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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

32,000+

Available grants

$8.25B

Total funding

$6K

Median grant

32,000+ grants
$8.25B total
$6K median

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32,423 Results based on applied filters

Ryan Jones Animal Welfare Grant

Shiawassee Community Foundation
Private
Shiawassee County, Michigan
Unspecified amount
The Ryan Jones Animal Welfare Grant, established in memory of Ryan Jones, supports animal welfare organizations in Shiawassee County. It prioritizes programs that ensure humane care for cats and may fund initiatives like spay/neuter for feral cat colonies. Grants vary in amount based on available funding and are awarded to qualifying tax-exempt non-profits, schools, and governmental entities dedicated to charitable purposes.
Animal Welfare - Domestic Animals & Pets

American Veterinary Medical Foundation (AVMF) Veterinary Pharmacology Fellowship Grant

American Veterinary Medical Foundation
Private
United States
Up to US $10,000
The American Veterinary Medical Foundation (AVMF) Veterinary Pharmacology Fellowship Grant supports graduate students pursuing careers in veterinary pharmacology research. Funded in collaboration with the Veterinary Pharmacology Research Foundation, this grant offers up to $10,000 for a one-year fellowship. It covers expenses related to training, professional travel, stipends, and scholarly activities, aiming to enhance the number and quality of skilled researchers in the field.
Veterinary Science & Services

American Urological Association: Medical Student Fellowships

American Urological Association Inc
Private
Canada, Central America +2 more
US $4,000
The American Urological Association offers Medical Student Fellowships to enhance urological research. This program allows exceptional medical students to engage in mentored research with leading urologic scientists, receiving a stipend of $4,000. The initiative aims to cultivate the next generation of urologic researchers. Importantly, research projects no longer require a full 10-week commitment during summer, providing greater flexibility for participants. This fellowship is a significant opportunity for young investigators to contribute to advancements in urological care.
Urology

American Urological Association: Residency Research Award

American Urological Association Inc
Private
Canada, Central America +2 more
US $10,000
The American Urological Association's Residency Research Award supports urology residents in their research training, aimed at fostering future leaders in urologic research. Each award provides $10,000 for essential research supplies and resources for projects lasting 3-12 months. Recipients must dedicate 80% of their time to research during this period, ensuring they build a strong foundation for their research careers.
Urology

Saratoga Arts: Arts Education Grants

Saratoga Arts
Private
Fulton County, New York, Montgomery County, New York +1 more
US $1,000 - US $7,500
Saratoga Arts offers Arts Education Grants aimed at providing hands-on learning experiences for a closed group of learners. Projects can be applied for in amounts of $1,000 to $7,500 and must include at least three separate sessions. These grants support both In-School and Community-Based educational initiatives, ensuring that participants engage with art in innovative ways. The Pre-Proposal deadline allows applicants to seek feedback on their proposals before final submission.
Art Education

Kelley Therapeutic Shoe Fund

The Berkshire Taconic Community Foundation
Private
Berkshire County, Massachusetts
US $100 - US $500
The Kelley Therapeutic Shoe Fund, established by Jane Kelley through the Berkshire Taconic Community Foundation, provides financial assistance for therapeutic shoes to eligible elderly or disabled residents of Berkshire County, MA. Grants typically range from $100 to $500 and are aimed at those whose shoe needs are not covered by insurance. Eligible applicants must demonstrate a financial need and be advised by healthcare providers regarding their footwear requirements.
Health & Medicine Human & Social Services

Monument Mountain School Center Fund

The Berkshire Taconic Community Foundation
Private
Berkshire County, Massachusetts
Up to US $3,000
The Monument Mountain School Center Fund, established to support Monument Mountain Regional High School projects, provides grants up to $3,000. As the fund transitions from its founding organization, it aims to enhance educational offerings by prioritizing innovative initiatives that benefit the entire school community. Eligible applicants include students, teachers, and staff who must ensure funding does not replace existing school district financial commitments. This foundation advocates for inclusivity and does not support discriminatory practices.
Education - K through 12 Curriculum Development

Carnegie Mellon University: Scholarly Project Funding

Carnegie Mellon University
Private
Allegheny County, Pennsylvania
US $750
The Carnegie Mellon University Scholarly Project Funding offers financial support for graduate students pursuing research essential to their degree programs. With grants of $750, it assists those whose resources are depleted. This funding, provided by the Graduate Student Assembly and the Office of the Provost, requires students to be enrolled during the funding period and to complete necessary application forms. Eligible expenses include books, travel, and research-related costs, enhancing the academic journey at CMU.
Education - Higher Education

Grove Family Fund #2 – HACC

The Foundation for Enhancing Communities
Private
Dauphin County, Pennsylvania
Unspecified amount
The Grove Family Fund #2 at HACC provides essential scholarships to students pursuing their education at Harrisburg Area Community College. This fund supports both full-time and part-time students, emphasizing the importance of academic achievement with a minimum GPA of 2.0. Eligible candidates must be enrolled in nursing or Dental Hygiene programs, demonstrating financial need. The fund is managed by The Foundation for Enhancing Communities, which is dedicated to enhancing local community welfare through various charitable initiatives.
Education - Higher Education

The Garman Builders Phil Shatto Legacy Scholarship

The Foundation for Enhancing Communities
Private
United States
Up to US $2,000
The Garman Builders Phil Shatto Legacy Scholarship, established by the Home Builders Association of Metropolitan Harrisburg, supports local youth pursuing education in construction-related fields. Annually, 5-10 scholarships of up to $2000 are awarded based on academic performance and career aspirations, with a focus on students entering the Building/Construction Industry. This initiative, active since 1987, encourages future workforce development in essential sectors like Architecture and Engineering.
Vocational & Trade Education

The Howard C. Gale Excellence Scholarship

The Foundation for Enhancing Communities
Private
United States
Up to US $2,000
The Howard C. Gale Excellence Scholarship, offered by the Home Builders Association of Metropolitan Harrisburg, awards 5-10 scholarships of up to $2000 each to high-achieving students. Eligible candidates must graduate from a career or technology center in Dauphin, Cumberland, or Perry county, possess a minimum GPA of 3.5, and intend to pursue a career in the construction industry or related fields, such as Architecture or Engineering.
Education - Higher Education

Cyberinfrastructure for Sustained Scientific Innovation (358751)

National Science Foundation (NSF)
Federal Government
United States
US $600,000 - US $5,000,000
The Cyberinfrastructure for Sustained Scientific Innovation (CSSI) program by the National Science Foundation aims to provide flexible funding opportunities to address evolving needs in cyberinfrastructure. It supports various award classes, including Elements for small groups, Framework Implementations for larger interdisciplinary teams, and Transition to Sustainability for established CI projects. These initiatives focus on developing integrated CI services, ensuring sustainable impact, and promoting collaboration across scientific disciplines to enhance research and innovation.
Cyberinfrastructure

PLTW Gateway- New Program ( Georgia)

Project Lead the Way inc.
Private
Cherokee County, Georgia, Clayton County, Georgia +8 more
Up to US $20,000
The PLTW Gateway - New Program in Georgia offers public and charter schools the chance to implement Project Lead the Way's innovative curriculum. Eligible schools can apply for a total of $20,000, distributed over two years, to support the introduction of PLTW Gateway units. Schools are required to offer at least one unit in the 2026-2027 academic year and an additional unit in the following year, enhancing STEM education for students.
Education - K through 12 Curriculum Development

PLTW Gateway- Program Expansion ( Georgia)

Project Lead the Way inc.
Private
Cherokee County, Georgia, Clayton County, Georgia +8 more
US $10,000
The PLTW Gateway Program Expansion in Georgia aims to support public and charter schools in expanding their existing PLTW Gateway programs. Eligible schools must be located in specific Georgia counties, and the total grant award is $10,000 for the 2026-2027 period. Funds can cover participation fees, required technology, and training-related costs, while salaries, benefits, and other non-allowable expenses are excluded. This initiative promotes STEM education in the region.
Education - K through 12 Curriculum Development

Historic Preservation Certified Local Government Grant

State of New Jersey Department of Environmental Protection
State/Local Government
New Jersey
US $15,000 - US $50,000
The Historic Preservation Certified Local Government Grant, administered by the New Jersey Department of Environmental Protection, aims to enhance local historic preservation efforts. This program supports local governments in identifying significant historic resources and implementing protective measures. By providing financial and technical assistance, it fosters broad participation in preserving the state's rich heritage, ensuring that significant sites are recognized and safeguarded for future generations.
Historic Preservation

Illuminate the Arts Grant: Mid-size Nonprofit Arts Organizations

Creative Philadelphia (City of Philadelphia - Office of the Mayor)
State/Local Government
Philadelphia County, Pennsylvania
US $5,000 - US $7,000
The Illuminate the Arts Grant (ITAG) aims to support Philadelphia's creative sector, particularly those historically underfunded. With $1.5M available, grants between $5,000 and $7,000 will be awarded to mid-size nonprofit arts organizations with budgets from $100,000 to $500,000. This initiative, established to aid recovery from the COVID-19 pandemic, focuses on enhancing public access to the arts and fostering cultural vibrancy in economically marginalized neighborhoods.
Arts / Culture Access & Participation

Illuminate the Arts Grant: Small Nonprofit Arts Organizations

Creative Philadelphia (City of Philadelphia - Office of the Mayor)
State/Local Government
Philadelphia County, Pennsylvania
US $3,000 - US $5,000
The Illuminate the Arts Grant (ITAG) supports small nonprofit arts organizations in Philadelphia with operating budgets under $100,000. A total of $1.5 million will be allocated to enhance creative practices and expand access to the arts in underserved neighborhoods. This initiative, established in 2021, seeks to uplift historically marginalized communities and foster Philadelphia's cultural vibrancy while ensuring equitable distribution of funds through collaboration with local advisory committees.
Arts / Culture Access & Participation

American Urological Association: Research Scholar Award

American Urological Association Inc
Private
Canada, Central America +2 more
Up to US $80,000
The American Urological Association's Research Scholar Award offers $40,000 annually for one or two years of mentored research training. This program aims to attract promising young investigators into urologic research, providing essential support to clinical and postdoctoral fellows within five years of completing their doctorate or residency and early career faculty within their first five years. This funding opportunity is crucial for fostering the next generation of urologic researchers.
Urology

Illuminate the Arts Grant: Individual Artists

Creative Philadelphia (City of Philadelphia - Office of the Mayor)
State/Local Government
Philadelphia County, Pennsylvania
US $1,500 - US $2,000
The Illuminate the Arts Grant (ITAG), administered by Creative Philadelphia, aims to uplift Philadelphia's creative sector through $1.5M in funding for individual artists and small organizations. Targeting historically underfunded communities, ITAG supports artistic practices while enhancing public access to the arts. Established post-COVID-19, this initiative fosters a vibrant cultural ecosystem and encourages applications from individual artists earning less than $66,850 annually, promoting inclusivity and resilience in the city's arts landscape.
Arts / Culture Access & Participation

American Urological Association Rising Stars in Urology Research Award

American Urological Association Inc
Private
Canada, Central America +2 more
Unspecified amount
The American Urological Association Rising Stars in Urology Research Award supports physician-scientists in their journey to become independent researchers in urology. By providing supplemental salary support for up to five years, the program ensures awardees maintain protected research time while receiving competitive compensation. This initiative encourages promising researchers to compete for further funding and enhances their training in urologic research, ultimately advancing the field and improving patient care.
Urology

AUA Data Research Grant Program

American Urological Association Inc
Private
Canada, Central America +2 more
Approximately US $2,000
The AUA Data Research Grant Program, funded by the American Urological Association Inc, aims to enhance urologic research by fostering a diverse group of dedicated professionals. This initiative focuses on bridging knowledge gaps in urology care and cultivating physician scientists through access to comprehensive data sources and mentorship from AUA Data Committee experts. By supporting innovative research, the program contributes significantly to the advancement of patient care in urology.
Urology

Nonprofit Security Grant Program (NSGP) - Alabama

Alabama Law Enforcement Agency (ALEA)
State/Local Government
Alabama
Unspecified amount
The Nonprofit Security Grant Program (NSGP) in Alabama offers funding to nonprofit organizations at high risk of terrorist attacks. Managed by the Alabama Law Enforcement Agency, the program aims to enhance security through equipment upgrades, training, and collaboration among organizations and local agencies. Eligible applicants must be 501(c)(3) organizations demonstrating a clear risk. This initiative supports a proactive approach to safeguarding vulnerable communities against potential threats.
Domestic / Homeland Security Nonprofit Growth & Development

Nonprofit Security Grant Program (NSGP) - Alaska

Alaska Division of Homeland Security and Emergency Management
State/Local Government
Alaska
Up to US $200,000
The Nonprofit Security Grant Program (NSGP) in Alaska supports nonprofit organizations at high risk of terrorist attacks by providing funding for physical security enhancements. With up to $1,650,000 available in 2025, individual awards may reach $200,000. This initiative aims to improve security posture, address capability gaps, and foster collaboration among community and government agencies, ensuring a comprehensive approach to emergency preparedness and resilience against evolving threats.
Domestic / Homeland Security Nonprofit Growth & Development

Nonprofit Security Grant Program (NSGP) - Arkansas

Arkansas Division of Emergency Management
State/Local Government
Arkansas
Up to US $600,000
The Nonprofit Security Grant Program (NSGP) in Arkansas provides crucial funding for nonprofit organizations at high risk of terrorist attacks. With up to $2,400,000 available in 2025, individual awards can reach $200,000. This program focuses on enhancing security measures, closing capability gaps, and fostering collaboration among community representatives and government agencies. It aims to strengthen community preparedness through effective planning, training, and awareness campaigns, ensuring a comprehensive approach to safety and resilience.
Domestic / Homeland Security Nonprofit Growth & Development

Nonprofit Security Grant Program (NSGP) - Georgia

Georgia Emergency Management and Homeland Security Agency
State/Local Government
Georgia (US state)
Up to US $600,000
The Nonprofit Security Grant Program (NSGP) in Georgia, managed by the Georgia Emergency Management and Homeland Security Agency, aims to enhance the security of nonprofits at high risk of terrorist attacks. This program supports the development of security measures, addresses identified vulnerabilities, and fosters collaboration among community organizations and security agencies. By providing essential funding for equipment, training, and planning, NSGP strengthens the overall resilience of communities against extremist threats.
Domestic / Homeland Security Nonprofit Growth & Development

Nonprofit Security Grant Program (NSGP) - Idaho

Idaho Office of Emergency Management (IOEM)
State/Local Government
Idaho
Up to US $2,137,500
The Nonprofit Security Grant Program (NSGP) in Idaho provides crucial funding for nonprofits at high risk of terrorist attacks. With up to $2.1 million available in 2025, individual awards may reach $200,000. The program aims to enhance security through equipment upgrades and training, while fostering collaboration between nonprofits and local government agencies. This initiative is vital for improving community resilience and safeguarding vulnerable populations from evolving threats.
Domestic / Homeland Security Nonprofit Growth & Development

Center for Effective Districts

Texas Education Agency
State/Local Government
Texas
US $2,750,000
The Center for Effective Districts, overseen by the Texas Education Agency, aims to enhance public education by providing technical assistance to district leaders and education service centers. This initiative supports the implementation of the Texas Strategic Leadership program, embedding the Effective District Framework in district planning and performance management. The goal is to improve educational outcomes for all students in Texas by fostering effective district-level strategies and collaboration.
Civic Leadership Development

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.