more of the following priority areas: AI-driven assessment and diagnosis; personalized and adaptive interventions; equitable access to care; data infrastructure for predictive analytics; technology innovation; prevention for public health; and ethical standards for AI integration.

Grant Guidelines

To advance its mission to build a responsible and equitable technology ecosystem, the Kapor Foundation makes strategic grants across three focus areas: (1) Computing Education, (2) Innovation, and (3) Governance.

Within each focus area, we fund research on critical topics at the intersection of racial equity and tech, capacity-building that strengthens coalitions and movement-building infrastructure, and policy advocacy that drives systemic change.

Funding Priorities

We fund organizations and initiatives aligned with our core focus areas:

Given advances in Al, a new vision of education is urgently needed — one that ensures students are equipped with the technical skills to build emerging technologies and the critical skills to navigate their socio-technical implications. We fund computing education initiatives across K-12, postsecondary, and alternative pathways that expand computing participation at scale, shift policy to ensure equitable access, and expand the pipeline of educators prepared to teach computing.

2. 

Al is being designed, developed, and deployed rapidly, yet the communities most affected by its impacts are largely excluded from its creation and subsequent economic benefits. We support organizations and individuals that build responsible Al technologies, leverage technology to close gaps in access and opportunity, and invest in initiatives and coalitions that advance responsible Al in the entrepreneurship and venture capital ecosystems.

3.

As Al adoption accelerates, bolder approaches to regulation are necessary to protect marginalized communities from technological harm, expand economic opportunity, and ensure the benefits of technology reach everyone. We support efforts that build awareness of key policy issues, develop policy agendas, and mobilize coalitions.

For 2026, our priority advocacy areas are: 1) computing education, 2) algorithmic bias, 3) Al safeguards for children, 4) data center development, and 5) surveillance and civil rights.

The MPPEP Phase 3 program aims to enhance processing capabilities for invasive, wild-caught catfish, benefiting both processors and fishers. By increasing processing capacity and volume, the initiative seeks to create fair wages and stable job opportunities, fostering economic growth in rural areas. This grant will support innovative strategies that ensure sustainable practices and elevate incomes within the community, thus contributing to the overall development of the meat and poultry sector.

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Interventional Research Studies of Brentuximab Vedotin-Based Novel Combinations in AITL and PTCL-NOS

This competitive program is designed to support interventional InvestigatorSponsored Research aimed at generatin clinical evidence for brentuximab vedotin in novel combination approaches in angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma–not otherwise specified (PTCL-NOS).

Project Types and Area of Interest

Studies considered for Pfizer support should address key clinical and scientific gaps in the use of brentuximab vedotin in AITL and PTCL-NOS irrrespective of CD30 expression, with a focus on evaluating the safety and efficacy of novel brentuximab vedotin–based combinations with therapies available for PTCL treatment that are supported by a clear scientific rationale grounded in mechanism of action and/or disease biology.

About Disabled Veterans National FoundationThe Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability. The Disabled Veterans National Foundation (DVNF) provides critically needed support to disabled and at-risk veterans who leave the military wounded—physically or psychologically—after defending our safety and freedom.

About Grants to Provide Stability (GPS) ProgramThe Disabled Veterans National Foundation’s GPS (Grants to Provide Stability) Program is a grant program for veterans who find themselves in temporary financial setback. DVNF will provide up to $1,000 (not guaranteed) to help eligible veterans pay for rent or mortgage and essential utilities such as water or electricity. Applications are open on a monthly basis. Please note that each veteran can only be approved once per fiscal year (October – September).

Creative West

Established in 1974 as a nonprofit U.S. Regional Arts Organization (USRAO), Creative West was founded on the belief that place matters to the creative process. Fifty years later, communities of place, practice, experience, and identity remain fundamental to our work, framing our understanding of how culture is creatively produced and collectively experienced.

Creative West empowers artists and culture-makers with direct, practical resources, delivered regionally.

We offer practical, equity-centered learning experiences and funding opportunities that connect and inspire artists, culture-bearers and communities to build a more inclusive sector, strengthen the arts field, and catalyze change.

National Arts Futures Fellowship

The National Arts Futures Fellowship (NAFF) is a six-month virtual leadership development program rooted in democracy, wellness, and belonging. It calls on early and mid-career arts and culture professionals from all backgrounds to step into their power as civic leaders and cultural innovators—building the skills, networks, and vision needed to shape a future where creativity drives justice, care, and connection.

Fellows join a national network committed to strengthening public life, nurturing collective wellness, and fostering deep belonging across communities. Together, they learn, experiment, and act—advancing a shared vision of leadership that is sustainable, community-rooted, and future-focused.

Each fellow enters NAFF with a Personal Action Project (PAP)—a concrete idea they will develop and implement with support from peers, coaches, guest experts, and flexible seed funding of $250–$1,000. Projects may include launching a cultural initiative, organizing a community campaign, supporting artist-led advocacy, seeking a public leadership role, or piloting another form of civic or community action. Throughout the fellowship, each project evolves through coaching, peer feedback, strategy sessions, and real-world experimentation. Fellows conclude the program by sharing their project, leadership growth, and next steps at the National Fellows Summit.

What’s New in Cohort Two?

• Cohort Two expands NAFF from six to seven monthly sessions and adds two new elements that support fellows in moving their Personal Action Projects from development into implementation:
• Seed Funding: Fellows may request $250–$1,000 in flexible funding to test, pilot, or implement their projects during the fellowship.
• Artists Thrive Framework: Fellows will use the framework to assess their work, identify opportunities for growth, and strengthen artist-led advocacy, collaboration, and community impact.

Guiding Principles

• Democracy — Use the arts to strengthen civic participation, expand public trust, and make decision-making more accessible and inclusive.
• Wellness — Treat care, rest, and healing as strategic leadership tools for sustaining movements and communities.
• Belonging — Create spaces where leaders can thrive together across differences, build trust, and celebrate shared humanity.

What kinds of projects are supported?

Examples: Running for office, launching cultural programs, organizing campaigns, supporting policies. Projects can be local, regional, or national in scope.

About Disabled Veterans National FoundationThe Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability. The Disabled Veterans National Foundation (DVNF) provides critically needed support to disabled and at-risk veterans who leave the military wounded—physically or psychologically—after defending our safety and freedom.About Comfort Kits and Grab N' Go ProgramIn addition to our direct outreach, the DVNF also supports like-minded organizations that share our commitment to serving veterans. Approved organizations can apply to receive Comfort Kits for distribution to veterans in their communities. These kits are designed to meet the unique needs of veterans and offer critical support where they are needed most.

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

Womens Foundation Of California

Since our founding in 1979, our work at Women’s Foundation California has evolved and expanded. Over the decades, we have celebrated our milestones and reflected on our journey as we continue to push towards what’s next. The Women’s Foundation California is a statewide, publicly supported foundation dedicated to achieving racial, economic, environmental, and gender justice by centering the experience and expertise of communities most impacted by systemic injustice. Our vision is to build a feminist future for California.

We amplify, mobilize, and redistribute power and resources to community leaders advancing racial, economic, environmental, and gender justice. This is achieved through grants to community-led organizations, grassroots leadership training through the Solís Policy Institute, and convenings to unite advocates, donors, policymakers, grantmakers, academics, and others, sharing knowledge to strengthen California’s social justice movement.

Bea Solís Power Fund

Our Bea Solís Power Fund invests in the leadership of our Solís Policy Institute alum as they continue to build racial, economic, environmental, and gender justice beyond our training.

This year, our Bea Solís Power Fund solidified our commitment to empowering transformation by disbursing $18,000 in small grants for essential resources to support alums to continue with their advocacy work.

Together, we can ensure that the creative doers and thinkers, movers, and shakers across our SPI alum network have the resources they need to build our shared feminist future. 

Alkermes

At Alkermes, we apply our deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders, including addiction, serious mental illness and sleep disorders. With our portfolio of marketed medicines and investigational pipeline candidates, we seek to make a meaningful difference in the way people manage these chronic diseases. Our patient-inspired science, integrated research strategy, sophisticated development capabilities and specialized commercial infrastructure enable us to pursue the development and commercialization of innovative new medicines, including those for people with conditions that have traditionally been overlooked or stigmatized.

Our greatest strengths at Alkermes are our people and our inherent empathy for patients, families and caregivers. Neurological and psychiatric disorders strike people at the core of who they are and impact many facets of their lives. We work with urgency to develop new treatment options for people living with these conditions.

Pathways APN Research Awards

The Alkermes Pathways Advanced Practice Nurse (APN) Research Awards™ program is designed to empower the advanced practice nursing community by offering funding opportunities that recognize their vital role in evidence-based care and the advancement of mental health research.

The Alkermes Pathways APN Research Awards provide opportunities for individual grants of up to $10,000 per project for licensed psychiatric-mental health nurse practitioners who are actively engaged in clinical, academic, and/or community health settings and are committed to advancing research in schizophrenia or bipolar I disorder.

Monitoring and Synthesis to Inform Offshore Development and Marine Ecosystem Management in California: 2027 Request for Proposals

California's ocean waters are among the most closely monitored in the world, with numerous independent programs tracking biological and physical variables across a range of spatial and temporal scales. These programs support fisheries management, protected-species recovery, marine protected area management, and ecosystem assessment. Baseline monitoring data is critical as California’s offshore areas are being considered for offshore development, including for ocean energy. Such development introduces additional potential drivers of disturbance to the California Current Large Marine Ecosystem (CCLME), and their potential effects on the surrounding environment will need to be considered.

The California Ocean Protection Council (OPC) and California Sea Grant College Program (CASG) are soliciting proposals for applied research that will strengthen the state's ability to detect and understand ecological change and disturbance in the CCLME as offshore development opportunities continue to be considered. This solicitation supports two complementary tracks to assess baseline conditions for current and/or future offshore development in California, including offshore energy: Track 1 addresses whether existing monitoring can detect disturbance against natural and/or climate-driven variability, and Track 2 supports the collection of targeted new field data where monitoring is absent or out of date. Proposals may combine elements of both tracks; hybrid proposals are evaluated on the same criteria as single-track proposals and receive no preference for combining tracks.

A total of $2,700,000 is available for funding: Ocean Protection Council will contribute $2,300,000 of state funds and California Sea Grant will contribute $400,000 of NOAA federal funds, contingent upon availability of funds from the Ocean Protection Council and NOAA. Total project budgets must be a minimum of $50,000 and may not exceed $750,000 (to include indirect costs, if any). It is anticipated that 3 to 5 projects will be awarded. The amount of funding requested should be appropriate for the scope of work proposed; this will be assessed in proposals as part of the evaluation criteria. 

Interface Health Foundation

Interface Health Foundation is a non-profit, 501c3 tax-exempt organization driven by a collective vision of positive change. In healthcare industry policy, understanding the intricate dynamics of funding and its impact on public access, quality, and cost remains paramount. IHF is dedicated to advancing analysis and research into the crossroads of healthcare industry policy, structural frameworks and affordability.

At IHF, our mission is clear: to empower and support student-led research endeavors that shed light on critical healthcare policy and structural issues affecting the public. Through our initiatives, we seek to foster a deeper understanding of the complex dynamics shaping the healthcare landscape.

Interface Health Foundation: Research Grant

Healthcare administrative grant award opportunities are highly competitive and allow candidates to stand out as they enter the job market. Through this IHF grant award, you will get the opportunity to pull together research and content on topics that aren't fully studied or publicized. Depending on the grant topic, some grantees will also have access to a preceptor who is an executive leader in the healthcare field. The preceptor will serve as a valuable resource to the grantee during the development of the research paper and beyond.

An example of a research topic is the impact of legislated acute care nurse staffing levels on the following: nursing professional job satisfaction, the patient experience, and the standard nursing quality indicators as part of nursing Magnet status accreditation.

Mary Kay Ash Foundation

Guided by Mary Kay Ash’s dream to enrich the lives of women everywhere, the Mary Kay Ash Foundation® raises and distributes funds to invest in breakthrough cancer research and clinical trials to find a cure for women-related cancers and ending domestic violence.

Since 1996, the Mary Kay Ash Foundation®, a 501(c)3 organization, has contributed more than $100 million to organizations aligned with its two-fold mission. In addition, the Foundation supports awareness initiatives, community outreach programs, and advocates for legislation to ensure women are healthy and safe. Through our global charitable foundations in Brazil, Canada, China and the United States, we are collectively making a deeper impact on the lives of women around the world.

Mary Kay Ash Foundation: Cancer Research Grant

The Mary Kay Ash Foundation is a non-profit public foundation, which focuses on funding research for innovative grants for translational research of cancers affecting women (ovarian, uterine, breast, endometrial or cervical cancer among others). Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately, such research would lead to improvement in diagnosis, prognosis, prevention, or treatment of the cancer. Each year the Foundation extends invitations to NCI designated cancer institutes and accredited medical schools to apply. Only one application is accepted per institution.

Grant proposals are reviewed by a Scientific Research Review Committee comprised of notable members of the American medical and scientific community. Grants are awarded up to $100,000 (combined direct and indirect costs) for a two-year period. The Foundation anticipates funding between 10 and 15 grants annually. 

Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

The Challenge

Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

The Challenge

Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.