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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

32,000+

Available grants

$8.25B

Total funding

$6K

Median grant

32,000+ grants
$8.25B total
$6K median

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32,483 Results based on applied filters

Drug Discovery Predoctoral Fellowship

Pharmaceutical Research And Manufacturers Of America Fnd Inc (PhRMA)
Private
United States
Up to US $60,000
The Drug Discovery Predoctoral Fellowship by the PhRMA Foundation supports PhD candidates engaged in thesis research in drug discovery. This fellowship offers $30,000 annually for 12 to 24 months, encouraging innovative research that integrates multiple scientific disciplines. Applicants must be full-time, in-residence students at accredited U.S. universities and have completed significant coursework. The funding is conditional upon continued enrollment and is intended for stipend support, with some funds allowable for research-related incidentals.
Pharmacology

Drug Delivery Predoctoral Fellowship

Pharmaceutical Research And Manufacturers Of America Fnd Inc (PhRMA)
Private
United States
Up to US $60,000
The Drug Delivery Predoctoral Fellowship by the PhRMA Foundation supports promising PhD candidates in drug delivery research at accredited U.S. universities. It provides $30,000 per year for 12 to 24 months, aimed at enhancing the understanding of drug formulation and delivery technologies. The fellowship emphasizes innovative research that leads to improved patient outcomes and fosters collaboration among diverse research teams, ensuring that all individuals have access to groundbreaking medicines.
Pharmacology

Drug Delivery Postdoctoral Fellowship

Pharmaceutical Research And Manufacturers Of America Fnd Inc (PhRMA)
Private
United States
Up to US $120,000
The PhRMA Foundation offers a Drug Delivery Postdoctoral Fellowship aimed at fostering biopharmaceutical innovation and enhancing research capabilities in drug delivery. This fellowship supports both U.S. and non-U.S. citizens who are involved in collaborative research training at accredited U.S. universities. Awardees receive a stipend of $60,000 per year for 12 to 24 months, with funding contingent on ongoing employment in the postdoctoral program. Ideal candidates are encouraged to expand their skills in new research environments.
Pharmacology

Drug Discovery Postdoctoral Fellowship

Pharmaceutical Research And Manufacturers Of America Fnd Inc (PhRMA)
Private
United States
Up to US $120,000
The Drug Discovery Postdoctoral Fellowship by the PhRMA Foundation supports researchers in a multidisciplinary training program at accredited U.S. universities. Aimed at enhancing credentials in drug discovery, it funds innovative research with potential human applications. Proposals should focus on biological validation of drug targets across various scientific disciplines. The fellowship provides $60,000 in annual stipend support for up to 24 months, contingent on the awardee's continued employment at the university.
Pharmacology

William “Bill” J. Brooks Memorial Fund Grant

Shiawassee Community Foundation
Private
Shiawassee County, Michigan
Unspecified amount
The William “Bill” J. Brooks Memorial Fund Grant, established in 2021, aims to support community beautification projects in Shiawassee County. This grant honors the legacy of Bill Brooks, a dedicated community member and U.S. Navy veteran, who was passionate about enhancing his hometown of Owosso. Eligible non-profits can apply for funding to implement projects such as tree and flower planting, community gardens, and educational programs, fostering a vibrant and sustainable environment.
Greening & Beautification

Houston Affiliate Grantmaking Program

Community Foundation of the Ozarks Inc.
Private
Texas County, Missouri
Up to US $750
The Houston Affiliate Grantmaking Program, supported by the Community Foundation of the Ozarks, aims to enhance the quality of life for Houston residents through impactful grantmaking. Eligible applicants include 501(c)(3) organizations and other IRS-approved entities serving the city. Organizations can apply for funding up to $1,300 to support their initiatives and community projects. This program emphasizes collaboration and leadership to foster community growth and development.
Economic Services & Development

Nancy Armbrust Impact Award

Greater Green Bay Community Foundation
Private
Brown County, Wisconsin, Kewaunee County, Wisconsin +2 more
US $5,000
The Nancy Armbrust Impact Award, presented by Schreiber Foods Foundation, honors women who significantly enhance community life. With a $5,000 grant for a nonprofit of the recipient's choice, the award empowers initiatives supporting women and girls. Recipients are recognized at the Women's Fund event around International Women's Day. This annual award celebrates Nancy Armbrust's legacy as a dedicated community leader, encouraging others to inspire and uplift women in their communities.
Women & Girl Services

Canine Healthcare Fund Grant

National Disaster Search Dog Foundation
Private
United States
Up to US $1,000
The Canine Healthcare Fund Grant provides vital medical coverage for SDF-trained canines throughout their lives, ensuring they receive top-notch veterinary care at no expense to their handlers or agencies. Additionally, it extends support to non-SDF-trained handlers of active and retired disaster search canines, covering veterinary costs for wellness, illness, and injury not funded by their organizations. Each handler may receive up to $1,000 annually to help manage these essential healthcare expenses.
Animal Welfare - Domestic Animals & Pets

CIS NAV Application Development Grant

Texas Education Agency
State/Local Government
Texas
US $200,000
The CIS NAV Application Development Grant, administered by the Texas Education Agency, aims to enhance student support data management for Communities In Schools (CIS) affiliates throughout Texas. The grant will fund the creation of a secure, cloud-based application that facilitates real-time access to student data, improving operational efficiency and allowing CIS staff to concentrate on delivering direct support to students. This initiative will significantly reduce administrative burden and streamline processes.
Education Computer Science & Engineering

SMAC: Artist Growth Grants

Southwest Minnesota Arts Council
Private
Big Stone County, Minnesota, Chippewa County, Minnesota +16 more
Up to US $4,000
The SMAC Artist Growth Grants support artists at any career stage in the SW MN region, promoting artistic development and audience expansion. Grants of up to $4,000 cover costs such as supplies, mentorship, workshops, and studio rentals. Eligible applicants must be permanent residents of the area, at least 18 years old, and may have only one pending application at a time. Ineligible projects include those lacking an art focus or tied to for-profit activities.
Artist Training & Development

SUS: Mid Career Award

Society of University Surgeons
Private
Canada, United States
US $40,000
The SUS Mid Career Award offers $40,000 for one year to SUS members in the US or Canada with prior research funding, supporting their ongoing work in surgical sciences. Eligible applicants must have experience as a principal investigator on independent or smaller grants, or hold a career development award. This award serves as bridge funding for those who have recently applied for independent grants but were not funded, fostering continued research and innovation.
Surgery

Cyberinfrastructure for Sustained Scientific Innovation (358751)

National Science Foundation (NSF)
Federal Government
United States
US $600,000 - US $5,000,000
The Cyberinfrastructure for Sustained Scientific Innovation (CSSI) program by the National Science Foundation aims to provide flexible funding opportunities to address evolving needs in cyberinfrastructure. It supports various award classes, including Elements for small groups, Framework Implementations for larger interdisciplinary teams, and Transition to Sustainability for established CI projects. These initiatives focus on developing integrated CI services, ensuring sustainable impact, and promoting collaboration across scientific disciplines to enhance research and innovation.
Cyberinfrastructure

Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (R03 Clinical Trial Optional) (351101)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $100,000
The Limited Competition Small Grant Program supports NCATS CTSA Program KL2 scholars, enhancing their transition to independent academic translational scientists. This R03 funding facilitates various research projects, including pilot studies and methodology development, aimed at generating preliminary data for future R01 applications. The program is designed for short-term projects utilizing limited resources, promoting innovative research in clinical and translational science.
Health & Medicine Biology

IU Health Values Fund Grant Pilot & Feasibility Program: Research

Indiana Clinical and Translational Sciences Institute (CTSI)
Association/Society
Indiana
Up to US $50,000
The IU Health Values Fund Grant Pilot & Feasibility Program supports early-career researchers in advancing their careers and securing funding. It emphasizes pilot clinical trials that align with IU Health's core values: purpose, excellence, compassion, and teamwork. This program is designed to benefit patients in the IU Health system by fostering innovative research that meets medical and scientific standards, ultimately contributing to the improvement of healthcare outcomes.
Diseases & Conditions

IDeA Networks of Biomedical Research Excellence (INBRE)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
Alaska, Arkansas +22 more
Unspecified amount
The IDeA Networks of Biomedical Research Excellence (INBRE) program aims to enhance biomedical research capacity in underfunded states by fostering collaborations among research institutions. By supporting faculty research, mentoring, and student involvement, INBREs create pathways for undergraduate students to enter biomedical careers. This initiative not only promotes institutional partnerships but also strengthens research infrastructure, ultimately contributing to a more robust scientific community in IDeA states.
Biology Health & Medicine

Trainee Investigator Award

American Academy Of Sleep Medicine Foundation
Private
United States
US $500 - US $1,000
The Trainee Investigator Award, offered by the AASM Foundation, recognizes outstanding research presented by AASM Student/Resident Members at the SLEEP annual meeting. This prestigious award includes a $1,000 prize for the top candidate, along with three honorable mentions each receiving $500. It aims to promote the professional growth of early-career researchers in sleep medicine, encouraging innovative contributions to the field. Nominations require submitting an abstract for the SLEEP 2026 meeting.
Sleep

YoungArts National Competition

YoungArts (National Foundation For Advancement In The Arts Inc.)
Association/Society
United States
US $250 - US $10,000
The YoungArts National Competition, established in 1981, supports exceptional young artists aged 15-18 in the U.S. through a competitive application process. Winners receive financial awards up to $10,000, mentorship from renowned artists, and lifelong artistic support. This prestigious program allows participants to affirm their identity as artists while gaining access to a robust network of peers and mentors, exclusive opportunities, and national recognition, making it a vital stepping stone in their creative journeys.
Arts / Culture Access & Participation

Community Based Substance Use Disorders Services Access

North Carolina Department of Health and Human Services (NCDHHS)
State/Local Government
North Carolina
Up to US $500,000
The North Carolina Department of Health and Human Services (NCDHHS) is offering grants for community-based services targeting substance use disorders. This initiative aims to expand access to essential services while addressing gaps in care across the state. Eligible organizations can apply for project budgets up to $500,000 annually, with at least 12 contracts expected to be awarded. The funding supports prevention, treatment, and support services to enhance the health and wellbeing of North Carolinians.
Addiction & Substance Use Disorders

PLTW Gateway- New Program ( Georgia)

Project Lead the Way inc.
Private
Cherokee County, Georgia, Clayton County, Georgia +8 more
Up to US $20,000
The PLTW Gateway - New Program in Georgia offers public and charter schools the chance to implement Project Lead the Way's innovative curriculum. Eligible schools can apply for a total of $20,000, distributed over two years, to support the introduction of PLTW Gateway units. Schools are required to offer at least one unit in the 2026-2027 academic year and an additional unit in the following year, enhancing STEM education for students.
Education - K through 12 Curriculum Development

PLTW Gateway- Program Expansion ( Georgia)

Project Lead the Way inc.
Private
Cherokee County, Georgia, Clayton County, Georgia +8 more
US $10,000
The PLTW Gateway Program Expansion in Georgia aims to support public and charter schools in expanding their existing PLTW Gateway programs. Eligible schools must be located in specific Georgia counties, and the total grant award is $10,000 for the 2026-2027 period. Funds can cover participation fees, required technology, and training-related costs, while salaries, benefits, and other non-allowable expenses are excluded. This initiative promotes STEM education in the region.
Education - K through 12 Curriculum Development

Historic Preservation Certified Local Government Grant

State of New Jersey Department of Environmental Protection
State/Local Government
New Jersey
US $15,000 - US $50,000
The Historic Preservation Certified Local Government Grant, administered by the New Jersey Department of Environmental Protection, aims to enhance local historic preservation efforts. This program supports local governments in identifying significant historic resources and implementing protective measures. By providing financial and technical assistance, it fosters broad participation in preserving the state's rich heritage, ensuring that significant sites are recognized and safeguarded for future generations.
Historic Preservation

American Society of Biomechanics: Student Travel Awards

The American Society of Biomechanics
Private
Allegheny County, Pennsylvania
Unspecified amount in in-kind support
The American Society of Biomechanics offers Student Travel Awards to facilitate the attendance of student members at its annual meeting. These awards include complimentary registration for eligible students who have authored accepted abstracts for presentation. This initiative aims to promote the exchange of ideas among students and professionals in biomechanics and related fields, enhancing their academic and professional development through participation in this important event.
Biomechanics

Grassroots Grants Program (GGP)

American Golf Industry Coalition
Association/Society
United States
Unspecified amount
The Grassroots Grants Program (GGP) aims to enhance participation in golf among underrepresented communities, including racial minorities, women, and veterans. Launched in May 2021, it has awarded $1.8 million to 155 organizations, promoting diversity, equity, and inclusion in the sport. The program supports tax-exempt organizations focused on self-sustainability and offers funding for golf instruction, equipment, and access to facilities. Priority is given to those not receiving substantial backing from major golf organizations.
Diversity, Equity & Inclusion Golf

Travel Reimbursements

Idaho Stem Action Center Foundation
Private
Idaho
Unspecified amount
Travel reimbursements are available for individuals attending approved STEM AC events. Participants will receive a reimbursement link via email after their attendance is confirmed. It is essential to complete the required forms and attach necessary documents promptly to avoid delays. Familiarize yourself with the reimbursement limits and policies of both STEM AC and Idaho. Payments may take up to 30 days after submission, ensuring timely responses to any inquiries.
STEM / STEAM Education

i-STEM Instructor Stipend

Idaho Stem Action Center Foundation
Private
Idaho
More than US $2,000
The i-STEM Instructor Stipend offers an exciting opportunity for educators and industry professionals to collaborate in enhancing STEM education in Idaho. Participants will lead a 4-day workshop, delivering hands-on instruction and creating materials kits for educators. Instructors will receive a $2000 stipend, travel reimbursement, and support for substitute costs, while assistants from Idaho's education sector can also receive stipends. This initiative aims to connect classroom learning with real-world applications.
STEM / STEAM Education

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.