Upcoming Webinar
Instrumentl Fall Launch: Grant Work, Leveled Up.
Thu, Oct 29 or Wed, Nov 4 @ 2PM ET

Skip to main content
Main content

Best Puerto Rico Grants for Nonprofits

Find the perfect Puerto Rico grants for nonprofits on Instrumentl. 9,000+ Puerto Rico grants for nonprofits in the United States.

9,000+

Available grants

$2.55B

Total funding

$5K

Median grant

9,000+ grants
$2.55B total
$5K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

8,987 Results based on applied filters

Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Risk and Protective Factors of Family Health initiative invites research proposals to explore family health and resilience, addressing health disparities in minority communities. Key submission deadlines are set for various dates from February 2025 to February 2027. This program is supported by the National Institutes of Health, highlighting the importance of family well-being as a critical area for advancing health equity. Proposals should focus on interventions that improve family health outcomes.
Family Services Minority Services Health Disparities & Social Determinants of Health

Toward Translation of Nanotechnology Cancer Interventions (TTNCI; R01 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,900,000
The National Cancer Institute (NCI) invites applications for the Toward Translation of Nanotechnology Cancer Interventions (TTNCI) program. This funding opportunity focuses on advanced pre-clinical research aimed at developing nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards will support the maturation of innovative nanomedicines using nanoparticles and nano-devices, enhancing cancer treatment efficacy. Successful projects will progress towards further NCI translational programs, such as the NExT initiative.
Cancer / Oncology Nanomaterials & Nanotechnology

Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional) (357744)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
This funding opportunity supports exceptionally promising Early Stage Investigators in genomics, encouraging innovative research across various fields such as genomic sciences and medicine. Applicants must submit their proposals by 5:00 PM local time of their organization. The initiative, led by the US Dept. of Health & Human Services through the NIH, aims to foster long-term career development in genomic research while addressing its ethical, legal, and social implications.
Genetics & Genomics Medical Ethics

Dean John A. Knauss Marine Policy Fellowship

Woods Hole Oceanographic Institution (WHOI)
Private
American Samoa, Guam +4 more
Unspecified amount
The Dean John A. Knauss Marine Policy Fellowship offers a unique opportunity for early career professionals to engage in marine and Great Lakes science and policy within the U.S. government. This one-year, paid fellowship encourages graduate students from accredited programs to explore impactful coastal resource issues. Interested applicants should connect with their local Sea Grant program or the National Sea Grant Office for guidance, especially if they are from Massachusetts, to ensure a competitive application.
Marine Biology Marine / Ocean Conservation Environmental Policy +2 more

Medtronic Grants and Donations

Medtronic
Corporate
Anoka County, Minnesota, Argentina +77 more
Unspecified amount
Medtronic is a global leader in medical technology, dedicated to enhancing healthcare access and supporting the communities it serves. Through its Grants and Donations program, Medtronic provides financial assistance for medical education, independent conferences, and charitable events, emphasizing collaboration with healthcare stakeholders. The program aims to alleviate pain, restore health, and extend life, positively impacting millions of patients worldwide. For more information, visit Medtronic's FAQs on grants and donations.
Diabetes Cardiovascular Diseases & Systems Digestive System Health & Diseases +9 more

Animal and Veterinary Innovation Centers (U18)

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
American Samoa, Guam +4 more
Up to US $7,500,000
The Animal and Veterinary Innovation Centers (U18) funding opportunity, led by the FDA, aims to foster collaborations with academic institutions to tackle critical veterinary health challenges. This includes addressing Highly Pathogenic Avian Influenza, promoting genomic advancements in agriculture, and developing veterinary solutions for minor species. Applications are invited to enhance animal health and public safety, with Letters of Intent due prior to the July 2024 deadline.
Genetics & Genomics Epidemiology & Public Health Veterinary Science & Services +2 more

True Inspiration Awards

Chick Fil A Foundation Inc
Corporate
Canada, Puerto Rico +1 more
US $30,000 - US $350,000
The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.
Youth Development & Leadership Civic Leadership Development Healthy Habits & Behaviors +11 more

CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed) (355038)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $900,000
The NIH Countermeasures Against Chemical Threats (CounterACT) initiative invites applications for basic research on chemical agents affecting the nervous system. This program aims to explore the toxicity mechanisms of chemical warfare agents, industrial chemicals, and pesticides. Researchers are encouraged to generate data that could reveal new therapeutic targets and manifestations of toxic exposures, contributing to public health safety against potential chemical threats.
Environmental Chemistry & Toxicology Neurological Diseases & Disorders

Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,400,000
This funding opportunity aims to support innovative mechanistic research that enhances precision probiotic therapies. It encourages studies that identify person-specific features influencing probiotic responses, focusing on the variability among individuals. The goal is to develop strategies to improve probiotic clinical outcomes by understanding the biological patterns linked to probiotic effectiveness. Applications should demonstrate rigorous mechanistic studies and preliminary data supporting the correlation between host biology and probiotic response.
Microbiology Microbiomes

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
This funding opportunity aims to advance mechanistic research on precision probiotic therapies through a phased R61/R33 award mechanism. The initiative supports innovative studies identifying unique host characteristics that influence probiotic responses, addressing the variability in clinical outcomes. By focusing on person-specific features, the goal is to enhance the effectiveness of probiotics and overcome barriers to treatment success, ultimately leading to tailored probiotic interventions that better meet individual health needs.
Microbiomes

EPSCoR Research Infrastructure Improvement (RII): EPSCoR Research Fellows

National Science Foundation (NSF)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The EPSCoR Research Infrastructure Improvement (RII): EPSCoR Research Fellows program, funded by the National Science Foundation (NSF), aims to enhance research capacity and workforce development in STEM. This initiative fosters collaborations between underrepresented researchers and leading institutions, providing essential resources and support. With two tracks available—one focusing on NSF and the other on NASA—this program uniquely positions Fellows to leverage transformative research experiences and contribute to sustainable advancements in their respective fields.
Economics Sociology Mathematics +10 more

Fiscal Year 2027 Regional Nutrition Hubs

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The Fiscal Year 2027 Regional Nutrition Hubs initiative by the US HHS aims to enhance nutrition services across regional health centers. By providing targeted technical assistance, the program seeks to improve health outcomes through effective nutritional interventions. This initiative supports HRSA's mission to expand access to high-quality healthcare services, ultimately benefiting communities by addressing dietary needs and managing health conditions. With a focus on collaboration, the program is set to strengthen the health infrastructure at the local level.
Nutrition & Healthy Eating

Pulitzer Center Rainforest Reporting Grant

Pulitzer Center
Private
Benin, Bolivia +34 more
US $8,000 - US $15,000
The Pulitzer Center Rainforest Reporting Grant supports journalists reporting on critical issues in tropical forests, particularly in the Amazon, Congo Basin, and Southeast Asia. This grant encourages innovative and collaborative proposals while providing essential resources and training. Grants typically range from $8,000 to $15,000, focusing on underreported topics that connect local and global perspectives. The initiative emphasizes transparency, governance, and in-depth reporting to combat illegal wildlife trade and harmful extraction practices.
Botanical Conservation Journalism Forestry

Syringe Service Program Grant

The Comer Family Foundation Inc
Private
District of Columbia, Puerto Rico +1 more
US $2,500 - US $20,000
The Syringe Service Program Grant, offered by The Comer Family Foundation, aims to enhance harm reduction initiatives by funding syringe access programs across the U.S. These programs provide sterile syringes, education, and support services to mitigate the risks associated with drug use, including HIV and hepatitis transmission. Priority is given to organizations in underserved areas and those led by marginalized communities. Grants are available for operational costs, program development, and staff training, with a focus on sustainability and local partnerships.
Drug Use Disorder

Core State Injury Prevention Program (Core SIPP) (363398)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Core State Injury Prevention Program (Core SIPP) aims to enhance public health infrastructure and partnerships to prevent unintentional injuries through data-driven strategies. Focusing on key areas such as traumatic brain injury, falls among older adults, and drowning, it seeks to improve community safety by strengthening data use and fostering collaborations. This initiative supports states in identifying local injury concerns, thus promoting evidence-based prevention approaches and increasing the capacity for sustained public health actions.
Wounds & Injuries Suicide Prevention Brain Injuries

Investigator-Focused Award (Parent R35)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH's Investigator-Focused Award (Parent R35) aims to support research programs for investigators at all career stages, including Early Stage Investigators. This funding provides stability and freedom in research, allowing for innovative and ambitious studies without the constant pressure of securing new grants. Key benefits include flexibility in research direction, opportunities to tackle significant questions, and a greater potential for scientific breakthroughs, fostering a robust research environment.
Health & Medicine

Hanna H. Gray Fellows Program: Faculty Phase

Howard Hughes Medical Institute
Private
Puerto Rico, United States
Up to US $1,080,000
The Hanna H. Gray Fellows Program, supported by the Howard Hughes Medical Institute, aims to enhance diversity in the academic research community. It provides funding of $250,000 and a $20,000 annual expense allowance for early-career researchers committed to fostering an inclusive scientific culture. Eligible applicants must hold a PhD or MD, commit to at least 75% research effort, and have no more than 24 months of postdoctoral experience. This initiative empowers fellows to become leaders in science.
Science Health & Medicine Medical Education & Professional Training

Citi Foundation Blueprint for Housing Grant

Citi Foundation
Corporate
Alameda County, California, Alexandria City, Virginia +51 more
US $1,000,000

Our Work:

The Citi Foundation commits $20 million to help nonprofit housing developers overcome financial and operational barriers to building and preserving affordable housing in the U.S.

Apply for Funding

Citi Foundation primarily provides funding through open Requests for Proposals (RFP). This model enables us to engage and support a broad range of organizations across the globe to tackle some of the most pressing social issues of our time. Each RFP launched is accompanied by detailed information on goals, selection criteria and relevant application deadlines.

Housing Affordability

Citi's Blueprint for Housing Opportunity

Recognized as the number one affordable housing lender in the U.S. by Affordable Housing Finance magazine, Citi knows increasing supply is essential to addressing housing affordability — one of the defining economic challenges of our time. That’s why we are putting our capital, community impact and expertise toward helping more Americans access housing they can truly afford.

Equitable & Affordable Housing Nonprofit Growth & Development

AACR Maximizing Opportunity for New Advancements in Research in Cancer (MONARCA) Grant for Latin America

American Association for Cancer Research
Association/Society
Argentina, Belize +23 more
US $55,000
The AACR Maximizing Opportunity for New Advancements in Research in Cancer (MONARCA) Grant aims to support early-career cancer researchers in Latin America. This initiative addresses the critical need for local evidence and knowledge in cancer control, helping to cultivate a pipeline of skilled investigators. By promoting research across various cancer-related fields, the grant facilitates opportunities for professional development and aims to enhance the region's capabilities in addressing public health challenges related to cancer.
Cancer / Oncology

Paul Calabresi Career Development Award for Clinical Oncology (K12 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Paul Calabresi Career Development Award for Clinical Oncology aims to enhance the training of clinician-scientists in clinical and translational cancer research. This funding opportunity encourages the career growth of researchers but does not permit Scholars to lead independent clinical trials. Instead, it allows participation in clinical trials under the mentorship of an experienced researcher, fostering a collaborative approach to cancer research.
Cancer / Oncology Biotechnology Health Policy & Advocacy +1 more

Rapid Response Opioid And Pain Management ECHO Funding Opportunity

Association of State and Territorial Health Officials (ASTHO)
Association/Society
American Samoa, Guam +4 more
Up to US $140,000
The Rapid Response Opioid and Pain Management ECHO Funding Opportunity by the Association of State and Territorial Health Officials (ASTHO) aims to enhance clinician training in effective pain management strategies. This initiative focuses on non-opioid treatments, substance use screening, and risk reduction counseling, promoting compassionate care while addressing public health challenges and ensuring continuity for patients affected by prescription disruptions. The program seeks to improve overall health outcomes and reduce risks associated with opioid use.
Drug Use Disorder Chronic / Acute Pain

Partnership Agreement Grants, FY 2027

National Endowment for the Arts (NEA)
Federal Government
American Samoa, Guam +4 more
US $400,000 - US $1,500,000
The Partnership Agreement Grants for FY 2027, offered by the National Endowment for the Arts (NEA), support state and regional arts agencies in enhancing community arts accessibility. These grants leverage federal funding to attract significantly more state contributions, fostering a robust federal-state partnership. Each state arts agency develops a tailored arts plan, ensuring that local priorities and goals are effectively addressed. This collaborative approach amplifies the impact of federal arts funding across the nation.
Art & Culture Arts / Culture Access & Participation Art Education +2 more

Scaling Pathways to Homeownership

Capital One Foundation
Corporate
American Samoa, Guam +4 more
US $200,000
  • Innovative: An approach that brings fresh thinking, tools, or models to homeownership in ways that challenge the status quo and demonstrate a disruptive, future-oriented vision with potential to inspire or shift broader field practice.
  • Impactful: A solution with meaningful potential to expand homeownership through knowledge and action, featuring clear and measurable progress indicators that demonstrate capacity to shift trajectories for low- and moderate-income households.
  • Bridge-Building: An initiative that effectively connects and unifies a wide range of stakeholders, fostering meaningful collaboration across sectors or perspectives. The strongest submissions will reflect strong community partnerships across the housing ecosystem.
  • Durable: A sustainable pathway that addresses root causes of homeownership barriers rather than just symptoms, with compelling evidence of potential to elicit robust support from broad private, philanthropic, and public funding sources over time.
Homeownership Equitable & Affordable Housing

HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $350,000 - US $750,000
The HEAL Initiative aims to combat the opioid crisis through action-oriented research that enhances the translation of addiction epidemiology, prevention, treatment, and recovery services into practice. It prioritizes scalable, evidence-based approaches targeting various levels, including individual and community. The initiative supports a range of methods for research deployment, emphasizing collaboration between researchers and decision-makers to improve outcomes for those affected by addiction and related chronic pain.
Epidemiology & Public Health Addiction & Substance Use Disorders Drug Use Disorder +2 more

L.L.Bean Charitable Donations

L.L. Bean
Corporate
American Samoa, Guam +4 more
Unspecified amount
L.L.Bean Charitable Donations supports outdoor initiatives that bring communities together. The program encourages partnerships with inspiring individuals and organizations. To apply, ensure requests are made at least eight weeks before the event. Please note that the program does not fund individuals, advertising, specific schools, or projects outside the U.S. For more information, visit their website to learn how to get involved.
Outdoor Recreation Outdoor Equity

A Holistic Approach to Study Non-Addictive Natural Products for Pain Management

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Center for Complementary and Integrative Health (NCCIH) seeks to fund interdisciplinary research on non-addictive natural products for chronic pain management. This initiative supports the NIH HEAL Initiative by emphasizing safe, prevention-oriented strategies. Research should focus on the holistic effects of natural products across various biological systems, optimizing dosages, and identifying optimal intervention timing to enhance therapeutic outcomes. The goal is to generate foundational insights that will guide future translational research for effective pain management.
Chronic / Acute Pain Anesthesia and Pain Medicine

Promotion of Doctoral Studies Scholarships- Pre-candidacy Doctoral Students

Foundation for Physical Therapy Research
Private
United States
Up to US $45,000
The Promotion of Doctoral Studies Scholarships, offered by the Foundation for Physical Therapy Research, provides a $7,500 annual scholarship for doctoral students completing coursework at accredited institutions. Applicants may receive up to $15,000 in pre-candidacy scholarships and a total of $45,000 throughout their doctoral program. The Foundation encourages research in areas such as acute care, cardiology, pulmonary health, and PT education, fostering a new generation of skilled researchers in physical therapy.
Physical Therapy Medical Education & Professional Training Aging / Gerontology +2 more

Puerto Rico Grants for Nonprofits Highlights

Puerto Rico grants for nonprofits provide funding to support education, disaster recovery, public health, and cultural preservation. The following grants empower organizations to address critical challenges, promote resilience, and foster sustainable development across Puerto Rico.


Search Instrumentl's Puerto Rico Grants Database


Find 834 funding opportunities for nonprofits in Puerto Rico, with $698M available. Instrumentl helps organizations discover funding sources through automated deadline tracking, curated grant searches, and research-driven funder insights to drive local progress.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Puerto Rico Grants for Nonprofits

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

800+ Puerto Rico grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

500+ Puerto Rico grants for nonprofits over $25K in average grant size

400+ Puerto Rico grants for nonprofits over $50K in average grant size

16 Puerto Rico grants for nonprofits supporting general operating expenses

500+ Puerto Rico grants for nonprofits supporting programs / projects

400+ Grants on Instrumentl focused on Disaster Relief / Humanitarian Aid

200+ Grants on Instrumentl focused on Cardiovascular Diseases & Systems

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Puerto Rico grants for Nonprofits?

Most grants are due in the first quarter.

Q1
31.5%
Q2
23.7%
Q3
19.8%
Q4
25.0%

Typical Funding Amounts

What's the typical grant amount funded for Puerto Rico Grants for Nonprofits?

Grants are most commonly $318,750.

$375 $375 Min.
$318,750 $318.8 K Median
$1,385,019 $1.4 M Average
$80,000,000 $80 M Max.

Browse Grants by Other Territories and Regional Locations