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Best St. Charles County Grants for Nonprofits in Missouri

Discover active funding opportunities in St. Charles County Grants for Nonprofits. 37,000+ grants are available for a wide range of missions and programs with additional grants in Jackson County, St. Louis County, and Greene County.

70

Available grants

$1.6M

Total funding

$10K

Median grant

70 grants
$1.6M total
$10K median

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Last updated: October 5, 2026. Next update: November 1, 2026.

US $2,500 - US $50,000

Spectrum Digital Education Grants

Applications due Feb 27, 2027
Spectrum Digital Education Grants support nonprofit organizations in educating communities about broadband benefits and usage. These grants aim to bridge the digital divide, particularly for seniors and those with disabilities or ethnically diverse backgrounds. Applicants must demonstrate community partnership, address specific needs, and provide measurable impact metrics. With a focus on financial feasibility and meaningful outcomes, this initiative ensures that underrepresented urban and rural communities gain access to essential digital resources, fostering long-term improvement in their lives.
Charter Communications / Spectrum Mobile LLC

US $20,000 - US $50,000

The Spirit of St. Louis Women’s Fund Grant

Letter of inquiry due Jun 19, 2028
The Spirit of St. Louis Women's Fund Grant aims to enhance the Greater St. Louis community through informed grant-making, fostering women's engagement in philanthropy. The fund prioritizes diversity, equity, and inclusion while supporting organizations focused on arts, education, environment, health, and social services. Grants range from $5,000 to $25,000 for single-year projects and $100,000 for multi-year initiatives. Eligible nonprofits must demonstrate community impact and financial stability, ensuring effective use of funds to address pressing needs.
Spirit of St. Louis Women's Fund

Up to US $100,000

Gateway Regional Environment Fund Grant Program

Letter of inquiry due Mar 9, 2027
The Gateway Regional Environment Fund Grant Program, managed by the St. Louis Community Foundation, aims to support initiatives in the St. Louis metro area that reduce the carbon footprint. By funding projects that address greenhouse gas emissions, GREF plays a crucial role in combating climate change locally. This program encourages community engagement and innovation to create a sustainable future for the region.
St Louis Community Foundation

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Up to US $100,000

Policy Campaign Grants

Applications due Jan 31, 2027
The Policy Campaign Grants by the Deaconess Foundation empower organizations to drive systemic change through policy advocacy and grassroots efforts. With funding up to $100,000, these grants aim to support urgent campaigns that enhance voter engagement and community organizing. By strengthening local movements, the foundation seeks to address racial and structural inequities in Eastern Missouri and Southern Illinois, fostering a path towards liberation and community well-being.
Deaconess Foundation

US $5,000 - US $50,000

Marillac Mission Fund: Responsive Grants

Applications due Feb 2, 2027
The Marillac Mission Fund offers responsive grants primarily for established organizations addressing poverty and vulnerability in the St. Louis area. Focus areas include support for older adults living independently, immigrants and refugees, veterans (existing grantees only), and human trafficking prevention. Grant types include program/project funding and general operating support, with a preference for organizations demonstrating alignment with Catholic moral teachings and serving specific populations. Applications are currently limited to existing grantees in designated focus areas.
Marillac Mission Fund

Up to US $100,000

United Way of Greater St. Louis: Targeted Fund

Applications due Oct 12, 2026
The United Way of Greater St. Louis Targeted Funding aims to provide flexible, one-year grants to nonprofits addressing urgent community needs through emergency, emergent, or innovative approaches. Funding will focus on basic needs, health and wellness, crisis response, and more across 16 counties. Priority will be given to areas identified as having the greatest needs based on recent assessments, ensuring that support is directed where it is most needed.
United Way Of Greater St Louis Inc

US $20,000

PLTW Computer Science - New Program (Ameren)

Applications due Mar 27, 2027

PLTW Computer Science

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a long-time supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to high schools interested in implementing or expanding their PLTW Computer Science programs.

At a time when computer science affects how we work and live, PLTW Computer Science empowers students in grades 9-12 to become creators, instead of merely consumers, of the technology all around them. The program's interdisciplinary courses engage students in compelling, real-world challenges. As students work together to design solutions, they learn computational thinking – not just how to code – and become better thinkers and communicators. Students take from the courses in-demand knowledge and skills they will use in high school and for the rest of their lives, on any career path they take.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Computer Science programs beginning in the next academic year.

PLTW Program Status

New Program

Project Lead the Way inc.

US $20,000

PLTW Gateway - New Program (Ameren)

Applications due Mar 27, 2027

PLTW Gateway

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a long-time supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to schools interested in implementing or expanding their PLTW Gateway programs.

Middle school is a time of exploration, a time when students are figuring out what they're passionate about today and how that relates to who they'll become tomorrow. During this transitional time, PLTW Gateway's 10 units empower students to lead their own discovery. The hands-on program boosts classroom engagement and excitement, drives collaboration, and inspires “aha! moments” and deep comprehension. And as students engage in PLTW's activities in computer science, engineering, and biomedical science, they see a range of paths and possibilities they can look forward to in high school and beyond.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Gateway programs beginning in the next academic year.

PLTW Program Status

New Program

Grant Award and Distribution Schedule

  • Total Award: $20,000
    • First Year: $10,000
    • Second Year: $10,000

Project Lead the Way inc.

US $30,000

PLTW Engineering - New Program (Ameren)

Applications due Mar 27, 2027

PLTW Engineering

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a long-time supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to high schools interested in implementing or expanding their PLTW Engineering programs.

PLTW Engineering empowers students to step into the role of an engineer, adopt a problem-solving mindset, and make the leap from dreamers to doers. The program's courses engage students in compelling, real-world challenges that help them become better collaborators and thinkers. Students take from the courses in-demand knowledge and skills they will use in high school and for the rest of their lives, on any career path they take.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Engineering programs beginning in the next academic year.

PLTW Program Status

New Program

Grant Award and Distribution Schedule

  • Total Award: $30,000
    • First Year: $15,000
    • Second Year: $15,000

Project Lead the Way inc.

US $20,000

PLTW Gateway - New Program (Burns and McDonnell)

Applications due Nov 6, 2026
The PLTW Gateway program, in partnership with Burns and McDonnell, aims to enhance STEM education by supporting schools in eligible counties to implement PLTW Gateway units. With a total grant of $20,000, schools are encouraged to offer at least one unit per academic year, fostering real-world skills and engagement in STEM fields. This initiative seeks to increase access and participation in high-quality STEM learning experiences, ultimately preparing students for future careers.
Project Lead The Way Inc

US $20,000

PLTW Computer Science - New Program (Burns and McDonnell)

Applications due Nov 6, 2026
The PLTW Computer Science program, supported by Burns and McDonnell, aims to enhance STEM education in various communities by funding schools to implement PLTW courses. This partnership promotes student engagement with real-world challenges, preparing them for future careers in technology. With a total grant of $20,000, schools must offer multiple PLTW courses over two years, ensuring access to quality education for underserved populations.
Project Lead The Way Inc

US $40,000

PLTW Engineering - New Program (Burns and McDonnell)

Applications due Nov 6, 2026
The PLTW Engineering program, in partnership with Burns and McDonnell, aims to enhance STEM education by providing grants to public and charter schools in specific counties. This initiative empowers students to engage with real-world challenges through hands-on learning experiences. Eligible schools must offer PLTW Engineering courses, ensuring access to quality education for students from diverse backgrounds. With a total grant of $40,000 over two years, this program seeks to inspire the next generation of engineers and innovators.
Project Lead The Way Inc

US $20,000

Seeding the Future Grants

Applications due Feb 28, 2027
The Seeding the Future Grants, offered by the Deaconess Foundation, provide annual operating funds of $20,000 to organizations that align with the foundation's mission of enhancing community health in Eastern Missouri and Southern Illinois. These grants support initiatives that advocate for systemic change, public policy advancement, and the expansion of civic infrastructure, fostering partnerships for intergenerational health improvements. Eligible organizations must possess a 501(c)(3) status or work with a fiscal agent.
Deaconess Foundation

Up to US $100,000

Gateway Children’s Charity Grant

Applications due Jul 31, 2027
The Gateway Children’s Charity Grant, offered by YouthBridge Community Foundation, focuses on funding early childhood programs in underserved areas of metropolitan St. Louis. With grants available for capital expenses up to $100,000 and capacity-building support up to $50,000, GCC aims to enhance educational quality and infrastructure. Eligible applicants must be 501(c)(3) organizations serving youth from preschool to kindergarten. This initiative represents a significant opportunity to improve childhood education and community welfare.
Youthbridge Community Foundation

Up to US $200,000

Nonprofit Security Grant Program (NSGP - MO)

Applications due Jul 8, 2027
The FY 2025 Nonprofit Security Grant Program (NSGP) aims to enhance the physical and cybersecurity of nonprofit organizations at risk of extremist attacks. This initiative focuses on improving security postures, addressing capability gaps, and fostering collaboration among organizations and local agencies. By providing essential funding for planning, equipment, and training, the NSGP seeks to protect vulnerable facilities and ensure a coordinated community response to security challenges.
Missouri Department of Public Safety (DPS)

US $60,000

GM on Main Street Grant Program

Applications due Feb 14, 2027
The GM on Main Street Grant Program, led by Main Street America, focuses on enhancing the safety and vibrancy of downtowns through innovative road safety and traffic calming projects. Funded by General Motors, this program seeks transformative ideas that promote pedestrian safety and accessibility, making downtown areas more inviting for residents and visitors. Eligible applicants include non-profits and local governments in designated counties, with a strong emphasis on projects that are inclusive, feasible, and easily replicable.
National Main Street Center Inc.

US $10,000 - US $75,000

Holman Enterprises Community Grants

Applications due Apr 30, 2027
Holman Enterprises Community Grants aim to support low-income communities by providing essential resources like food, housing, education, and healthcare. With financial aid of $10,000 for single-year support or $15,000 for multi-year commitments, these grants focus on organizations dedicated to enhancing opportunities for low-income individuals in the areas served. This initiative reflects Holman Enterprises Inc's commitment to community welfare and social responsibility.
Holman Enterprises Inc

US $50,000 - US $1,500,000

Safety Net Funding

Applications due Apr 17, 2027

United Way of Greater St. Louis

Our Mission: The United Way of Greater St. Louis mission is to mobilize the community with one goal in mind – helping people live their best possible lives. We unite people, resources and funding to help build strong and equitable communities where everyone can thrive.

Safety Net

United Way’s Safety Net is a collaborative network of agencies that deliver an array of essential direct services to address the region’s most pressing needs, helping families and individuals remain and work toward stability. Safety Net agencies provide direct services that address basic, urgent needs – such as access to food and housing— as well as supports that help move individuals and families toward stability, including education, health and well-being, workforce access, and financial mobility.

Safety Net Funding

United Way of Greater St. Louis is now accepting applications for its Safety Net Funding cycle and invites all eligible agencies across its 16-county region in Missouri and Illinois, including those not currently receiving United Way funding, to apply. United Way equips 160 local nonprofits with vital funding and training resources to support measurable impact across its five impact areas. Organizations selected will receive a three-year contract and become part of the UWGSL member agency network.

United Way’s Impact Areas

  • Basic Needs 
  • Community Stability and Crisis Response 
  • Early Childhood and Youth Success 
  • Health and Wellbeing 
  • Jobs and Financial Mobility 

While needs are great across the five impact areas, United Way will use data derived from its landscape analysis of community needs to inform how service areas will be prioritized to ensure the region has access to a strong and resilient network as needs arise.

United Way Of Greater St Louis Inc

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St. Charles County Grants for Nonprofits Highlights

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Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grant Funding Trends in Missouri

Average Grant Size

What's the typical amount funded for Missouri?

Grants are most commonly $101,542.

$101,542

Total Number of Grants

What's the total number of grants in St. Charles County Grants for Nonprofits year over year?

In 2024, funders in Missouri awarded a total of 44,064 grants.

2022 39,922

2023 39,688

2024 44,064

Top Grant Focus Areas

Among all the St. Charles County Grants for Nonprofits given out in Missouri, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for St. Charles County Grants for Nonprofits changing over time?

Funding has increased by -15.61%.

2022 $4,698,402,122

2023 $5,287,874,816
12.55%

2024 $4,462,369,205
-15.61%

Missouri Counties That Receive the Most Funding

How does grant funding vary by county?

St Louis County, Jackson County, and St Louis City receive the most funding.

County Total Grant Funding in 2024
St Louis County $2,185,711,864
Jackson County $1,234,679,326
St Louis City $1,054,441,922
Greene County $223,079,775
Clay County $178,423,081

Related Grants in Missouri

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Browse Grants by Counties within Missouri

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