Best Large Grants for Nonprofit Organizations in California

The Community Possible Grant Program by U.S. Bank aims to foster economic and workforce advancement, as well as safe and affordable housing. By partnering with 501(c)(3) nonprofit organizations, the program seeks to drive lasting change within communities through collaborative grantmaking. Priority is given to organizations that promote diversity, equity, and inclusion, and that address multiple pillars of work, home, and play. This initiative reflects U.S. Bank's commitment to creating a more equitable society.

The Costco Wholesale Charitable Contributions program prioritizes support for children, education, and health services within local communities. Nonprofit organizations seeking assistance must be 501(c)(3) certified and focus on monetary requests. Applications are reviewed within 4-6 weeks, factoring in community needs and collaboration. However, Costco limits grants to 10% of the program budget and typically restricts organizations to one request per fiscal year. They do not fund individuals or direct aid for various specific purposes.

Mission

The Social Science Research Council (SSRC) is an independent, international, nonprofit organization founded in 1923. The Council fosters innovative research, nurtures new generations of social scientists, deepens how inquiry is practiced within and across disciplines, and mobilizes necessary knowledge on important public issues.

Driving University Impact: Expanding the Public Exchange Network

With generous support from the William and Flora Hewlett Foundation, the Social Science Research Council is pleased to invite U.S. R1 research universities in SSRC’s College and University Fund for the Social Sciences to apply for funding to join the Public Exchange Network. Public Exchange is a new network that turns university research expertise into real-world action and impact. Foundedat the University of Southern California in 2020 and expanded to Washington University in St. Louis in 2025, Public Exchange connects researchers with government, nonprofit, and industry partners to tackle pressing challenges—from disaster recovery and climate solutions to food insecurity and homelessness prevention. Since its founding, Public Exchange has developed high-impact collaborations between 48 partners and 142 researchers including:

• CLEAN LA and CLEAN STL: One of the largest free soil testing programs for lead in Los Angeles County following the January 2025 wildfires, and a related program in St. Louis to test soil and air for contaminants following the May 2025 EF-3 tornado;
• The California Solar Canal Initiative: An ambitious public-private research collaboration to advance solar panel infrastructure along California’s 4,000 miles of open aqueduct, conserving water and generating renewable energy;
• Food Base LA: LA County’s first food systems data dashboard, helping LA County and non-profit partners target distribution of millions of pounds of food and related resources to families experiencing food insecurity;
• ShadeLA: A people-powered campaign to cool Los Angeles ahead of the 2028 Olympics and Paralympics by advancing natural and built shade cover in the region.

Partners have included the City and County of Los Angeles, the State of California, the City of St. Louis, Yelp, Solar AquaGrid, the United Nations Foundation, Keck Medicine of USC, the Southern California Association of Governments, Santa Clarita Valley Water Agency, the Sustainable Entertainment Alliance, the Los Angeles Regional Food Bank, Department of Angels and many more. In addition to real-world impact positively affecting millions of lives, Public Exchange collaborations have resulted in over $18m in research funding, some helping to incubate new centers or areas of research, more than 40 academic journal publications, hundreds of media hits, and dozens of student career opportunities. 

The Public Exchange Model

Public Exchange is a partner-driven program, working collaboratively with external partners to: (1) define a research scope, timeline, and deliverables; (2) identify the right team of multidisciplinary academic experts to analyze the problem; (3) provide project management from concept and strategy development to project outputs and tools delivery; and (4) manage the public and stakeholder engagement related to the project, as well as communications and design needs. Public Exchange staff are not researchers, but come from government, industry, and non-profit backgrounds, uniquely equipping project teams to understand partners’ needs and lead projects to action. Staff oversee activities including partnership and proposal development, funder cultivation, research translation, dissemination, and communications, impact and scaling strategy, administrative support, cross-sector convening, and more, to maximize the real-world impact of university expertise. Public Exchange builds results-driven teams that deliver measurable impact and lasting solutions for partners.

How the Public Exchange Network Works

No single university – even a large R1 – has enough faculty expertise available to meet the needs of every partner. The Public Exchange Network was designed to help universities work together seamlessly to build robust partnerships and generate more collective impact. Universities joining the network are independent but affiliated members, with full control over their own program and project portfolios. As a national network with local, on-the-ground capacity, Public Exchange Network members can also share approaches that work, scale solutions to common problems, and build cross-regional partnerships together. 

As an institutional partner in the Public Exchange Network, universities will build capacity to develop, test and implement solutions to the most urgent problems in their regions and beyond. Universities joining the Public Exchange Network get:

• The tools, templates and training they need to start right away;
• A shared brand they can plug into on day one;
• A network of faculty, past and potential partners and philanthropic relationships, benefitting everyone in the network. 

SSRC Public Exchange Network Expansion Grants

Public Exchange Network Expansion grants will cover 75-80% of the minimum estimated annual costs for two years to launch a new Public Exchange. To launch a Public Exchange, universities must have the following in place: (1) a staff executive director with experience launching and leading social impact partnerships, (2) a project seed fund, and (3) a modest operations budget. We also recommend some in-kind project management support from an existing university staff member. The grant includes a two-year Public Exchange Executive Director (ED) compensation subsidy of $300,000 to launch the Public Exchange on campus, and a 2-year license to use the Public Exchange brand. New Public Exchange Network members will also receive ongoing support and guidance from current Public Exchange leadership and staff at USC and WashU, including recruitment support and intensive training for hiring and onboarding an executive director, a sub-site on the Public Exchange website, incubation and project management support from current Public Exchange staff, and a suite of tools for developing and implementing Public Exchange projects.

In addition, every university in the Public Exchange Network benefits from central communications support (currently housed at USC), and access to a collaborative network of project partners, researchers, and funder relationships. Separately, SSRC will select a local research fellow to study and document how the Public Exchange model develops within and between host institutions during the grant term, and how the Public Exchange Network universities work together to effect larger-scale change. 

Expectations

Institutions selected to join the Public Exchange Network are expected to:

• Hire an Executive Director who can launch and lead efforts to incubate social impact projects with public and private sector partners;
• Have in place before public launch: (1) an executive director, (2) a seed fund, (3) a modest operations budget, and (4 – recommended) some in-kind project management support. 
• Develop and sustain at least three high-impact research partnerships during the two-year grant tenure;
• Invest modest resources during the grant term that demonstrate commitment to continuing the Public Exchange model after the end of philanthropic support. This is estimated at approximately $85-$90k annually (with some variation considering local labor markets) to support an operations and project seed fund and any additional capital needed for the Executive Director hire beyond the subsidy. 
• Coordinate with the SSRC research fellow who will examine the impact of Public Exchange at their university and across the network. 
• Work with faculty across their university. Public Exchange can live anywhere within a university at the school or central level. The majority of Public Exchange projects to date at USC and WashU have included researchers from two or more schools, and grantees must be able to work with faculty university-wide. 

The Global Impact Cash Grants by Cisco Systems Foundation support innovative early-stage solutions aimed at addressing significant social problems. Targeting nonprofit and nongovernmental organizations, these grants focus on four key sectors: crisis response, education, economic empowerment, and climate regeneration. Eligible organizations must demonstrate alignment with these areas, particularly serving underserved communities. The foundation seeks to leverage technology for impactful solutions, ensuring sustainability and community resilience through strategic investments.

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

Monarch Watch offers a Free Milkweeds Grant for habitat restoration projects aimed at supporting the monarch butterfly population. The program provides free milkweed plugs to schools and educational non-profits that demonstrate clear educational goals, long-term maintenance plans, and adequate space for the plants. With over 730,000 milkweeds distributed since 2015, this initiative plays a vital role in restoring habitats along key migration routes in the eastern and western U.S.

The Amgen Foundation Inc focuses on non-healthcare donations and sponsorships that target humanitarian, social, educational, and community programs. They offer support to organizations outside the U.S. healthcare community, particularly those recognized as tax-exempt public charities. Eligible organizations must serve specific Amgen communities throughout the U.S. This initiative aims to enhance health outcomes and address critical societal needs, thereby reducing the burden of disease and improving lives.

The PNC Foundation aims to enhance the lives of individuals in local communities through partnerships with nonprofit organizations. Their focus includes promoting educational opportunities, particularly for early childhood education, and supporting economic development initiatives. Grants are available for organizations that benefit low- to moderate-income families and enhance community growth. The foundation prioritizes programs that foster sustainability and diversity, ensuring a lasting impact on the communities they serve.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Sidney Stern Memorial Trust Grant supports charitable, scientific, medical, and educational organizations that are 501(c)(3) certified. This private funder emphasizes impactful service to diverse populations without discrimination. Grants must be utilized within the United States and cannot be awarded to individuals, political candidates, or lobbying efforts. The Trust is dedicated to enhancing the general welfare through soundly-managed initiatives that contribute significantly to community needs.

The Stantec Community Engagement Grant is dedicated to enhancing the quality of life in communities where Stantec operates. Focused on arts, education, environment, and health and wellness, the grant supports initiatives that foster sustainable development and responsible practices. Organizations seeking funding must align with Stantec's values, emphasizing ethical practices and community impact. Preference is given to projects located near Stantec offices, ensuring a more significant local impact through their contributions.

The Audacious Project Grant Program, supported by TED, aims to catalyze social impact by funding bold solutions to pressing global challenges. This initiative encourages changemakers to develop transformative ideas into actionable plans, with a focus on various issues, including health and education. The program operates on a rolling basis, welcoming applications from individuals and organizations with a proven track record and a budget of at least $2 million. Join us in creating lasting change for a better world.

The Pacific Life Foundation Grants aim to positively impact communities through strategic funding in areas such as arts, education, and health. Nonprofits with tax-exempt status can apply for grants up to $15,000 for program support or $25,000 to $100,000 for capital projects. This initiative emphasizes collaboration and innovative solutions to meet community needs while honoring the legacy of Pacific Life and its employees.

The Del E. Webb Foundation Grant offers financial support ranging from $5,000 to $3,000,000 for nonprofit organizations operating in Arizona, California, or Nevada. The foundation prioritizes projects that enhance self-sufficiency and have long-term benefits, particularly in child and health initiatives. Eligible organizations must be 501(c)(3) public charities and demonstrate a commitment to community service. The application process involves submitting a Letter of Intent, followed by a formal application if invited.

The Tri-Counties Blood Bank Fund Grants, established by the Santa Barbara Foundation, support nonprofit organizations in Santa Barbara County. With nearly $5 million in restricted funds, grants are available for Indigent Care, Education, and Scholarships related to blood services. Eligible organizations must be 501(c)(3) certified, while federal and state-operated hospitals are ineligible. The grant period is up to one year, requiring a final report within 13 months of award. This initiative enhances community health through education and support.

The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation supports nonprofit organizations that enhance community welfare. Focus areas include agriculture, education, fighting hunger, and public safety. Eligible applicants must have IRS 501(c)(3) status and a Taxpayer Identification number. Requests are prioritized for programs directly benefiting communities near Perdue facilities across various states. The foundation emphasizes responsible stewardship and community engagement in all funding decisions.

The LA County Arts & Culture Organizational Grant Program offers funding to nonprofit arts organizations in Los Angeles County. This two-year grant supports projects that enhance cultural services and provide accessible arts programming for diverse communities. Eligible organizations must demonstrate a commitment to arts through their budget and have a history of programming. The program aims to foster artistic initiatives that positively impact local residents, ensuring a vibrant cultural landscape in the region.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

The Los Angeles Dodgers Foundation (LADF) Annual Grant Program supports organizations addressing critical community needs in the Greater Los Angeles Area. Since 1995, LADF has focused on education, healthcare, homelessness prevention, and youth development. The program allocates grants three times a year, promoting impactful initiatives that benefit underserved populations. LADF actively collaborates with grantees to enhance visibility and engagement, ensuring a significant difference in the lives of local youth and families.

The Explore the Coast Grants from the California State Coastal Conservancy aim to support public agencies, tribes, and nonprofits in enhancing access to California's coastal areas for communities facing barriers. This initiative prioritizes projects that facilitate enjoyable coastal experiences, reduce obstacles, and inspire stewardship among historically excluded groups. Eligible projects include transportation services, adaptive recreational activities, and community engagement events, ensuring that all Californians can connect with their coastal environment.

The S. Mark Taper Foundation, established in 1989, is a private family foundation committed to improving lives through support for nonprofit organizations in Southern California. It funds projects in arts, education, health, and more, with grant sizes ranging from $50,000 to over $100,000. Eligible organizations must be 501(c)(3) certified and serve specific counties. Notably, those receiving funding in the past three years are ineligible to apply.

The Breakaway Fund, initiated by the Samueli Foundation, aims to empower nonprofits in Orange County by providing unrestricted funding between $50,000 and $100,000. This innovative financial support is designed to overcome barriers in staffing, leadership development, and infrastructure enhancement. By focusing on key areas such as talent, systems, and expertise, the fund facilitates growth and collaboration among organizations, ensuring a thriving community that prioritizes well-being and opportunity for all residents.

The Build OC Fund, under the Samueli Foundation, aims to enhance community well-being in Orange County, California, by funding capital projects for nonprofit organizations. Grants of up to $1,000,000 support facility acquisition, construction, renovation, or equipment purchases, helping organizations deliver essential services. Eligible applicants must demonstrate site control and a commitment to the community, with a focus on realistic projects that align with the foundation's mission. Prioritization is given to projects nearing completion.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.