Best Puerto Rico Grants for Nonprofits

This funding opportunity aims to enhance health outcomes by tackling healthcare disparities in non-communicable and chronic diseases across Latin America. It encourages interdisciplinary research teams to collaborate with Latin American institutions, focusing on innovative clinical and community-based interventions. Applications are accepted for various deadlines between 2025 and 2027, with a particular emphasis on addressing significant health burdens experienced by U.S. Hispanics/Latinos. This initiative seeks to foster meaningful partnerships to improve health equity.

The AARP Community Challenge Grant: Capacity-Building Microgrant offers $2,500 to support projects that enhance community livability for residents aged 50 and older. Initiated in 2017, it has funded over 1,700 projects nationwide, focusing on immediate improvements and long-term progress. Eligible organizations include nonprofits and government entities, aiming to implement innovative programs in areas like disaster preparedness, walkability, and home modifications. This initiative fosters inclusive communities and empowers older adults.

The AARP Community Challenge Grant supports innovative projects that enhance community livability for people aged 50 and older. Funded by the AARP Foundation, these demonstration grants range from $10,000 to $25,000 and aim to improve pedestrian safety, expand broadband access, and reconnect divided communities. Since 2017, AARP has awarded over $20 million in grants, fostering immediate improvements and long-term progress across the United States, including Puerto Rico and the U.S. Virgin Islands.

The NCI Pathway to Independence Award (K99/R00) aims to support talented postdoctoral researchers in their transition to independent faculty positions. This program provides essential NCI research funding to help awardees establish competitive, independent research careers. Applications must be submitted by 5:00 PM local time of the applicant's organization, ensuring timely consideration for this critical funding opportunity.

The NCDDG program supports innovative research aiming to discover and develop new treatments for mental disorders, including substance use and alcohol use disorders. This initiative encourages collaborations between academic and industry partners to advance neurostimulation techniques and drug/device development. Applicants are invited to submit proposals that focus on specific projects utilizing the U01 mechanism, with a clear emphasis on rationally designed candidate agents and cutting-edge technologies. Letters of Intent are encouraged 30 days prior to the submission deadline.

The National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program invites applications to foster innovative research in treating mental disorders and substance use issues. This initiative promotes collaboration between academia and industry, supporting diverse, multidisciplinary projects aimed at developing rational therapies and neurostimulation techniques. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline to enhance project alignment with funding goals.

The Partners for Fish and Wildlife Program, managed by the U.S. Fish and Wildlife Service, assists private landowners in restoring and protecting vital habitats for fish and wildlife. Since its inception in 1987, the program has provided technical assistance and financial support to enhance conservation efforts across the United States. By collaborating with local stakeholders, the program establishes habitat goals and directs resources effectively to conserve important ecosystems, benefiting both wildlife and the American people.

The National Institute of Allergy and Infectious Diseases (NIAID) is calling for applications for four Leadership and Operations Centers (LOCs) as part of its HIV/AIDS Clinical Trials Network initiative. These LOCs will guide research on HIV therapeutics, prevention, and treatment strategies across diverse populations. The initiative aims to enhance evidence-based practices and improve health outcomes for individuals affected by HIV, ultimately contributing to the goal of ending the HIV epidemic.

The T32 Training Program aims to enhance the participation of individuals from underrepresented backgrounds in cardiovascular, pulmonary, hematologic, and sleep disorders research. This initiative, funded by the NIH, supports institutions committed to diversity and health disparity populations. By providing training opportunities for students and postdoctoral trainees, the program seeks to foster research that improves health outcomes for these communities. Note that appointed trainees cannot lead independent clinical trials but can gain experience in trials conducted by mentors.

The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for up to four Clinical Trials Network Laboratory Centers (LCs). These LCs will support HIV prevention and treatment strategies by providing necessary laboratory infrastructure and technologies for clinical trials. They will ensure rigorous laboratory testing and oversight, enhance sample integrity, and utilize advanced data management systems to meet evolving demands in HIV research and testing.

The NIAID aims to support four Clinical Trials Networks (CTNs) by funding Statistical and Data Management Centers (SDMCs) to enhance HIV research. These SDMCs will oversee study designs, data collection, and compliance with regulatory standards while ensuring data quality and integration. This initiative is a crucial step toward ending the HIV epidemic, fostering innovative methods, and adhering to NIH data sharing policies. Applications for the SDMCs are now being solicited.

The NIA Postdoctoral Fellowship Award aims to enhance diversity in the translational research workforce for Alzheimer's disease and related dementias (AD/ADRD). This fellowship supports promising candidates from diverse backgrounds in developing essential translational research skills. The program emphasizes interdisciplinary approaches to treatment, prevention, and early detection of AD/ADRD while providing research experience under the guidance of mentors in clinical trials, fostering a diverse and effective research community.

The NIA Predoctoral Fellowship Award aims to enhance diversity in the translational research workforce focusing on Alzheimer's disease and related dementias. This funding opportunity supports promising predoctoral candidates from underrepresented backgrounds, fostering their research training and skills in various aspects of AD/ADRD. By encouraging interdisciplinary teamwork, the program seeks to develop a diverse workforce capable of contributing significantly to the prevention, treatment, and management of these conditions.

The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for Clinical Trials Units (CTUs) as part of its effort to combat HIV/AIDS. This initiative aims to support innovative clinical trials and implementation research to improve prevention and treatment strategies. With a focus on both domestic and international research sites, CTUs will play a crucial role in addressing the HIV epidemic and enhancing participant recruitment and retention. This funding opportunity is authorized under the Public Health Service Act.

The Cellular Senescence Network (SenNet) aims to establish a Data Coordination and Integration Center (DCIC) to enhance data management and accessibility within the NIH Common Fund. This initiative focuses on the submission, harmonization, and dissemination of SenNet-generated data, ensuring high-quality integration and usability. The DCIC will support both Stage 1 and Stage 2 outputs, fostering organizational outreach activities and promoting cross-study comparability through robust data infrastructure and tools.

The Ernest Morgan Memorial Scholarship, managed by CommunityGiving, supports central Minnesota student athletes and leaders to pursue higher education outside their home states. This scholarship aims to expand students' horizons and experiences, with a total award of $5,000 available. Open to high school seniors from specific schools, applicants are encouraged to apply online and demonstrate their leadership or athletic skills. This initiative enhances educational opportunities and fosters personal growth among local youth.

The Intervention Research to Improve Native American Health initiative aims to enhance health outcomes in Native American communities through innovative research. This program supports studies focused on health promotion, disease prevention, and culturally informed treatment strategies. Key deadlines for grant applications are October 21, 2025, and January 7, 2026. By addressing health disparities and leveraging community strengths, the initiative fosters sustainable interventions tailored to specific cultural contexts.

The Climate Smart Communities Initiative (CSCI) Grant supports US-based projects aimed at enhancing community resilience against climate change. With a budget of $1.5-2 million, grants typically range from $75,000 to $115,000. CSCI prioritizes projects that focus on historically disinvested populations facing climate vulnerabilities, emphasizing equity, nature-based solutions, and community capacity building. The initiative encourages collaboration between climate adaptation practitioners and local government entities to address climate impacts effectively.

The John Jamison Iron Mountain Education Fund provides scholarships to encourage educational pursuits among the children of Iron Mountain employees. Established in 2004, it awards $2,000 to selected applicants and $4,000 to those majoring in STEM fields. Eligibility includes dependent children of full-time employees at the Director level and below, along with deceased employees' children. The number of scholarships varies annually based on available funds, supporting students in their quest for higher education.

The NIH Director’s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director’s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.

The Samuel Robinson Award is a scholarship for college juniors and seniors attending Presbyterian-related institutions. To qualify, students must memorize the Westminster Shorter Catechism's 107 questions and answers within 18 months. Eligible applicants for 2024 are those graduating in 2024 or 2025. This award encourages academic achievement and religious education among students committed to their faith and educational pursuits.

The Leadership Development Grants empower women in the PC(USA) to enhance their leadership skills through educational opportunities. This initiative fosters personal growth and active participation within the Presbyterian Women community, ultimately strengthening the church's mission. Eligible women can apply for grants to attend various leadership events, ensuring that they can contribute effectively to the church's goals while developing their unique gifts and talents.

The Social Impact Fund - Nationwide Grant supports innovative solutions addressing health care access, food security, and economic empowerment. Funded by the American Heart Association, this grant prioritizes community-led projects from organizations with under $10M in revenue. Eligible entities include both for-profit and nonprofit organizations based in the U.S. and Puerto Rico. Grants can provide up to $250,000 to initiatives that demonstrate measurable impact, fostering sustainable change in health and wellness.

The Raskob Foundation offers domestic grants to organizations located in the U.S. and its territories. Founded in 1945, this private, non-profit foundation focuses on supporting Catholic institutions. Eligible applicants must be tax-exempt 501(c)(3) organizations, listed in the P.J. Kenedy Official Catholic Directory. However, requests from individuals and certain projects, such as debt reduction or completed projects, are not accepted. The foundation emphasizes its commitment to philanthropy and community support.

The Leadership Development Grants for Young Women, offered by Presbyterian Women, empower women aged 18-30 to enhance their leadership skills through participation in educational events. With grants of up to $2,000 for the Commission on the Status of Women and $1,000 for the Ecumenical Advocacy Days, this program fosters personal and community growth within the Presbyterian Church (U.S.A.). Eligible applicants must be active in PC(USA) and meet specific grant requirements.

The OVW Fiscal Year 2026 State and Territory Domestic Violence and Sexual Assault Coalitions Program aims to empower state and territory coalitions in their vital mission to combat domestic violence and sexual assault. This program, under the guidance of the US DOJ's Office on Violence Against Women, provides essential funding to enhance the effectiveness of these organizations, facilitating their role in promoting safety and justice for victims and survivors across the nation.

The Coordinating Agricultural Development & Innovation (CADI) initiative fosters trade growth in Eastern Europe, the South Caucasus, and Central Asia by removing barriers to U.S. agricultural exports. Funded by the USDA's Foreign Agricultural Service, CADI aims to inject over $622 million into the U.S. economy while preventing potential losses exceeding $50 billion. The awardee will conduct essential research and provide actionable recommendations to support U.S. farmers and enhance trade relationships, ensuring a prosperous agricultural sector.