Best Large Grants for Nonprofit Organizations

The Medical Scientist Training Program (MSTP) aims to cultivate a diverse group of physician-scientist leaders to address the nation's biomedical research needs. This program supports institutions in creating integrated dual-degree training that results in both medical and research doctorate degrees. By combining clinical practice with scientific research, MSTP graduates will advance health-related research, focusing on improving training effectiveness, alumni retention in research careers, and workforce diversity. NIGMS emphasizes comprehensive training elements for impactful careers.

South Dakota Community Foundation

As a statewide community foundation, we work with donors, nonprofits and community leaders to strengthen philanthropy in South Dakota every day.

Grants

The South Dakota Community Foundation offers an array of grants to help state nonprofits realize their dreams and continue investing in their communities. 

Vermillion Area Community Foundation Grant

The Vermillion Area Community Foundation was established in 2000 for the sole purpose of creating an endowed fund to build financial resources, that aren’t depleted each year and are forever and perpetual, to assist with capital projects that address community needs and that impact and enhance the quality of community life for residents of all ages.

South Dakota Community Foundation rules require VACF to fund tangible items rather than ongoing operating costs or salaries.

Court Reporter Equipment Grant

Students enrolled in a court reporter training program in Iowa. The maximum award is up to $2,000 to reimburse students for the purchase of court reporter equipment and software for the court reporter training program.

The PLTW Engineering program, in partnership with Phillips 66, aims to expand access to quality STEM education in underserved communities. With a total grant of $10,000 available for the 2026-2027 academic year, the initiative focuses on middle and high school programs that foster student engagement in engineering and computer science. Priority will be given to schools with high-needs student populations, ensuring equitable educational opportunities and workforce preparedness for future generations.

The AHC REACH Grant, offered by the Arkansas Humanities Council (HumanitiesAR), supports innovative humanities-based projects in Arkansas. These projects aim to connect communities to their history and promote understanding through various activities including storytelling, public programs, and education initiatives. While it encourages projects that engage diverse audiences, it excludes fundraising, political advocacy, and certain educational courses. The grant reflects a commitment to accessibility and inclusivity in the humanities.

The Engineering Biological and Biomedical Systems (EBBS) program, funded by the National Science Foundation (NSF), aims to advance our understanding of biological systems and improve human health through innovative engineering solutions. It supports research that combines mechanistic insights with experimental techniques to develop novel biomedical technologies, enhance biomanufacturing processes, and explore therapeutic applications. Projects focusing on engineering principles for biological responses and rehabilitation are encouraged, while drug design and clinical trials are outside the program's scope.

The JSI Scholarship, provided by the Foundation for Rural Service, awards $5,000 to four high school seniors interested in science, math, medicine, or engineering. Sponsored by a member of NTCA–The Rural Broadband Association, recipients are encouraged to return to rural communities after graduation. This initiative aims to enhance rural life through education and support, promoting the development of future leaders in essential fields.

The Betenbough Homes Community Grant is designed to support 501(c)(3) organizations that serve communities in West Texas, particularly Amarillo, Lubbock, Midland, and Odessa. The grant aims to enhance organizational efforts rather than cover operating costs. Non-evangelical organizations can apply for up to $7,500, while evangelical organizations may receive up to $20,000. Applications should be submitted at least eight weeks before the funding deadline.

The Wichita Falls Area Community Foundation offers the WFACF Grant Cycle to support 501(c)(3) organizations and charitable projects in North Texas. Grants aim to promote philanthropy and enhance community well-being across various sectors including arts, education, and health. Eligible applicants must be located in specific counties and adhere to grant policies. The foundation is dedicated to responsible funding to meet the needs of the community while ensuring compliance with regulations.

The Sidney Stern Memorial Trust Grant supports charitable, scientific, medical, and educational organizations that are 501(c)(3) certified. This private funder emphasizes impactful service to diverse populations without discrimination. Grants must be utilized within the United States and cannot be awarded to individuals, political candidates, or lobbying efforts. The Trust is dedicated to enhancing the general welfare through soundly-managed initiatives that contribute significantly to community needs.

The MMUF Advancement Program offers Adjunct Faculty Fellowships designed for alumni of the Mellon Mays Undergraduate Fellowship. These fellowships provide essential resources and time to focus on research and scholarship, aiding individuals in securing tenure-track positions. Each fellow receives a $10,000 stipend, a six-month award period, a mentor, and funding to attend a conference. This initiative supports diverse perspectives in higher education, fostering an inclusive academic environment.

Continental Resources is dedicated to supporting the communities where it operates by investing in health, education, and industry advocacy. Their charitable donations focus on initiatives that promote healthy lifestyles, enhance educational programs, and advocate for the oil and gas industry, which is vital for job creation and energy security. By standing alongside their industry peers, they aim to educate the public about the benefits of oil and natural gas, fostering a brighter future for all.

The Collaborative Program Grant for Multidisciplinary Teams, funded by the US Dept. of Health & Human Services: National Institutes of Health (NIH), supports integrated teams of researchers tackling ambitious projects that individual efforts cannot achieve. This program promotes collaboration among experts with complementary skills, aiming for significant advancements in their fields. Teams are encouraged to pursue innovative objectives that have the potential to transform research landscapes.

South Dakota Community Foundation

As a statewide community foundation, we work with donors, nonprofits and community leaders to strengthen philanthropy in South Dakota every day.

Grants

The South Dakota Community Foundation offers an array of grants to help state nonprofits realize their dreams and continue investing in their communities. 

Wessington Springs Area Community Foundation Grant

The WSACF is a donor supported organization dedicated to supporting and enriching the future of the Wessington Springs Community by providing financial support to community oriented organizations and projects.

The Saw Island Foundation offers grants focusing on education, science, and health, primarily targeting nonprofit organizations in the San Francisco Bay Area. Their education grants support scholarships and program partnerships, while science and health grants aim to enhance life experiences through improved health outcomes. Eligible applicants must be 501(c)(3) organizations, and the foundation emphasizes innovative collaborations that demonstrate measurable impact in their communities.

Dr. C. D. Rao Memorial Scholarship

Students pursuing engineering studies.

Awards

• (2) $1,300.00

Concrete Advancement Foundation

Vision

To be the resilient resource to collaboratively support concrete as the leading sustainable building material.

Goals

• Goal 1: To fund and manage highly credible and impactful research to achieve societal goals
  • Decarbonization
  • Resilient, sustainable and affordable communities
  • World-class sustainable infrastructure
• Goal 2: Disseminate knowledge and create educational tools for the benefit of stakeholders
  • Attract and advance the concrete industry workforce
  • Tools and programs to advance communities and societal goals
• Goal 3: To be the resilient resource for collaboratively funding the advancement of the concrete industry
  • Bring together industry stakeholders to provide the financial resources and governance needed to accomplish the Foundation's goals
  • Measure progress and success of the Foundation goals and ensure strategic, long-term alignment and communication with stakeholder audiences

Funding

The Foundation funds research and education programs that are consistent with our mission of increasing the quality, professionalism and sustainability of the ready mixed concrete industry.

Those wishing to perform research on concrete materials topics may consult the list of research needs developed by NRMCA's Research Engineering & Standards Committee. Please note that this list is only a guide, and neither guarantees funding of a particular topic, nor precludes research on topics not listed.

The PPC Foundation Grants support charitable organizations with 501(c)(3) status, distributing 10% of pre-tax profits annually. Grants range from under $500 to over $2,500, with varying documentation requirements. The foundation emphasizes community involvement and prefers charities in areas where they operate. They do not fund political, religious entities without separate social service programs, or organizations primarily funded by public tax support. This initiative reflects their commitment to compassionate service and community prosperity.

The Courageous Innovation Award, presented by the Santa Fe Community Foundation, celebrates nonprofits that utilize bold and innovative strategies to tackle persistent issues in northern New Mexico. Nominations are open to all community members, including nonprofit staff and volunteers, until May 8, 2026. This prestigious award reflects the Foundation's commitment to fostering positive change and supporting organizations that align with its funding priorities, such as Arts, Education, and Health.

The RI Beacon Foundation Grant aims to enhance community welfare by supporting U.S.-based 501(c)(3) organizations primarily in Rhode Island. The Foundation seeks to promote goodwill, sponsor impactful initiatives, and foster partnerships through donations and volunteerism. By focusing on health, education, and civic causes, it endeavors to create a significant positive impact within the community while maintaining a commitment to inclusivity and non-discrimination.

About JoCo Bar

The Johnson County Bar Association has served the legal community since 1938. Through leadership, member services, professional development, and community engagement, JoCo Bar supports attorneys, judges, and legal professionals throughout Johnson County.

Johnson County Bar Annual Awards

Each year, JoCo Bar recognizes outstanding service, professionalism, leadership, and dedication within our legal community.

The Don Miler "Spirit" Award

In 2009, the JoCo Bar Board of Directors created the Don Miller “Spirit” Award. Named for Don Miller, a longtime friend, colleague, and honorary member of JoCo Bar, the award recognizes the optimistic spirit he demonstrated throughout his life and the way he inspired and encouraged others.

The award is presented to a current or honorary JoCo Bar member who maintains an optimistic spirit that inspires and encourages others through their professional and personal life. The recipient also demonstrates the warmth and friendliness of a loyal friend and colleague.

The Michael J. Colligan Fund, established by the Hamilton Community Foundation, honors veterans by providing financial support for bands in Memorial Day, Veterans Day, and Fourth of July parades. It also funds speakers on military topics and preserves historical memorabilia. This initiative reflects a commitment to patriotism and community pride, ensuring that the sacrifices of veterans are recognized and celebrated, while fostering civic engagement and remembrance within the community.

The Impact 100 Ozark Grantmaking Program aims to empower women by funding significant grants to enhance community welfare in eastern Christian County. The Community Foundation of the Ozarks seeks to support transformational projects that demonstrate impactful change. With two grants available, one for $14,000 and another for $35,000, the initiative encourages innovative proposals that can be initiated within six months of receipt, ensuring that the funding leads to lasting benefits.

The National Science Foundation (NSF) is funding initiatives to enhance the value of scientific datasets through innovative artificial intelligence (AI) methods. This program aims to facilitate interdisciplinary research and unlock new insights by applying AI for feature extraction, metadata generation, and dataset integration. Proposals should ensure data security and promote collaboration with various sectors to advance AI-driven scientific discovery. By aligning with NSF priorities, researchers can contribute to cutting-edge science and technology for broader participation in STEM.

The Northern Chautauqua Community Grants Program, managed by the Northern Chautauqua Community Foundation, aims to enhance the community's quality of life through strategic investments in nonprofit initiatives. Established in 1986, the foundation supports various sectors including arts, environment, health, and neighborhood revitalization. Grants typically range from $1,000 to $15,000, fostering innovative solutions to local challenges and empowering residents to realize a healthier, more prosperous community.

South Carolina Research Authority

SCRA is a public, non-profit corporation chartered in 1983 by the State of South Carolina. Its mission is to fuel South Carolina’s innovation economy by accelerating technology-enabled growth of academia, entrepreneurship, and industry. SCRA's vision is focused in becoming a leading catalyst in making South Carolina the top choice for technology-focused industry, entrepreneurs, investors, and academics.

SCRA supports its stakeholders in key technology sectors, which include but are not limited to, Advanced Materials/ Manufacturing; Life Sciences; Clean Tech, Sustainability, and Resilience, and Information Technology. SCRA grant funding is made possible, in part, by Industry Partnership Fund (IPF) contributions. Contributors receive a dollar-for-dollar South Carolina income tax credit, making it a no-cost way to create a direct, positive economic effect and job creation. 

Academic Matching Grant 

Managed by the Academic Innovations team, the objective of the Academic Matching Grant is to expand academic engagement in research and development by validating and advancing technology concepts towards the potential of a license opportunity, and/or company formation. Key milestones include: market opportunity and technical feasibility, in the IDEATION stage of startup development. 

Qualifying technologies are recommended by the institution’s Technology Transfer Office, or equivalent; Institutions are responsible for the technical review and prioritization of applications, and review opportunities with the Academic Innovations team. Based upon the review, SCRA will provide application materials and instructions. 

About JoCo Bar

The Johnson County Bar Association has served the legal community since 1938. Through leadership, member services, professional development, and community engagement, JoCo Bar supports attorneys, judges, and legal professionals throughout Johnson County.

Johnson County Bar Annual Awards

Each year, JoCo Bar recognizes outstanding service, professionalism, leadership, and dedication within our legal community.

Earl E. O'Connor Civility Award

Presented to a JoCo Bar member who demonstrates a commitment to civility in the practice of law through professionalism, honor, integrity, preparation, and advocacy.