Best Large Grants for Nonprofit Organizations in Minnesota

The School Based Services Mini Grant, offered by the Minnesota Department of Human Services, aims to enhance mental health services in schools. It targets Minnesota school districts, especially those in rural and tribal areas, providing seed funding to develop sustainable behavioral health infrastructures. This initiative focuses on improving access to care through qualified providers, telehealth capabilities, and Medicaid billing systems, ensuring that all students have the support they need to thrive.

The NHLBI Career Transition Award (K22) program supports postdoctoral fellows in transitioning their research to extramural institutions. The program includes a mentored intramural phase (up to two years) followed by an extramural phase (three years), totaling five years of support. Applications have multiple deadlines, including October 12, 2024, and February 12, 2025, among others. Successful transition depends on the awardee's progress during the mentored phase, evaluated by NHLBI.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CRRP 

Through the competitive Collaborative Regional Research Programme (CRRP), we promote regional research that has potential to improve our understanding of global change and its implications while contributing to a sound scientific basis for policymaking in areas affected by global change. Under this pillar, APN supports collaborative research that contributes to the evolving science-policy arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction and the UN Decade of Ocean Science as well as ongoing and new global change and sustainability research programmes.

Activities of interest under the CRRP Programme

APN promotes regional collaborative research that improves understanding of the physical, biological and human dimensions of change in the Earth system and advances actionable science that informs decision-making. APN accepts proposals that engage at least 3 member/approved countries in the region, and prioritise collaboratively designed, actionable research with non-academic stakeholders. Proposals must address one or more of the following activities:

• Collaborative research on global change and sustainability that particularly addresses GAPS, ANALYSIS, SYNTHESIS and ASSESSMENT work.
• Collaborative research that develops PATHWAYS and MECHANISMS to achieve sustainable development, and develop adaptation strategies.
• Collaborative PLACE-BASED INTEGRATIVE RESEARCH, particularly from developing countries.
• Collaborative research that is CO-DESIGNED to contribute to the Paris Agreeemnt, Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, Post-2020 Global Biodiversity Framework, UN Decade of Ocean Science (2021-2030), and the accumulation of scientific knowledge at IPCC, IPBES, etc.

The Lloyd K. Johnson Foundation, established in 1975, provides grants under $3,500 to nonprofit organizations and public entities in the North Shore region. Focused on areas like social welfare, arts and culture, education, community development, and environmental protection, the Foundation has awarded over $18 million in grants. It aims to enhance opportunities for local residents, particularly those in low-income situations, and supports initiatives that foster long-term positive impacts.

The Laura Jane Musser Fund was established by the estate of Laura Jane Musser of Little Falls, Minnesota to continue the personal philanthropy, which she practiced in her lifetime.

Environmental Initiative Program

The Laura Jane Musser Fund assists public or not-for-profit entities to initiate or implement projects that enhance the ecological integrity of publicly owned open spaces, while encouraging compatible human activities. The Fund’s goal is to promote public use of open space that improves a community’s quality of life and public health, while also ensuring the protection of healthy, viable and sustainable ecosystems by protecting or restoring habitat for a diversity of plant and animal species.

Projects must..

• Focus on protecting/restoring a sustainable ecosystem that is a defined, public open space.
• Promote public access to and use of the defined open space.
• Involve active participation of local community members, with a particular appreciation for volunteer and youth engagement and stakeholder contributions.
• Contain measurable outcomes within the first 12-18 months.
• Include a plan for the long term financial and environmental sustainability of the proposed program.

Projects during any one grant period will be eligible for either:

• implementation grants or 
• planning grants

Environmental Initiative - Implementation Grant Program

Implementation grant applications must demonstrate clear evidence of local community active participation and support.

Projects will be eligible for either planning or implementation funds during any one grant period.

The Festivals Grant, offered by the Minnesota Humanities Center, aims to support cultural festivals and events across Minnesota. With funding of $1.5 million available for each of the fiscal years 2026 and 2027, eligible organizations can apply for grants to enhance community engagement through arts programming, staffing, and logistics. Applicants may seek up to $200,000 per year, fostering cultural connections and celebrating local traditions.

The Lloyd K. Johnson Foundation offers grants over $3,500 to nonprofits and public entities aiming to enhance community welfare, arts, education, economic development, and environmental stewardship. Operating since 1975, the foundation prioritizes projects that benefit residents in Cook, Lake, and Southern St. Louis Counties. Eligible applicants must have a 501(c)(3) designation or work with a fiscal sponsor. The foundation does not fund private foundations or projects for election campaigns or direct religious purposes.

Who We Are

The humanities help us understand ourselves, our communities, and our histories. By increasing collective understanding, we can spark positive change and create a more just society.

We curate stories, co-create engagement opportunities, increase knowledge, and produce resources in the areas of education, civic renewal, immersive experiences, and public programming to catalyze ideas. Our grantmaking allows us to strengthen the bonds between us, celebrate our past and traditions, appeal to the best within ourselves, and educate the next generation of leaders.

Ethnic Media Grants

Through the State of Minnesota’s 2025-2027 biennial legislation and the Arts and Cultural Heritage Fund (Legacy), the Minnesota Humanities Center (MHC) will administer $472,500 for ethnic media grants to ethnic media organizations that work to create, celebrate, and teach the art, culture, and heritage of the many diverse cultural groups that make up Minnesota, including but not limited to Indigenous organizations, communities whose culture and heritage have been historically underrepresented, recent immigrant communities, and veterans.

The Legislature in providing this funding is seeking to fund ethnic media organizations throughout Minnesota to create video content in a language other than English.

An applicant that receives funding under this grant opportunity must do at least one of the following:

• Preserve and honor the cultural heritage of Minnesota,
• Provide education and student outreach in cultural diversity,
• Support the development of culturally diverse humanities programming, including arts programming, or
• Empower communities in building identity and culture, including preserving and honoring communities whose Indigenous cultures are endangered or disappearing.

The Health Care Workplace Safety Grant program, established by Minnesota's 2023 Session Law, aims to enhance safety in health care environments by funding initiatives that train staff in de-escalation and support services. With a total of $1.5 million available through 30 grants, each grant may provide up to $50,000 to improve workplace safety and prevent violence, ensuring a secure atmosphere for both staff and patients.

The AGRI First Bite Farm to School and Early Care Grant, offered by the Minnesota Department of Agriculture, aims to assist school districts and early childhood education centers in developing local procurement practices. This grant supports projects that emphasize Minnesota-grown foods, including taste tests and increased menu offerings. Applicants can receive $2,500 to $5,000 without a cash match, fostering a strong connection between local agriculture and education.

Minnesota Department of Health

Mission: Protecting, maintaining and improving the health of all Minnesotans.

Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.

Rural Health Transformation Program Funding 

The federal Rural Health Transformation Program (RHTP) was created by H.R.1 (Section 71401 of Public Law 119-21) on July 4, 2025. It is a federal initiative to help states support rural communities in improving health care access, quality, and outcomes by transforming the health care delivery ecosystem. The RHTP focuses on promoting innovation, strategic partnerships, infrastructure development, and workforce investment in rural communities. Minnesota has outlined their initiatives online (learn more about Minnesota's Rural Health Transformation Program).

Grant recipients will select activities from broad RHTP initiatives designed to advance the overarching goals of improving health outcomes and access to care for rural Minnesotans, sustainably expanding the rural health care workforce, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments. 

Entity Type: Federally Qualified Health Centers (FQHCs)

Estimated Number of Awards: 5

Estimated Maximum Award in Budget Period 1: $1,900,000

Applicants may request up to the maximum award.

Minnesota Department of Health

Mission: Protecting, maintaining and improving the health of all Minnesotans.

Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.

Rural Health Transformation Program Funding 

The federal Rural Health Transformation Program (RHTP) was created by H.R.1 (Section 71401 of Public Law 119-21) on July 4, 2025. It is a federal initiative to help states support rural communities in improving health care access, quality, and outcomes by transforming the health care delivery ecosystem. The RHTP focuses on promoting innovation, strategic partnerships, infrastructure development, and workforce investment in rural communities. Minnesota has outlined their initiatives online (learn more about Minnesota's Rural Health Transformation Program).

Grant recipients will select activities from broad RHTP initiatives designed to advance the overarching goals of improving health outcomes and access to care for rural Minnesotans, sustainably expanding the rural health care workforce, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments. 

Entity Type: Tribal Nations (Bois Forte Band of Chippewa; Fond du Lac Band of Lake Superior Chippewa; Grand Portage Band of Lake Superior Chippewa; Leech Lake Band of Ojibwe; Lower Sioux Indian Community; Mille Lacs Band of Ojibwe; Oyate (Upper Sioux); Prairie Island Indian Community; Red Lake Nation; White Earth Nation)

Estimated Number of Awards: 10

Estimated Maximum Award in Budget Period 1: $150,000 - $807,996

Applicants may request up to the maximum award.

The Environmental Initiative Grant Program by the Laura Jane Musser Fund aims to support public and nonprofit entities in enhancing the ecological integrity of open spaces. It promotes community involvement in planning and implementing projects that improve quality of life and public health while protecting ecosystems. Grants range from $8,000 for planning to $35,000 for implementation, targeting projects in specific states, fostering sustainability, and ensuring active local participation.

About Regions

Regions Financial Corporation is a member of the S&P 500 Index and is one of the nation's largest full-service providers of consumer and commercial banking, wealth management and mortgage products and services. Regions serves customers across the South, Midwest and Texas.

Regions Foundation

Regions Foundation supports community investments that positively impact the communities served by Regions Bank. The Foundation engages in a grantmaking program focused on priorities including economic and community development; education and workforce readiness; and financial wellness. The Foundation is a nonprofit 501(c)(3) corporation funded primarily through contributions from Regions Bank.

Matching Gifts Program

Full-time associates and recent retirees (up to 5 years after retirement) of Regions and its affiliated companies can request a Regions Matching Gift to eligible organizations. The recipient organization must be a 501(c) or 170(c) organization located in the Regions footprint (except for accredited educational institutions, which may be located anywhere in the United States) and has a primary mission that clearly fits one of these categories:

• Economic and community development: Supporting economic prosperity through affordable housing, job creation, small-business development, homebuyer education and retention, neighborhood revitalization and stabilization, food security/hunger relief.
• Education and workforce readiness: Supporting career prosperity through student competency and skill building, college and career readiness, educational access and success, credential building and employment and educator training and resources.
• Financial wellness: Supporting financial prosperity through K-12 and college financial education, adult and workforce financial empowerment.
• Arts and culture: Organizations that promote visual or performing arts, historic or science museums, zoos, botanical gardens, libraries, parks or public radio and television.
• Service members and Veterans: Organizations that have a primary mission of supporting U.S. military service members and veterans.
• Individuals with disabilities: Organizations that have a primary mission of supporting individuals with disabilities.

Regions Matching Gifts for Recent Retirees

Retirees of Regions and its affiliated companies are eligible for the Matching Gift Program for up to 5 years after retirement (the gift date must be within the first 5 years of retirement). Regions will match donations of $25 or more, up to a total of $1,000 per year per retiree.

The Regions Community Affairs team will contact the organization on your behalf to verify the gift and review eligibility.

About Regions

Regions Financial Corporation is a member of the S&P 500 Index and is one of the nation's largest full-service providers of consumer and commercial banking, wealth management and mortgage products and services. Regions serves customers across the South, Midwest and Texas.

Regions Foundation

Regions Foundation supports community investments that positively impact the communities served by Regions Bank. The Foundation engages in a grantmaking program focused on priorities including economic and community development; education and workforce readiness; and financial wellness. The Foundation is a nonprofit 501(c)(3) corporation funded primarily through contributions from Regions Bank.

Matching Gifts Program

Full-time associates and recent retirees (up to 5 years after retirement) of Regions and its affiliated companies can request a Regions Matching Gift to eligible organizations. The recipient organization must be a 501(c) or 170(c) organization located in the Regions footprint (except for accredited educational institutions, which may be located anywhere in the United States) and has a primary mission that clearly fits one of these categories:

• Economic and community development: Supporting economic prosperity through affordable housing, job creation, small-business development, homebuyer education and retention, neighborhood revitalization and stabilization, food security/hunger relief.
• Education and workforce readiness: Supporting career prosperity through student competency and skill building, college and career readiness, educational access and success, credential building and employment and educator training and resources.
• Financial wellness: Supporting financial prosperity through K-12 and college financial education, adult and workforce financial empowerment.
• Arts and culture: Organizations that promote visual or performing arts, historic or science museums, zoos, botanical gardens, libraries, parks or public radio and television.
• Service members and Veterans: Organizations that have a primary mission of supporting U.S. military service members and veterans.
• Individuals with disabilities: Organizations that have a primary mission of supporting individuals with disabilities.

Regions Matching Gifts for Full-Time Associates

Regions supports organizations important to our associates through the Regions Matching Gifts Program. This program, which is open for use for all full-time Regions associates, affiliate associates and recent retirees, allows you to make an even greater difference to your favorite charities by doubling your tax-deductible contributions to these organizations. 

The Big Bets Fellowship: Economic Opportunity in the United States is a transformative 4-month program designed to empower emerging leaders to tackle economic challenges head-on. With a focus on innovative solutions for job creation, affordable housing, and equitable access to resources, the fellowship equips participants with essential skills and a supportive network. The initiative aims to drive systemic change and promote sustainable economic prosperity, addressing inequalities while fostering resilient communities across the nation.

Minnesota Department of Health

Mission: Protecting, maintaining and improving the health of all Minnesotans.

Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.

Rural Health Transformation Program: Healthcare Workforce Retention Program

Program Description

Minnesota’s RHTP covers a broad range of initiatives designed to transform the state of the rural health system by improving health outcomes and access to care for rural Minnesotans, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments.

This RFP seeks proposals to understand systemic factors leading to provider/clinician burnout; develop, pilot and scale responsive solutions to decrease burnout; and link the solutions to improved working conditions to improvements in provider retention and patient experience and/or outcomes. 

Arbor Rising Grant, established in 2010, is a NYC-based nonprofit providing unrestricted multi-year funding and capacity-building support to nonprofits focused on alleviating poverty. The grant process occurs every three years, with the next round in 2025 being invitation-only. Eligible organizations must demonstrate high potential and effective leadership, typically operating on a modest budget. Arbor Rising prioritizes applicants from the NYC metro area while expanding to cover the lower 48 US states.

The Green Fertilizer Program Grant in Minnesota offers approximately $3.8 million to agricultural and rural electric cooperatives for investments in green fertilizer production facilities. Eligible projects must utilize renewable energy and green hydrogen, with a minimum grant award of $250,000. The program emphasizes strong business readiness and requires matching funds from cooperatives. Successful applicants must be licensed, in good standing, and committed to sustainable practices for fertilizer production, ensuring environmental responsibility in the agricultural sector.

The James M. Cox Foundation Grant offers support to nonprofit organizations focused on conservation, early childhood education, family empowerment, and health. Organizations must be 501(c)(3) tax-exempt and located in areas where Cox Enterprises operates. Grant applications are accepted year-round, with deadlines before Trustee meetings. Preference is given to organizations with a history of local engagement. This foundation embodies the philanthropic spirit of its founder, James M. Cox, by giving back to the community.

The Health Information Outreach Award, funded by the National Library of Medicine, aims to enhance access to essential health information for underrepresented populations and healthcare professionals. This initiative focuses on improving health literacy and equity through diverse projects, including training, technology access, and community outreach. Eligible organizations from select Midwestern states can apply, prioritizing innovative solutions that address health disparities and promote informed health decisions among vulnerable communities.

Minnesota Historical Society

The Minnesota Historical Society preserves Minnesota's past, shares our state's stories and connects people with history in meaningful ways, for today and for tomorrow. Because history matters!

We're part of Minnesota's rich history. Since 1849, we've grown to become one of the largest and most prestigious historical societies in the country. We play an important role in our state's historic preservation, education and tourism; and provide the public with award-winning programs, exhibitions and events.

We owe it to future generations to be good stewards of the past.

Native American Museum Fellowship

The Native American Museum Fellowship (NAMF) Program is a ten-week paid fellowship that will introduce Native community members to the museum field through three weeks of seminar and workshops and seven weeks of an MNHS internship program. These ten weeks are designed to engage and expose fellows to relevant cultural resources within MNHS and partnership sites, the broader public history of Minnesota and neighboring states, and professional opportunities within the museum field– ranging from Tribal historic preservation to exhibit curation. Fellows will learn about career paths and the various requirements for working in museum spaces, both on and off of reservation lands, as well as the particular challenges faced by Native American communities in terms of preserving tribal history and disturbing the institutionalized historical narratives of who Native people were and are.

The first three weeks of the program will be an in-depth seminar that will focus on the function of museums, cultural resources, public history, and tribal historic preservation fields. Through a mix of readings, podcasts, videos, discussions, exhibit analyses and guest speakers, fellows will come to have a better understanding of the day-to-day workings of museums and historic sites, and the values and practices that inform these institutions. The cohort will travel often to MNHS partnering sites and will have the opportunity to visit various Native organizations in or around the Twin Cities. Fellows will be placed within the Minnesota Historical Society network for the remainder of the fellowship where they will complete a hands-on internship experience of their choice.

Participants in the program will receive a living expense stipend for the duration of the program as well as travel expense reimbursement, a stipend pending completion of the seminar portion of the program, and a paid internship for the remaining seven weeks.

Topics covered

• Collections
• Conservation
• Tribal and Institutional Partnerships
• Tribal Historic Preservation
• Cultural Resource Stewardship
• Exhibitions
• ​Archaeology/NAGPRA
• Section 106
• And more!

Program Requirements

NAMF is designed as a ten week hybrid program with a home base of the Minnesota History Center, located in St. Paul. The 3-week seminar portion of the program has mandatory in-person attendance to receive the full stipend. A 20-hour per week paid internship could be all in-person or hybrid, depending on the internship supervisor. Travel to historic sites and communities will be required throughout the program period with travel arranged through program staff. 

Please Note: Fellows are expected to find their own housing upon accepting their letter of admittance. Mileage accumulated from out-of-town trips and lodging used during seminar will be reimbursed (within reason) to eliminate financial barriers during your time as a NAMF fellow. 

The La Crescent Community Foundation, established in 1995, aims to enhance the quality of life in the La Crescent area through targeted grants. It supports various community projects, including park improvements and educational initiatives, while prioritizing organizations that uphold non-discrimination policies. The Foundation's grants focus on local needs, with a preference for applications from schools and local government agencies. Recent efforts include funding for a new event center, demonstrating a commitment to community development.

SC Johnson Grants aim to enhance community welfare through charitable contributions, focusing on health, sustainability, and opportunity. Since 1937, the company has committed five percent of its pretax profits to support registered charities and nonprofit organizations, especially in areas where it operates. The grant program prioritizes initiatives addressing healthcare access, environmental conservation, and educational equity, ensuring that efforts align with the values of community service and corporate responsibility.

The Conservation Connect Fellowship Program, offered by the National Forest Foundation, invites graduate students to engage in hands-on conservation projects. This fellowship provides practical experience, mentorship from conservation professionals, and training in collaborative leadership. Fellows will gain a deep understanding of forest management and expand their professional networks. With a focus on developing future conservation leaders, the program seeks students passionate about public lands and community engagement.

Provider Capacity Grants for Rural and Underserved Communities: Round Four

The Department of Human Services (DHS) Grants, Equity, Access, and Research (GEAR) Division (STATE) has the authority to enter into grant contracts that will increase the number and capacity of Home and Community-Based Services (HCBS) providers in rural and or serving rural or underserved communities pursuant to Minnesota Statutes, section 256.01, subdivision 2(a)(6). This grant opportunity is funded through the Minnesota Legislature Laws of Chapter 61 - MN Laws Section 59. PROVIDER CAPACITY GRANTS FOR RURAL AND UNDERSERVED COMMUNITIES. Grant applicant represents that it is duly qualified and willing to perform the services set forth in this grant application to the satisfaction of STATE.   

Funding Requirements

The primary goals of this funding are to reduce disparities, increase access, and advance equity in the availability and delivery of Home and Community-Based Services (HCBS) across Minnesota. Successful capacity-building proposals must strengthen and enhance HCBS, with a particular focus on expanding existing HCBS programs’ access in rural and underserved communities. Applicants are required to clearly describe how the proposed funding will be used to build capacity, improve access, and enhance the delivery of HCBS. Proposals must also demonstrate compliance with all applicable HCBS licensing requirements and operational standards.

Grant funds will be awarded competitively to organizations that serve Medical Assistance (MA) recipients who are eligible for Home and Community-Based Services (HCBS), that are enhancing/expanding existing services to serving MA recipients eligible for HCBS. Funds must be used by organizations that currently serve MA recipients eligible for HCBS. Only organizations currently licensed and enrolled in MHCP are eligible to apply for this grant funding.  

Vocational Rehabilitation Program Contract

The Minnesota Department of Employment and Economic Development (“DEED”) Vocational Rehabilitation Services (“VRS”) requests applications from organizations and businesses to work as a vocational rehabilitation (“VR”) program community partner (“Community Partner”) to provide job-related services to individuals who are eligible for VRS. The State anticipates issuing multiple contracts for this work.