Best Large Grants for Nonprofit Organizations

The Consolidated Funding Application (CFA) by the Mayor's Office of Homeless Services invites proposals from organizations to aid individuals and families at risk of homelessness or currently homeless, including those living with HIV/AIDS. This competitive grant offers multiple funding sources for FY25, including the U.S. Department of Housing and Urban Development and Maryland State funds, to support essential services and programs for vulnerable populations.

The Gene and Jerry Jones Family Arlington Youth Foundation is committed to enhancing the lives of Arlington youth through significant financial contributions. They provide grants to 501(c)(3) nonprofit organizations that focus on youth programs in areas like athletics, health, education, and the arts. Recently, a $1 million donation supported the North Texas Youth Education Town, which offers educational and recreational services. This initiative aims to create a sustainable impact on the community and support local youth for years to come.

The Anna M. Heilmaier Charitable Foundation, established in 1993, supports non-profit organizations in Saint Paul and the East Twin Cities metro region, focusing on music, arts, and healthcare initiatives. With an annual budget of approximately $300,000, grants can reach up to $150,000 for major projects, with a maximum of $50,000 for other grants. The foundation prioritizes projects that benefit local communities, specifically in healthcare and classical music.

The Food and Agricultural Sciences National Needs Graduate and Postgraduate Fellowships program, managed by the USDA's NIFA, aims to enhance the training of new graduate students in food and agricultural sciences. It provides essential funding for master's, DVM, and doctoral students, focusing on developing the next generation of experts to address critical needs in agricultural sciences. This initiative supports U.S. citizens and residents in achieving their educational goals and contributing to the USDA's mission.

Our Guiding Vision

A community where strong and accessible education can expand worlds and change lives.

History of the Trust

The Hamilton Family Charitable Trust comprises two generations of the Hamilton family with a long history of philanthropy in the Philadelphia region. Since 1992, the family has been committed to improving educational opportunities for children and youth, a mission established by Dorrance (Dodo) Hamilton (1928–2017), mother and grandmother of the family Trustees. The family extended their philanthropic reach to Palm Beach County, FL and Aquidneck Island, RI in 2017. The family convenes four times annually to honor this legacy, supporting myriad programs that enhance the lives of the young people they serve.

Hamilton Family Foundation Grant

Program Focus

• Data-driven literacy-based programs focused on developing robust reading and writing skills with a strong history of success.
  • These can be programs that:
    • Take place during school hours, after school, or during the summer.
    • Take place across school systems, but the funding can support only nonsectarian programming including within a religious institution.
  • Grades K-8 programs should devote at least 70 percent of their time directly to instruction and activities in reading and writing.
  • Grades 9-12 programs should provide innovative approaches to students in under-resourced areas for success in higher education, from the college admission process and acceptance through to completion.
  • Youth workforce development programs that focus on quality career exploration and preparation initiatives.
  • Recreational programs with a strong academic component.

Things To Consider

• First-time grants: generally designated for program support. The Trust rarely funds new staff positions for initial grants.
• Continuing partners: generally made for either programmatic or operational support.
• Multi-year grants: requests are typically reserved for grantees with five (5) years or more of consecutive funding from the Trust. Multi-year grants require approval prior to application submission. Approval is generally communicated in response to the LOI.

South Arts Inc

Headquartered in Atlanta, Georgia, South Arts is a nonprofit regional arts organization empowering artists, organizations, and communities, and increasing access to arts and culture.

In partnership with the National Endowment for the Arts and the State Arts Agencies of Alabama, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, and Tennessee — with additional funding from other public and private donors such as the Doris Duke Foundation, the Ford Foundation, and Mellon Foundation — South Arts supports artists and organizations through a rich and responsive portfolio of grants, fellowships, and programs. Why? Because South Arts believes that the arts elevate the region, increasing connectedness and inspiring meaningful change in the process.

Our mission: Advancing Southern vitality through the arts.

Arts in Community Grants

Program Description

Arts in Community Grants are designed to support deeper engagements between Southern communities and artists. Through these grants supported by the National Endowment for the Arts, we aim to increase access to the arts, expand audiences for artists, and broaden our reach. Eligible projects require a Southern artist/company visiting another Southern state for public activities, offering access to arts programming by professional artists. Funding supports Southern film directors, traditional artists, visual artists, performing artists, or writers:

• film (documentary, fiction, experimental, and animation),
• traditional arts (music, dance, storytelling, and visual arts/crafts),
• visual arts (crafts, drawing, experimental, painting, photography, sculpture, and mixed media),
• performing arts (theater, music, opera, musical theater, and dance), and
• literary arts (fiction, creative nonfiction, and poetry).

Projects require an artist or artist ensemble and a host or partner organization. Project must include at least two in-person or live, virtual public activities – both a public presentation (a film screening, performance, reading, or exhibition) and an educational/community engagement activity (a workshop, demonstration, lecture, facilitated discussion, or master class). The grant requires a dollar-for-dollar cash match.

The Direct Services Grant Program, initiated by the John T. Gorman Foundation, aims to support organizations addressing the basic needs of vulnerable Maine residents, including hunger, housing, and crisis support. This grant prioritizes initiatives that strengthen families and empower communities, ensuring that essential services are accessible. The Foundation seeks to bolster educational achievements for young children, aid successful transitions for older youth, and support low-income families and seniors, ultimately fostering a thriving community in Maine.

The Climate Justice Organizing Fund aims to support grassroots organizations working towards climate justice by providing essential resources for capacity building and strategic development. This initiative focuses on addressing interconnected issues such as racial and health equity, food security, and affordable housing, ensuring that communities most affected by climate change have the tools and training needed to advocate for their rights and implement effective strategies for long-term success.

The William Penn Foundation aims to reduce annual untreated sewage overflows in Philadelphia by 5 billion gallons by 2035. This initiative focuses on addressing outdated infrastructure that contributes to pollution during extreme weather events. By engaging communities, particularly those most affected, the foundation seeks innovative solutions to improve water quality and public health. This effort aligns with ongoing successes since the Clean Water Act and highlights the need for equitable access to clean waterways.

The NIDCD is offering funding to advance HIV/AIDS research, particularly focusing on areas related to communication disorders. This initiative supports low-risk clinical trials and encourages researchers to align their proposals with high priority topics identified by the NIH Office of AIDS Research. Applications must be submitted by the local deadline, with optional Letters of Intent due 30 days prior to the proposal deadline. This opportunity aims to enhance understanding and treatment in this crucial health area.

The Community Endowment of Lexington Grant Program aims to foster philanthropic initiatives that address both immediate and long-term needs in Lexington. Celebrating its 10th anniversary, the program will provide up to $100,000 in funding for innovative projects, with individual grants capped at $15,000. Focus areas include health services, arts, environment, and community building, encouraging collaboration among local organizations to enhance the quality of life for residents.

The Bogliasco Fellowships, awarded by the Bogliasco Foundation, provide a unique opportunity for individuals in the arts and humanities to develop significant new work in a serene Italian setting. Open to all ages and nationalities, these one-month Fellowships foster creativity and collaboration among exceptional artists and scholars. Candidates must demonstrate notable achievements in their fields and can apply multiple times, with previous recipients waiting five years before reapplying. A conversational level of English is required to thrive in this international community.

The Women Building Community Grants, offered by the Community Foundation of Brazoria County, Texas, aim to address critical issues affecting women and children in Brazoria County. With a total funding of $17,000 available, the grants support projects focused on life-skills education, self-sufficiency, and collaboration. Eligible organizations must be 501(c)(3) nonprofits based in the county. This funding cycle prioritizes impactful initiatives that foster community development and empowerment.

The Asian Cultural Council's Graduate Fellowship provides financial support for travel and living expenses to graduate students from Asia studying in the U.S. It offers $15,000 for one academic year, potentially renewable for another year, covering essential costs while pursuing full-time coursework. This initiative fosters international cultural exchange and enhances academic training in the arts. Eligible applicants must be enrolled full-time in accredited graduate programs and commit to at least two consecutive semesters of study.

The Jeanne D'Arc Credit Union Donation Request aims to support local non-profits that enhance community well-being through initiatives focused on health, education, and economic revitalization. The foundation encourages applications for event sponsorships and charitable projects that align with their mission of fostering vibrant neighborhoods and providing essential services. Interested organizations should submit requests at least six weeks before their events for timely consideration.

The FY26 Defense Established Program to Stimulate Competitive Research (DEPSCoR) aims to enhance research capabilities in eligible states by increasing the number of university researchers and institutions conducting relevant science and engineering research. Sponsored by the Department of Defense, this program will fund multiyear awards to promote research aligned with national security needs. Applications require a multi-stage submission process, emphasizing early registration and timely proposal submissions.

The Grand Rapids Community Foundation's Fund for Community Good supports projects that promote equity and justice across various sectors, including education, health, and economic prosperity. This unrestricted fund invites partnerships with 501(c)(3) nonprofits and government entities, primarily focusing on Kent County, Michigan. The foundation prioritizes initiatives that dismantle systemic racism and foster inclusive opportunities, ensuring all community members can thrive. Eligible applicants can submit pre-applications year-round for potential funding.

The Thomas Wilson Foundation, established in 1875, is dedicated to enhancing the health and welfare of children in Baltimore City. It provides funding for medical research, medical services, and social and community programs aimed at supporting youth. The Foundation specifically targets initiatives that benefit children and youth aged 18 and under, ensuring that resources are directed towards improving their overall well-being and access to essential services.

Department of Health and Human Services 

The Department of Health and Human Services manages the delivery of health and human related services for all North Carolinians, especially our most vulnerable people – children, elderly, disabled and low-income families. The department works closely with health care professionals, community leaders and advocacy groups; local, state and federal entities; and many other stakeholders to make this happen.

Community Services Block Grant

The Community Services Block Grant is the sole source of federal funding for North Carolina’s Community Action Agencies that provide a wide range of services and programs to assist needy families with children. CSBG funding supports projects that:  

• Decrease poverty in communities.
• Address the needs of low-income individuals, including the homeless, migrants and the elderly.
• Provide services and activities addressing employment, education, better use of available income, housing, nutrition, emergency services and/or health.

The CSBG State Plan is required for North Carolina to receive CSBG block grant funds, and it describes major program provisions, eligible entities, training and technical assistance, and program benefits.

The Community Grants Program: East Hawaii Fund supports nonprofit organizations working to enhance the well-being of East Hawai‘i communities. It prioritizes projects that address educational opportunities, strengthen intergenerational relationships, promote economic sufficiency, and improve social conditions. Grants typically last one year, up to $10,000, and encourage collaborative efforts among various community sectors. Eligible applicants include nonprofit organizations, community groups, and school projects that align with the fund's priorities.

The External Collaborative Research Grants by Boehringer Ingelheim support academic and clinical scientists in proposing research studies. These grants facilitate collaboration with Boehringer Ingelheim, which may provide intellectual and financial support. Applicants must assume full responsibility for their research while complying with regulatory standards. The funding should cover research costs, excluding salary support for the collaborative partner. Interested investigators must apply online for consideration.

Northern Chautauqua Community Foundation

Vision: We envision a vibrant, prosperous northern Chautauqua community, rich in opportunity today and tomorrow.

Our Mission

To realize our vision we focus on:

• strategic and responsive grant making
• encouraging local philanthropy and building permanent endowments for the future
• actively serving as a community leader and partner for the benefit and enrichment in our community.

Scholarships

Northern Chautauqua Community Foundation proudly manages over 200 individual scholarship funds,

James & Dolores Selan Memorial Scholarship

The James & Dolores Selan Memorial Scholarship is awarded to northern Chautauqua County students who are enrolled at Cornell University, Syracuse University, or SUNY College of Environmental Science and Forestry to study Forestry, Ornithology, and other environmentally-focused disciplines.

The Fund for Omaha Grant, managed by the Omaha Community Foundation, aims to strengthen local nonprofits by addressing funding gaps and enhancing community services. Priorities include economic opportunity, affordable housing, maternal health, and mental health support. Eligible applicants are public, tax-exempt organizations serving the Omaha area with annual budgets of $5 million or less. This initiative fosters connections and improves community well-being by providing essential resources and opportunities.

About the Living Well Foundation

The Living Well Foundation is a non-profit public charity that was established upon the sale of a local public hospital in 2006. Its goals are to enhance the quality of life and health of the citizens of Ouachita Parish and the 7 surrounding parishes and to assist in collaborative and innovative networking within the region. The Living Well Foundation supports several projects in the northeast Louisiana area that seek to improve the medical, dental, and behavioral health of the population, especially kids.

Specific initiatives include dental hygiene clinics with the University of Louisiana at Monroe (ULM) Department of Dental Hygiene, suicide prevention/intervention, dementia/Alzheimers cognitive deficit disorders, and school-based health centers with local school boards and medical providers, including federally qualified health centers (FQHCs) and others. Other projects that provide behavioral health support services on school campuses and in communities are supported with area non-profit agencies and clinical professionals.

Grant Information

Grants are typically awarded to non-profits whose projects address the following:

• Activities related to rendering care to the sick and injured or in the promotion of health;
• Activities designed and conducted to promote the general health of the community; and,
• Activities undertaken in cooperation with public or private institutions or agencies engaged in providing health services to residents of the District.

The Foundation favors making grants that meet one or more of the following criteria:

• The grant would help assure the continued existence or creation of accessible, affordable health care facilities or services in the District or the service area that are responsive to the needs of the community.
• The grant would support the provision of health care to the disadvantaged, the uninsured, and/or the underinsured.
• The grant would support the goal of improved health care or wellness to the service area.
• The project would include an education component within its goals for participant self-sufficiency or self-awareness over time.
• The project would have a plan of sustainability upon conclusion of Foundation funding.

NewYork-Presbyterian

NewYork-Presbyterian is one of the nation’s most comprehensive, integrated academic healthcare systems, dedicated to providing the highest quality, most compassionate care and service to patients in the New York metropolitan area, nationally, and around the world. In collaboration with two renowned medical schools, Weill Cornell Medicine and Columbia University Vagelos College of Physicians and Surgeons, NewYork-Presbyterian is consistently recognized as a leader in innovative, patient-centered clinical care, research and medical education.

Summer Youth Enrichment Grant

NewYork-Presbyterian is dedicated to partnering with community-based organizations (CBOs) that provide impactful summer programs for youth and adolescents. Through the Summer Youth Enrichment Grant (SYEG), we invest in young people when opportunities for enrichment, a sense of belonging, and access to safe spaces are essential for their growth and well-being.

Grant Overview

SYEG provides grants of up to $50,000 to support summer initiatives that provide engaging, developmentally appropriate, and relevant programming to children and adolescents. The grant supports a wide range of program types, including but not limited to:

• Arts and Creative Expression
• Leadership and Civic Engagement
• Physical Fitness
• Academic Development
• Career and Job Readiness

Special consideration will be given to organizations whose programs primarily serve youth in the following communities: Corona, Crown Heights, Lower East Side, Mount Vernon, Peekskill, Washington Heights & Inwood, White Plains, University Heights.

This grant supports both new and existing programs that will take place during the summer months.

The TAC Rural Arts Project Support offers funding for diverse arts projects that enhance community engagement and vitality in rural Tennessee. Eligible applicants include local nonprofits and government entities. Projects can involve professional artists, workshops, public performances, and initiatives to improve accessibility for underserved populations. Ineligible uses of funding include K-12 education projects, insurance, and capital improvements. This grant fosters artistic collaboration and innovation in rural settings.