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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

33,000+

Available grants

$8.25B

Total funding

$6K

Median grant

33,000+ grants
$8.25B total
$6K median

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32,595 Results based on applied filters

HAF: Impact Grants (Formerly Innovation Grant)

Hemophilia Alliance Foundation
Private
United States
Up to US $50,000
The Hemophilia Alliance Foundation's Impact Grants aim to support organizations enhancing services for individuals with inherited bleeding disorders. Since its inception in 2009, the foundation has awarded over $6.6 million, enabling innovative projects that expand capacity and collaboration. Eligible applicants include local organizations and federally-funded treatment centers, emphasizing creativity in project proposals. Priority will be given to initiatives that address unserved populations and foster educational advancements in the community.
Diseases & Conditions

Educators Professional Development Scholarship

Homer Foundation
Private
Kenai Peninsula Borough, Alaska
Unspecified amount
The Educators Professional Development Scholarship, established by the Homer Foundation, supports local public school educators seeking to enhance their skills and obtain continuing education credits. Eligible educators can use funds for class tuition, professional development supplies, transportation, and guest speakers. This initiative aims to empower educators within the community, ensuring they have access to essential resources for their professional growth.
Teacher Development & Training

LeMaster / Auvil Scholarship

Community Foundation of North Central Washington
Private
Whitman County, Washington
Unspecified amount

The Community Foundation of NCW is a tax-exempt philanthropic organization that helps individuals, families, businesses, and agencies support charitable causes throughout Chelan, Douglas, and Okanogan counties.

LeMaster / Auvil Scholarship

This scholarship was originally established in the early 1960s to honor the memory of Merceda LeMaster a teacher at the then one room Orondo School. The entire community of Orondo has contributed to the growth of this scholarship fund. Among those contributors were Grady and Lillie Auvil who, wanting to assure the scholarship continued in perpetuity, made provisions in their wills. The fund came to the Community Foundation in 2008 through the estate of Lillie Auvil. This scholarship supports graduating seniors from Chelan, Eastmont, or Waterville High School, with special emphasis on students who attended Orondo School. The committee seeks to award students who demonstrate financial need, leadership, academic potential, and participation in extracurricular activities.

Education - Higher Education

OREF Resident Clinician Scientist Training Grant

Orthopaedic Research and Education Foundation
Private
United States
Up to US $20,000
The OREF Resident Clinician Scientist Training Grant aims to prepare residents for research-intensive careers in orthopaedic surgery. Grants up to $20,000 are available for one year, covering research expenses without salary. Projects must demonstrate clinical relevance and be feasible for residents as independent studies. Both laboratory and clinical research are encouraged, with potential for publication. Progress reports and annual reviews are required to ensure funding compliance.
Orthopedics

Annetta Carter Memorial Fund Grants

California Botanical Society
Association/Society
Mexico
Up to US $1,000
The Annetta Carter Memorial Fund Grants support botanical research on the green plants of Baja California. Open to members of the California Botanical Society, proposals can include studies outside Baja that address relevant issues. The funding may cover research, travel, supplies, and minor equipment, with a budget limit of $1,000. Preference is given to applicants who secure necessary permits, especially foreign scientists collaborating with local experts. There is no fixed deadline for submissions.
Plant Science

Diane & Thomas Perry Scholarship

The Community Foundation Of Harrisonburg And Rockingham County
Private
Virginia
Unspecified amount

The Community Foundation of Harrisonburg & Rockingham County

At The Community Foundation of Harrisonburg & Rockingham County, we make it easy to give back to the community we all love through comprehensive and trusted charitable giving. We partner with donors, professional advisors and nonprofits to fund local needs through community endowments and support to charities. By expertly managing these funds in-house or with local financial advisors, we’re able to power the arts, faith-based initiatives, environmental grants, human services, domestic and wildlife animal organizations and educational initiatives that help to strengthen our community and make it a vibrant place to live and work. 

Diane & Thomas Perry Scholarship

This scholarship was established to support current graduating seniors from public high schools in the city of Harrisonburg, and the counties of Rockingham, Page and Shenandoah, who plan to attend a four-year Virginia public college or university to further their education.

This scholarship will be awarded to students planning to work toward a bachelor’s degree with a science/pre-med, business or education major. 

This scholarship is renewable.

Education - Higher Education

Maryland Victims of Crime Fund

Maryland Governor’s Office of Crime Prevention, Youth, and Victim Services
State/Local Government
Maryland
US $50,000 - US $75,000

Description

The Maryland Victims of Crime Fund, administered by the State Board of Victim Services under the authority of the Governor’s Office of Crime Prevention, Youth, and Victim Services, provides for advocacy and support services to victims of crime through the creation of new ideas and the enhancement of existing programs in Maryland.

History

The Maryland Victims of Crime Fund was created by the Maryland General Assembly during the 1991 Legislative Session. This legislation created a source of revenue for programs across Maryland serving victims of crime. The primary purpose of the Fund is to ensure implementation of the Declaration of Crime Victims’ Rights Amendment to the Maryland Constitution and the Federal Guidelines for treatment of and assistance to crime victims and witnesses, along with other laws adopted to benefit victims and witnesses of crime.

Crime Victim Services

Grace Ekman Whitley Scholarship

Community Foundation of North Central Washington
Private
United States
Unspecified amount

The Community Foundation of NCW is a tax-exempt philanthropic organization that helps individuals, families, businesses, and agencies support charitable causes throughout Chelan, Douglas, and Okanogan counties.

Grace Ekman Whitley Scholarship

Grace Ekman Whitley taught school in Leavenworth, Manson, Tonasket and Wenatchee High Schools. She had no children, but she loved the children in her classrooms as her own. This scholarship was established at the Community Foundation in order to support graduating seniors from Cascade, Manson, Tonasket and Wenatchee High Schools. Each year, the committee seeks to award students who demonstrate perseverance and commitment, work ethic, strong academic improvement, motivation, and who have overcome disadvantages.

Education - Higher Education

The Laura W. R. and George N. Appell Research Grants

The Firebird Foundation
Private
Maine
Up to US $40,000
The Laura W. R. and George N. Appell Research Grants, offered by The Firebird Foundation, support the preservation of oral literature and traditional ecological knowledge among indigenous communities. Established to honor the Appell couple's dedication to the Rungus Momogon of Sabah, Malaysia, these grants provide up to $40,000 for community-based projects. They encourage collaboration with community members to safeguard their cultural heritage and environmental knowledge, addressing the urgent need to document rapidly disappearing art forms.
Anthropology & Cultural Studies Linguistics

Arts Council of Anne Arundel County Strategic Impact Grant

Arts Council Of Anne Arundel County Inc
Private
Anne Arundel County, Maryland
US $5,000 - US $50,000

 Arts Council of Anne Arundel County

Our mission is to provide leadership, funding, and support that promotes artistic excellence and historic preservation and to advocate for resources and education that expand arts opportunities for all, helping to create an enriched and healthy community.

Strategic Impact Grant

This grant opportunity is focused on capacity building. It is designed to fund projects that result in substantive, organizational transformation, taking the organization’s operations or performance to the next level. 

Examples of potentially fundable requests could include, but are not limited to, capital projects, collection acquisitions, software investment, or other capacity-building expenses.

Nonprofit Growth & Development Arts / Culture Access & Participation

OREF Mentored Clinician Scientist Grant

Orthopaedic Research and Education Foundation
Private
United States
US $20,000
The Mentored Clinician Scientist Grant, funded by the Orthopaedic Research and Education Foundation, supports the career development of clinician scientists by providing dedicated research time for up to five years. Eligible applicants must have a proven track record in research, evidenced by receiving NIH K08 or K23 funding. This grant is renewable annually based on scientific progress and available funding, fostering a strong future in academic surgery.
Orthopedics

Silcon Carbide Cladding Lead Test Rod Development-Phase 1

United States Department of Energy (DOE)
Federal Government
American Samoa, Guam +4 more
Up to US $50,000,000
The Silicon Carbide Cladding Lead Test Rod Development-Phase 1 project aims to advance the use of silicon carbide cladding for nuclear fuel rods. It focuses on the research, development, and fabrication of cladding specimens for reactors, with testing planned for both unirradiated and irradiated samples. The project is poised to provide critical performance data for future commercial lead test rods, enhancing safety and efficiency in light water reactors.
Engineering Materials Science and Engineering Emerging Technology Development +1 more

Built to Learn Program

Interagency Commission on School Construction
Federal Government
Maryland
Unspecified amount

The IAC Mission

The mission of the Interagency Commission on School Construction is to achieve a safe, healthy, and educationally sufficient learning environment for every child attending a public school in Maryland. Our vision is a fiscally sustainable statewide portfolio of Pre-K-12 school facilities that will remain educationally sufficient for current and future generations of students and teachers.

Built to Learn Program

Purpose

Provides for up to $2.2 billion in school construction project funding through Maryland Stadium Authority (MSA) issued special revenue bonds and provides for management of the projects by MSA.

Minimum Project Cost: $4,000,000

Funding Allocation Methods

  • Calculated allocations based on estimated bond proceeds are set for Anne Arundel County, Baltimore City, Baltimore County, Frederick County, Howard County, and Montgomery County.
  • The other 17 LEAs share the remainder of the allocations, capped in proportion to their September 2019 enrollments.
  • Maximum State Allocation is established for individual projects.
  • Funding allocations must be used within 10 years of award.

State/Local Participation: State/Local cost share % applied

Education - K through 12

VCA: Teaching Artist Roster

Virginia Commission for the Arts
State/Local Government
Virginia
Unspecified amount
The VCA Teaching Artist Roster aims to identify and support qualified Teaching Artists for educational and community programs. This online resource provides access for organizations seeking professional artists experienced in diverse teaching methodologies. Eligible applicants include individual artists and nonprofit organizations, emphasizing artistic and instructional excellence. The program promotes innovative collaborations in the arts while ensuring a commitment to effective teaching practices. It is a valuable tool for enhancing educational impact through the arts.
Art Education

Charter School Facility Grant Program – (SB740)

California State Treasurer's Office
State/Local Government
California
Unspecified amount
The Charter School Facility Grant Program (SB740) aims to provide financial assistance for charter school facilities, specifically targeting schools that enroll a significant percentage of students eligible for free or reduced-price meals. This program, now managed by the California School Finance Authority, offers annual grants to help offset facility costs. Funding availability is announced annually on the CSFA website, ensuring support for schools in need of financial aid for their operational expenses.
Education - K through 12

The Local Preservation Partners Grant

Connecticut Department of Economic and Community Development
State/Local Government
Connecticut
US $5,000 - US $100,000
The Institutional Support for Capacity Building Grant for Historic Preservation Nonprofits, offered by the Connecticut Department of Economic and Community Development, aims to enhance the operational capacity of local nonprofit historic preservation organizations. This grant provides funding based on organizational budgets, ranging from $5,000 to $50,000 per year. By fostering greater stability and capabilities, the program supports the effective management and planning of historic preservation initiatives, ultimately benefiting the communities these organizations serve.
Historic Preservation

ASPCA Shelter Grants: Critical Shelter Infrastructure

American Society for the Prevention of Cruelty to Animals (ASPCA)
Private
United States
US $25,000 - US $100,000

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

  • Critical shelter infrastructure
  • Strengthening shelter essentials
  • Increasing the number of spay/neuter surgeries year-over-year 
  • Major capital projects that increase spay/neuter capacity
  • Special projects that increase spay/neuter capacity

Shelter Grants

Critical Shelter Infrastructure

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

Animal Welfare - Domestic Animals & Pets

RFP for Library Needs Assessment and Facility Planning Services

San Mateo County Libraries
State/Local Government
San Mateo County, California
Unspecified amount

San Mateo County Libraries

San Mateo County Libraries have been an integral part of its diverse community for over a century. Originally established by the San Mateo County Board of Supervisors in 1912 as a County Free Public Library, the San Mateo County Library Joint Powers Authority (JPA) was established in 1999. The Library JPA is comprised of the cities of Atherton, Belmont, Brisbane, East Palo Alto, Foster City, Half Moon Bay, Millbrae, North Fair Oaks, Pacifica, Portola Valley, San Carlos, Woodside, and the unincorporated areas of the county. The Library JPA is a separate, independent entity with its own Governing Board, consisting of elected officials from each member entity. An Operations Committee composed of City and County representatives from each member entity also provides guidance.

San Mateo County Libraries provide unmatched service to our community members, and we are consistently ranked as one of the best libraries in the nation. Developed through recent strategic planning work, our vision is to ignite growth through transformative experiences, and it is our mission to strengthen our communities by creating an inclusive sense of place and an environment of learning.

RFP for Library Needs Assessment and Facility Planning Services

San Mateo County Libraries (“Library”) seeks proposals from qualified firms or consultants in response to this Request for Proposals (RFP) to provide planning and assessment services for one or more of the following projects:

  • Woodside Library Needs Assessment
  • North Fair Oaks Library Needs Assessment
  • Administration Building Facility Needs Assessment

Through these projects, the Library seeks to evaluate current conditions, identify current and future service and facility needs, and develop recommendations to inform future planning, capital investment, and operational decision-making.

Library & Information Science Library Services

Ellis W. Rowe Memorial Scholarship

Hampton Roads Community Foundation
Private
Chesapeake City, Virginia, Isle of Wight County, Virginia +4 more
US $400 - US $6,000
The Ellis W. Rowe Memorial Scholarship, managed by the Hampton Roads Community Foundation, supports students from South Hampton Roads pursuing higher education. Established to aid those in financial need, this scholarship has awarded over $20 million since 1950. Applicants must be U.S. citizens or permanent residents, demonstrate financial need, and enroll full-time in a four-year accredited college. Award amounts range from $400 to $6,000, depending on available funds and individual circumstances.
Academic Scholarship Programs

American Association for Anatomy: Short-Term Visiting Scholarship

American Association For Anatomy
Private
Bernalillo County, New Mexico
US $1,000

About Us

The American Association for Anatomy (AAA) is the professional home for more than 2,000 students, teachers, and practitioners of the anatomical sciences.

Short-Term Visiting Scholarship

Provides travel expenses for members to facilitate visiting a laboratory or participating in a course outside their home institution.

Anatomy

ALSCW Dissertation Fellowship

Association of Literary Scholars, Critics, and Writers Inc
Private
West Virginia
Unspecified amount
The ALSCW Dissertation Fellowship supports scholars whose doctoral dissertations focus on literary history and aesthetics. It offers a three-week residency in a fully equipped cabin in West Virginia, providing an ideal environment for writing and research. The fellowship encourages applicants to submit their cover letters, CVs, dissertation chapters, and letters of recommendation. Preference is given to candidates with advanced-stage dissertations, fostering a community that values diverse literary perspectives.
Writing & Literature

Glen Hawk Sr. Endowed Scholarship Fund

Community Foundation of the North State
Private
United States
Unspecified amount

Community Foundation of the North State

The Community Foundation builds trust through relationship, integrity, and by providing safe places for donors to give their resources.

We are a nonprofit, public charity serving the people of Shasta, Siskiyou and Tehama counties, with a mission to impact the region through the power of giving.

Scholarships

The Community Foundation of the North State manages many scholarship funds that are awarded to graduating high school seniors as well as students already in an undergraduate program. Some scholarships were started by families or individuals; others by businesses or organizations. All scholarships share one important focus: helping young people reach their educational goals.

Glen Hawk Sr. Endowed Scholarship Fund

This scholarship benefits a Shasta County graduating high school senior who is pursuing a vocational or technical certification at an accredited technical school or community college.

The Glen Hawk Sr. Endowed Scholarship Fund was established by Helen Hawk, in memory of her husband. Glen Hawk Sr. served on the Shasta High School Board of Directors from 1979-1989.

Vocational & Trade Education

Henry Gray Distinguished Educator Award

American Association For Anatomy
Private
Multnomah County, Oregon
US $2,000
The Henry Gray Distinguished Educator Award, presented by the American Association for Anatomy, recognizes exceptional contributions in human anatomy education across various formats, including gross anatomy and embryology. This prestigious award is open to full-time or emeritus faculty who are current AAA members. Nominees must submit a nomination form along with letters of recommendation. The award includes a $2,000 travel stipend for attending the AAA Annual Meeting, supporting educators dedicated to advancing anatomical sciences.
Anatomy

CfA Postdoctoral Fellowship

Smithsonian Institution (SI)
Federal Government
Middlesex County, Massachusetts
Unspecified amount
The CfA Postdoctoral Fellowship at the Smithsonian Astrophysical Observatory offers a three-year program for emerging astrophysics researchers, with a potential fourth-year renewal. The fellowship provides a stipend of $81,500, an annual research budget of $18,000, and comprehensive health benefits. Eligible candidates should have less than two years of post-PhD research experience, with an emphasis on outstanding research skills in various astrophysical fields. This opportunity is open to English-speaking applicants from all nations.
Astronomy & Astrophysics

Smithsonian Astrophysical Observatory Predoctoral Fellowship Program

Smithsonian Institution (SI)
Federal Government
Middlesex County, Massachusetts
Unspecified amount
The Smithsonian Astrophysical Observatory Predoctoral Fellowship Program offers an enriching opportunity for graduate students in astronomy-related fields. Established in 1985, it enables students to conduct research under the guidance of experienced SAO scientists. The fellowship lasts six months or longer, with compensation starting at $42,588 annually, increasing to $49,000 from July 2024. Applicants must be enrolled in a full-time Ph.D. program and ready for dissertation research, ensuring a robust academic experience.
Astronomy & Astrophysics

Youth Advisory Council (YAC) Regular Grants

Barry Community Foundation
Private
Barry County, Michigan
Up to US $3,000
The Youth Advisory Council (YAC) Regular Grants, provided by the Barry Community Foundation, aim to fund initiatives that significantly benefit the youth in Barry County, Michigan. Grants up to $3,000 are available, with proposals due on March 15th and October 15th. Additionally, mini grants of up to $300 can be submitted year-round. This program empowers local youth by requiring that grant applications be written by youth members of their organizations, fostering leadership and community engagement.
Youth Services

Shelby County Trailblazer Scholarship

The Community Foundation of Louisville
Private
Shelby County, Kentucky
US $6,000

Community Foundation of Louisville

Founded in 1984, the Community Foundation of Louisville mobilizes people, networks, and capital to spark meaningful change in and beyond Louisville. Just as our name signifies, here, community comes first. With over $874 million in assets, over 2,200 charitable funds, and collaborations with hundreds of local partners, we connect real investments with relevant causes. The Foundation has addressed and continues to address a wide range of community needs. The key priorities of the Foundation’s mission are to remove barriers to accessing capital and resources and to open opportunities for all. Working with neighbors, changemakers, and community investors, we’re inspiring greater generosity to move us all forward.

Scholarships

Since 1984, the Community Foundation of Louisville has provided tens of millions of dollars in scholarships to support students with their educational goals. We assist donors in establishing scholarship funds so that a quality education can be available for everyone.

Shelby County Trailblazer Scholarship

The Shelby County Trailblazer Scholarship is designed to provide scholarship assistance in the form of grants to help defray post-secondary educational expenses of students graduating from public high schools in Shelby County, Kentucky who are the first in their family to attend post-secondary education institutions. Recipients of this scholarship are Trailblazers because if they come from a home where attending college may not be expected or considered possible, their motivation to be the first requires tremendous drive and determination.

Education - Higher Education

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.