Best St. Charles County Grants for Nonprofits in Missouri

Nestlé Purina Animal Welfare Grants focus on enhancing the well-being of pets and their owners through monetary donations to 501(c)(3) tax-exempt pet welfare organizations in the U.S. These grants support capacity building, capital improvements, and spay/neuter funding. The program aims to strengthen relationships between pets and people, particularly in communities near Nestlé Purina facilities, ensuring that both pets and their owners thrive together.

Nestlé Purina

Unspecified amount

GM Corporate Giving Grants

Letter of inquiry due Sep 30, 2027

The GM Corporate Giving Grants support U.S.-based 501(c)(3) nonprofit organizations focused on STEM education and transportation initiatives. Applications are accepted from January to September, with a requirement to submit requests at least three months before the program’s start date. GM emphasizes charitable contributions in the communities where it operates, ensuring that organizations align with its values. The grant amount is not limited and is assessed based on the proposed program's merit and needs.

General Motors Foundation Inc

Unspecified amount

Tilles Fund Grant

The Tilles Fund Grant focuses on innovative charitable investments in the Greater St. Louis Area, aiming to support children with developmental, intellectual, and physical disabilities. The foundation seeks to partner with effective non-profit organizations that demonstrate measurable outcomes in education and community impact. Since 1926, the Tilles Foundation has been committed to providing essential services and educational opportunities, ensuring disadvantaged children have the tools they need for a brighter future.

Rosalie Tilles Nonsectarian Charity Fund 313743

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Up to US $100,000

Gateway Regional Environment Fund Grant Program

Letter of inquiry due Mar 9, 2027

The Gateway Regional Environment Fund Grant Program, managed by the St. Louis Community Foundation, aims to support initiatives in the St. Louis metro area that reduce the carbon footprint. By funding projects that address greenhouse gas emissions, GREF plays a crucial role in combating climate change locally. This program encourages community engagement and innovation to create a sustainable future for the region.

St Louis Community Foundation

Up to US $25,000

Episcopal Presbyterian Health Trust Grant

Applications due Oct 2, 2026

The Episcopal Presbyterian Health Trust Grant, managed by the St. Louis Community Foundation, focuses on enhancing health care access and addressing chronic diseases. Grants are awarded biannually, prioritizing maternal and infant health in the second cycle. Organizations are encouraged to submit one Letter of Intent (LOI) annually, ensuring their proposals align with the funding priorities to foster sustainable health solutions in the community.

St Louis Community Foundation

Up to US $1,000

Firefighter Grant Program

Applications due Aug 31, 2027

The Firefighter Grant Program by Missouri American Water aims to support local fire departments with financial assistance up to $1,200. This initiative is part of the company's commitment to enhancing community safety and well-being. Eligible applicants include both professional and volunteer fire departments within designated service areas. Funds can be used for essential items such as protective gear, communication equipment, firefighting tools, and training materials, ensuring that fire services are well-equipped to respond effectively.

Missouri American Water

US $10,000

PLTW Engineering - Program Expansion (Ameren)

Applications due Mar 27, 2027

PLTW Engineering

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a long-time supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to high schools interested in implementing or expanding their PLTW Engineering programs.

PLTW Engineering empowers students to step into the role of an engineer, adopt a problem-solving mindset, and make the leap from dreamers to doers. The program's courses engage students in compelling, real-world challenges that help them become better collaborators and thinkers. Students take from the courses in-demand knowledge and skills they will use in high school and for the rest of their lives, on any career path they take.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Engineering programs beginning in the next academic year.

PLTW Program Status

Program Expansion

Project Lead the Way inc.

Unspecified amount

Section 5310 – Enhanced Mobility of Seniors and Individuals with Disabilities Grant

Applications due Feb 20, 2027

The Section 5310 – Enhanced Mobility of Seniors and Individuals with Disabilities Grant, administered by the East-West Gateway Council of Governments, aims to enhance transportation access for seniors and individuals with disabilities in the St. Louis region. This federal funding supports projects that improve mobility, including vehicle acquisition, travel training, and barrier removal at bus stops. Eligible applicants include non-profits and government entities focused on serving these communities.

East-West Gateway Council of Governments

Unspecified amount

Lutheran Foundation of St. Louis Grants

Applications due Dec 1, 2026

The Lutheran Foundation of St. Louis provides grants aimed at improving the lives of individuals in the greater St. Louis area. With a focus on strategic priorities such as community engagement and support for vulnerable populations, the foundation encourages organizations to apply for funding that aligns with its mission. Grants are available to 501(c)(3) organizations serving specific counties, and applicants are encouraged to demonstrate measurable impact through their proposed programs.

Lutheran Foundation of St. Louis

Unspecified amount

PNC Foundation: Foundation Grant

The PNC Foundation aims to enhance the lives of individuals in local communities through partnerships with nonprofit organizations. Their focus includes promoting educational opportunities, particularly for early childhood education, and supporting economic development initiatives. Grants are available for organizations that benefit low- to moderate-income families and enhance community growth. The foundation prioritizes programs that foster sustainability and diversity, ensuring a lasting impact on the communities they serve.

PNC Foundation

Up to US $100,000

United Way of Greater St. Louis: Targeted Fund

Applications due Oct 12, 2026

The United Way of Greater St. Louis Targeted Funding aims to provide flexible, one-year grants to nonprofits addressing urgent community needs through emergency, emergent, or innovative approaches. Funding will focus on basic needs, health and wellness, crisis response, and more across 16 counties. Priority will be given to areas identified as having the greatest needs based on recent assessments, ensuring that support is directed where it is most needed.

United Way Of Greater St Louis Inc

Up to US $10,000

Congregation Mini Grants

Lutheran Foundation of St. Louis

Lutheran School Mini Grants

The Foundation continues to encourage congregations to reach out to their surrounding communities through organized, effective social service outreach ministry efforts. We also recognize congregations are looking for innovative ways, outside the traditional social service outreach model, to build relationships and engage their communities.

We look to accomplish this in two ways:

Supporting congregations as they work to engage and serve their neighbors and community through planning and program implementation grants.
Strengthening the ability of congregations to engage in community engagement efforts through coaching assistance, mentoring, and training (through Send Me St. Louis).Examples of Possible Ministry Projects

Congregation Community Engagement is defined for this Funding Focus Area as activities, services, or efforts designed to reach out to others on a local level (St. Louis metropolitan region). Examples include both serving the immediate needs of people and efforts to engage and build relationships with the community. The focus is on bringing the care of Jesus Christ into the lives of hurting people in the community, rather than serving the congregation’s own members. This funding focus area is not meant to support “Word and Sacrament” activities.

Health care/mental health services
Fitness/healthy living programs
English as a second language
After-school mentoring/tutoring
Social activities for seniors
Community revitalization
Recreation activities
Home repair/beautification
Partnerships with local schools/other institutions
Social enterprise/business that benefits the community and/or creates space for relationships
One-time events (run by the congregation) to meet a need in the community

Idea Exploration

Congregations should know what they want to do and have an idea of how to get started. If you are not at this point, coaching services to assist your congregation are offered through Lutheran Foundation’s relationship with Send Me St. Louis. Services include coaching and guidance on:

mapping the congregation’s and community’s assets,
researching opportunities for social service outreach ministry, and/or
planning for a social service outreach ministry.

There are no grant deadlines for the Congregation Mini Grants. Application can be made at any time of the year.

Unspecified amount

Brinker International Charitable Giving Program

The Brinker International Charitable Giving Program focuses on giving back to communities through support for kids, hunger, and education. Organizations eligible for funding must be 501c(3) non-profits and submit requests at least six weeks prior to events. The program does not support individuals, political or religious organizations, or explicit discrimination policies. Funding is provided through monetary donations or in-kind contributions like dining certificates.

Brinker International

US $5,000

PLTW Launch - Program Expansion (Burns and McDonnell)

The PLTW Launch program, in collaboration with Burns and McDonnell, aims to enhance STEM education by expanding access to innovative educational modules in eligible schools. This initiative supports public and charter schools in targeted counties, focusing on increasing student engagement in STEM fields. Through grant funding, participating schools can introduce new PLTW Launch modules and provide essential training for teachers, fostering a richer learning environment to prepare students for future careers in science, technology, engineering, and mathematics.

Applications due Jun 30, 2027

Unspecified amount

ECF of The Boeing Company: St. Louis Missouri Chapter Grant Program

The Employees Community Fund (ECF) of The Boeing Company supports charitable organizations in the St. Louis area through grants focused on Health and Human Services, Education, Arts & Culture, and Civic Engagement. Applications for 2024 will be accepted from April 1 to June 30, with odd-numbered years prioritizing health initiatives. ECF has invested over $165 million in the community, empowering employees to make a significant impact through collaborative giving.

Employees Community Fund Of The Boeing Company

Up to US $20,000

PLTW Launch - New Program (Burns and McDonnell)

The PLTW Launch program, supported by Burns and McDonnell, aims to enhance student engagement in STEM education within eligible communities. This initiative will provide grants to schools that implement at least one PLTW Launch module in the 2025-2026 academic year, followed by another module in subsequent years. The program is designed to empower students with hands-on learning experiences that connect real-world challenges to essential skills, fostering a stronger future in STEM fields.

Applications due Mar 27, 2027

US $5,000

PLTW Launch - Program Expansion (Ameren)

PLTW Launch

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to schools interested in implementing and our expanding their PLTW Launch programs.

PLTW Launch's 43 interdisciplinary modules bring learning to life. The program empowers students to adopt a design-thinking mindset through compelling activities, projects, and problems that build upon each other and relate to the world around them. And as students engage in hands-on activities in computer science, engineering, and biomedical science, they become creative, collaborative problem solvers ready to take on any challenge.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Launch programs beginning in the next academic year.

PLTW Program Status

Program Expansion

Project Lead the Way inc.

US $1,000 - US $10,000

Enbridge - Safe Community First Responder Program

Pre proposal due Nov 15, 2026

The Enbridge Safe Community First Responder Program is designed to support emergency response organizations across Canada and the U.S. by providing grants for safety equipment, training, and educational programs. Launched in 2002, it has invested over $22 million in enhancing community safety. Eligible organizations include fire departments and medical services located near Enbridge operations. Grants typically range from $1,000 to $10,000, helping improve the capabilities of first responders in rural and underserved areas.

Enbridge

US $10,000

PLTW Gateway - Program Expansion (Burns and McDonnell)

The PLTW Gateway program, in collaboration with Burns & McDonnell, aims to enhance STEM education by expanding access to Project Lead The Way initiatives in eligible communities. By providing grants for program expansion, the initiative encourages schools to implement new PLTW units and train teachers, empowering students with essential skills for future careers. This partnership seeks to inspire a new generation of learners through hands-on, real-world challenges, thereby fostering greater participation in STEM fields across various regions.

Applications due Feb 14, 2027

US $60,000

GM on Main Street Grant Program

The GM on Main Street Grant Program, led by Main Street America, focuses on enhancing the safety and vibrancy of downtowns through innovative road safety and traffic calming projects. Funded by General Motors, this program seeks transformative ideas that promote pedestrian safety and accessibility, making downtown areas more inviting for residents and visitors. Eligible applicants include non-profits and local governments in designated counties, with a strong emphasis on projects that are inclusive, feasible, and easily replicable.

National Main Street Center Inc.

Up to US $200,000

Nonprofit Security Grant Program (NSGP - MO)

Applications due Jul 8, 2027

The FY 2025 Nonprofit Security Grant Program (NSGP) aims to enhance the physical and cybersecurity of nonprofit organizations at risk of extremist attacks. This initiative focuses on improving security postures, addressing capability gaps, and fostering collaboration among organizations and local agencies. By providing essential funding for planning, equipment, and training, the NSGP seeks to protect vulnerable facilities and ensure a coordinated community response to security challenges.

Missouri Department of Public Safety (DPS)

Unspecified amount

PNC Foundation: Grow Up Great Grant

The PNC Foundation's Grow Up Great Grant is a significant initiative aimed at enhancing educational opportunities for children from birth to age 5. With a commitment of $500 million, this program focuses on improving school readiness through support in vocabulary development, social-emotional learning, and the arts. By partnering with community-based nonprofits, PNC aims to foster stronger, smarter, and healthier communities, ensuring a brighter future for the next generation.

PNC Foundation

US $30,000

PLTW Engineering - New Program (Ameren)

Applications due Mar 27, 2027

PLTW Engineering

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Engineering programs beginning in the next academic year.

PLTW Program Status

New Program

Grant Award and Distribution Schedule

Total Award: $30,000
- First Year: $15,000
- Second Year: $15,000

Project Lead the Way inc.

US $50,000 - US $1,500,000

Safety Net Funding

Applications due Apr 17, 2027

United Way of Greater St. Louis

Our Mission: The United Way of Greater St. Louis mission is to mobilize the community with one goal in mind – helping people live their best possible lives. We unite people, resources and funding to help build strong and equitable communities where everyone can thrive.

Safety Net

United Way’s Safety Net is a collaborative network of agencies that deliver an array of essential direct services to address the region’s most pressing needs, helping families and individuals remain and work toward stability. Safety Net agencies provide direct services that address basic, urgent needs – such as access to food and housing— as well as supports that help move individuals and families toward stability, including education, health and well-being, workforce access, and financial mobility.

Safety Net Funding

United Way of Greater St. Louis is now accepting applications for its Safety Net Funding cycle and invites all eligible agencies across its 16-county region in Missouri and Illinois, including those not currently receiving United Way funding, to apply. United Way equips 160 local nonprofits with vital funding and training resources to support measurable impact across its five impact areas. Organizations selected will receive a three-year contract and become part of the UWGSL member agency network.

United Way’s Impact Areas

Basic Needs 
Community Stability and Crisis Response 
Early Childhood and Youth Success 
Health and Wellbeing 
Jobs and Financial Mobility

While needs are great across the five impact areas, United Way will use data derived from its landscape analysis of community needs to inform how service areas will be prioritized to ensure the region has access to a strong and resilient network as needs arise.

United Way Of Greater St Louis Inc

US $10,000 - US $75,000

Holman Enterprises Community Grants

Applications due Apr 30, 2027

Holman Enterprises Community Grants aim to support low-income communities by providing essential resources like food, housing, education, and healthcare. With financial aid of $10,000 for single-year support or $15,000 for multi-year commitments, these grants focus on organizations dedicated to enhancing opportunities for low-income individuals in the areas served. This initiative reflects Holman Enterprises Inc's commitment to community welfare and social responsibility.

Holman Enterprises Inc

US $10,000

PLTW Engineering - Program Expansion (Burns and McDonnell)

The PLTW Engineering Program Expansion by Burns and McDonnell aims to enhance STEM education in eligible communities. This initiative supports schools in expanding their existing PLTW Engineering programs, providing students with hands-on experiences and essential skills. The program focuses on empowering students through new courses and teacher training, ensuring access for underrepresented populations. By fostering excitement around STEM, Burns and McDonnell is committed to shaping the future workforce and enhancing educational opportunities in critical areas.