Best Operating Grants for Nonprofits

The Advancing Equity Through Oral Health Funds, initiated by CareQuest Institute, seeks to transform oral health systems by supporting projects that dismantle disparities faced by marginalized communities. The program encourages organizations to propose innovative solutions that enhance access to dental care, engage community voices, and promote policies that ensure equitable health outcomes for all. This initiative aims to create a more integrated and accessible healthcare system, particularly for historically underserved populations.

Iowa Workforce Development

Iowa Workforce Development (IWD) is a state agency committed to providing employment services for individual job seekers and to serving employers by helping them find the skilled workforce they need. 

IWD supports employers through its Business Engagement Division and provides a variety of resources and one-on-one support. This includes helping employers to post jobs, recruit veterans, apply for qualifying federal tax credits, and connect with workforce training programs available through several state programs.

Iowa Registered Apprenticeship Development Program (84F)

As part of its commitment to growing Registered Apprenticeship (RA) across industries, Iowa provides annual RA program funding through the Iowa Registered Apprenticeship Development Program (84F). 

The Iowa Registered Apprenticeship Development Fund (84F) provides financial assistance to apprenticeship sponsors who start or expand new registered apprenticeship programs with 20 or fewer apprentices in eligible high-demand occupations. 

These competitive grants support a newly created RA program with an eligible high-demand occupation by helping with ongoing program costs, fees, or related expenses.

Awarded funds: Given as a one-time reimbursement of expenses incurred in establishing a registered apprenticeship program.

Applicants can apply for more than one grant if they have multiple eligible occupations within their registered apprenticeship program; grant awards for applicants receiving more than one grant in the same calendar year will be capped at $50,000.

The Gloria Barron Prize for Young Heroes honors 25 exceptional young leaders aged 8 to 18 from diverse backgrounds across the U.S. and Canada. Each winner receives $10,000 for education or service projects, a personalized plaque, and media opportunities. Selection focuses on impactful service activities primarily initiated by the young hero, demonstrating qualities of courage, generosity, and moral purpose. This prize encourages youth to inspire others and create positive change in their communities.

The UCP Research Grant Program aims to enhance clinical and translational research focused on cerebral palsy and related neurodevelopmental disabilities. Grants of up to $20K support innovative studies, with a preference for projects addressing early diagnosis and treatment. Applications from U.S. and Canadian researchers are encouraged, particularly from those affiliated with UCP. The program promotes collaboration and aims to transform care through sustainable treatment solutions.

The Israel Experience College Merit Scholarship Program, offered by the Jewish United Fund of Metropolitan Chicago, provides $1,000 scholarships to high school and college students up to age 23. This program seeks to recognize emerging leaders who demonstrate commitment to the Jewish community, Israel, and exhibit leadership skills. Applicants must be residents or students in metropolitan Chicago and show evidence of community service. Participation in post-Israel communal activities is encouraged.

First Horizon Foundation

Through the First Horizon Foundation we are constantly investing in organizations across our footprint that do important work every day to make the places we serve better and stronger.

Focus areas

We focus on five key areas where our support drives long-term growth and well-being in the communities we serve.

• Improving the well-being of our communities
• Investing in the financial future
• Educating and developing the next generation of leaders
• Promoting excellence and enrichment in the arts
• A more sustainable tomorrow and future

The First Horizon Foundation Grant aims to enhance communities in Louisiana through targeted contributions in arts, education, environment, financial literacy, and health. The foundation focuses on improving community well-being, investing in future leaders, and promoting sustainability. Eligible organizations include those in Acadiana, Baton Rouge, Monroe, New Orleans, Lake Charles, and Shreveport. However, funding is not provided for individuals, political organizations, or charities redistributing funds, ensuring support is directed where it can lead to meaningful community impact.

The Technical Skills Training Grant (ND) is designed to support workforce development by funding training programs for displaced workers, particularly in response to the COVID-19 pandemic. With three tracks, the grant offers financial assistance for non-degree training, internal upskilling, and automation-related training. Track A can provide up to $200,000, while Tracks B and C offer up to $100,000 and $200,000 respectively. This initiative aims to create a skilled workforce to meet labor market demands.

Iowa Workforce Development

Iowa Workforce Development (IWD) is a state agency committed to providing employment services for individual job seekers and to serving employers by helping them find the skilled workforce they need. 

IWD supports employers through its Business Engagement Division and provides a variety of resources and one-on-one support. This includes helping employers to post jobs, recruit veterans, apply for qualifying federal tax credits, and connect with workforce training programs available through several state programs.

Advanced Manufacturing Pathways Development (AMP’D) Iowa Program

Program Purpose

The purpose of the Advanced Manufacturing Pathways Development (AMP’D) Iowa is to increase training opportunities in the targeted industry of advanced manufacturing (manufacturing). AMP'D Iowa will reimburse Iowa manufacturing employers a portion of expenses to train and/or upskill new or current employees due to the implementation of new technology, creation of new workforce pipelines, and to address the skilled labor gap.

Iowa’s manufacturing sector spans a wide variety of industries and products including but not limited to: agricultural and construction equipment, tires, windows, lighting, medical devices and machinery, appliance/furniture, food production, fuels, and the biotech industry, impacting not just the economy of Iowa, but the entire nation. This is not an exhaustive list of Iowa’s manufacturing sector but represents a description of the variety of the manufacturing industries within Iowa.

Applicants for the AMP’D Iowa program are not limited to these stated industries and are encouraged to review the eligibility requirements for this opportunity. Through Work Based Learning (WBL), manufacturing employers will increase domestic skills of Iowa’s manufacturing workforce and ensure a well-trained workforce to meet the growing demand for the future.

Waseca Area Foundation

The Waseca Area Foundation was created from the contributions of Waseca area residents, starting with the All School Reunion of 1988. Former classmates and current area residents shared an interest in the present and future of the Waseca community.

The Waseca Area Foundation is a Community Fund with a close affiliation with the St. Paul & Minnesota Community Foundation, which allows a broader investment opportunity with little cost to local funds. The Waseca Area Foundation is a 501(c)3 charitable non profit with tax exempt status under Minnesota and Federal Law.

Waseca Area Foundation’s mission is to provide an opportunity for groups or individuals to leave a legacy through contributions which build a permanent community fund committed to meeting the changing needs of the Waseca area.

New Richland Area Foundation Grant

Focus Area

• Provide grants for agencies that serve residents of the New Richland Area.
• Provide grants for community development projects and programs, which are responsive to the changing community needs in promoting quality education, cultural, wellness, recreational, social service, environmental and civic opportunities.

The McKnight Brain Research Foundation Innovator Awards aim to support innovative research in cognitive aging and memory loss, offering two 3-year grants of $750,000 each. Targeted at early-career investigators, the program encourages high-risk, high-gain proposals that explore clinical translational research and the biological mechanisms of cognitive aging. By fostering emerging scientific leaders, the initiative seeks to advance transformative discoveries in this critical area of aging research, enhancing understanding and treatment of age-related cognitive decline.

The River Branch Foundation Grant supports organizations focused on environmental issues, particularly permanent land protection in northeast Florida. Applicants must submit a detailed letter describing their project, as the foundation does not use a standard application form. Grants are awarded at the foundation's discretion to 501(c)(3) non-profits throughout the year, with funds disbursed in June and December. Interviews and proposal analysis occur in May and November.

The John Taylor Babbitt Foundation offers grants to support nonprofit organizations in preventing sudden cardiac death through initiatives such as acquiring AEDs and providing CPR training. Applications are accepted on a rolling basis and should include a detailed estimate of funding needs and commitments. The foundation emphasizes timely use of funds and adherence to safety regulations, ensuring a positive impact on diverse populations, including student athletes and vulnerable groups.

The Homeland Security Grant Program (HSGP) for Federally-Recognized Tribes in California aims to enhance security projects. For fiscal year 2024, the program focuses on addressing high-priority preparedness gaps to bolster tribal capabilities in preventing and responding to terrorism. Funds must support statewide preparedness activities, ensuring tribes can effectively mitigate risks and recover from potential threats. This initiative is crucial for improving community safety and resilience against acts of terrorism.

The Barbara Stone Foundation

Barbara Stone served as a champion for individuals with disabilities and the Foundation strives to continue her legacy. The Barbara Stone Foundation is a 501 (C) 3 non-profit organization based in Greenville County, South Carolina.

Our primary focus is to influence community systems policies and culture to result in equitable opportunities for individuals with disabilities. We do this by identifying gaps in the system, investing in or creating our own innovative programs, leveraging partnerships in the community and through our signature initiative Greenville CAN. Greenville CAN is a multi-stakeholder collective impact coalition focused on creating systemic community change through specific community projects focused on people with disabilities. Through our multi-faceted approach we believe we can achieve our vision of a community where all people with disabilities flourish.

Barbara Stone Community Leadership Award

Barbara Stone was an instrumental leader in the Greenville community when it came to the services and rights of people with disabilities. Her decades-long mission made a profound impact on the quality of life of many people with disabilities in Greenville County. Like Barbara, there are many dedicated individuals in Greenville who still carry on her legacy of service and giving. It is with great pride that the Barbara Stone Foundation has created an annual Community Leadership Award to honor an individual who has shown the same commitment, initiative and spirit. If you know of an individual who you think embodies some of the same characteristics as Ms Stone, we invite you to nominate this person. 

Barbara Stone led efforts to unify community and government leaders to establish day program options for children with disabilities and employment workshops for adults. In 1968, she helped establish a day camp for children and adults with disabilities and special needs which has grown into a wonderful summer camp called Camp Spearhead. Because of her, seeds were planted to establish many services that still exist today. Barbara’s legacy and determination to support individuals’ lives is now carried on through the Foundation which bears her name.

The Colorado AAPI Circle Fund, supported by The Denver Foundation, aims to empower Asian, Asian-American, Native Hawaiian, and Pacific Islander communities in Colorado. By increasing resources and enhancing civic engagement, the fund seeks to uplift these communities, particularly those facing significant challenges. Organizations that connect with this mission and meet eligibility requirements, including being a 501(c)(3) nonprofit, are encouraged to apply for funding to further these vital initiatives.

The Accelerating Impact for Hard-to-Treat Cancers Award, offered by the Children's Cancer Research Fund, focuses on pre-clinical research to enhance treatment outcomes for pediatric cancers that are difficult to treat. The award supports innovative studies, including pilot projects and the development of new technologies. As a nonprofit, CCRF has invested over $235 million in initiatives since 1981, aiming to improve therapies and support for children battling cancer, thereby fostering safer and more effective treatment options.

The Eliminating Disparities in Childhood Cancers Award, offered by the Children’s Cancer Research Fund, supports innovative research aimed at reducing health disparities in childhood cancer. This initiative prioritizes proposals that identify modifiable risk factors and mechanisms of disparities, emphasizing the importance of improving access to care and treatment outcomes. With over $235 million invested since 1981, CCRF is dedicated to enhancing the quality of life for children and families affected by cancer.

The Healthy After Cancer Award, offered by the Children's Cancer Research Fund, focuses on enhancing the quality of life for childhood cancer survivors. This funding supports research aimed at addressing the long-term effects of cancer therapy, prioritizing survivorship interventions over new treatment development. With a commitment to improving health outcomes for young survivors, this award underscores the importance of addressing unique challenges faced by this population.

The ECCF: Children's Health Fund aims to enhance the lives of Erie County residents by providing essential medical services, educational rehabilitation, and emotional support to children in need. This fund focuses on supporting tax-exempt nonprofits that serve the local community, ensuring that children receive the care and resources they require. With a vision of a thriving and empowered Erie County, the fund plays a crucial role in addressing community needs and fostering positive change.

About Us

Children’s Cancer Research Fund is a national nonprofit dedicated to ending childhood cancer. Our main focus is to support the research of bright scientists across the country whose ideas can make the greatest impact for children fighting cancer. We also fund resources and programs that help kids and families as they navigate the difficult experience of cancer treatment and survivorship.

Since 1981, we’ve contributed over $235 million to research, support programs for children and families, and awareness and education outreach. In 2024, over 81 percent of funds raised went directly to these program services areas.

Children’s Cancer Research Fund (CCRF) is a national nonprofit committed to finding safer, more effective therapies for kids battling cancer. Thanks to donors and partners around the country, we have contributed over $235 million to research, education and awareness, and quality-of-life programs for childhood cancer families. We believe kids deserve safer, less toxic treatments, and we’re committed to funding groundbreaking research and services that enhance healing and care.

In 2026, Children’s Cancer Research Fund will focus our research funding efforts on three main areas:

• Hard-to-Treat Cancers
• Survivorship
• Health Disparities

Accelerating Hope: Clinical Trials for Hard-to-Treat Cancers Award

This funding opportunity is limited to support for clinical trials focused on hard-to-treat cancers, prioritizing Phase 0 – Phase 2 studies. Learn more about eligibility criteria and other key details below.

The Women and Girls Fund of Waukesha County (WGF) provides grants up to $20,000 to support local nonprofit projects that empower women and girls. Focus areas include health, self-sufficiency, and empowerment, addressing needs such as mental health, economic security, and education. Since its inception, the WGF has awarded over $2 million to organizations throughout Waukesha County, fostering safety and well-being for women and girls in the community.

The Do it Best Foundation Grant supports nonprofit organizations focused on community needs, particularly in health and wellness, youth enrichment, the arts, and community development. Grants typically range from $5,000 to $20,000, with no strict limits based on quarterly applications. Eligible organizations must have 501(c)(3) status and be located near specific areas. This initiative aims to enhance community resources and foster connections among residents.

MyCAP Planning and Implementation, Round A

The My Career and Academic PlanMyCAP Planning and Implementation Grants provide supplementary support to districts/schools who are working to improve the college, career, and civic readiness for all students.

The purpose of this competitive grant opportunity is to provide supplementary support to school districts with high schools interested in entering the planning phase of My Career and Academic Plan (MyCAP) or school districts that are currently engaged in the early stages of whole school implementation of My Career and Academic PlanMyCAP in high schools. The My Career and Academic PlanMyCAP process requires schools to convene a multi-role team to create a scope and sequence in the three domains identified as necessary for college, career, and civic readiness — personal/social/mental health, career development, and academic and future planning — for every grade to guide the implementation of My Career and Academic PlanMyCAP. This grant will provide planning team members the supplementary support necessary to attend professional development, to hold team meetings outside-of-school hours to create a scope and sequence for every grade, or to support the My Career and Academic PlanMyCAP team as they begin implementation of the scope and sequence and allow for continuation of team meetings outside of school hours, attend additional trainings, purchase curriculum that supports My Career and Academic PlanMyCAP.

Funding will support the team’s work by:

• allow a team made up of diverse roles to meet outside of school hours for the creation of a high school scope and sequence;
• pay for substitutes while team members attend in-person trainings;
• design and/or begin the implementation plan for the rollout of My Career and Academic PlanMyCAP; 
• identify 2 metrics for assessment of student success.

The Funding for Optimal Comprehensive Universal Screeners (FOCUS) grant, provided by the New Jersey Department of Education, supports Local Education Agencies (LEAs) in implementing high-quality universal literacy screeners for grades K-3. With a budget of $5.25 million, this initiative aims to enhance early literacy identification and instruction, ensuring compliance with state literacy standards. The grant fosters a data-driven approach to literacy education and promotes effective practices across New Jersey's educational landscape.

The John Edelman Scholarship supports student veterans pursuing careers in mental health counseling, offering five scholarships of $10,000 each. This initiative, funded by Student Veterans of America, emphasizes the importance of mental health support for veterans. Eligible candidates must be enrolled as full-time students in the 2025-2026 academic year and maintain strong academic performance. The scholarship aims to reward exceptional achievement and encourage further study in disciplines that promote mental well-being.

The Kansas Department of Commerce offers an Economic Development Grant to support for-profit businesses and agricultural cooperatives in non-entitlement areas of Kansas. This loan must be repaid, but 25% may be forgiven if projects are completed successfully. Funding up to $750,000 is available from a total allocation of $1 million for 2025, aimed at infrastructure improvements and business expansion.