Best Operating Grants for Nonprofits

The Capacity Building Grant - Comprehensive Organizational Assessment & Reports (COAR) Grant Program by the Marillac Mission Fund aims to enhance nonprofit infrastructure and leadership. This initiative supports organizationally-ready nonprofits by providing funding for core capacity building, fostering sustainable practices to better serve vulnerable populations in the St. Louis area. The program emphasizes organizational assessments to evaluate strengths and weaknesses, ultimately facilitating growth and positive change.

The Marillac Mission Fund provides funding for capacity building grants aimed at enhancing the effectiveness of nonprofits focused on vulnerable populations. Eligible organizations must have a history of receiving MMF funding and be located in the St. Louis area. Grants can support various improvement activities including strategic planning and resource development, with a maximum award of $25,000 per year. This program seeks to empower nonprofits to better serve their communities and advocate for those in need.

The Marillac Mission Fund offers responsive grants primarily for established organizations addressing poverty and vulnerability in the St. Louis area. Focus areas include support for older adults living independently, immigrants and refugees, veterans (existing grantees only), and human trafficking prevention. Grant types include program/project funding and general operating support, with a preference for organizations demonstrating alignment with Catholic moral teachings and serving specific populations. Applications are currently limited to existing grantees in designated focus areas.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Help with healthcare costs for Paroxysmal Nocturnal Hemoglobinuria (PNH)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Paroxysmal Nocturnal Hemoglobinuria (PNH), also known as Marchiafava– Micheli syndrome, is a rare disease that is characterized by impaired bone marrow function and destruction of red blood cells. PNH is a rare disease that affects the circulatory system.

The Wabash Valley Community Foundation offers Seed Grants to support preliminary projects aligned with the "See You in Terre Haute" Community Plan. Grants up to $10,000 assist nonprofits in enhancing community services, including economic development and health initiatives. Applicants must match at least 25% of the funds and complete projects within 12 months. The Foundation aims to fund ten grants over the next 18 months, fostering growth and engagement in Vigo County.

Herold and Retta Reuss Public Safety Scholarship

Applicants must demonstrate the drive and ability to be successful in pursuing a college education and/or a certification process in the fields aforementioned. Financial information is requested, but not necessarily a determining factor. Students who receive this scholarship may apply for further support in subsequent years.

The Arts Alive! Organizational Grants, funded by the Weld Community Foundation, support innovative projects that enhance the arts in Weld County. These grants aim to expand artistic access, promote cultural diversity, and foster community engagement through the visual, performing, and literary arts. Ideal proposals should serve underserved populations, offer measurable outcomes, and have a positive impact on local artistic endeavors, ensuring a vibrant cultural landscape in the community.

The Hot Springs Area Community Foundation offers Early Literacy Grants to enhance early childhood language and literacy skills. With funding between $2,500 and $10,000 for the 2025–2026 period, the program prioritizes initiatives that connect children from birth to age four with literacy resources. Special emphasis is placed on proposals that expand phonics instruction and engage parents and communities in early learning, continuing the mission to prepare young learners for academic success.

Yaddo's Residency provides a tranquil retreat for artists in Saratoga Springs, New York, fostering creativity through undisturbed work in a supportive environment. Open to professional and emerging artists across various disciplines, residencies last from two weeks to two months and include room, board, and a studio. Applications are evaluated solely on the quality of the work, encouraging diverse talents to apply without publication or performance requirements.

The Periodic Paralysis Grant, offered by the Patient Advocate Foundation, assists individuals diagnosed with periodic paralysis in managing out-of-pocket healthcare costs. Eligible applicants must be in treatment or planning to begin treatment for this rare muscle disease. The fund covers various expenses, including medication copays and insurance premiums, ensuring that patients can afford essential care. With a mission to empower and support patients, this grant plays a crucial role in navigating healthcare challenges.

The Perkins V Plus Reserve Grant aims to enhance educational resources for Georgia’s public schools, particularly in rural areas and those with significant career and technical education student populations. By focusing on student outcomes and providing essential support, the Georgia Department of Education seeks to prepare all students for successful lives beyond graduation. Eligible recipients include local educational agencies currently receiving Perkins funding, ensuring targeted support where it is most needed.

The Mount Carmel Foundation Legacy Grant is dedicated to enhancing healthcare in Southeast Kansas, continuing a legacy of philanthropy since 1983. It supports nonprofit healthcare providers with project budgets ranging from $5,000 to $100,000. Funded initiatives have included advanced medical technology, patient care enhancements, and facility upgrades. Organizations aligned with Catholic teachings are prioritized, particularly those serving Bourbon, Cherokee, and Crawford Counties, ensuring vital healthcare access for the community.

The Centre PACT Grants, established by the Centre Foundation, empower high school students in Centre County to engage in philanthropy. This program encourages youth to identify community needs and support local nonprofits through fundraising and grant distribution. Focused on Basic Needs Access, Education Access, Health and Wellness, and Environmental initiatives, these grants foster a culture of giving and aim to create a positive impact on the lives of young people in the community.

The Massachusetts Office of Grants and Research (OGR) will be accepting State-Share Applications from eligible state applicants for the Homeland Security Grant Program (HSGP) from the DHS, FEMA. Proposed funding allocations are an approximation and contingent upon the anticipated receipt of federal funds.

OGR anticipates that approximately $1.5 million will be made available for state agencies to competitively solicit for the purpose of addressing homeland security needs.

The Charlotte Yeoman Martin Scholarship at Montana State University supports American Indian undergraduate students from Montana high schools who demonstrate financial need and have overcome personal adversity. Preference is given to first-generation college students. This scholarship aims to enhance access to higher education for those facing economic challenges and may be renewed for up to four years, helping students achieve their academic goals and contribute positively to society.

The William Penn Foundation's RFP invites proposals aimed at improving public spaces in Greater Philadelphia through inclusive design. Projects should focus on enhancing accessibility and enjoyment for individuals of all backgrounds and abilities. Solutions may involve removing barriers and creating welcoming environments in public areas such as parks, libraries, and community centers. Collaborative approaches that leverage partnerships are encouraged to maximize impact and effectiveness in achieving these goals.

The PVF Social Worker/CASA Grants program supports vulnerable youth in foster care by providing grants of up to $500 to Social Workers and Court Appointed Special Advocates (CASAs). These funds can address critical needs such as medical care, educational supplies, and extracurricular activities. Applications are open for the 2026-2027 school year, and eligible applicants include Social Workers and CASAs in various California counties. The Foundation is dedicated to innovative grantmaking that maximizes philanthropic impact.

The Three Lakes Community Foundation, established in 2013, supports initiatives that enhance community life in Three Lakes. With over $120,000 in grants awarded, the foundation aims to foster partnerships among local nonprofits and enhance services in education, health, and the arts. They invite grant requests from organized groups, ensuring a focus on projects that benefit the public and uphold community values. The foundation prioritizes innovative ideas that differentiate Three Lakes from other communities.

The Caroline J. S. Sanders Trust 1 Grant, established in 1968, aims to support charitable causes with a focus on education, social welfare, and training for the handicapped. Grants typically range from $2,000 to $15,000, with a preference for organizations based in Pennsylvania. Eligible applicants must be 501(c)(3) organizations. The trust does not fund endowments, general operating expenses, or political support, making it a valuable resource for community-focused initiatives.

The Three Lakes Community Foundation, established in 2013, provides Short Form Grants under $1000 to support local innovative projects. These grants aim to enhance community quality of life, support education, arts, and community development, and foster collaboration among local nonprofits. Eligible applicants include local nonprofits, schools, and government entities. The Foundation prioritizes projects that promote community efficiency and distinguish Three Lakes from other areas, ensuring the longevity and vibrancy of the community.

The Conner Firstman "Film Like a Champion" Scholarship at Montana State University supports students pursuing a degree in Film. This scholarship emphasizes a passion for videography and Bobcat Athletics, reflecting MSU's commitment to hands-on learning and community engagement. As Montana's leading public research university, MSU fosters innovation and prepares graduates to contribute meaningfully to society. Award amounts vary, providing opportunities under the Arts and Architecture and Film and Photography scopes.

The George Foundation Scholarship provides over $1.5 million annually to over 150 local students pursuing higher education in Texas. This scholarship targets high-performing student leaders with financial needs and automatically renews for up to four years. Applicants must be residents of Fort Bend County and maintain a minimum GPA of 2.5. The program supports both graduating seniors and non-traditional students, emphasizing inclusivity for unique educational journeys.

The NIDCD Research Career Enhancement Award for Established Investigators (K18) supports seasoned researchers in enhancing or redirecting their research through new skills acquisition. This funding opportunity addresses critical questions in hearing, balance, smell, taste, voice, speech, and language sciences. Key deadlines for applications span from June 2024 to February 2027, ensuring ample opportunity for researchers to apply and contribute to these vital fields.

The NIDCD Research Career Enhancement Award for Established Investigators (K18) program supports established researchers in enhancing their skills and redirecting their research towards critical areas such as hearing, balance, smell, taste, voice, speech, and language sciences. This program is crucial for fostering innovation and advancing the understanding of these fields. Important deadlines for applications include June 10, 2024, and October 8, 2024, among others.

Jayden DeLuca Foundation

Dedicated to raising awareness for children’s heart defect and disease — the number one birth defect in the nation — The Jayden DeLuca Foundation is a testament to the life of Jayden Riley DeLuca.

In Jayden’s name, we are dedicated to supporting children and families facing the challenges of congenital heart defects and disease. We are committed to building a better future by providing financial support through our patient assistance fund, building a community of like families through sharing resources and providing encouragement to those navigating pediatric heart conditions and continuing to invest in dedicated heart research programs.

Our efforts create a meaningful impact — advancing medical and scientific research, improving access to treatment and amplifying awareness of cardiac diseases.

The funds we raise directly support pediatric heart research, treatment advancements and community programs, extending Jayden’s light and legacy far into the world.

Patient Assistance Fund

Our Patient Assistance Fund is dedicated to supporting families with financial support due to complications related to congenital heart disease. Financial assistance may include, but is not limited to:

• Travel assistance related to CHD medical care
• Medical bills related to CHD and not covered by insurance
• CHD specialized equipment not covered by insurance

Eligible applicants may be reimbursed up to $1,500 quarterly for expenses related to CHD complications. Applicants must submit corresponding receipts alongside their application to be considered for this reimbursement program.

Department of Labor and Workforce Development

The New Jersey Department of Labor and Workforce Development is dedicated to protecting our workforce, strengthening our businesses, and promoting the dignity of work.

The Division of Workforce Development is responsible for New Jersey’s workforce services, including vocational rehabilitation services, veteran’s services, and more. The division oversees the One-Stop Career Centers throughout the state, which offer a variety of programs and services to help employers meet their need to secure talented workers.

New Jersey Competitive Integrated Employment (CIE): Implementation & System Advancement (Phase II)

Grant Overview

Grant funds will be awarded to successful applicants who were previously awarded NJCIE Pilot Program grant funds from the NJCIE Pilot Program launched in 2024. Building on the success of the initial NJCIE Pilot launched in 2024, this next phase focuses on advancing participant outcomes and strengthening employer partnerships through more structured, outcome-driven service delivery models. This Phase II opportunity supports community rehabilitation providers in refining and scaling strategies that connect career pathway development, industry-recognized credential attainment, and competitive integrated employment. The program places an increased emphasis on measurable outcomes, including retention, wage progression, and long-term employment stability, while continuing to support the transition toward fully integrated employment opportunities statewide.

The purpose of the NJCIE program is to provide an opportunity for community rehabilitation providers to strengthen organizational capacity and pilot innovative employment and training services for people with disabilities that are intended to lead to competitive integrated employment. 

The Child Neurology Foundation offers a Summer Scholarship for first, second, or third-year medical students interested in neurodevelopmental disabilities or child neurology. This scholarship provides $3,500 for clinical research focused on neurodevelopmental disabilities in children or young adults, conducted under the supervision of a qualified subspecialist. Applications are evaluated based on their importance, originality, and contribution to the medical student's development.