Best Large Grants for Nonprofit Organizations in Minnesota

About Regions

Regions Financial Corporation is a member of the S&P 500 Index and is one of the nation's largest full-service providers of consumer and commercial banking, wealth management and mortgage products and services. Regions serves customers across the South, Midwest and Texas.

Regions Foundation

Regions Foundation supports community investments that positively impact the communities served by Regions Bank. The Foundation engages in a grantmaking program focused on priorities including economic and community development; education and workforce readiness; and financial wellness. The Foundation is a nonprofit 501(c)(3) corporation funded primarily through contributions from Regions Bank.

Matching Gifts Program

Full-time associates and recent retirees (up to 5 years after retirement) of Regions and its affiliated companies can request a Regions Matching Gift to eligible organizations. The recipient organization must be a 501(c) or 170(c) organization located in the Regions footprint (except for accredited educational institutions, which may be located anywhere in the United States) and has a primary mission that clearly fits one of these categories:

• Economic and community development: Supporting economic prosperity through affordable housing, job creation, small-business development, homebuyer education and retention, neighborhood revitalization and stabilization, food security/hunger relief.
• Education and workforce readiness: Supporting career prosperity through student competency and skill building, college and career readiness, educational access and success, credential building and employment and educator training and resources.
• Financial wellness: Supporting financial prosperity through K-12 and college financial education, adult and workforce financial empowerment.
• Arts and culture: Organizations that promote visual or performing arts, historic or science museums, zoos, botanical gardens, libraries, parks or public radio and television.
• Service members and Veterans: Organizations that have a primary mission of supporting U.S. military service members and veterans.
• Individuals with disabilities: Organizations that have a primary mission of supporting individuals with disabilities.

Regions Matching Gifts for Full-Time Associates

Regions supports organizations important to our associates through the Regions Matching Gifts Program. This program, which is open for use for all full-time Regions associates, affiliate associates and recent retirees, allows you to make an even greater difference to your favorite charities by doubling your tax-deductible contributions to these organizations. 

The Therapeutic Giving program by Johnson & Johnson focuses on funding initiatives that enhance patient access to treatment and advance health equity, particularly in immunology. Eligible nonprofit organizations can apply for support aimed at improving health outcomes through innovative programs. The initiative prioritizes measurable impacts over fundraising activities, emphasizing the importance of addressing healthcare disparities and promoting disease awareness efforts for diseases like rheumatoid arthritis and psoriasis.

The Pinetop Assistance League (PAL) Grant provides crucial financial support to elderly blues musicians, ensuring their well-being during emergencies. This grant, part of the Pinetop Perkins Foundation's mission, offers assistance for medical expenses, home care, and essential living costs. Eligible applicants must be professional artists aged 50 or older with a household income below $35,000. By addressing these needs, PAL plays a vital role in preserving the legacy and care of blues musicians.

The Lloyd K. Johnson Foundation offers grants over $3,500 to nonprofits and public entities aiming to enhance community welfare, arts, education, economic development, and environmental stewardship. Operating since 1975, the foundation prioritizes projects that benefit residents in Cook, Lake, and Southern St. Louis Counties. Eligible applicants must have a 501(c)(3) designation or work with a fiscal sponsor. The foundation does not fund private foundations or projects for election campaigns or direct religious purposes.

The NHLBI Career Transition Award (K22) program supports postdoctoral fellows in transitioning their research to extramural institutions. The program includes a mentored intramural phase (up to two years) followed by an extramural phase (three years), totaling five years of support. Applications have multiple deadlines, including October 12, 2024, and February 12, 2025, among others. Successful transition depends on the awardee's progress during the mentored phase, evaluated by NHLBI.

Crisis Response Grant Program

The Crisis Response Grant Program funds local law enforcement agencies and local units of government to maintain or expand crisis response teams in which social workers or mental health providers are sent as first responders when calls for service indicate that an individual is having a mental health crisis.

RFP Part 1: Overview

Program Description

The purpose of this request for proposal is to fund local law enforcement agencies and local governments to start, maintain, or expand crisis response teams in which social workers or mental health professionals serve as first responders when calls for service involve an individual in crisis. Funding may support a range of models including Crisis Intervention Teams (CIT), mobile crisis teams, co-responder models, alternative response teams (ART), and other social worker/mental health-led response approaches that improve safety, reduce unnecessary justice system involvement, and connect individuals to appropriate care.

The Lloyd K. Johnson Foundation, established in 1975, provides grants under $3,500 to nonprofit organizations and public entities in the North Shore region. Focused on areas like social welfare, arts and culture, education, community development, and environmental protection, the Foundation has awarded over $18 million in grants. It aims to enhance opportunities for local residents, particularly those in low-income situations, and supports initiatives that foster long-term positive impacts.

Commodity Supplemental Food Program

1.2 Program Description

The Commodity Supplemental Food Program (CSFP) is a federally funded grant program of the Food and Nutrition Service (FNS), an agency of the United States Department of Agriculture (USDA). The grant is administered through the Minnesota Department of Health in the Supplemental Nutrition Program section of the Child and Family Health division.

CSFP provides a monthly food package of USDA commodity foods to augment the diets of those who are 60 years of age and older, of low income and considered to be at nutritional risk.

Subject to the availability of federal funds, MDH awards grants to qualified local agencies to operate the program in designated geographic service areas within the State.

The Environmental Initiative Grant Program by the Laura Jane Musser Fund aims to support public and nonprofit entities in enhancing the ecological integrity of open spaces. It promotes community involvement in planning and implementing projects that improve quality of life and public health while protecting ecosystems. Grants range from $8,000 for planning to $35,000 for implementation, targeting projects in specific states, fostering sustainability, and ensuring active local participation.

The Tribal Wildlife Grants (TWG) program, offered by the US Department of the Interior's Fish and Wildlife Service, provides vital technical and financial assistance to federally recognized Tribes. This funding supports various conservation activities, including habitat protection, species monitoring, and wildlife management, helping to preserve both culturally significant species and ecosystems. TWG grants empower Tribes to implement their conservation priorities effectively and sustainably.

The Wabtec Direct Grant Program focuses on creating sustainable impacts in local communities by funding 501(c)(3) non-profit organizations. Emphasizing education and environmental stewardship, the program supports initiatives that improve literacy, academic outcomes, and workforce readiness. Grants range from $1,000 to $10,000, prioritizing organizations that engage local Wabtec employees in volunteerism. The program promotes equitable access and non-discrimination while ensuring measurable results in funded projects.

The AGRI First Bite Farm to School and Early Care Grant, offered by the Minnesota Department of Agriculture, aims to assist school districts and early childhood education centers in developing local procurement practices. This grant supports projects that emphasize Minnesota-grown foods, including taste tests and increased menu offerings. Applicants can receive $2,500 to $5,000 without a cash match, fostering a strong connection between local agriculture and education.

The National Institutes of Health (NIH) is inviting applications for the Screening, Brief Intervention, and Referral to Treatment or Prevention (SBIRT/P) program. This funding opportunity aims to explore innovative methods for addressing alcohol, tobacco, and other drug use among adults facing health disparities. The initiative seeks research proposals that will implement and evaluate SBIRT/P strategies in collaboration with healthcare and community partners. This approach is crucial for enhancing public health and ensuring effective interventions.

The Health Care Workplace Safety Grant program, established by Minnesota's 2023 Session Law, aims to enhance safety in health care environments by funding initiatives that train staff in de-escalation and support services. With a total of $1.5 million available through 30 grants, each grant may provide up to $50,000 to improve workplace safety and prevent violence, ensuring a secure atmosphere for both staff and patients.

Minnesota Department of Transportation

In creating the Department of Transportation in 1976, the Legislature determined that MnDOT would be the principal agency to develop, implement, administer, consolidate and coordinate state transportation policies, plans and programs (Minn. Stat. Ch. 174).

MnDOT makes special efforts to consider the social, economic and environmental effects of its decisions and aggressively promotes the efficient use of energy resources for transportation purposes. It also maintains close working relationships with the many public and private individuals, groups and associations involved in transportation.

Greater Minnesota Transportation Alternatives Solicitation

The Transportation Alternatives Solicitation is a competitive grant opportunity for local communities and regional agencies to fund projects for pedestrian and bicycle facilities, historic preservation, Safe Routes to School and more. Minnesota will be soliciting projects for approximately $12.5 million in available grant funding across the state where the total is sub-targeted to the seven area transportation partnerships (ATPs).

Greater Minnesota applicants must submit a letter of intent describing the key components of their project. A regional representative will contact applicants to help review the project proposal and the steps necessary for delivering a federally funded project prior to local communities and regional agencies submitting a full grant application. 

The Laura Jane Musser Fund was established by the estate of Laura Jane Musser of Little Falls, Minnesota to continue the personal philanthropy, which she practiced in her lifetime.

Environmental Initiative Program

The Laura Jane Musser Fund assists public or not-for-profit entities to initiate or implement projects that enhance the ecological integrity of publicly owned open spaces, while encouraging compatible human activities. The Fund’s goal is to promote public use of open space that improves a community’s quality of life and public health, while also ensuring the protection of healthy, viable and sustainable ecosystems by protecting or restoring habitat for a diversity of plant and animal species.

Projects must..

• Focus on protecting/restoring a sustainable ecosystem that is a defined, public open space.
• Promote public access to and use of the defined open space.
• Involve active participation of local community members, with a particular appreciation for volunteer and youth engagement and stakeholder contributions.
• Contain measurable outcomes within the first 12-18 months.
• Include a plan for the long term financial and environmental sustainability of the proposed program.

Projects during any one grant period will be eligible for either:

• implementation grants or 
• planning grants

Environmental Initiative - Implementation Grant Program

Implementation grant applications must demonstrate clear evidence of local community active participation and support.

Projects will be eligible for either planning or implementation funds during any one grant period.

The Festivals Grant, offered by the Minnesota Humanities Center, aims to support cultural festivals and events across Minnesota. With funding of $1.5 million available for each of the fiscal years 2026 and 2027, eligible organizations can apply for grants to enhance community engagement through arts programming, staffing, and logistics. Applicants may seek up to $200,000 per year, fostering cultural connections and celebrating local traditions.

Minnesota Department of Health

Mission: Protecting, maintaining and improving the health of all Minnesotans.

Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.

Rural Health Transformation Program Funding 

The federal Rural Health Transformation Program (RHTP) was created by H.R.1 (Section 71401 of Public Law 119-21) on July 4, 2025. It is a federal initiative to help states support rural communities in improving health care access, quality, and outcomes by transforming the health care delivery ecosystem. The RHTP focuses on promoting innovation, strategic partnerships, infrastructure development, and workforce investment in rural communities. Minnesota has outlined their initiatives online (learn more about Minnesota's Rural Health Transformation Program).

Grant recipients will select activities from broad RHTP initiatives designed to advance the overarching goals of improving health outcomes and access to care for rural Minnesotans, sustainably expanding the rural health care workforce, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments. 

Entity Type: Tribal Nations (Bois Forte Band of Chippewa; Fond du Lac Band of Lake Superior Chippewa; Grand Portage Band of Lake Superior Chippewa; Leech Lake Band of Ojibwe; Lower Sioux Indian Community; Mille Lacs Band of Ojibwe; Oyate (Upper Sioux); Prairie Island Indian Community; Red Lake Nation; White Earth Nation)

Estimated Number of Awards: 10

Estimated Maximum Award in Budget Period 1: $150,000 - $807,996

Applicants may request up to the maximum award.

Minnesota Department of Health

Mission: Protecting, maintaining and improving the health of all Minnesotans.

Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.

Rural Health Transformation Program Funding 

The federal Rural Health Transformation Program (RHTP) was created by H.R.1 (Section 71401 of Public Law 119-21) on July 4, 2025. It is a federal initiative to help states support rural communities in improving health care access, quality, and outcomes by transforming the health care delivery ecosystem. The RHTP focuses on promoting innovation, strategic partnerships, infrastructure development, and workforce investment in rural communities. Minnesota has outlined their initiatives online (learn more about Minnesota's Rural Health Transformation Program).

Grant recipients will select activities from broad RHTP initiatives designed to advance the overarching goals of improving health outcomes and access to care for rural Minnesotans, sustainably expanding the rural health care workforce, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments. 

Entity Type: Federally Qualified Health Centers (FQHCs)

Estimated Number of Awards: 5

Estimated Maximum Award in Budget Period 1: $1,900,000

Applicants may request up to the maximum award.

Minnesota Department of Health

Mission: Protecting, maintaining and improving the health of all Minnesotans.

Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.

Rural Health Transformation Program: Healthcare Workforce Retention Program

Program Description

Minnesota’s RHTP covers a broad range of initiatives designed to transform the state of the rural health system by improving health outcomes and access to care for rural Minnesotans, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments.

This RFP seeks proposals to understand systemic factors leading to provider/clinician burnout; develop, pilot and scale responsive solutions to decrease burnout; and link the solutions to improved working conditions to improvements in provider retention and patient experience and/or outcomes. 

Arbor Rising Grant, established in 2010, is a NYC-based nonprofit providing unrestricted multi-year funding and capacity-building support to nonprofits focused on alleviating poverty. The grant process occurs every three years, with the next round in 2025 being invitation-only. Eligible organizations must demonstrate high potential and effective leadership, typically operating on a modest budget. Arbor Rising prioritizes applicants from the NYC metro area while expanding to cover the lower 48 US states.

Who We Are

The humanities help us understand ourselves, our communities, and our histories. By increasing collective understanding, we can spark positive change and create a more just society.

We curate stories, co-create engagement opportunities, increase knowledge, and produce resources in the areas of education, civic renewal, immersive experiences, and public programming to catalyze ideas. Our grantmaking allows us to strengthen the bonds between us, celebrate our past and traditions, appeal to the best within ourselves, and educate the next generation of leaders.

Ethnic Media Grants

Through the State of Minnesota’s 2025-2027 biennial legislation and the Arts and Cultural Heritage Fund (Legacy), the Minnesota Humanities Center (MHC) will administer $472,500 for ethnic media grants to ethnic media organizations that work to create, celebrate, and teach the art, culture, and heritage of the many diverse cultural groups that make up Minnesota, including but not limited to Indigenous organizations, communities whose culture and heritage have been historically underrepresented, recent immigrant communities, and veterans.

The Legislature in providing this funding is seeking to fund ethnic media organizations throughout Minnesota to create video content in a language other than English.

An applicant that receives funding under this grant opportunity must do at least one of the following:

• Preserve and honor the cultural heritage of Minnesota,
• Provide education and student outreach in cultural diversity,
• Support the development of culturally diverse humanities programming, including arts programming, or
• Empower communities in building identity and culture, including preserving and honoring communities whose Indigenous cultures are endangered or disappearing.

The Big Bets Fellowship: Economic Opportunity in the United States is a transformative 4-month program designed to empower emerging leaders to tackle economic challenges head-on. With a focus on innovative solutions for job creation, affordable housing, and equitable access to resources, the fellowship equips participants with essential skills and a supportive network. The initiative aims to drive systemic change and promote sustainable economic prosperity, addressing inequalities while fostering resilient communities across the nation.

The School Based Services Mini Grant, offered by the Minnesota Department of Human Services, aims to enhance mental health services in schools. It targets Minnesota school districts, especially those in rural and tribal areas, providing seed funding to develop sustainable behavioral health infrastructures. This initiative focuses on improving access to care through qualified providers, telehealth capabilities, and Medicaid billing systems, ensuring that all students have the support they need to thrive.

The James M. Cox Foundation Grant offers support to nonprofit organizations focused on conservation, early childhood education, family empowerment, and health. Organizations must be 501(c)(3) tax-exempt and located in areas where Cox Enterprises operates. Grant applications are accepted year-round, with deadlines before Trustee meetings. Preference is given to organizations with a history of local engagement. This foundation embodies the philanthropic spirit of its founder, James M. Cox, by giving back to the community.

Minnesota Historical Society

The Minnesota Historical Society preserves Minnesota's past, shares our state's stories and connects people with history in meaningful ways, for today and for tomorrow. Because history matters!

We're part of Minnesota's rich history. Since 1849, we've grown to become one of the largest and most prestigious historical societies in the country. We play an important role in our state's historic preservation, education and tourism; and provide the public with award-winning programs, exhibitions and events.

We owe it to future generations to be good stewards of the past.

Native American Museum Fellowship

The Native American Museum Fellowship (NAMF) Program is a ten-week paid fellowship that will introduce Native community members to the museum field through three weeks of seminar and workshops and seven weeks of an MNHS internship program. These ten weeks are designed to engage and expose fellows to relevant cultural resources within MNHS and partnership sites, the broader public history of Minnesota and neighboring states, and professional opportunities within the museum field– ranging from Tribal historic preservation to exhibit curation. Fellows will learn about career paths and the various requirements for working in museum spaces, both on and off of reservation lands, as well as the particular challenges faced by Native American communities in terms of preserving tribal history and disturbing the institutionalized historical narratives of who Native people were and are.

The first three weeks of the program will be an in-depth seminar that will focus on the function of museums, cultural resources, public history, and tribal historic preservation fields. Through a mix of readings, podcasts, videos, discussions, exhibit analyses and guest speakers, fellows will come to have a better understanding of the day-to-day workings of museums and historic sites, and the values and practices that inform these institutions. The cohort will travel often to MNHS partnering sites and will have the opportunity to visit various Native organizations in or around the Twin Cities. Fellows will be placed within the Minnesota Historical Society network for the remainder of the fellowship where they will complete a hands-on internship experience of their choice.

Participants in the program will receive a living expense stipend for the duration of the program as well as travel expense reimbursement, a stipend pending completion of the seminar portion of the program, and a paid internship for the remaining seven weeks.

Topics covered

• Collections
• Conservation
• Tribal and Institutional Partnerships
• Tribal Historic Preservation
• Cultural Resource Stewardship
• Exhibitions
• ​Archaeology/NAGPRA
• Section 106
• And more!

Program Requirements

NAMF is designed as a ten week hybrid program with a home base of the Minnesota History Center, located in St. Paul. The 3-week seminar portion of the program has mandatory in-person attendance to receive the full stipend. A 20-hour per week paid internship could be all in-person or hybrid, depending on the internship supervisor. Travel to historic sites and communities will be required throughout the program period with travel arranged through program staff. 

Please Note: Fellows are expected to find their own housing upon accepting their letter of admittance. Mileage accumulated from out-of-town trips and lodging used during seminar will be reimbursed (within reason) to eliminate financial barriers during your time as a NAMF fellow. 

The Harlene and Marvin Wool Foundation Grant supports non-profit organizations in the St. Louis area that enhance lives through health, education, social services, and the arts. With a focus on empowering the economically disadvantaged, the foundation welcomes applications from 501(c)(3) organizations. Key priority areas include education, health and wellness, family and child empowerment, and cultural engagement, aiming to foster community growth and development.