Best Grants for Rare Diseases in Indiana

Indiana nonprofits working on economic and workforce advancement, safe and affordable housing, or community arts and culture can access funding via US Bancorp Foundation’s Community Possible Grant Program. 501(c)(3) organizations, especially those led by people of color and serving designated U.S. Bank communities, may be eligible to support programs that could complement rare disease–related community needs.

Indiana 501(c)(3) nonprofits supporting children, education, or health and human services can seek monetary program support that may benefit rare disease initiatives in their communities. Grants from Costco Foundation help fund programs with clear community need, measurable outcomes, collaboration, and a broad base of financial support, with applications typically reviewed within 4–6 weeks.

Indiana 501(c)(3) nonprofits developing innovative human services or health-related programs can access funding through Creag Foundation to tackle pressing social problems, including rare or chronic disease challenges. Eligible organizations must have held 501(c)(3) status for at least one year and may submit a letter of inquiry to be considered.

Nonprofit 501(c)(3) organizations supporting youth health, education, and welfare, including in Indiana, can apply for Dan Paul Foundation grants up to US $15,000. Programs may include early childhood development, child advocacy, homelessness and poverty services, refugee enrichment, or environmental education, and organizations addressing respiratory or other rare diseases in children may be eligible if aligned with this mission.

Early-stage, impact-first nonprofits and mission-driven for-profits in Indiana and beyond can seek up to US $300,000 from the Draper Richards Kaplan Foundation to scale proven social or environmental solutions. Focused on bold, scalable models for underserved communities, organizations working on health, including rare and respiratory diseases, may be eligible if they meet DRK’s growth and geography criteria.

Nonprofit and nongovernmental organizations using technology for crisis response, education access, economic empowerment, or climate resilience initiatives, including those in Indiana, can apply for Global Impact Cash Grants up to US $100,000. Cisco Systems Foundation supports programs serving predominantly economically underserved communities, with year-round applications beginning with a brief letter of inquiry.

Indiana educational institutions, government programs, 501(c)(3) nonprofits, and 501(c)(4) volunteer fire companies can seek State Farm Companies Foundation support for safety, education, and community development initiatives. Grants from State Farm Companies Foundation help Indiana organizations working on issues like community safety, disaster preparedness, housing, food insecurity, and STEM or college and career success programs; rare disease projects may be eligible if they align.

Nonprofit cultural institutions in the U.S. offering arts and science programs, especially those engaging youth and demonstrating lasting impact, can seek more than US $100,000 for program, capital, or limited general support. William Randolph Hearst Foundation prioritizes large, well-established organizations; Indiana groups working in arts education or STEAM may be competitive if they meet these criteria.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The Labcorp Charitable Foundation, a private 501(c)(3) entity, aims to enhance healthcare access and education for all. With grant opportunities focusing on food programs, healthcare services for underserved populations, and STEM initiatives, it seeks to support community health and well-being. Organizations eligible for funding must be U.S.-based and hold tax-exempt status. Requests are reviewed biannually, in March and September, to foster impactful community projects.

Indiana organizations and social enterprises working on education, children’s health, or family economic stability for low-income urban youth can seek project or scale-up support of more than US $50,000. Michael & Susan Dell Foundation funds eligible entities in the U.S., India, and South Africa that align with its mission and values and request at least $50,000.

Indiana 501(c)(3) nonprofits offering early childhood education or community economic development programs in PNC service areas can apply for PNC Foundation support. Grants from PNC Foundation help Indiana organizations expand early learning, affordable housing, small business assistance, workforce readiness, arts, and other services for low- and moderate-income children, families, and neighborhoods.

Nonprofit charities in Indiana seeking support for humanitarian, social, science education, community, environmental, or contemporary arts projects can apply for Roche Corporate Donations and Philanthropy. With a mission to strengthen communities, Roche provides accredited charities with funding for innovative, sustainable programs, which may include work connected to health or rare disease–related needs.

Nonprofit organizations worldwide, including those in Indiana, can apply for Semnani Family Foundation grants to support health, education, and humanitarian services for marginalized communities. Programs addressing health care access, diseases and conditions, children’s and women’s health, disaster relief, and related human and social services may be competitive for this funding.

Nonprofit 501(c)(3) organizations conducting charitable, scientific, medical, or educational work in the U.S., including Indiana, may be eligible for support to run or expand their programs. Grants from Sidney Stern Memorial Trust help tax-exempt organizations with broadly impactful services, including those addressing respiratory or other rare diseases, strengthen their operations and community reach.

Indiana 501(c)(3) nonprofits working on community development, basic needs, workforce education, arts, environment, or inclusion can seek sponsorship support that strengthens local economic and social vitality. Focused on housing, jobs, and hunger, Bank of America Foundation invites proposals that may benefit rare disease organizations whose programs intersect with these community priorities.

Nonprofit 501(c)(3) organizations and aligned for-profits can seek the Storytelling Grant to share the impact of their preservation, education, or wellness work, including in Indiana. Grants from Jesse W Couch Charitable Foundation help fund communications and storytelling projects, and organizations addressing health, wellness, or mental health within rare disease communities may be eligible. Awards are more than US $50,000.

Nonprofit 501(c)(3) organizations serving the Southern U.S. with health, medical assistance, or related human services programs may be eligible for funding that could include rare disease work. Focused on relieving hardship, Robinson Foundation supports single-year projects from established charities active more than three years, including those in southern states near Indiana’s region.

Indiana community service nonprofits can access funding through Insperity for philanthropic grants or event sponsorships that advance important service and fundraising goals. Eligible 501(c)(3) organizations must either be Insperity clients, actively supported by Insperity employees, or serve communities where employees live and work, and may include programs connected to respiratory or other rare disease needs.

Georgia nonprofits, public schools, and local government entities in Indiana communities near Georgia-Pacific facilities can access funding through Georgia-Pacific Foundation for education, environmental, entrepreneurship, and community enrichment initiatives. Programs that strengthen long-term well-being in these areas, including those serving people with respiratory or other rare diseases, may be eligible if they meet the foundation’s investment priorities.

Nonprofit 501(c)(3) organizations, public schools, and libraries in Indiana can seek unrestricted support for environmental and human services programs, including operating or project costs. Grants from Lawrence Foundation help U.S.-headquartered groups, including those addressing rare or respiratory diseases within broader community or environmental initiatives, with awards typically ranging from US $5,000 - US $10,000.

Nonprofit 501(c)(3) organizations in Indiana working on basic needs, community development, cultural enrichment, or volunteer-driven programs can apply for Ameriprise Financial’s national Community Grants. With a mission to strengthen communities, Ameriprise Financial provides U.S. nonprofits with support for hunger relief, housing and shelters, financial literacy, workforce readiness, and neighborhood revitalization initiatives.

Nonprofit 501(c)(3) organizations can seek project funding in areas like health care, social services, education, and environmental programs, including work that may support rare or respiratory disease needs in Indiana. With a mission to improve our world, Dr Scholl Foundation provides U.S. nonprofits with US $5,000 - US $25,000 in one-year grants through an annual October–March cycle.

Indiana 501(c)(3) nonprofits improving economic stability, workforce readiness, health, or disaster relief can seek project, general operating, or capital support that benefits local communities. O'Reilly Automotive Foundation funds U.S.-based organizations in areas like health and social services, which may include programs serving people affected by rare or chronic respiratory diseases.

Nonprofit 501(c)(3) organizations in Indiana working on youth education, family services, food security, housing, or environmental stewardship can apply for Chick Fil A Foundation’s True Inspiration Awards, offering US $30,000 - US $350,000 for impactful community programs. Organizations serving rare disease populations through these types of services may be eligible.

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

Non-sectarian human and social service nonprofits addressing disadvantage and self-reliance can receive US $5,000 - US $250,000 in funding, including organizations in Indiana. Gupta Family Foundation provides support to smaller 501(c)(3) entities and qualifying foreign organizations working in areas like poverty alleviation, disability services, and disaster relief, with most funds reaching beneficiaries.