Best Calhoun County Grants for Nonprofits in South Carolina

The TURTLE Program aims to empower Tribal Entities by fostering a skilled workforce in biomedical research. It supports undergraduate and graduate students in health research, ensuring they complete their degrees and transition into impactful careers. With phased awards, the program emphasizes effective training and mentoring, inviting eligible organizations to apply. Applications will undergo NIH's peer-review process, ensuring only the most meritorious proposals are funded, ultimately enhancing Tribal health research capabilities.

The TIRBEE funding opportunity supports federally-recognized Tribes and Tribal Entities in establishing or enhancing Institutional Review Boards. This initiative aims to strengthen the capacity for biomedical research involving human participants within these communities by improving review and oversight capabilities. Eligible organizations are invited to apply, with applications subject to NIH's standard peer-review process to ensure only the most meritorious proposals are considered.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance our understanding of somatic mutations and their impact on human biology and disease. This initiative will establish a Tissue Procurement Center (TPC) to collect and provide clinically relevant tissue samples from a diverse set of healthy donors. The TPC will support ongoing research by ensuring high-quality, well-characterized specimens are available for functional analyses, advancing the field of somatic mosaicism.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance understanding of biological processes and disease mechanisms due to somatic mutations in human tissues. Since 2023, it has produced multi-omic datasets from various human tissues. The NIH plans to advance this initiative by establishing the National Somatic Mosaicism Commons Data Analysis & Organizational Center, which will oversee data management, develop analytical tools, and provide training to facilitate research and clinical applications.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to uncover biological processes and disease mechanisms influenced by somatic mutations. Since its inception in 2023, it has produced valuable multi-omic datasets from diverse human tissues. The upcoming Stage 2 Genome Characterization Centers will focus on understanding the impact of these mutations in both healthy and clinically significant samples, enhancing our knowledge of somatic mosaicism's role in human health and disease.

In collaboration with Cummins Inc., the American Library Association (ALA) invites applications from U.S. public libraries to participate in A Year of STEM, 12 months of curated STEM programming to foster curiosity and STEM-mindedness in early childhood learners across the country. 

Twenty-five libraries will be chosen to participate in A Year of STEM, receiving professional development to prepare them for the project, copies of a newly created A Year of STEM programming guide developed by librarian advisors, a $5,000 programming stipend, four STEM kits (to be delivered quarterly), and support from ALA’s Public Programs Office staff throughout the project implementation period.

LRPenn.com is home to the novels, plays, and screenplays of LR Penn. His books specializes in Thrillers, Dramatic Comedies, and Film Noir. Thanks to the generous support of our sponsors, grants may be available to nonprofit theater companies in the United States with 501(c)(3) status that are staging productions of plays written by LR Penn.  

The National Institutes of Health (NIH) is continuing its support for the NeuroNEXT initiative, which focuses on conducting clinical trials and biomarker validation studies for neurological disorders. This infrastructure aims to foster innovation and enhance the development of effective neurotherapeutics for both adult and pediatric populations. While applications for network clinical research sites are not currently being solicited, this notice allows potential applicants to prepare collaborative and responsive applications.

The Homeless Veterans' Reintegration Program (HVRP) aims to assist veterans experiencing homelessness by providing tailored employment services. This federal initiative focuses on helping veterans transition to stable employment through job training, case management, and connections to local supportive services. HVRP aligns with national priorities to enhance career outcomes for veterans, ensuring they receive the necessary tools and resources for sustainable employment and integration into the workforce.

The Native Public Health Resilience (NPHR) program is a new funding opportunity aimed at supporting Tribes and Tribal Organizations in delivering essential public health services. Sponsored by the Indian Health Service, this initiative seeks to bolster public health infrastructure and resilience within tribal communities, ensuring they have the necessary resources to address health challenges effectively. Eligible applicants will receive financial assistance to enhance their public health capabilities and improve community health outcomes.

The NIH Stroke Clinical Trials Network (StrokeNet) aims to enhance stroke treatment and recovery through a robust national infrastructure. Funded by the National Institutes of Health, this initiative focuses on clinical trials that evaluate innovative therapies for stroke patients and those at risk. The program is currently not soliciting applications but encourages the development of collaborations to support the national coordinating center and data management efforts, ultimately improving outcomes for individuals affected by stroke.

The NIDA Avenir Program aims to cultivate innovative leaders in addiction science by funding exceptional early stage investigators (ESIs) embarking on pioneering research. Launched in 2015, this initiative encourages high-risk, high-reward mechanistic studies related to Substance Use Disorders (SUDs) across diverse scientific domains. Applications from new investigators and those outside addiction research are welcomed, fostering interdisciplinary approaches that enhance understanding of SUD mechanisms. The program supports ESIs who may lack preliminary data but demonstrate potential for impactful contributions.

The BRAIN Initiative aims to advance innovative neurotechnologies by funding early-stage clinical studies for devices that record or stimulate the human central nervous system. This initiative encourages collaborations between clinical researchers and device manufacturers to facilitate groundbreaking studies. By addressing the challenges of obtaining safety and utility data, this program supports both non-invasive and significant risk devices, providing essential insights into their functionality and design. Applications are currently not being solicited, allowing time for meaningful project development.

The BRAIN Initiative, led by the NIH, aims to advance neurotechnologies at institutions with limited NIH funding. This funding opportunity encourages collaboration and knowledge transfer to integrate innovative neurotechnologies into research and training programs. While applications are currently not being solicited, potential applicants should start developing partnerships and projects in preparation for future submissions. This initiative will enhance the dissemination of BRAIN technologies and support novel research practices.

Stars, Stripes & Skilled Trades

General Motors invites eligible 501(c)(3) nonprofit organizations to submit proposals for Stars, Stripes & Skilled Trades, a workforce development initiative designed to support veterans, transitioning service members, and military-connected family members—including spouses—in building lasting careers in manufacturing, automotive, and skilled trades. GM is seeking scalable, results-driven programs that create clear pathways to quality careers while recognizing the experience and leadership that veterans and military families bring to American industry. 

We're looking for existing initiatives that:

• Serve career-transitioning service members, veterans, and military-connected family members
• Provide industry-recognized training, certifications, or credentials
• Connect participants to mentorships, quality jobs, and long-term career pathways in manufacturing, automotive technician roles, or skilled trades.

Grant Range

• $100,000 | $250,000 | $500,000

Mellon Foundation

The Andrew W. Mellon Foundation was established in 1969 to strengthen, promote, and defend the arts and humanities as essential to democratic societies. Throughout our history, Mellon has held true to our founding commitments, secure in our conviction that the arts and humanities are essential to the health of a multivocal and democratic society. From our earliest days, we have aspired to build partnerships with our grantees, offering expertise and counsel in addition to funding

In recent years, Mellon has expanded on these core principles by actively prioritizing social justice across all of our grantmaking. This strategic shift builds on our long history of advocating for and investing in expanded access to higher education, humanities, and the arts, and addressing historical inequities in these fields. Our vision for Mellon’s future includes a focus on justice for all in all that we do—rooted in the Foundation’s long-held historic belief in the impact and power of the arts and humanities. At Mellon, we make grants to actively support communities and ideas that unlock the power in the arts and humanities that helps connect us all.

Humanities in Place Grant Program

The Andrew W. Mellon Foundation actively works with our grantee partners and we are deeply immersed in the fields in which we invest. Our grants are designed to activate the spirit of learning through the creation and sharing of bold new ideas and the inspiration felt in art, expression, spaces, and scholarship. 

From Alaska to Guam and the Borderlands to the Midwest, America is a constellation of unique heritages, traditions, and stories. In communities of all sizes, people are striving to expand the ways we can understand and authentically engage with the history that is all around us. Our Humanities in Place grants fund place keepers, artists, institutions, and storytellers who shine a spotlight on historically overlooked sites, and the communities and stories that surround them. In doing so, they help broaden our shared understanding and open new paths to discover what unites us, what makes us unique, and what we can learn from one another.

Melton Foundation

The Melton Foundation is an international 501(c)(3) non-profit organization registered in the USA, and a leading proponent of Global Citizenship education and practice worldwide. Established nearly thirty years ago with the credence that collaborations across boundaries can forge sustainable solutions to the world’s most pressing challenges, today, our programs reach millions of young leaders, having crystallized into a network of over 750 life-long Melton Fellows spread across 40+ countries. Our primary operations are in Chile, China, Germany, Ghana, India, and the United States of America, with legal subsidiaries in Bangalore, India; Jena, Germany; Temuco, Chile; and Accra, Ghana. 

Through our fellowship and collaborative programs we promote and enable global citizenship as a way for individuals and organizations to work together across boundaries of place and identity to solve challenges in an interconnected world.

Melton Foundation Action Grants

The Melton Foundation offers grants year-round to support Melton Fellows in developing skills, perspective and wider networks to further their capacity as global citizens and contribute towards building an equitable, sustainable, and peaceful world.

In almost 10 years of granting, more than 100 Fellows’ initiatives have been awarded with a Melton Foundation grant to

• Build awareness and/or further awareness raising around global issues and the Sustainable Development Goals (SDGs),
• Develop individual and collective responsibility for sustained, collaborative action,
• Grow capacity to collaboratively drive and sustain social impact at the local and/or global level,
• Further the design, implementation and evaluation of collaborative actions that embody the spirit of global citizenship practice and further social impact, or
• Support coordinated social-impact efforts in a particular or across (emerging) Melton Foundation Hub regions to promote global citizenship practice (s) and the organization’s mission.

The Climate Program Office (CPO) FY2026 Earth System Science and Services Partnership (ESSSP) aims to enhance NOAA's mission through collaborative research and activities. It focuses on understanding changes in Earth's systems and their impacts on ecosystems and communities. Eligible applicants include academic institutions offering doctoral degrees in NOAA-related sciences. The total funding available is approximately $10 million, supporting initiatives that encompass research, data evaluations, and stakeholder engagement.

The project titled 'Aquatic Fauna Response to Ecosystem Restoration in Southwest Florida' aims to assess the effects of the Comprehensive Everglades Restoration Plan (CERP) on aquatic fauna. It will utilize a Monitoring and Assessment Plan (MAP) to evaluate responses of aquatic communities and inform future restoration efforts. This initiative is crucial for documenting CERP benefits and guiding further ecosystem restoration, ultimately benefiting the public by tracking progress in ecological recovery.

The R3PEATS Grassroots Rigor Projects, funded by the NIH, aim to enhance research practices through two project types: Metascience and Laboratory Capacity-Building. Metascience projects focus on creating tools and metrics to promote high-quality research, while Laboratory Capacity-Building projects help labs adopt new techniques and share data that influence research outcomes. This initiative is part of a broader effort to improve rigor, replicability, and reproducibility in scientific research.

The R3PEATS Multi-Team Triangulation initiative supports collaborative research teams to explore a central biomedical question using diverse methods and model systems. It emphasizes the importance of identifying biological variability and ensuring the robustness of findings through replication strategies. This program is part of the NIH Common Fund's Rigor, Replicability, & Reproducibility to Promote Excellence in Science, aiming to enhance the accuracy and translation of scientific discoveries.

The R3PEATS Rigor Scholar Cohort Awards (K12) are designed to empower early-career researchers by enhancing their skills in rigorous scientific practices. This initiative promotes collaboration across institutions to develop best practices in research methodologies, including preregistration and randomization. Participants will gain essential training to ensure excellence and transparency in scientific research, aligning with the NIH's commitment to improve replicability and reproducibility in the field.

Dennis Van der Meer Tennis Foundation

A 2021 International Tennis Hall of Famer, Dennis was the founder of the Professional Tennis Registry Foundation (PTR Foundation), now called Dennis Van der Meer Tennis Foundation, Professional Tennis Registry (PTR), and the Van Der Meer Tennis University.

Dennis Van der Meer Tennis Foundation is a nonprofit organization exempt from federal income tax under Section 501(c)(3) of the Internal Revenue Code. The Dennis Van der Meer Tennis Foundation provides support to deserving individuals and organizations globally. The foundation is also focused on bringing tennis within reach to countless people worldwide.

Nehemiah Atkinson Humanitarian Grant

This grant reflects the Foundation’s dedication to giving and serving others. It is awarded to individuals who have shown an extraordinary commitment to enhancing the lives of those around them.

The Foundation supports projects that promote and preserve the legacy, vision, and spirit of our founder, Dennis Van der Meer. We will only consider funding for educational, life enrichment, mentoring, and tennis programs.

Dennis Van der Meer Tennis Foundation

A 2021 International Tennis Hall of Famer, Dennis was the founder of the Professional Tennis Registry Foundation (PTR Foundation), now called Dennis Van der Meer Tennis Foundation, Professional Tennis Registry (PTR), and the Van Der Meer Tennis University.

Dennis Van der Meer Tennis Foundation is a nonprofit organization exempt from federal income tax under Section 501(c)(3) of the Internal Revenue Code. The Dennis Van der Meer Tennis Foundation provides support to deserving individuals and organizations globally. The foundation is also focused on bringing tennis within reach to countless people worldwide.

Natural Disaster Relief Request

The Foundation stands with tennis professionals affected by the devastating hurricanes and other natural disasters in the U.S. in 2024. If you are a tennis pro facing hardships due to recent storms, we are here to help you get back on your feet. Our assistance program provides relief and resources specifically for tennis professionals affected by these events. Together, we can rebuild stronger.

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

• funding research to improve treatment options;
• providing treatment support and education for patients and their families;
• and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Patient Travel Grant Program

A mesothelioma diagnosis and treatment often require the patient and their family to incur numerous expenses as part of their treatment. Travel to treatment, alone, can cause a significant financial burden on the patient, which might even cause the patient to not seek treatment away from home, even it’s their best option. To ensure that all patients have the ability to seek specialized help and treatments, the Mesothelioma Applied Research Foundation administers its Travel Grant Program.

The Meso Foundation’s Patient Travel Grant Program, founded by Mary and Bob Cosentino, provides travel grants to patients and one caregiver traveling for an initial consult and/or for clinical trial treatments.

• The type of eligible travel must fall into at least one of these two categories:
  • One trip for one initial consultation with a mesothelioma specialist.
  • Multiple trips to participate in an interventional clinical trial (found on clinicaltrials.gov).

The Baugh Foundation supports progressive, inclusive, nonprofit organizations that reflect the love of Christ by providing assistance to those in need, enriching the lives of children and youth, keeping faith communities informed and engaged, and guarding the wall of separation between church and state.We welcome applications from progressive, faith-based organizations. At this time, the vast majority of our funding goes to progressive Baptist organizations or initiatives, and organizations that work to guard the separation of church and state. We believe that a free church in a free state is dependent upon a functioning democracy.Funding Priorities: 

• Social justice and advocacy
• Progressive faith-based journalism
• Meeting basic human needs
• Progressive faith-based post-secondary education
• Inclusivity initiatives
• Arts and enrichment

About the Hertz Foundation

Empowering the Nation’s Most EXCEPTIONAL Innovators

The Hertz Foundation identifies and empowers the nation’s most exceptional innovators in science and technology, fueling a lifelong community dedicated to solving our most pressing problems.

Hertz Community

Awards & Recognition

We’ve established several awards to recognize and support Hertz community members who are accelerating solutions to significant real-world challenges, either through their individual careers or volunteering to strengthen the Hertz Foundation’s work. In addition to providing financial and professional support at a critical time, we also hope to generate more awareness within the Hertz community and inspire collaborations that build on the momentum.

Newman-Galas Entrepreneurial Initiative

The Harold Newman and David Galas Entrepreneurial Initiative provides financial and professional support to Hertz Fellows who propose the most innovative entrepreneurial projects, with particular emphasis on collaboration among fellows. Awardees receive investments up to $25,000 to fund their work and receive mentoring from successful entrepreneurs within the fellows community.

Fueling Entrepreneurs

The initiative was established by honorary Hertz Fellow Harold Newman, a former member of our board of directors and a long-time supporter of and generous donor to the foundation. Newman changed the name to the Harold Newman and David Galas Entrepreneurial Initiative in honor of David Galas, a Hertz Fellow and chairman of the board. Through Newman’s substantial endowment, this award has helped enterprising fellows co-found 11 companies and develop new technologies with real-world impact.

The funds are provided with no strings attached, only the expectation that project leaders will be motivated to share their success with the foundation.