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Best Operating Grants for Nonprofits

Get operating grants for nonprofits covering essential expenses, staffing, program delivery, and organizational sustainability.

32,000+

Available grants

$9.00B

Total funding

$6K

Median grant

32,000+ grants
$9.00B total
$6K median

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32,423 Results based on applied filters

MCSF- Career & Technical Education Scholarship

Marine Corps Scholarship Foundation
Private
United States
US $2,500 - US $10,000
The MCSF Career & Technical Education Scholarship supports children of Marines pursuing non-degree certificate programs. It offers financial assistance to eligible applicants based on need, helping cover tuition, fees, and associated educational costs. With a minimum GPA requirement of 2.00 and a family income cap of $123,000, this scholarship ensures that all qualifying students have access to vocational training at accredited institutions. Applications are accepted year-round, providing flexibility for students.
Workforce Preparation & Job Readiness Vocational & Trade Education

Marr-Anderson Family Foundation Grant

Marr Anderson Family Foundation
Private
Maine
Unspecified amount

Marr Anderson Family Foundation

Founded in 2016, The Marr-Anderson Family Foundation is inspired to serve and strengthen families and their communities. John and Rebecca Marr have Maine roots as part of their heritage and have been long time residents of Falmouth, Maine. They believe in the importance of compassion, determination and encouragement. Their family foundation is a continuation of their philanthropic path to serve in the areas of health, education and catastrophic events. The foundation is a family collaboration, which includes daughters, Stephanie, Andrea and Jennifer.

The Marr-Anderson Family Foundation’s mission is to promote education, health and offer compassionate support during times of crisis. In support of their mission, the Marr-Anderson Family Foundation provides philanthropic support to public charitable organizations for the purpose of encouraging education and health. In addition, the Marr-Anderson Family Foundation offers encouragement for individuals to fulfill their dreams and provides philanthropic aid during difficult times when one’s dreams may be put on hold.

Marr-Anderson Family Foundation Grant

The Marr-Anderson Family Foundation provides philanthropic support to public charitable organizations for the purpose of encouraging education and health. The Marr-Anderson Family Foundation provides grants only to public charitable organizations that fall within Section 501(a)(1) or 501(a)(9) and that further these purposes.

The Marr-Anderson Family Foundation supports non-profit organizations that align with our mission to promote education, health and offer compassionate support during times of crisis. The foundation’s objective is to support organizations that further these efforts.

Education Health & Medicine Crisis Intervention

2025-2026 ESC Statewide Services for Students with Visual Impairments (SSVI)

Texas Education Agency
State/Local Government
Texas
Up to US $5,539,891
The 2025-2026 ESC Statewide Services for Students with Visual Impairments (SSVI) program, overseen by the Texas Education Agency, aims to provide essential services and support to school systems for students with visual impairments. This initiative focuses on enhancing the skills of teachers of visually impaired students, ensuring better educational outcomes. With a total funding of $5,539,891, the program is crucial for retaining qualified teachers in the field and improving the educational experiences of affected students.
Vision Impairment Care & Services Special Needs Education Educational Access & Equity

BDP Summer Program

Johns Hopkins University
Private
Baltimore County, Maryland
US $6,000
The BDP Summer Program at Johns Hopkins University offers undergraduates the chance to engage in full-time research with Bloomberg Distinguished Professors for 10 weeks during the summer. This initiative supports over 80% of students who participate in research, providing essential mentorship and training in various academic fields. HOUR, established in 2017, administers the program, ensuring diverse student representation and enriching educational experiences through research opportunities.
After School / Summer Educational Programs Tutoring & Mentoring Academic Scholarship Programs

MHC Community Identity & Heritage Festival Grants

Minnesota Humanities Center
State/Local Government
Minnesota
Up to US $300,000
The MHC Community Identity & Heritage Festival Grants support diverse cultural communities in Minnesota by funding community events, music and jazz festivals, and cultural festivals featuring art installations and performances. These grants aim to enhance cultural engagement and celebrate the rich heritage of local communities, providing opportunities for individuals and organizations to showcase their artistic talents and foster community connections through vibrant festivals.
Community Culture & Heritage Arts / Culture Access & Participation Art Festivals +1 more

Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional)

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
This funding opportunity aims to enhance the development of medical products in rare diseases through innovative natural history studies. By generating high-quality data, the FDA seeks to bridge critical knowledge gaps and eliminate barriers in rare disease research. The initiative focuses on diseases with unmet needs, fostering significant impacts for those affected and facilitating the development of effective therapeutic solutions.
Rare Diseases Manufacturing Engineering Pharmacology +1 more

Reissue of RFA-FD-23-001- Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01 Clinical Trials Required)

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
American Samoa, Guam +4 more
Up to US $900,000
The RFA-FD-23-001 funding opportunity aims to support clinical trials for orphan products targeting rare diseases. It focuses on evaluating the efficacy and safety of treatments to address unmet medical needs. By promoting innovative and collaborative trial designs, the FDA seeks to enhance the approval rates of effective therapies for rare conditions, ultimately benefiting patients and advancing drug development in this critical area.
Rare Diseases Medical Ethics Human Genome & Genetics

Rooted Pathways Program

First Peoples Fund
Private
American Samoa, Guam +4 more
Up to US $55,000
The Rooted Pathways Program, initiated by First Peoples Fund, offers essential support to Native-led arts organizations, fostering their growth and stability. This funding empowers these organizations to thrive in their missions, providing unrestricted operating support and participation in a Learning Cohort. Eligible applicants include Native nonprofits and collectives with budgets under $500,000, and the program aims to uplift artists from U.S. federally recognized tribes. This initiative is part of the Wallace Foundation's broader commitment to enhancing well-being in the arts.
Artist Training & Development Community Culture & Heritage Arts / Culture Access & Participation +2 more

William Coon Jr. Scholarship

United States Adult Cystic Fibrosis Association (USACFA)
Association/Society
United States
US $2,500
The William Coon Jr. Scholarship, offered by the USACFA, provides four $2,500 awards annually for students with cystic fibrosis pursuing degrees in various fields. Applications require transcripts, proof of enrollment, and essays, focusing on financial need and academic performance. Winners receive full or half awards based on their enrollment status. This scholarship honors Bill Coon Jr.'s legacy, supporting individuals facing similar health challenges and promoting their educational aspirations.
Academic Scholarship Programs Cystic Fibrosis

Carlos Vieira Foundation Direct Help Grant

Carlos Vieira Foundation
Association/Society
Butte County, California, Colusa County, California +19 more
Up to US $500

Carlos Vieira Foundation

The Carlos Vieira Foundation is committed to making a meaningful difference in the lives of families living with autism, mental illness, and addiction. Through our Race For Autism Grant Program, we provide financial assistance for therapy, treatment, and essential services that many families might not otherwise afford. Race 2B Drug Free campaign giving youth the opportunity to stay off the streets and learn the sport of boxing through our 51FIFTY Boxing Clubs. Our Race to End the Stigma campaign brings awareness to the realities of mental health and addiction, encouraging open conversations and providing scholarships to students who advocate for change. By offering direct support, education, and community-driven programs, we strive to uplift and empower families facing these challenges with compassion and hope.

The Carlos Vieira Foundation is a 501(c)(3) charitable organization that focuses on the following three campaigns: Race for Autism, Race 2B Drug-Free, and Race to End the Stigma. CVF was built on one man’s dream of helping youth within our local communities. Through local support, CVF is able to assist youth across twenty-one counties within California’s central valley.

Direct Help Grant

Our mission is to provide services, medical necessities, and educational tools to families who live in Central California that are affected by Autism. 

Requested Items to be Purchased by Foundation if Grant is Awarded

If you are interested in additional items to total the allowed grant amount of $500, please email additional items, cost, service provider, vendor, or website/link to buy items to the Carlos Vieira Foundation. A recommendation letter is not required for any items that can be found on or are similar to those found on our approved websites: arktherapeutic.com, autism-products.com, funandfunction.com, pecsusa.com, and nationalautismresources.com

Autism Family Services

What’s Your Gap Grant

BreatheStrong CF
Association/Society
United States
Unspecified amount
The What’s Your Gap Grant, provided by BreatheStrong CF in partnership with the Closing the Gap Foundation, supports teens and adults living with cystic fibrosis. This grant alleviates financial barriers, allowing recipients to pursue health and wellness opportunities tailored to their individual goals. It aims to empower applicants who envision a healthier lifestyle but face challenges in achieving it, serving as a catalyst for positive change in their lives.
Cystic Fibrosis Wellness & Healthy Living

Paul Drury Memorial Scholarship

Boomer Esiason Foundation
Private
United States
Up to US $45,000
The Paul Drury Memorial Scholarship honors the legacy of Paul Drury, who inspired many while living with cystic fibrosis. This scholarship is aimed at siblings and children of individuals with CF, recognizing the crucial support family members provide. Eligible applicants must have a family member with CF, demonstrate academic achievement, and be enrolled in an educational program. This initiative highlights the importance of family in managing the challenges posed by cystic fibrosis.
Academic Scholarship Programs Cystic Fibrosis

Weitz Fellows

Weitz Family Foundation
Private
Douglas County, Nebraska, Lincoln County, Minnesota
US $56,500
The Weitz Fellows program, initiated in 2011 by the Weitz Family Foundation, connects recent Carleton College graduates with nonprofit organizations in Omaha and Lincoln. With a focus on enhancing career discernment and nonprofit appreciation, the program has evolved to include an open application process for interested organizations. Each fellow engages in a full-time role, supported by a $56,500 grant for salary and benefits, ensuring a valuable experience in the nonprofit sector.
Workforce Preparation & Job Readiness Apprenticeship & Internship Programs

Health Career Connection Internship

John Muir Health
Private
United States
Unspecified amount
The Health Career Connection Internship, offered by John Muir Health, is a 10-week full-time program aimed at empowering underrepresented college students in healthcare. This internship provides valuable mentorship, networking opportunities, and real-world experience, focusing on diverse backgrounds. It encourages participants to explore careers in health professions, particularly those from low-income and first-generation college student backgrounds. The program is designed to inspire and motivate interns as they embark on their professional journeys.
Education - Higher Education Minority Services Tutoring & Mentoring +1 more

CLIMB Near Peer Mentorship Program

John Muir Health
Private
United States
Unspecified amount in in-kind support
The CLIMB Near Peer Mentorship Program by John Muir Health offers a year-long mentorship initiative aimed at developing family medicine learners into community-engaged providers. This program supports high school, undergraduate, and medical students by pairing them with mentors in the healthcare field. Participants engage in weekly virtual meetings and receive guidance throughout their educational journey, fostering a diverse and inclusive future in healthcare professions.
Education - Higher Education Tutoring & Mentoring Education - High School

Kansas Office of Apprenticeship Project Grant

Kansas Department of Commerce
State/Local Government
Kansas
Up to US $100,000
The Kansas Office of Apprenticeship Project Grant aims to enhance the state's workforce by supporting Joint Apprenticeship Training Councils, educational institutions, and businesses that can demonstrate a commitment to increasing apprenticeship opportunities. Applicants must show how their projects align with industry demands and contribute to workforce growth. A 1:1 matching fund is required, ensuring that programs can expand effectively. The grant focuses on established programs with a proven track record, fostering long-term sustainability and job creation in Kansas.
Apprenticeship & Internship Programs Workforce Preparation & Job Readiness

HOME ARP Rental Production RFP

New Jersey Economic Development Authority
State/Local Government
New Jersey
Unspecified amount
The HOME ARP Rental Production RFP aims to support the development of affordable housing for low-income households, including those experiencing homelessness. It encourages collaboration with local housing authorities for project-based rental assistance and offers operating cost support for HOME-ARP units. A maximum of 30% of the funded units may be reserved for low-income occupants, thereby promoting mixed-income housing solutions and fostering community stability.
Real Estate & Housing Equitable & Affordable Housing

Island Thrift Simple Grant

Island Thrift
Private
Island County, Washington
US $100 - US $5,000

Island Thrift

Island Thrift is a nonprofit dedicated to helping Whidbey Islanders thrive since 1977. Through our efficiently run thrift store we offer:

  • An affordable shopping experience.
  • A convenient way to donate gently used donated items.
  • A generous community grants program.

Island Thrift is a 501(c)(3) Nonprofit Public Charity

Island Thrift Grants

Island Thrift awards grants for projects, events, and programs that support one of the following categories:

  • Kids – Serving those under 18 years of age
  • Quality of Life – Enhancements to community health, well-being, and living
  • Seniors – Serving senior citizens

Our grants are made possible by the generosity of our community through donations and purchases at our thrift store. We, therefore, prioritize awarding grants that benefit the Greater Oak Harbor community, the Greater Coupeville community, or the broader needs of all Whidbey Island residents.

Funding decisions are made by a majority vote of the board of directors and are driven by such factors as the number of people to be served, the needs and abilities of an organization, and the potential for funding from other sources.

Grants that are to be regifted to other groups or individuals are typically limited.

Available Grant Applications

There are two types of Island Thrift Grants corresponding to the total amount of your funding request: Simple Grant and Full Grant

Simple Grant

Simple Grant application is for one-time grants of $100 to $5,000 total

Senior Services Youth Services Wellness & Healthy Living +1 more

Human Trafficking Youth Prevention Education (HTYPE) Demonstration Program (363751)

US Dept. of Health & Human Services: Administration for Children & Families
Federal Government
United States
US $350,000 - US $400,000
The Human Trafficking Youth Prevention Education (HTYPE) Demonstration Program aims to empower local education agencies (LEAs) by funding initiatives that equip school staff to identify and respond to human trafficking signs. Collaborating with nonprofit partners, LEAs will provide students with essential knowledge on avoiding victimization and recognizing trafficking indicators. This program fosters a safer school environment by establishing reporting procedures and safety plans in consultation with local law enforcement, ultimately enhancing awareness and prevention of human trafficking in educational settings.
Education - K through 12 Teacher Development & Training Human Trafficking +2 more

Island Thrift Full Grant

Island Thrift
Private
Island County, Washington
More than US $5,000

Island Thrift

Island Thrift is a nonprofit dedicated to helping Whidbey Islanders thrive since 1977. Through our efficiently run thrift store we offer:

  • An affordable shopping experience.
  • A convenient way to donate gently used donated items.
  • A generous community grants program.

Island Thrift is a 501(c)(3) Nonprofit Public Charity

Island Thrift Grants

Island Thrift awards grants for projects, events, and programs that support one of the following categories:

  • Kids – Serving those under 18 years of age
  • Quality of Life – Enhancements to community health, well-being, and living
  • Seniors – Serving senior citizens

Our grants are made possible by the generosity of our community through donations and purchases at our thrift store. We, therefore, prioritize awarding grants that benefit the Greater Oak Harbor community, the Greater Coupeville community, or the broader needs of all Whidbey Island residents.

Funding decisions are made by a majority vote of the board of directors and are driven by such factors as the number of people to be served, the needs and abilities of an organization, and the potential for funding from other sources.

Grants that are to be regifted to other groups or individuals are typically limited.

Available Grant Applications

There are two types of Island Thrift Grants corresponding to the total amount of your funding request: Simple Grant and Full Grant

Full Grant

Full Grant application is for grants of more than $5,000+ total.

Senior Services Wellness & Healthy Living Health Disparities & Social Determinants of Health +1 more

Pathways in Technology Early College High School (P-TECH)

Texas Education Agency
State/Local Government
Texas
Unspecified amount
The Pathways in Technology Early College High School (P-TECH) initiative by the Texas Education Agency (TEA) provides an innovative educational model that combines high school and college experiences, enabling students to earn an associate degree while preparing for high-demand careers. Through partnerships with industry and institutions of higher education, students gain practical work experience and mentorship, ensuring they are college- and career-ready. This initiative emphasizes hands-on learning and alignment with workforce needs.
Educational Access & Equity Education - High School Vocational & Trade Education

Pink Gravel Fund

Emporia Community Foundation
Private
United States
Up to US $500

About the Emporia Community Foundation

Our Mission

To connect caring people with causes that build stronger communities within the Emporia area which includes Chase, Coffey, Greenwood, Lyon, Morris, Osage and Wabaunsee counties.

Pink Gravel Fund

The purpose of the Pink Gravel Fund is to provide funds to qualified individuals to cover expenses related to the treatment and recovery of breast cancer. 

Breast Cancer Health Care Access & Delivery

Society of Hospital Medicine Travel Grant

Society of Hospital Medicine (SHM)
Association/Society
United States
Up to US $2,000

Society of Hospital Medicine (SHM)

The Society of Hospital Medicine (SHM) is dedicated to promoting high-value care and achieving optimal outcomes for acutely ill patients. As part of this mission, SHM seeks to address inequities in acute patient care and contribute to a greater dialogue on this important issue. As the home for hospitalists, SHM activates and engages our community to

  • Advocate for our specialty, our members, and the diverse patients we serve.
  • Promote high-value care and optimal outcomes for acutely ill patients.
  • Meet the evolving educational needs of a dynamic specialty.
  • Cultivate an inclusive community for hospitalists and support career growth and wellbeing.
  • Advance the research and innovation of healthcare delivery, quality, safety, and experience across the care continuum.

Society of Hospital Medicine Travel Grant

The SHM Global and Rural Health Foundation brings our mission directly to patients in rural and underserved regions of the United States and abroad by offering small travel grants to hospital-based clinicians and practice administrators involved in this work. The Foundation also aims to amplify the stories of inequitable patient care and celebrate hospital medicine professionals enhancing outcomes.

The SHM Global and Rural Health Foundation awards travel grants of up to $2,000 per person for travel to qualifying relief programs. Travel grants will be awarded to support travel for work conducted through established nonprofits, such as Doctors Without Borders, or a program run by a nonprofit academic health center.

Disaster Relief / Humanitarian Aid Adventure Travel & Expeditions Rural Health Care

Edward & Ellen Roche Relief Foundation Grants

Uw Edward & Ellen Roche Relief Foundation
Private
New York
US $15,000 - US $25,000
The Edward & Ellen Roche Relief Foundation Grants support nonprofits that assist disadvantaged women and children in New York City. Established in 1953, the foundation prioritizes funding for programs that promote the well-being and self-sufficiency of low-income women and their families, particularly those that focus on job training and placement for unemployed or underemployed women. This targeted approach aims to empower vulnerable populations and foster economic independence.
Women & Girl Services Workforce Preparation & Job Readiness

Nexus Fund: Regional Regranting Program

Andy Warhol Foundation for the Visual Arts
Private
Cherokee County, Georgia, Clayton County, Georgia +9 more
US $6,000
The Nexus Fund: Regional Regranting Program, supported by the Andy Warhol Foundation for the Visual Arts, seeks innovative project proposals from individual artists or collaborations in the Metro Atlanta region. The fund emphasizes risk-taking and experimentation, awarding ten grants of $6,000 each, totaling $60,000. Projects must benefit local communities, adhere to public health guidelines, and be completed by September 30, 2025. Preference is given to multi-disciplinary and socially engaging proposals that address diverse audiences.
Arts / Culture Access & Participation Community Culture & Heritage Art for Social Change +2 more

Lost Tree Village Grants

Lost Tree Village Charitable Foundation Inc
Private
Martin County, Florida, Palm Beach County, Florida
US $5,000 - US $100,000
The Lost Tree Village Charitable Foundation is dedicated to enhancing the quality of life for underserved residents in Palm Beach and southern Martin Counties. It focuses on health, hunger, homelessness, and education, prioritizing projects benefiting children, families, individuals with special needs, and seniors. Grants are mainly for capital needs such as construction, renovations, and medical equipment. The Foundation encourages thoughtful applications from local 501(c)(3) organizations committed to community improvement.
Health & Medicine Education Basic Human Needs +3 more

Bill Kane Undergraduate Scholarship

Society Of Health And Physical Educators
Private
American Samoa, Guam +4 more
US $1,000
The Bill Kane Undergraduate Scholarship, awarded by SHAPE America, provides $1,000 annually to undergraduate students majoring in school-based health education at accredited institutions in the U.S. or territories. Eligible candidates must be full-time students with a GPA of at least 3.25. Alongside the scholarship, recipients receive a complimentary one-year membership with SHAPE America, promoting professional development in health and physical education.
Education - Higher Education Physical Fitness Epidemiology & Public Health +1 more

Operating Grants for Nonprofits Highlights

Operating grants for nonprofits provide essential funding to support day-to-day operations, staff salaries, and infrastructure. The following grants help organizations build capacity, maintain sustainability, and focus on achieving their mission-driven goals.


Search Instrumentl's Operating Grants Database


Explore 8,000+ funding opportunities for operational support, with $3.34B in resources. Instrumentl helps nonprofits secure essential funding by offering grant discovery tools, deadline tracking, and strategic funder analysis to ensure long-term success.

Grant Insights : Operating Grants for Nonprofits

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Operating grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Operating grants for nonprofits over $25K in average grant size

3,000+ Operating grants for nonprofits over $50K in average grant size

1,000+ Operating grants for nonprofits supporting general operating expenses

7,000+ Operating grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Youth Services

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits?

Most grants are due in the first quarter.

Q1
29.7%
Q2
24.7%
Q3
23.5%
Q4
22.1%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits?

Grants are most commonly $32,500.

$0 $0 Min.
$32,500 $32.5 K Median
$633,837 $633.8 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits of all types can apply for operating grants, but they are especially useful for organizations needing flexible funding to support the core work of their mission. Operating grants are ideal for nonprofits involved in general population well-being. Specific sectors include healthcare, education, social services, and the arts. Unlike project-based grants that fund specific initiatives, operating grants help with essential costs like staff salaries, rent, and general admin costs. Funders often look for groups with a clear mission who serve a meaningful purpose and have potential for long-term impact.

Based on Instrumentl’s live grant database for operating, grant deadlines are most common in Q1, accounting for 29.7% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Operating grants exist to help nonprofits function smoothly and grow effectively. The goal is to give organizations the financial means they need to focus on their mission, serve their communities, and support long-term stability. These grants allow nonprofits to improve everyday operations, invest in staff development, and expand programs. Funders want to see nonprofits thrive, not just survive, and providing operational support is a key element to making that happen.

Funding for operating grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $32,500, while the average grant awarded is $633,837. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Operating grants are often funded by private foundations like the popular Ford Foundation. Some government agencies offer grants to strengthen nonprofit infrastructure, especially in sectors like health, education, and social services. Corporate giving programs may also support nonprofits that align with their values and create lasting impact.

To improve the chances of getting operating grants, nonprofits should:

  • Showcase past impact – Use data and real-world examples to prove how your organization has already made a difference.
  • Prove how you align with funder priorities – Research what funders care about and explain how your nonprofit’s mission fits within their goals.
  • Prove financial stability – Funders want to support organizations that can manage funds responsibly and have a solid sustainability plan for the long-term.
  • Emphasize lasting growth – Describe how operating funds will help your nonprofit expand its reach, strengthen programs, and increase its overall impact.

For more advice on finding and winning operating grants, check out our step-by-step guide to general operating grants.

Instrumentl simplifies the process of applying for operating grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

Check out how Habitat for Humanity delivered over 200% ROI within just a few weeks.