Best Spartanburg County Grants for Nonprofits in South Carolina

About Father John Foundation GrantIn 1997 Monsignor John P. Hourihan established this perpetual charitable foundation for the purpose of funding care for the homeless and people with disabilities, especially the deaf and hard of hearing. The purpose of the Foundation is to financially assist churches and other non-profit organizations, that do not take more than insubstantial government funding, in administering their programs. Our giving focus is broad and considers programs that are: religious, educational, rehabilitational, social, and/or vocational. A priority is given to the deaf and homeless. All funding is given regardless of nationality, race or religion. The Foundation will continue its dedication to raising and distributing grants to be used by charities devoted to providing care and services to the homeless and disabled.

American Brain Foundation

The American Brain Foundation funds research across the spectrum of the brain and nervous system, because it is our best hope for improving treatments, advancing prevention strategies, and discovering cures. Brain diseases, disorders, and injuries are interconnected. When we cure one, we will cure many.

Next Generation Research Grants

The American Brain Foundation’s Next Generation Research Grants (NGRGs) support early career investigators conducting high-quality research aimed at better understanding, treating, and curing brain diseases. These grants are offered in collaboration with disease-focused partner organizations and reflect ABF’s Cure One, Cure Many research philosophy: the belief that breakthroughs in one area of research accelerate progress across many others.

Lawrence M. Brass, MD Clinical Research Training Scholarship in Stroke

This award aims to recognize the importance of good clinical research and to encourage early career investigators in clinical studies related to stroke, vascular neurology, and neurocritical care.

For the purpose of this scholarship, research is defined as “patient-oriented research conducted with human participants, or translational research specifically designed to develop treatments or enhance diagnosis of neurological disease. These areas of research include epidemiologic or behavioral studies, clinical trials, studies of disease mechanisms, the development of new technologies, and health services and outcomes research.” Disease-related studies not directly involving humans or human tissue are also encouraged if the primary goal is the development of therapies, diagnostic tests, or other tools to prevent or mitigate neurological diseases.

Agnes McCarthy Caregiver Foundation

The Agnes McCarthy Caregiver Foundation is a 501(c)(3) not-for-profit charity that provides hope and relief to caregivers who care for a loved one with mental health conditions.

Caregiver Grant

Family caregiving has become a public health issue that receives inadequate recognition in our country. While it can be rewarding to care for our loved ones, it often comes with significant physical, emotional and financial costs to the caregiver. On average, caregivers spend over 25% of their own income to support their loved one and provide 32 hours a week in unpaid care.

AMCF currently offers a $500 financial relief grant to assist family members with unexpected expenses due to their caregiving role. If you are a family caregiver to someone living with a mood or psychiatric condition like depression, anxiety, PTSD, bipolar, schizophrenia, or other mental health/co-occurring conditions, you are not alone, and we welcome you to apply for a caregiver grant today.

Additional Information

• To ensure our limited funds reach families with the greatest need, grants may require documentation confirming a diagnosed serious mental illness (SMI).  

• The $500 grant is limited to one award per household within a 12-month period.

• Applications are generally reviewed by our Board of Directors, with decisions made within 30 days of receipt.

T7 Social Impact GrantsThe T.D. Jakes Foundation (TDJF), in partnership with Wells Fargo, is proud to launch the Social Impact Grant Challenge, a transformative funding opportunity designed to identify, support, and amplify nonprofit organizations creating meaningful change in communities across the United States.

Designed around the T.D. Jakes Foundation's pillars of service (Educational Access & Workforce Readiness, financial inclusion, and community transformation and well-being), the Challenge seeks innovative nonprofit organizations that are addressing critical social issues through impactful, scalable, and sustainable solutions.

Finalists selected through this process will have the opportunity to showcase their organization through a live presentation at the inaugural Thriving Seven (T7) Summit, taking place November 12 –14 in Atlanta, Georgia. In addition to competing for grant funding, finalists will gain national visibility for their work and connect with nonprofit leaders, funders, and changemakers from across the country.Grant Funding: A total of $1,500,000 in grant funding is anticipated to be awarded: 

• One (1) - $500,000 grant
• One (1) - $250,000 grant
• Two (2) - $100,000 grant
• Eleven (11) - $50,000 grant

The SCORCH Program: Phase 2 aims to enhance the understanding of single cell biology in the context of HIV and Substance Use Disorder (SUD). Building on previous research, this initiative will explore new single cell approaches to investigate the interactions between SUD and HIV progression at various biological levels. By leveraging advanced techniques, the program seeks to identify candidate mechanisms and potential therapeutic targets, ultimately contributing to innovative solutions for SUDs and HIV-related challenges.

Helen Frankenthaler Foundation Inc

The Helen Frankenthaler Foundation supports the artist’s legacy through a variety of initiatives, including exhibitions, loans of artworks, research and publications, conservation, grants, educational programs for the public and the scholarly community, and the publishing of a catalogue raisonné. It is dedicated to promoting greater public interest in and understanding of the visual arts.

Established and endowed by the artist during her lifetime (1928-2011), the Foundation became active in 2013, on the closing of Frankenthaler’s estate. As the principal beneficiary of Frankenthaler’s estate, the Foundation maintains an extensive collection of her work in a variety of mediums, as well as her collection of works by other artists and original papers and materials pertaining to her life and work.

Visual Arts & Education Grant

The Helen Frankenthaler Foundation supports public engagement with the visual arts through philanthropic, educational, curatorial, and research initiatives. It has expanded its grantmaking to sustain museums and visual arts institutions, supporting exhibitions, scholarship, and education across the field. The Foundation’s grantmaking priorities are currently organized across three areas:

• Climate Action and Sustainability
• Cultural Resilience
• Visual Arts & Education
  • Project-based support for exhibitions, publications, public programs, and academic initiatives that advance the presentation, study, and interpretation of the visual arts.
  • The Foundation supports discrete, institutionally grounded projects that advance the presentation, study, and understanding of the visual arts. Competitive proposals typically include:
    • Exhibitions, publications, and public programs focused on modern and contemporary art
    • Projects that expand access to collections, archives, and curatorial research
    • Academic and institutional initiatives in art history, studio practice, visual studies, museum and curatorial studies, conservation, and related areas of scholarship and teaching—particularly those involving university museums, galleries, and special collections
    • Conferences, programs, or initiatives led by professional organizations whose missions address the visual arts
    • Exhibitions and scholarly or public programs related to the 2028 centennial of Helen Frankenthaler
    • Projects must be clearly defined in scope, duration, and outcomes, and supported by appropriate institutional capacity. Requests for Visual Arts & Education funds should not be framed as general operating support. 

Helen Frankenthaler Foundation Inc

The Helen Frankenthaler Foundation supports the artist’s legacy through a variety of initiatives, including exhibitions, loans of artworks, research and publications, conservation, grants, educational programs for the public and the scholarly community, and the publishing of a catalogue raisonné. It is dedicated to promoting greater public interest in and understanding of the visual arts.

Established and endowed by the artist during her lifetime (1928-2011), the Foundation became active in 2013, on the closing of Frankenthaler’s estate. As the principal beneficiary of Frankenthaler’s estate, the Foundation maintains an extensive collection of her work in a variety of mediums, as well as her collection of works by other artists and original papers and materials pertaining to her life and work.

Cultural Resilience Grant

The Helen Frankenthaler Foundation supports public engagement with the visual arts through philanthropic, educational, curatorial, and research initiatives. It has expanded its grantmaking to sustain museums and visual arts institutions, supporting exhibitions, scholarship, and education across the field. The Foundation’s grantmaking priorities are currently organized across three areas:

• Climate Action and Sustainability
• Visual Arts & Education
• Cultural Resilience
  • Unrestricted support to sustain institutional capacity and core programming across the visual arts field. 
  • The Foundation provides unrestricted support to organizations whose core work is centered in the visual arts. These grants are intended to sustain exhibitions, programs, and institutional activities; support staffing, operations, and organizational capacity; and to maintain continuity during periods of reduced public funding and broader pressures affecting the arts and culture sector.
    • Cultural Resilience support is not project-based and does not require a defined initiative. 

The National Science Foundation (NSF) Directorate for Engineering (ENG) fosters groundbreaking research in electrical, communications, and computing systems through programs like Electronic, Photonic, Magnetic, and Quantum Devices (EPMQD) and Circuits and Systems for Communications and Sensing (CSCS). These initiatives emphasize innovative foundational research, particularly in power and energy systems, while being open to transformative ideas without immediate commercial outcomes. Funding availability will shape the portfolios of ECCS awards.

The MPS Mathematical Sciences Research Programs (MPS MathSci) by the NSF supports diverse research initiatives in theoretical and applied mathematical sciences. Key areas include Algebra, Applied Mathematics, Combinatorics, and Mathematical Biology. The program encourages groundbreaking foundational research with flexible budgets and durations. Proposals do not need to promise immediate outcomes, allowing researchers to explore innovative concepts without the pressure of commercial viability.

The NSF Core Research in Biological Sciences (BIO Core) program supports innovative research that enhances our understanding of biological systems, from molecular to biome scales. This funding opportunity encourages interdisciplinary proposals and can fund both single and multi-investigator projects. The awards will vary in scope and duration, accommodating exploratory projects and long-term commitments, depending on available funding and alignment with the program's objectives.

The FY 2026 funding opportunity aims to support Indian Tribes and intertribal consortia in implementing approved Nonpoint Source management programs under the Clean Water Act Section 319. This initiative, funded by the EPA, focuses on addressing NPS pollution through best management practices as outlined in Tribal NPS Management Program Plans, ensuring the protection of water resources and promoting sustainability in Tribal lands.

The MPS Physics Research Programs, funded by the National Science Foundation (NSF), support transformative research in various fields of physics. This includes experimental and theoretical work in atomic and molecular physics, particle physics, gravitational physics, and more. The NSF aims to promote ambitious projects without the need for immediate commercialization, focusing instead on foundational advancements that push the boundaries of our understanding of the universe.

The National Science Foundation (NSF) is offering funding through the Engineering (ENG) program, focusing on foundational research in civil, mechanical, and manufacturing innovation. Key areas include advanced manufacturing systems, civil infrastructure, and intelligent dynamic systems. The NSF ENG encourages innovative and transformative proposals that may not require immediate commercial outcomes. Award sizes and durations will vary based on budget availability, aiming to support long-term research advancements.

The MPS Astronomical Sciences Research Programs, funded by the National Science Foundation, support innovative research in astronomical sciences. These initiatives aim to enhance our understanding of the universe through core research, technological advancements, and instrumentation. Topics include solar storm prediction, the discovery of exoplanets, and the study of black holes. Proposals should reflect ambitious, transformative ideas that may not require immediate practical outcomes, fostering long-term scientific exploration.

The NSF Expeditions in Computing program aims to foster transformative research in computer and information science. By funding projects up to $15 million over seven years, it encourages multidisciplinary teams to tackle ambitious research agendas that redefine the future of computing. The program supports innovative areas such as new architectures for intelligence, advanced robotics, and next-generation communication, emphasizing the importance of collaboration across various fields to achieve groundbreaking advancements.

The Emerging Frontiers in Research and Innovation (EFRI) program by the NSF aims to support transformative research in wave-based computing, fostering significant advancements in foundational engineering knowledge. With funding opportunities including EAGER awards and four-year grants up to $2 million, EFRI-WBC encourages interdisciplinary collaboration and innovative approaches to address strategic technology priorities. Proposals should articulate their potential long-term impacts on national science and technology missions, promoting a new era in computing methodologies.

The NSF MPS Chemistry Research Programs support groundbreaking research in chemical sciences, encompassing areas such as chemical catalysis, measurement, imaging, and theory. This initiative encourages innovative proposals that can lead to transformative advancements, without the necessity of immediate commercial applications. Researchers interested in exploring foundational concepts that could shape the future of chemistry are invited to submit their ideas for funding.

The National Science Foundation's Engineering Directorate (NSF ENG) promotes groundbreaking research in chemical, bioengineering, energy, and transport systems. Key programs include Chemical Process Systems, Engineering Biological and Biomedical Systems, Energy, Water, and Resource Engineering, and Transport Phenomena. NSF ENG seeks innovative, transformative proposals that push the boundaries of foundational research, regardless of immediate commercial applications, and emphasizes diverse funding opportunities based on availability.

The MPS Materials Research Programs, funded by the National Science Foundation, aim to enhance the understanding of materials and their diverse applications. These programs cover areas such as biomaterials, ceramics, condensed matter physics, and electronic materials. With an emphasis on transformative research, NSF MPS encourages proposals that are innovative and foundational, without the necessity for immediate commercial outcomes, fostering long-term advancements in materials science.

The ONR FY27 Young Investigator Program invites cutting-edge research proposals in priority areas that align with the interests of ONR Program Officers. This federal funding opportunity aims to support innovative projects led by early-career researchers, fostering advancements in science and technology relevant to the Navy. Interested applicants can find detailed eligibility criteria and contact information on the ONR website, encouraging collaboration and engagement in impactful research.

The Surveillance and Case Control Study of Stillbirth and Birth Defects (SUCCSSBD) aims to enhance the quality of birth defects and stillbirth surveillance in the U.S. By modernizing data collection through electronic case reporting, the initiative seeks to improve data quality and timeliness. The study will focus on identifying risk factors for birth defects and stillbirths, addressing a significant public health issue that affects thousands of pregnancies annually. CDC funding will support three key components in this effort.

The Preventing Violence Affecting Young Lives (PREVAYL 2.0) initiative aims to provide multiyear funding for state and local health departments to implement violence prevention strategies for adolescents and young adults. Key focuses include enhancing data-driven decision-making, building capacity for evidence-based strategies, integrating youth mental health support, fostering multisector collaborations, and prioritizing the prevention of various forms of violence, ensuring comprehensive support for youth development.

PetSmart Charities

We’re proud to celebrate over 30 years of being the leading funder of animal welfare in communities across North America. Since 1994, we’ve granted over $600 million to change-making organizations that help transform the lives of pets and those who love them.

Our Mission: We make the world a better place for pets by investing in community partners that advocate and care for the well-being of pets and all who love them.

Adoption Growth Grants 

Purpose

Adoption Growth grants drive lifesaving outcomes by supporting successful, sustainable in-store adoption programs, events, and results in partnership with PetSmart stores.

Funding Support

Funding may be used for costs associated with building or enhancing your organization’s adoption program in partnership with PetSmart stores, including:

• Staff positions supporting in-store adoption programs and events.
• Marketing and advertising for in-store adoption programs.
• Volunteer or foster support, incentives, and recruitment related to in-store adoption events.
• Event supplies, including containment and enrichment materials.
• Shelter software and technology needs.
• Vehicle repairs or transportation to adoption events.
• Innovative in-store adoption ideas and pilot programs.
• Other costs directly associated with facilitating PetSmart adoptions and in-store events.

There are two Cohorts under this funding: Cohort 1-  Accelerating in-store adoptions; and Cohort 2: Capacity Building.

Cohort 1- Accelerating in-store Adoptions

Applicants must have completed 500 or more adoptions in a PetSmart store in the U.S. within the last 12 months.

Preference will be given to organizations that demonstrate a clear plan to expand an existing in-store adoption program or introduce new in-store adoption models that will increase adoptions.

Four Required Steps

Applicants must complete all four required steps below before submitting a grant application:

• Step 1 - Watch the kick-off video and complete the Adoption Accessibility Questionnaire
• Step 2 - Confirm eligibility and connect with your Adoptions Grant Manager: After completing the questionnaire, you will receive an email confirming your eligibility. Eligible partners will be invited to a call with their Adoptions Grant Manager to discuss the grant opportunity, expectations, and potential fit.
• Step 3 - Engage your PetSmart store partners: Discuss your intent to apply, align on goals, and gain their commitment to support the success of your in-store adoption program.
• Step 4-  Submit your application.

The National Violent Death Reporting System (NVDRS) is a crucial surveillance initiative by the CDC aimed at understanding violent deaths and suicides. This funding opportunity supports state and local entities in modernizing NVDRS, enhancing data collection and reporting processes. Key activities include timely data updates, modernization assessments, and pilot projects for improved data systems. The goal is to create a sustainable national surveillance system that provides reliable data to inform public health actions and enhance violence and suicide prevention efforts.

About USA Track & Field Foundation Inc

The USA Track & Field Foundation was established in 2002. Our Foundation provides a means to attract and guide funds to new and innovative track & field programs, with an emphasis on providing opportunities for youth and elite athletes.

Mission: 

To support the development of emerging elite athletes, while fostering integration within the broader track & field community. To facilitate the physical, educational, social and character development of youth track & field athletes and to help prepare them to mature and succeed in adult life.Team and Club SupportThe USA Track & Field Foundation may be able to provide support to certain Elite Track & Field / Running clubs in the US.

About She+ Foundation The SHE+ Foundation, formerly known as The Patty Brisben Foundation for Women’s Sexual Health, was founded by Patty Brisben in 2005 after she recognized the profound need for a movement to address the too often ignored aspects of women’s sexual health. The SHE+ Foundation is committed to changing the narrative. We are here to advocate, educate, and fund research that advances the understanding and treatment for women’s sexual health, and improves quality of life for all women.Mission: Our mission is to advance women's sexual health and well-being through groundbreaking research, comprehensive education, and unwavering support. We strive to eradicate stigma, empower women with knowledge, and ensure equitable access to quality healthcare for all, regardless of socioeconomic status, race, or geography.About She+ Foundation GrantWe fund a wide range of projects that align with our mission to advance women's sexual health. This includes:

• Research Studies: Clinical and academic research aimed at understanding and improving women's sexual health.
• Educational Programs: Initiatives that provide education and awareness on topics related to women's sexual health.
• Community Outreach: Programs that engage and support local communities, offering resources and support for women's sexual health.
• Innovative Treatments: Development and implementation of new treatments and therapies for women's sexual health issues.

The NSF Geosciences Core Research program funds innovative projects across atmospheric, geospace, earth, and ocean sciences. It encourages proposals that push the boundaries of knowledge in fundamental research, promoting interdisciplinary approaches. This initiative seeks transformative ideas that may not have immediate commercial applications but are crucial for advancing scientific understanding and addressing complex environmental challenges. Researchers are invited to explore various domains or integrate multiple disciplines to enhance our comprehension of the Earth and its systems.