Best Puerto Rico Grants for Nonprofits

The Bureau of Land Management's Plant Conservation and Restoration Program (PCRP) aims to enhance the native seed supply chain, crucial for restoring resilient public lands. By collaborating with various partners, PCRP seeks to improve rangeland health, restore wildlife habitats, and create job opportunities. In 2026, the focus will be on local seed collections, supporting farmers entering the native seed market, and developing innovative technologies to ensure effective restoration outcomes and ecological resilience.

The Rural Decentralized Water System Grant Program aims to assist low to moderate-income individuals in financing household water wells and decentralized wastewater systems. This program provides grants to eligible nonprofit organizations to create a revolving fund for loans and sub-grants. Funds can be utilized for constructing, refurbishing, or replacing water well and wastewater systems, ensuring safe and efficient water management for rural communities.

The DOJ's FY 2026 BIDEN Program aims to address immigration-related challenges by providing funding to eligible state and local governments. This initiative focuses on enhancing law enforcement's capacity to apprehend criminal aliens, investigate gang activities, and manage court operations related to crimes committed by aliens. By supporting these critical efforts, the program aims to improve public safety and uphold the rule of law in communities across the nation.

The Health Promotion and Disease Prevention Research Centers are offering supplemental funding for Special Interest Projects (SIPs) aimed at enhancing public health practices. These projects will focus on innovative health promotion and disease prevention strategies to mitigate leading health risks in the U.S. The initiative supports ten specific SIPs, including studies on cancer care, alcohol use reduction, and emergency preparedness, thereby fostering research that translates into real-world health improvements.

This funding opportunity aims to establish a U.S. network for active surveillance of pediatric acute respiratory illnesses and gastroenteritis. The initiative will focus on respiratory and enteric viruses, assessing the effectiveness of prevention products such as vaccines. Recipients will follow CDC protocols to enroll patients and confirm viral infections, ultimately reducing hospitalizations and enhancing public health strategies for children's healthcare.

The US Flu Vaccine Effectiveness (VE) Network aims to enhance the effectiveness of vaccines against influenza and other respiratory pathogens, which are significant contributors to morbidity and mortality. This funding opportunity invites proposals for surveillance studies, including annual VE assessments, acute respiratory illness tracking, household transmission research, and immunogenicity studies. Applicants can apply for either Component A or B, with the option to include additional components based on their primary selection.

The INCLUDE Project aims to enhance the health and quality of life for individuals with Down syndrome by generating comprehensive genomic and multi-omics data. This initiative encourages applicants to submit samples to NIH-supported resources, facilitating the exploration of molecular mechanisms related to health conditions associated with Down syndrome. The data will be shared via the INCLUDE Data Hub, promoting collaboration within the research community, though no direct funding is available to applicants.

The National Cancer Institute (NCI) is set to release a Notice of Funding Opportunity (NOFO) aimed at advancing informatics technologies for cancer research. This initiative will support the development of tools that enhance data acquisition, management, and analysis throughout the cancer continuum. By focusing on technologies with proven impact, the NOFO seeks to optimize and sustain resources critical for cancer biology, diagnosis, treatment, and epidemiology.

The National Network of STI Clinical Prevention Training Centers (NNPTC) aims to enhance the education and training of clinicians and disease intervention professionals in STI patient care. This initiative focuses on improving the ability of healthcare providers and systems to effectively diagnose, manage, and counsel individuals at risk for STIs, ultimately reducing morbidity and enhancing public health outcomes on both local and national levels.

The Laboratory Flexible Funding Model (LFFM) aims to enhance state food testing laboratories' capabilities, supporting an integrated food safety system. By prioritizing sample testing and food defense preparedness in microbiology, chemistry, and radiochemistry, this cooperative agreement facilitates method development and expands testing capacity, ensuring safer food for consumers.

The U.S. Department of Agriculture's Animal and Plant Health Inspection Service is offering at least $10 million in funding for the National Clean Plant Network (NCPN) program, aimed at supporting the production of pathogen-free plant material. This initiative focuses on establishing Clean Plant Centers across the U.S. to enhance competitiveness for specialty crop producers. Key priorities include optimizing clean plant distribution and advancing innovative technologies to increase awareness of clean plants' importance.

The Habitable Worlds Observatory (HWO) is a pioneering space mission concept aimed at discovering life beyond our solar system, as highlighted in the Astro2020 survey. The HWO-PSI program seeks to reduce risks for future missions by advancing scientific investigations that inform mission design. As HWO enters its pre-formulation phase, it addresses significant astrophysical questions and technical challenges, ultimately striving for groundbreaking discoveries in our understanding of the universe.

The Federal Transit Administration (FTA) is offering $610 million in competitive grants through the Fiscal Year 2026 Grants for Buses and Bus Facilities Program. This funding aims to support capital projects related to buses and bus facilities, including the replacement, rehabilitation, and purchase of buses and equipment, as well as the construction or leasing of bus-related facilities, encouraging advancements in public transit infrastructure.

The Federal Transit Administration (FTA) is offering approximately $589 million in competitive grants through the Low or No Emission Grant Program. These funds support the purchase or lease of low-emission and zero-emission transit buses, along with the construction and leasing of necessary facilities. This initiative aims to enhance sustainable public transportation solutions. Further details and the full announcement will be available on Grants.gov under opportunity FTA-2026-011-TPM-LWNO.

The FY26 Bureau of Land Management Forest and Woodlands Resource Management program aims to enhance forest health and promote sustainable management practices. It supports initiatives under Executive Order 14225 and The One Big Beautiful Bill, focusing on fire resiliency, habitat conservation, and recovery from pests and diseases. Activities may include tree planting, thinning, and vegetation control, alongside necessary planning and analysis for compliance with environmental regulations.

The FY26 Bureau of Land Management Invasive and Noxious Plant Management program focuses on preventing and controlling invasive species that threaten public lands and native plant communities. These invasive plants impose significant economic burdens and disrupt ecosystems. The program aims to enhance detection, rapid response, and education on invasive species, while also promoting rehabilitation efforts and biological control to protect valuable resources on public lands.

The FY26 Bureau of Land Management program focuses on mitigating abandoned mine hazards to safeguard public health and the environment. With over 160,000 abandoned mine features on BLM-administered lands, the program prioritizes high-risk sites for inventory and restoration. Through partnerships with various stakeholders, it aims to reduce environmental degradation, comply with quality standards, and return lands to productive uses, including recreation and wildlife habitat. This holistic approach ensures safety and enhances ecosystem integrity.

The Plant Protection Act Section 7721 PPDMDPP provides funding to safeguard U.S. specialty crops and natural resources from invasive plant pests and diseases. With up to $90 million available in FY 2027, projects will focus on early detection and mitigation strategies across six goal areas, including pest identification and public outreach. This initiative aims to enhance agricultural resilience and support proactive measures against harmful pests, ensuring the protection of vital agricultural systems.

The OVW Fiscal Year 2026 Training and Services to End Abuse in Later Life Program aims to provide essential resources to combat abuse against individuals aged 50 and older. Funded by the US DOJ's Office on Violence Against Women, this initiative supports states, Tribal governments, and nonprofit organizations in addressing various forms of abuse, including domestic violence, sexual assault, and economic exploitation. Applications are due by September 16, 2026, ensuring timely assistance to vulnerable populations.

The FY26 Bureau of Land Management Recreation and Visitor Services Program aims to enhance public recreational experiences on BLM-managed lands while supporting local economies. The program aligns with key legislation such as the EXPLORE Act and the Great American Outdoors Act, prioritizing projects that improve visitor services. Funding will focus on initiatives that directly enhance recreation and visitor experiences to ensure a positive impact on the American public in fiscal year 2026.

The FY26 Bureau of Land Management Fuels Management and Community Fire Assistance program aims to strategically manage vegetation to reduce wildfire risks and impacts. By fostering community preparedness and collaboration with partner organizations, the program enhances local capacities for wildfire mitigation and fuels management. These efforts not only protect communities but also create jobs and promote conservation, aligning with national priorities for sustainable resource use and community resilience against wildfires.

The NIOSH Exploratory/Developmental Grant Program (R21) aims to enhance understanding of occupational diseases and injuries. It focuses on identifying risks, developing prevention strategies, and translating scientific discoveries into effective measures. Applicants are encouraged to describe the health burdens addressed, outline research activities, and demonstrate potential impacts on occupational safety. This initiative supports innovative concepts, model systems, and technologies that can significantly improve workplace health outcomes.

The Teaching Health Center Graduate Medical Education (THCGME) Program aims to equip residents with the skills to deliver exceptional healthcare, especially in rural and underserved areas. By funding the training of residents in HRSA-supported primary care residency programs, it fosters a diverse healthcare workforce capable of meeting the needs of various populations. This initiative not only enhances the quality of care but also strengthens community health systems.

This funding opportunity aims to enhance a web-based ordering portal for distributing 1.5 million HIV and STI self-tests to high-burden communities. By optimizing access to these self-tests, the initiative seeks to raise awareness, prevent new infections, and improve the health outcomes of users, thereby contributing to better overall public health and wellbeing.

This funding opportunity aims to enhance the global response to rabies through innovative, cost-effective tools. The initiative focuses on reducing human rabies cases and advancing canine rabies elimination, particularly in high-burden regions. Research areas include tracking vaccination efforts, managing rabies exposure investigations, improving laboratory systems, and assessing the economic impact of interventions. Ultimately, it seeks to develop strategies that protect public health and ensure the sustainability of rabies-free status in the U.S.

The CDC's Comprehensive Suicide Prevention Program for States aims to enhance public health approaches to suicide prevention across the U.S. By targeting high-risk groups, such as veterans and rural populations, the program utilizes data to identify prevention areas, assess existing programs, and implement evidence-based strategies. Key outcomes include improved partner engagement and a measurable reduction in suicide rates. This initiative allows potential applicants to prepare by reviewing relevant data and forming strategic partnerships ahead of future opportunities.

The Statewide Perinatal Quality Collaboratives initiative aims to enhance the health of pregnant and postpartum women and their newborns through quality improvement strategies. Funded by the CDC, the program encompasses two components: state-based Perinatal Quality Collaboratives and a National Network coordinating center. Key strategies include strengthening data systems and fostering partnerships to improve healthcare services and outcomes. Ultimately, this initiative seeks to implement successful quality improvement initiatives that ensure better coordination and health outcomes for mothers and newborns across the United States.