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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

33,000+

Available grants

$8.25B

Total funding

$6K

Median grant

33,000+ grants
$8.25B total
$6K median

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32,595 Results based on applied filters

VCA General Operating Support: Medium and Large Arts Organizations

Virginia Commission for the Arts
State/Local Government
Virginia
More than US $5,000
The VCA General Operating Support program provides vital funding for medium and large arts organizations in Virginia, aimed at supporting their operational needs. Eligible organizations must have a minimum cash income of $150,000 from the previous year and meet specific criteria to ensure they can deliver quality arts programming. This funding aims to strengthen the cultural fabric of Virginia by enabling these organizations to expand and enhance their services for the community.
Art Education Music Education Public / Community Art +5 more

NIHCM Foundation: Investigative and General Reporting Award

The National Institute for Health Care Management
Private
United States
US $20,000
The NIHCM Foundation Investigative and General Reporting Award honors outstanding reporting that enhances understanding of U.S. health care affordability and quality. A $20,000 prize is awarded to the winner, with entries evaluated for quality, originality, and impact. Eligible submissions include stories published in 2025 from national outlets, focusing on insightful reporting that informs health care policymakers and consumers about rising costs and access solutions.
Health Care Access & Delivery Health Policy & Advocacy Health Insurance +3 more

SAF National Awards Program: Carl Alwin Schenck Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $500
The Carl Alwin Schenck Award, presented by the Society of American Foresters, honors exemplary contributions in forestry education. This prestigious award recognizes individuals with at least ten years of professional experience who demonstrate outstanding teaching abilities and commitment to forestry. Awardees receive a $500 honorarium, complimentary registration for the SAF national convention, and up to $500 for travel expenses. This award underlines the importance of effective education in advancing sustainable forestry practices.
Forestry Education - Higher Education

Building Hope: Future Forward Schools Prize & Fellowship Program

Building Hope
Private
United States
US $50,000
The Building Hope: Future Forward Schools Prize & Fellowship Program aims to enhance career exploration for middle and high school students. This initiative, launched by Building Hope in partnership with American Student Assistance, recognizes schools that excel in career-connected learning. Awardees receive funding, mentorship, and resources to empower students from diverse backgrounds, ensuring they develop essential skills for future success. With $50,000 available for five schools, this program fosters innovation and prepares students for a changing economy.
Education - Middle School Education - High School Academic Success & Enrichment +1 more

Wayne Rush Scholarship

Montgomery County Community Foundation Inc.
Private
Montgomery County, Indiana, Tippecanoe County, Indiana
Unspecified amount
The Wayne Rush Scholarship, established in memory of Wayne Rush, supports North Montgomery High School graduates pursuing agriculture studies at Purdue University. This scholarship reflects Wayne's commitment to community service and agriculture, offering financial assistance to eligible students who demonstrate need. Priority is given to those involved in 4-H. The scholarship is available annually, contingent on funding, ensuring that future generations can benefit from Wayne's legacy of education and community engagement.
Academic Scholarship Programs Educational Access & Equity Education - Higher Education +3 more

Tick-borne Pathogen Award

Bay Area Lyme Foundation
Private
United States
US $150,000
The Tick-borne Pathogen Award, sponsored by Bay Area Lyme Foundation, offers $150,000 to support innovative research on non-Borrelia tick-borne pathogens. This grant aims to attract scientific talent to explore co-infections with Lyme disease and other related infections. Eligible candidates include researchers from academia or the private sector at the post-doctoral level or higher, with a focus on improving diagnostics and therapies for tick-borne diseases. Applications must present a viable proof-of-concept project.
Microbiology Infectious & Parasitic Diseases Lyme Disease +1 more

Aflac Charitable Fund Competitive Grant

Central Carolina Community Foundation
Private
Calhoun County, South Carolina, Clarendon County, South Carolina +9 more
US $1,000 - US $10,000
The Aflac Charitable Fund Competitive Grant supports local nonprofit organizations in South Carolina, focusing on health and education. Priority is given to programs aiding pediatric cancer patients and their families, as well as life skills initiatives. Organizations must comply with state regulations and can only submit one application per cycle. Previous applicants can reapply in future cycles, but declined applications do not carry over automatically. This initiative is managed by the Central Carolina Community Foundation.
Education Health & Medicine Pediatric Cancers +3 more

SAF National Awards Program: Student Leadership Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $500
The SAF National Awards Program recognizes exceptional student leaders in forestry. The Student Leadership Award honors an SAF student member demonstrating leadership skills at various levels. Recipients receive a $200 honorarium, complimentary convention registration, and up to $500 for travel expenses. Additionally, the recipient's faculty advisor and SAF Student Chapter benefit from $150 each. This award aims to encourage student engagement and excellence in sustainable forestry and resource management.
Forestry Education - Higher Education

Dr. Carol J. Chrisman Nursing Scholarship

Ashland County Community Foundation
Private
United States
Unspecified amount
The Dr. Carol J. Chrisman Nursing Scholarship, offered by the Ashland County Community Foundation, supports registered nurses and nursing students from Ashland County pursuing advanced degrees at Ashland University. This scholarship honors Dr. Chrisman's legacy in nursing and community health, encouraging local nurses to further their education. Eligible applicants include full-time nursing students and those employed in public health within the area, with prior recipients allowed to reapply once.
Education - Higher Education Career / College Preparation Education - High School +3 more

Big Bald Dave Adventure Scholarship

Yellowstone Club Community Foundation
Private
United States
Unspecified amount
The Big Bald Dave Adventure Scholarship, provided by the Yellowstone Club Community Foundation, honors Dave Mueller's passion for outdoor adventure. It offers a unique summer trip for Big Sky students in grades 9-11 who demonstrate leadership and a love for the outdoors. Supported by Adventures Cross Country, this scholarship is a wonderful opportunity for students to engage in enriching experiences while giving back to the community. Notably, it is not based on financial need.
Academic Success & Enrichment Education - High School Student Retention & Drop-Out Prevention +2 more

Community Development Block Grant (CDBG)

Georgia Department of Community Affairs
State/Local Government
Georgia (US state)
Up to US $1,250,000
The Community Development Block Grant (CDBG) program, administered by the Georgia Department of Community Affairs, supports diverse community projects aimed at improving housing, public facilities, and economic development. This initiative is designed to benefit low and moderate-income individuals, ensuring that essential services and opportunities are available to those in need. By fostering local development, CDBG plays a critical role in enhancing community growth and prosperity across Georgia.
Equitable & Affordable Housing Sanitation & Clean Drinking Water Economic Services & Development +1 more

Brave Beginnings Grants

Will Rogers Motion Picture
Private
United States
Unspecified amount
Brave Beginnings Grants, under the Will Rogers Motion Picture Pioneers Foundation, focus on enhancing neonatal care by providing vital equipment to hospitals. Since 2006, the program has awarded approximately $1 million annually to Neonatal Intensive Care Units (NICUs) across the U.S. Following a suspension due to COVID-19, the 2026 grant cycle is now open, with applications due by February 13, 2026. This initiative aims to ensure the availability of lifesaving equipment for newborns in critical need.
Obstetrics & Neonatal Care Children’s Health & Pediatrics

Variety Sunshine Coach Grant Program

Variety the Children's Charity of Southern California
Private
Imperial County, California, Kern County, California +8 more
Unspecified amount
The Variety Sunshine Coach Grant Program aids children with special needs in Southern California by providing essential resources for mobility, education, and healthcare. Celebrating over 30 years, this initiative offers specially equipped Sunshine Coaches to transport children to necessary services. Organizations must be 501(c)(3) and demonstrate a commitment to serving children aged 0-18. By removing barriers, the program ensures inclusivity and opportunity for every child in the community.
Child Care Services Children’s Mental Health Children’s Health & Pediatrics +1 more

Community Fund for Women & Girls Pathways for Women & Girls Program Grant

Community Foundation for Greater New Haven
Private
Fairfield County, Connecticut, New Haven County, Connecticut
Up to US $15,000
The Community Foundation for Greater New Haven offers grants up to $15,000 through the Community Fund for Women & Girls. This initiative aims to enhance economic security for women by supporting nonprofits focused on workforce training, entrepreneurship, housing stability, and innovative childcare solutions. Eligible organizations must serve the Greater New Haven area and comply with tax-exempt status requirements. Priority is given to programs that provide wraparound services to ensure comprehensive support for women in need.
Women & Girl Services Women's Rights & Equality Women's Health +2 more

Mielke Family Foundation Grant

Community Foundation for the Fox Valley Region
Private
Calumet County, Wisconsin, Outagamie County, Wisconsin +2 more
Up to US $10,000
The Mielke Family Foundation Grant supports innovative educational initiatives that enhance the lives of individuals in the Appleton and Shawano areas, focusing on health care, arts, and intergenerational programs. Established in 1963, the foundation prioritizes projects that reflect community demographics and foster collaboration. Grants are awarded annually through a responsive cycle, emphasizing proposals that engage local individuals, particularly in the fields of youth development and aging. The foundation actively seeks to empower its communities through education and creativity.
Community Health Education Art Education Senior Services +5 more

Region 12 Opioid Abatement Council Emergency Fund

Douglas County Community Foundation
Private
Douglas County, Colorado
US $20,000 - US $100,000
The Region 12 Opioid Abatement Council Emergency Fund aims to support organizations focused on opioid and substance use disorder (OUD/SUD) prevention, intervention, treatment, recovery, or harm reduction. Eligible applicants include non-profits, governmental bodies, academic institutions, healthcare providers, and businesses. This funding addresses financial hardships caused by unexpected budget shortfalls or increased service demand due to crises in the community, ensuring continued support for those affected by OUD/SUD.
Addiction & Substance Use Disorders Drug Use Disorder

Community Charter Network Scholarship

Central Indiana Community Foundation
Private
United States
Unspecified amount
The Community Charter Network Scholarship, provided by the Central Indiana Community Foundation, assists students from Fall Creek Academy or University Heights Preparatory Academy in covering post-secondary educational expenses. This scholarship aims to support those who demonstrate financial need and excel academically. Eligible applicants include former students of these institutions or residents within the IPS district. Awards vary based on available funds and may cover tuition, fees, and other educational costs.
Education - Higher Education Vocational & Trade Education Academic Scholarship Programs +3 more

Mosaic Opioid Recovery Municipal Matching Grant

Massachusetts Department of Public Health’s Bureau of Substance Addiction Services (BSAS)
State/Local Government
Massachusetts
Up to US $150,000
The Mosaic Opioid Recovery Municipal Matching Grant aims to distribute $3.75 million to municipalities in Massachusetts over three years, supporting initiatives to address the opioid crisis. Funded by RIZE, the program matches municipal opioid settlement funds to enhance community efforts in prevention, harm reduction, and recovery services. Eligible projects can receive up to $50,000 individually or $150,000 through collaborative efforts, fostering partnerships among municipalities and nonprofit organizations to improve public health outcomes.
Addiction & Substance Use Disorders Drug Use Disorder

Thorpe Foundation Grants: Support For Youth Grant

James R. Thorpe Foundation
Private
Hennepin County, Minnesota
Unspecified amount
The James R. Thorpe Foundation provides support for youth-focused organizations in Minneapolis, prioritizing those that serve low-income communities. With a commitment to fostering self-awareness, academic skills, and artistic engagement, the Foundation aims to assist youth aged 12 to 18 in their transition to adulthood. Grants are typically awarded for general operating costs or program support, ensuring impactful aid reaches smaller nonprofits with budgets under $3 million.
Academic Success & Enrichment After School / Summer Educational Programs Youth Development & Leadership +2 more

Andrew F. Evans Memorial Scholarship

Montana State University
State/Local Government
Montana
Unspecified amount
The Andrew F. Evans Memorial Scholarship, offered by Montana State University, supports full-time seniors in the School of Film and Photography pursuing the Film Option or Integrated Lens-Based Media program. Applicants must maintain a minimum 3.0 GPA overall and a 3.25 GPA in their major, demonstrating strong commitment to a career in cinematography. This scholarship aligns with MSU's mission to foster innovation and prepare graduates for impactful careers in the arts.
Education - Higher Education Film Career / College Preparation +2 more

NTCF Toolbox Grants

North Texas Community Foundation
Private
Tarrant County, Texas
US $20,000 - US $50,000
The NTCF Toolbox Grants support Tarrant County-based nonprofits by providing capacity building resources focused on fundraising and strategic planning. These transformative grants aim to enhance organizational stability and effectiveness in serving vulnerable communities facing poverty, poor health, and educational challenges. Eligible nonprofits must be 501(c)(3) organizations with a minimum operating budget of $50,000 and demonstrate impact in areas like education and housing. Note: An LOI is required before full proposal submission.
Education Employment Services Health & Medicine +2 more

Children's Fund Charity Selection

The Children’s Fund, Inc
Private
Austin County, Texas, Brazoria County, Texas +7 more
US $20,000 - US $25,000
The Children's Fund, Inc. is a volunteer-driven organization that raises funds to support children's charities in the Houston area. Grants typically range from $20,000 to $25,000, targeting specific needs such as equipment or training rather than general operating expenses. The Fund prioritizes charities with small budgets, limited fundraising capabilities, and minimal exposure to larger organizations, ensuring that their contributions significantly impact local children's health and welfare.
Children’s Mental Health Children’s Health & Pediatrics Pediatric Cancers

Native Forward Scholars Fund Internship Assistance Program

Native Forward Scholars Fund
Association/Society
United States
Unspecified amount
The Native Forward Scholars Fund Internship Assistance Program empowers Native students by providing financial support for internships in non-STEM fields. This initiative breaks down financial barriers, enabling students to gain practical experience in areas like public policy, education, and cultural preservation. Through this program, students enhance their skills while contributing positively to their Tribal communities. The funding covers essential costs such as travel and living expenses, ensuring transparency and accountability in financial assistance.
Public Policy Education - Higher Education Academic Success & Enrichment +4 more

Deb Duethorn Memorial Scholarship Fund

Central New York Community Foundation Inc
Private
New York
Unspecified amount
The Deb Duethorn Memorial Scholarship Fund honors the legacy of Deb Duethorn, a dedicated flight nurse and educator, by providing financial support for students pursuing careers in nursing, emergency medical services, law enforcement, or firefighting. Established after her passing in 1996, this scholarship aims to make education more accessible, reflecting the Central New York Community Foundation's commitment to equity and opportunity. Only one scholarship is awarded, making it a significant opportunity for eligible applicants.
Academic Scholarship Programs Nursing Firefighting & Fire Prevention +2 more

Equitable & Inclusive Communities Grant

Centre County Community Foundation Inc.
Private
Centre County, Pennsylvania
Up to US $2,370
The Equitable & Inclusive Communities Grant, launched by Centre Foundation in 2024, aims to empower Centre County by promoting equity-centered leadership and capacity building. With $2,352 available, it supports programs addressing Diversity, Equity, Inclusion, and Belonging in areas like Arts, Education, and Health. Eligible applicants include IRS 501(c)(3) public charities, schools, and government entities, ensuring compliance with the Foundation’s Nondiscrimination Policy.
Art & Culture Workforce Preparation & Job Readiness Wellness & Healthy Living +3 more

Associated General Contractors of Indiana (AGCI) Scholarship

Central Indiana Community Foundation
Private
Indiana
Unspecified amount
The Associated General Contractors of Indiana (AGCI) Scholarship, established by AGC/I, aims to support construction students in Indiana by covering educational expenses. Eligible applicants must be Indiana residents, enrolled in construction-related programs, and have completed at least 60 credit hours. The scholarship encourages students to pursue careers in the construction industry within Indiana, emphasizing leadership and professional experience. Awards can be used for tuition, fees, and other educational costs.
Education - Higher Education Vocational & Trade Education Education - High School +3 more

Prospera Foundation Grant

Community Foundation for the Fox Valley Region
Private
Calumet County, Wisconsin, Outagamie County, Wisconsin +3 more
Up to US $5,000
The Prospera Foundation Grant aims to positively impact local communities through financial literacy, sustainable housing, and poverty alleviation. This private funder, associated with the Community Foundation for the Fox Valley Region, prioritizes support for tax-exempt organizations dedicated to enhancing quality of life and promoting diversity, equity, and inclusion. By collaborating with nonprofits aligned with these values, the grant seeks to empower individuals and foster prosperous communities.
Poverty Alleviation & Services Food Access & Hunger Financial Literacy +4 more

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.