Best Puerto Rico Grants for Nonprofits

The Abbey Mural Prize, established in 1932, supports the creation and restoration of public murals across the United States. This prestigious award, administered by the National Academy of Design since 1940, emphasizes projects that enhance community engagement and social activism through art. Grants typically range from $10,000 to $40,000, with a total annual funding cap of $125,000. Eligible applicants include artists, architects, and nonprofit organizations committed to impactful mural projects.

The Procter & Gamble Strategic Fund Grant aims to enhance lives through impactful initiatives such as infant development, hygiene, and oral care. As a highly competitive fund, it supports IRS-designated 501(c)(3) organizations that provide national programs where P&G can uniquely add value. Interested applicants should carefully assess their eligibility and align with the grant's specific focus areas before applying.

The John & Sandy Goldwater State Challenge Grant, offered by Kids’ Chance of America, aims to provide scholarships for children of workers injured on the job. This initiative focuses on increasing scholarship funds, expanding the number of awards, and enhancing the average scholarship value. States selected for funding must submit progress reports and participate in a longitudinal impact study by 2028, ensuring accountability and positive outcomes for the children supported.

The Kids’ Chance of America: Emergency Grant Program aims to provide essential support to state organizations facing unexpected challenges in funding scholarships for children of injured workers. This initiative ensures that these children can continue their education despite unforeseen financial hardships. Grants can be utilized for scholarships, room, board, and educational fees, emphasizing the importance of maintaining educational support for deserving students during the 2023-2024 academic year.

The Judd Travel Awards at the University of Minnesota provide essential funding for graduate and professional students to pursue international study, internships, or research projects. With a maximum award of $2,500, these grants aim to enhance cultural exposure and support various academic endeavors abroad, including language study and field research. Eligible applicants must be in good academic standing and plan travel during 2026, ensuring their projects contribute to the internationalization of their academic experience.

The BRAIN Initiative Advanced Postdoctoral Career Transition Award (K99/R00) aims to enhance diversity in neuroscience by supporting talented postdoctoral researchers from various backgrounds. This program facilitates their transition to independent faculty positions, providing essential NIH research support to help launch competitive research careers. Applications are due in February, June, and October for standard grants, and in March, July, and November for renewals.

The Lots of Compassion Grant, supported by KidsGardening and Mrs. Meyer’s Clean Day, aims to transform vacant urban lots into thriving community gardens. By providing $20,000 to each of the 10 selected grantees, the initiative focuses on empowering under-resourced communities, fostering social connections, and enhancing mental health. The grant prioritizes organizations that involve diverse participants and demonstrate significant community impact, ensuring that the gardens not only flourish but also cultivate kindness and compassion.

The Leukemia & Lymphoma Society's Equity in Access Research Grants aim to enhance equitable access to care for blood cancer patients and survivors. This program funds research to identify effective interventions that increase participation in clinical trials among underrepresented groups. Projects can receive up to $500,000 annually for a maximum of five years, with a total budget cap of $2.5 million. The initiative seeks to address systemic barriers that hinder clinical trial enrollment and improve healthcare access.

The It Gets Better Project is offering 50 grants of up to $10,000 each to public and charter schools across the U.S. to enhance inclusivity for LGBTQ+ youth. Schools can propose projects such as enhancing library resources, artistic installations, or establishing support groups. The initiative aims to empower LGBTQ+ students and foster a supportive environment, ensuring that every school can participate in uplifting their communities and promoting equality.

Gabby's Dream Scholarship honors the memory of Gabriella Garven, who tragically passed away but chose to be an organ donor, saving five lives. This scholarship aims to support Muskingum County high school seniors pursuing higher education. Applicants must maintain a GPA of 3.5 or higher and demonstrate involvement in extracurricular activities. By providing financial assistance, this scholarship helps students achieve their dreams, reflecting Gabby's spirit of kindness and generosity, and empowering them to make a positive impact in their communities.

The NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3) invites applications for the execution of investigator-initiated, interventional clinical trials across various phases. This program supports researchers in finalizing preparations necessary for trial initiation, including IRB establishment and staffing. Successful UG3 projects may transition to the UH3 phase, emphasizing the need for hypothesis-driven studies with significant clinical impact within NIAMS's research mission.

The FY 2026 Continuum of Care Competition and Youth Homelessness Demonstration Program Grants aim to eliminate homelessness through community collaboration. The program provides funding to various entities to help rehouse individuals and families in need, especially those affected by domestic violence and youth experiencing homelessness. Additionally, it focuses on promoting access to mainstream resources and enhancing self-sufficiency among those impacted by homelessness, particularly targeting youth aged 24 and younger.

The Centers of Excellence in Healthcare Quality and Safety program aims to establish a collaborative network of healthcare systems and public health partners to enhance patient and healthcare worker safety. This initiative focuses on improving the quality and resilience of U.S. healthcare delivery across various settings, including hospitals and outpatient facilities. By fostering partnerships, the program seeks to effectively detect, respond to, and prevent safety threats, ensuring a higher standard of care and safety for all.

The Jobs Plus NOFO for FY2026, issued by the US HUD's Office of Public and Indian Housing, aims to enhance job opportunities for public housing residents. This initiative encourages innovative programs that prepare individuals for employment in high-demand fields, ultimately fostering economic stability within communities. By focusing on workforce development, this funding opportunity seeks to empower residents through education and training, paving the way for long-term success and self-sufficiency.

The AISES SPRK-ing Interest in Computer Science program engages Indigenous K-12 students through fun coding and robotics activities. By utilizing Sphero BOLT and Indi robots, students gain hands-on experience in STEM and computer science, fostering greater interest and competency in these fields. Participating schools receive essential materials and training, promoting a culturally relevant learning experience. Priority is given to middle schools, encouraging greater participation in STEM+CS education among Native students.

The National Meredith Willson Awards provide multi-year operating support to organizations using music for systemic change. The Music Man Foundation will award grants of $50,000 to $500,000 to 5-10 selected organizations in 2026, focusing on their impact through music. Eligible organizations must have 501(c)(3) status, a history of music programming, and a commitment to systemic change. Applications will be evaluated on leadership, organizational capacity, and alignment with grant criteria.

The EPSCoR Centers of Research Excellence in Science and Technology initiative, led by the National Science Foundation, aims to enhance the research capabilities of EPSCoR jurisdictions. By fostering STEM capacity and promoting geographic diversity, this program invites proposals that align with its goals. The focus is on strengthening local research infrastructure and talent development to boost competitiveness in science and technology fields across the nation.

The AAFP Family Medicine Chapter Alliance Grant Awards support the philanthropic efforts of AAFP Constituent Chapters and Chapter Foundations. Since 2006, these grants have been designed to fund activities that align with specific priority areas including education, outreach, and public health initiatives. Eligible applicants include AAFP Chapters and Foundations, focusing on projects that promote community health and wellness.

The General Departmental Sexual Risk Avoidance Education (GDSRAE) program, funded by the US Department of Health & Human Services, aims to empower youth to voluntarily abstain from non-marital sexual activity. Targeting high-risk areas, it promotes healthy decision-making through evidence-based education, focusing on self-regulation, healthy relationships, and the prevention of STIs and teenage pregnancies. Successful applicants must utilize medically accurate information and implement proven curricula to achieve desired outcomes.

Multiple Sclerosis Foundation

The Multiple Sclerosis Foundation, known in the MS community as MS Focus, is a nonprofit organization focused on providing free services that address the critical needs of people with MS and their families, helping them maintain the best quality of life. 

The symptoms of MS are unpredictable and may increase in severity over time. This presents physical, emotional, and financial challenges families must face. MS Focus is here to provide the support, education, and assistance needed to adapt to these challenging circumstances. Our primary focus is on providing individuals with MS the help they need to maintain their health and well-being, to continue to be productive and independent, and to keep a roof over their heads and a safe environment in their home. We do so with empathy, resourcefulness, and conscientious care.

Whom does MS Focus serve?

Our resources assist people who have MS, their families and caregivers, regional support groups, and healthcare professionals. Our programs and grants are available in the 50 U.S. states and Puerto Rico. Online resources, such as our educational materials or audio programs, are available throughout the world.

Assistive Technology Program

The Assistive Technology (AT) Program may help locate, partially fund, or provide full funding for one of a wide range of devices. These allow those with MS to function more independently in their daily lives, as well as more easily participate in recreational, educational, and vocational activities. These include:

• Aids for daily living
• Communication devices
• Computer aids
• Environmental control systems
• Home and vehicle modifications
• Orthotics
• Seating, positioning, and mobility devices
• Aids for vision and hearing
• Cooling aids

The T32 Training Program for Institutions That Promote Diversity aims to increase the involvement of individuals from underrepresented backgrounds in research related to cardiovascular, pulmonary, hematologic, and sleep disorders. This initiative seeks to support institutions dedicated to serving health disparity populations, ensuring they develop robust training programs. While trainees cannot lead independent clinical trials, they can gain valuable experience under the guidance of mentors, ultimately contributing to improved health outcomes for underserved communities.

The NSF National Innovation Corps (I-Corps) Teams program aims to bridge the gap between scientific research and marketable technologies. By providing NSF-funded researchers with entrepreneurial education, mentoring, and funding, it accelerates the transformation of foundational discoveries into viable products and services. Participants engage in hands-on customer discovery and business model assessments, leading to improved product-market fit and strategic partnerships. This initiative fosters collaboration between academia and industry, enhancing the commercialization of deep technologies.

The Innovation in Behavioral Health (IBH) Model (the “Model”) is an eight-year, voluntary service delivery and payment model promoting integrated care in behavioral health (BH) settings. The IBH Model will test the impact of a value-based payment (VBP) model aligned across Medicaid and Medicare that supports an integrated care delivery framework in specialty BH organizations and settings for adult Medicaid, Medicare, and dually eligible beneficiaries with moderate to severe mental health conditions and/or substance use disorders (SUDs).The Centers for Medicare & Medicaid Services (CMS), through its Center for Medicare & Medicaid Innovation (Innovation Center), will select up to eight state Medicaid agencies (SMAs) to participate in the Model. Implementation will begin in January 2025 and end in December 2032. The Model will have an eight-year performance period, which will be comprised of a three-year Pre-Implementation Period along with a five-year Implementation Period. Up to $7.5 million dollars in cooperative agreement award funding will be available to each selected Recipient over the course of the eight years. 

The Microplastics Research and Resource Coordination Center aims to foster collaboration among researchers in biomedical and material sciences to understand the health impacts of micro/nanoplastics (M/NPs). This initiative will enhance research reliability by standardizing sampling, analytical practices, and data harmonization. The center will lead efforts in best practices and provide essential guidance to the M/NPs research community, ultimately advancing knowledge and methodologies in this critical area of study.

The Smart Growth America Community Connectors Grant Program supports small and mid-sized cities in addressing divisive infrastructure caused by dangerous roads. With funding from the Robert Wood Johnson Foundation, this program aims to reconnect communities through temporary street safety projects while fostering skills and partnerships. Eligible teams must represent populations of 50,000 to 500,000 and include both government and community-based organizations. Priority will be given to projects benefiting low-income communities historically affected by disinvestment.

The FY26 Community Policing Development (CPD) Microgrants Program, led by the U.S. Department of Justice's Office of Community Oriented Policing Services (COPS), aims to enhance the capabilities of law enforcement agencies across the nation. By funding innovative and evidence-based pilot projects, this initiative seeks to improve officer and public safety, promote effective crime-fighting strategies, and foster community engagement. Applications are due by August 24, 2026.