Best Colleton County Grants for Nonprofits in South Carolina

KaBOOM! Multi-Sport Courts provide innovative playspaces designed to meet the needs of older youth. These customizable sports courts allow communities to engage in various sports such as basketball and volleyball, addressing the lack of play opportunities. With guidance from KABOOM! Project Managers, applicants can fundraise and collaborate with community members to create an inviting space for active play, ensuring sustainable maintenance and ownership post-project completion.

Grants

Through our grantmaking, we support nonprofits that serve South Carolina at local, regional and state levels to address root causes of poverty while honoring the dignity of every South Carolinian.

Starting in 2026, our grants focus primarily on systems change in the areas of

• economic mobility,
• housing security and
• health care (with health care systems change grants by invitation only).

By focusing our efforts and going deeper on these three issues, we aim to have an even greater impact on the nonprofits and communities we serve.

Systems Change Grants

Systems Change Grants fund organizations and coalitions that are working to change the policies, power structures and mindsets that cause and reinforce poverty in South Carolina. These grants specifically fund systems change that supports economic mobility and housing security.

Through these grants, we aim to generate a larger impact through more intentional funding, highly focused work and alignment across our Foundation’s activities.

What Systems Change Grants Support

• Organizations that are actively working on systems change that impacts people experiencing poverty and addresses economic mobility or housing security. To see how the Foundation defines these terms, visit our Strategic Plan webpage.
• Organizations that are seeking to change systems at the local, regional or state level. Systems Change Grants provide up to $75,000 annually for local or regional work.
  • State-level grants have a $100,000 maximum each year. 
• Organizations addressing systems change in at least one of the following ways:
  • Participating in advocacy and lobbying
    • Focus on changing policies, practices, processes, rules or laws
    • Impacting resource flows (i.e., reallocated and/or new funding streams)
    • Holding systems accountable to their intended purpose through the above as well as through litigation
  • Addressing unequal power
    • Focus on changing the distribution and dynamics of privilege, relationships and tradition
    • Organizing and building connections and coalitions that center community voices and perspectives
    • Civic engagement
  • Affirming the dignity of people experiencing poverty
    • Focus on changing the narrative around poverty
    • Focus on changing attitudes, mindsets, values, belief systems, norms, mental models and paradigms
  • Implementing big impact, scalable, or innovative solutions
    • Focus on changing results, especially for groups experiencing inequitable outcomes as a result of historic and current marginalization

All grants are for one year, with the possibility of renewal up to three years based on meeting reporting requirements and the availability of funding.

The Delta Dental of Missouri Grant Program aims to improve oral health in Missouri by funding initiatives that reduce oral disease, enhance access to quality dental care, and raise awareness, particularly among underserved populations. Grants range from over $5,000 to $100,000 and are awarded for one year, focusing on projects that increase access to care and demonstrate matching funds from other sources.

Delta Dental of Missouri's Community Donation Program aims to enhance community health through charitable contributions, focusing on organizations that serve Missouri and South Carolina. Preference is given to those with an oral health component. Eligible organizations must be 501(c)(3) registered, address the needs of at-risk populations, and be represented by an authorized member for support requests. This initiative underlines Delta Dental's commitment to community well-being and support.

Charlie's Heart Foundation Annual Grant Program supports small nonprofits focusing on mental well-being for families in underserved communities. Grants between $5,000-$30,000 are available, prioritizing organizations based in North Carolina. Eligible applicants must be 501(c)(3) tax-exempt and demonstrate alignment with the Foundation's mission, organizational need, and program sustainability. The Foundation does not fund individuals, private foundations, or religious organizations, ensuring a strong focus on impactful community programs.

The Craig Newmark Philanthropies Grants, established in partnership with the Bob Woodruff Foundation, aim to support military and veteran communities through funding initiatives that enhance health and well-being. Since 2020, this program has positively impacted over 1.6 million veterans, service members, and their families. The grants focus on improving health determinants, increasing access to healthcare, and facilitating veterans' successful transitions to civilian life.

The Rauschenberg Medical Emergency Grants, administered by the New York Foundation for the Arts, provide one-time funding up to $5,000 for artists facing unexpected medical emergencies. This program aims to alleviate financial burdens caused by medical costs, ensuring that artists can receive necessary care without delay. Eligible applicants must be practicing artists in visual arts, film, or choreography, and demonstrate financial need. This initiative supports artists of color, LGBTQ+ individuals, and those outside major coastal cities.

The Petco Foundation offers disaster relief support for animal welfare organizations affected by disasters. Eligible applicants include authorized members of IRS-designated 501c3 nonprofits, government agency representatives with operational insight, and invited for-profit entities focused on animal welfare. However, the foundation does not fund individuals, organizations outside the U.S., or those whose primary mission does not relate to animal welfare. This initiative aims to provide critical assistance during times of crisis.

We are living in a time of intensified state violence and mass criminalization. The current political climate has doubled down on surveillance, policing, incarceration, and the criminalization of protest, migration, and mutual aid. For directly impacted communities, the trauma is relentless — and those of us committed to resistance are feeling the weight of outrage fatigue.

But we know: the antidote to outrage fatigue is movement response. The expansion of state violence and mass incarceration often forces organizations to respond quickly to unanticipated events despite lacking the necessary resources or capacity.

The Strategic Opportunities Support (SOS) Fund-CJI’s rapid-response fund-is designed to support bold, strategic, and immediate actions by grassroots organizations on the front lines of resistance. The Fund awards grants up to $7,500 and enables organizations to move quickly and collaboratively in response to emerging threats and seize opportunities to advance justice, healing, and systemic transformation.

The Disability Inclusion Fund Grant, managed by Borealis Philanthropy, aims to support organizations advocating for disability inclusion, rights, and justice. As a partner in philanthropy, Borealis facilitates donor collaboratives to maximize impact across various communities and movements. Organizations interested in applying for this grant are encouraged to review the detailed FAQ for further information. This initiative is a vital step towards fostering inclusivity and promoting the rights of individuals with disabilities.

The Cameron Award supports field research on native rodents across the Americas, encouraging studies in ecology, behavior, physiology, and conservation. It is available to students in MS or PhD programs and postdoctoral researchers in the U.S. Applicants must be ASM members. Funds cover supplies, equipment, and travel, but not salaries or meeting travel. The award aims to enhance understanding of rodent ecology and their impact on ecosystems.

The Republic Services Community Grant Program supports local nonprofit organizations focused on neighborhood revitalization, safety, disaster relief, and social services. Eligible 501(c)(3) organizations can apply once annually through an online application process. The program emphasizes a non-discrimination policy, ensuring services are provided without bias. However, funding is not available for individuals, government entities, schools, or religious organizations. This initiative reflects Republic Services' commitment to community engagement and support.

The Bausch Foundation, established by Bausch Health Companies Inc., supports global charitable initiatives focused on disease prevention, improving patient outcomes, and education related to its core businesses. The Foundation also aids disaster recovery efforts and assists underserved communities. Applications for funding are accepted continuously, with quarterly reviews, ensuring timely support for impactful projects. All submissions must be unsolicited, and decisions by the Advisory Committee are final, fostering a transparent giving process.

The Gender Justice Organizing Fund Grant supports initiatives led by women, girls, trans, gender nonconforming, and LGBTQI+ individuals to achieve gender justice. Organizations must prioritize community organizing and demonstrate an understanding of systemic oppression. Grants from the Bread & Roses Community Fund are crucial for groups that lack traditional funding due to their commitment to amplifying marginalized voices. The fund emphasizes long-term strategies that foster sustainable social change in the Philadelphia area.

The Youth Programming Grant, offered by the Native American Agriculture Fund (NAAF), aims to support Native American farmers and ranchers through various projects. This grant focuses on providing essential business assistance, agricultural education, and advocacy services. By funding diverse initiatives, the NAAF seeks to promote the ongoing involvement of Native communities in agriculture, ensuring their sustainable growth and development within the sector.

The Mark Foundation Emerging Leader Award supports innovative cancer research led by early career investigators. Aimed at high-impact, high-risk projects, this grant is available to those employed by U.S. or Canadian non-profit academic institutions. Eligible applicants must be within three to eight years of starting their independent faculty research appointment. This award emphasizes multi-year independent funding and is not intended as the main funding source for the laboratory, ensuring that diverse research efforts are encouraged.

The Disability Foundation, in partnership with The Dayton Foundation, invites proposals for grants aimed at supporting organizations providing direct services to individuals with disabilities. Eligible applicants include community-based nonprofits and academic institutions. Grants, capped at $10,000, can be used for various purposes such as enhancing service accessibility, purchasing necessary equipment, and expanding services. This initiative seeks to empower disabled individuals by ensuring they receive essential resources and support.

The NIHCM Foundation is seeking innovative research proposals that address critical issues in U.S. health care, particularly focusing on drug pricing, provider consolidation, health care delivery, chronic disease management, and the role of artificial intelligence. Projects should aim to improve affordability and quality of care. We welcome submissions from a variety of researchers and organizations, with a preference for studies that can be completed within one year.

The NIHCM Journalism Grants support projects that enhance health reporting and education, targeting critical issues such as healthcare affordability, pharmaceutical pricing, provider market dynamics, and chronic disease management. This initiative emphasizes the importance of informing policymakers and the public on how to improve healthcare quality and access in the U.S. Proposals may also explore the role of artificial intelligence in healthcare delivery. Applications are welcome from journalists, nonprofits, and universities.

Casey's Cash for Classrooms Grants support K-12 public and nonprofit private schools through funding for physical improvements, material needs, teacher support, and community engagement. In 2025, $900,000 was awarded across 80 grants, allowing schools to enhance their learning environments. With a commitment to community engagement, Casey's has donated $15 million since 2019, emphasizing their dedication to making life better for communities and guests. Grants range from $3,000 to $50,000, with funds required to be used within 12 months.

The Lemelson Foundation Grant supports initiatives in invention education and entrepreneurship, aiming to empower young inventors and foster innovation. With over $300 million provided since its inception, the Foundation focuses on strengthening ecosystems for invention in the U.S. and developing countries. Organizations interested in aligning with their mission are encouraged to take an eligibility quiz and submit inquiries through their contact form. This commitment is crucial for driving impactful solutions to global challenges.

The Philanthropic Impact Fund (PIF) by Vanguard Charitable aims to strengthen nonprofit organizations and philanthropic infrastructure. It focuses on integrating AI, educating donors, and enhancing the narrative around the nonprofit sector. Grants typically range from $50,000 to $100,000, with larger requests considered. Organizations must be 501(c)(3) registered nonprofits to apply. This funding is a strategic investment in resilience and sustainability, addressing critical needs in the sector.

The Awards for Advancing Minority Mental Health, established by the American Psychiatric Association Foundation in 2003, aim to honor community organizations that promote mental health awareness in underserved minority communities. These awards recognize efforts to improve access to quality mental health services, enhance treatment quality, and address cultural barriers. Organizations must have been operational for at least two years and demonstrate innovative approaches to mental health challenges.

The Hemophilia Alliance Foundation's Impact Grants aim to support organizations enhancing services for individuals with inherited bleeding disorders. Since its inception in 2009, the foundation has awarded over $6.6 million, enabling innovative projects that expand capacity and collaboration. Eligible applicants include local organizations and federally-funded treatment centers, emphasizing creativity in project proposals. Priority will be given to initiatives that address unserved populations and foster educational advancements in the community.

The Kia Pet Adoption Grant, funded by the Petfinder Foundation as part of the Accelerate the Good program, supports organizations in the US, Canada, and Mexico with free or reduced-fee adoptions for dogs and cats. Grants are awarded monthly based on the number of adoptable pets listed on Petfinder.com until funds are depleted or November 1st. Grantees are required to report adoptions and share stories of pets adopted through this initiative.

The CTIA Wireless Foundation's Catalyst Grant Program aims to empower social entrepreneurs leveraging 5G technology to tackle critical challenges in American communities. With over $200,000 in unrestricted grants available, the program supports innovative projects that utilize 5G connectivity for social good. As 5G transforms communication and interaction, the Catalyst Grant seeks visionary leaders who can harness this potential to inspire meaningful change and enhance community engagement.

The Digital Wish Donation Program, initiated by Mobile Beacon, aims to provide affordable high-speed Internet access to K-12 schools, colleges, and libraries. For just $10 a month, participating institutions can receive donated mobile hotspots and discounted tablets, enabling them to enhance digital literacy and connectivity among underserved students. This initiative not only breaks down barriers to access but also fosters educational equality, ensuring that all learners have the tools they need to succeed in the digital age.