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Best Lee County Grants for Nonprofits in South Carolina

Looking for grants for 501(c)(3) nonprofit organizations working in Lee County, South Carolina? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

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$3.23B

Total funding

$5K

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9,000+ grants
$3.23B total
$5K median

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9,095 Results based on applied filters

2027-2028 Community Mental Health Services Block Grant

South Carolina Department of Behavioral Health and Developmental Disabilities
State/Local Government
South Carolina
Unspecified amount

2027-2028 Community Mental Health Services Block Grant

The BHDD federal fiscal year 2027-2028 Community Mental Health Services Block Grant Application was available for review and public comment from August 24-31, 2026.

Please note that this application serves as the Agency’s Community Mental Health Services Block Grant State Plan, required by Public Law 102-321, for providing comprehensive community mental health services to adults with a serious mental illness (SMI) and to children with a serious emotional disturbance (SED). The Block Grant is a noncompetitive formula grant that is provided to BHDD Office of Mental Health by the Substance Abuse and Mental Health Services Administration (SAMHSA).

Community Mental Health Services Block Grant (MHBG)

Each year, BHDD receives a two-year grant from SAMHSA. This grant is called the Community Mental Health Services Block Grant (MHBG). It is a noncompetitive grant based on a formula; funding is provided by SAMHSA to 59 recipients. The funding must be used to provide “comprehensive, community-based mental health services” to two types of people: adults with serious mental illnesses (SMI) and children with serious emotional disturbances (SED). Additionally, the funding can be used to help people who are having mental health crises, even if they have not been diagnosed with SMI or SED. Learn more about the block grant here.

There are many different services and programs that can be funded by the block grant – as long as the services fall into the category of “comprehensive, community-based mental health services” for the two types of people listed above, or the services are for people in crisis. This includes services like individual counseling, family counseling, group counseling, psychiatric services, medication management, transitional services, care coordination and crisis interventions.

BHDD provides block grant funding to each of its 16 community mental health centers (CMHCs) and several central administration programs. These CMHCs and programs provide a wide variety of services to patients and people in crisis.

BHDD also allocates block grant funding to nonprofit organizations through a competitive solicitation process. The next available solicitation will fund nonprofits from July 2026 – June 2029. Nonprofit organizations that are interested in applying for block grant funding should check this webpage in the summer of 2025 for more information about the next solicitation.

A Mental Health Planning Council is a required activity for this grant. The purpose of the Planning Council is to ensure collaboration among various state agencies and provide opportunities for people with lived experiences with mental illness to give feedback and input to BHDD. Specific state agencies are required to participate on the council. A minimum of 51% of the Planning Council members must be people with lived experiences with mental illness or family members of people with mental illnesses. 

Mental Health & Psychiatric Diseases Addiction & Substance Use Disorders

BJA FY 2026 John R. Justice (JRJ) Formula Grant Program

US Department of Justice: Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The BJA FY 2026 John R. Justice Formula Grant Program offers loan repayment assistance to local and state prosecutors and public defenders who commit to three years of service. Administered by state agencies, this program aims to alleviate the financial burden on legal professionals dedicated to public service. Applications are due by November 10, 2026, providing a crucial opportunity for eligible beneficiaries to secure support for their educational loans.
Crime & Justice Legal Services

Advancing coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management.

National Oceanic and Atmospheric Administration (NOAA)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $2,000,000
The National Oceanic and Atmospheric Administration (NOAA) is inviting proposals for projects that enhance coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management. This initiative aims to utilize natural infrastructure to bolster flood preparedness and resilience. Funding of up to $2,000,000 is available for selected projects, supporting research teams that collaborate with regional stakeholders. Proposals must be submitted via Grants.gov, ensuring accessibility to critical resources and information.
Habitat & Ecosystem Restoration Climate Change Resilience & Equity Coastal Conservation

OJJDP FY 2026 Second Chance Act Youth Reentry Program

US Department of Justice: Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Up to US $750,000
The OJJDP FY 2026 Second Chance Act Youth Reentry Program aims to provide critical support for moderate- to high-risk youth transitioning back into their communities after confinement. This funding opportunity encourages collaboration among state agencies, local governments, Tribes, and community organizations to deliver comprehensive reentry services and assist youth in overcoming challenges related to recidivism. Applications are due by November 9, 2026, at 8:59 p.m. ET.
Youth Services Crime & Justice Youth Development & Leadership

OJJDP FY 2026 Internet Crimes Against Children (ICAC) Task Force Program Support

US DOJ: Office of Juvenile Justice & Delinquency Prevention (OJJDP)
Federal Government
American Samoa, Guam +4 more
Up to US $1,200,000
The OJJDP FY 2026 Internet Crimes Against Children (ICAC) Task Force Program Support aims to fortify a national network of 61 multiagency task forces dedicated to combating child sexual exploitation facilitated by technology. This funding opportunity enhances training, prevention, and outreach efforts while fostering collaboration among law enforcement entities. Applications are due in JustGrants by November 9, 2026, at 8:59 p.m. ET, ensuring timely support for critical initiatives to protect children.
Youth Services Crime & Justice Crime Victim Services +1 more

Strengthening Collaboration Between Tuberculosis Control Programs and Affiliated Partners in the United States.

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +7 more
Unspecified amount
The CDC is offering funding to enhance collaboration among tuberculosis control programs and various partners in the U.S. This initiative aims to strengthen relationships with national TB control entities, federal agencies, academia, and community organizations. The goal is to promote health and quality of life by preventing, controlling, and eventually eliminating tuberculosis in the United States, building on previous funding opportunities.
Epidemiology & Public Health Infectious & Parasitic Diseases Preventative Healthcare +1 more

Advanced Rehabilitation Research Training (ARRT) Program - Employment (363964)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $245,000 - US $250,000
The Advanced Rehabilitation Research Training (ARRT) Program aims to enhance the research capabilities of individuals with advanced degrees, focusing on disability and rehabilitation research related to employment outcomes. Funded by the US HHS Administration for Community Living, this grant offers a 36-month project period, supporting multidisciplinary training for researchers, including those with disabilities, to contribute to high-quality research in the field.
Disability Care & Services Medical Rehabilitation Employment Services +1 more

Advanced Rehabilitation Research Training (ARRT) Program - Health and Function (363965)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $245,000 - US $250,000
The Advanced Rehabilitation Research Training (ARRT) Program, funded by the US HHS: Administration for Community Living, aims to enhance the capabilities of individuals with advanced degrees in conducting high-quality research focused on health and function outcomes for people with disabilities. The program offers advanced training opportunities over a 36-month period, specifically targeting rehabilitation researchers, including those with disabilities, to foster multidisciplinary approaches in disability and rehabilitation research.
Medical Rehabilitation Medical Education & Professional Training Disability Rights & Justice

Small Business Innovation Research Program (SBIR) Phase II (363967)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $280,000 - US $287,500
The Small Business Innovation Research Program (SBIR) Phase II aims to enhance technological innovation in the private sector, focusing on improving the lives of individuals with disabilities through research and development. Administered by the US HHS Administration for Community Living, this program supports small businesses in addressing the needs of these individuals. Grants are available for a 24-month project period, allowing projects to expand upon Phase I results to achieve greater commercial application and societal impact.
Disability Care & Services Medical Rehabilitation Emerging Technology Development +1 more

Small Business Innovation Research (SBIR) program, Phase I (363966)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $95,000 - US $100,000
The Small Business Innovation Research (SBIR) program, Phase I, aims to stimulate technological innovation in the private sector, enhancing the role of small businesses in meeting Federal research needs. Specifically, ACL's SBIR program focuses on improving the lives of individuals with disabilities through research and development products. The initiative includes 11 grants with a 6-month project period to assess the feasibility of innovative concepts, contributing to economic and social benefits.
Disability Care & Services Emerging Technology Development Business Development

Advanced Rehabilitation Research Training (ARRT) Program - Community Living and Participation (363963)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $245,000 - US $250,000
The Advanced Rehabilitation Research Training (ARRT) Program, funded by the US HHS: Administration for Community Living, aims to enhance the skills of researchers in the field of disability and rehabilitation. By providing advanced training over a three-year period, this program focuses on improving community living and participation outcomes for individuals with disabilities. It seeks to equip scholars with the necessary tools to conduct high-quality, multidisciplinary research, ultimately benefiting the disability community.
Disability Care & Services Medical Rehabilitation Medical Education & Professional Training

Alzheimer's Disease Programs Initiative (ADPI) - Developing Dementia-Capable Community Health Worker Programs in the National Aging Network

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $200,000 - US $250,000
The Alzheimer's Disease Programs Initiative (ADPI) aims to foster the development of dementia-capable community health worker programs within the National Aging Network. This initiative, supported by the US HHS: Administration for Community Living (ACL), seeks to enhance dementia screening, reduce barriers to care, and improve access to essential services for individuals with dementia and their caregivers. By integrating community health workers into aging services, the program aspires to elevate the quality of life for those affected.
Aging / Gerontology Mental Health & Psychiatric Diseases Health Care Access & Delivery +2 more

K-12 Backpack Feeding Program Mini-Grants

Sodexo Stop Hunger Foundation
Corporate
United States
US $1,000

Sodexo Stop Hunger Foundation

The Sodexo Stop Hunger Foundation goes beyond food aid to create lasting change. Through innovative programs, strategic partnerships and volunteer action, Stop Hunger tackles the root causes of food insecurity.

In 2025, Sodexo Stop Hunger Foundation and the Hunger Center awarded grants to 131 programs representing 118 communities in 37 states plus the District of Columbia. Collectively, these programs provided an estimated 22,000 backpacks full of shelf-stable food items for students to take home for the weekend or holidays when school meals are not served.

Since 2006, the Sodexo Stop Hunger Foundation has been a driving force behind weekend and holiday hunger relief for students across the U.S. Through support of food backpack programs, the Foundation partners with local food banks and schools to discreetly provide K-12 students with backpacks filled with nutritious, shelf-stable meals. These backpacks are distributed in safe, familiar settings – typically on the last school day before a weekend or school break – ensuring that all children who rely on free or reduced-price school meals don’t go hungry when school is out.

K-12 Backpack Grant

The K-12 Backpack Grant is an initiative launched by the Sodexo Stop Hunger Foundation and administered in partnership with the Congressional Hunger Center to support community backpack programs. Grants of $1,000 will be issued to community organizations with established backpack feeding programs that provide students with shelf-stable, nutritious meals when school is out of session.

Food Delivery & Distribution Services Food Access & Hunger Food Security

Fiscal Year (FY) 2027 Department of War (DoW) Multidisciplinary Research Program of the University Research Initiative (MURI) (363905)

US DOD: U.S. Army Materiel Command
Federal Government
American Samoa, Guam +4 more
Up to US $7,500,000
The FY 2027 Department of War Multidisciplinary Research Program (MURI) funds U.S. academic teams engaged in innovative basic research addressing future defense challenges. Established in 1985, MURI emphasizes collaboration across multiple scientific disciplines to tackle complex, DoW-relevant issues. By fostering partnerships among faculty, postdoctoral researchers, and students, the program aims to advance the U.S. defense industrial base and nurture a skilled scientific workforce, contributing to significant breakthroughs in military technology and economic growth.
Engineering Science Workforce Preparation & Job Readiness +1 more

OJJDP FY 2026 Victims of Child Abuse Act Training and Technical Assistance for Child Abuse Professionals

US DOJ: Office of Juvenile Justice & Delinquency Prevention (OJJDP)
Federal Government
American Samoa, Guam +4 more
Up to US $2,850,000
The OJJDP FY 2026 Victims of Child Abuse Act Training and Technical Assistance program aims to enhance the skills of child abuse professionals. This initiative will promote coordinated investigations and improve intervention strategies for child abuse victims. By providing essential training on effective interviewing, investigative techniques, and interagency collaboration, the program seeks to elevate the quality of care and support available to affected children and families. Applications are due by November 5, 2026.
Youth Services Crime & Justice Crime Victim Services

BJA FY 2026 Rural Violent Crime Reduction Initiative

Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Up to US $250,000
The BJA FY 2026 Rural Violent Crime Reduction Initiative aims to empower local law enforcement in rural areas to combat violent crime effectively. This funding opportunity provides resources for personnel, technology, and data analytics to enhance crime prevention strategies. Eligible applicants can utilize updated equipment and training to address specific violent crime challenges, ensuring safer communities through innovative approaches and strategic resource allocation. Applications are due by November 6, 2026.
Crime & Justice Rural Development Community / Public Safety +1 more

Fiscal Year (FY) 2027 Department of War Multidisciplinary Research Program of the University Research Initiative (MURI)

US DOD: Dept. of the Navy, Office of the Chief of Naval Research
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Fiscal Year 2027 Department of War Multidisciplinary Research Program aims to fund innovative research teams from U.S. universities. Established in 1985, this initiative addresses complex challenges faced by the Department of War, fostering collaboration across various scientific disciplines. By integrating world-class faculty and graduate students, the program seeks to cultivate a skilled workforce poised to enhance the U.S. defense capabilities and contribute to the advancement of the defense industrial base.
Engineering Education - Higher Education Science +1 more

State Biomonitoring Cooperative Agreement

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $750,000 - US $900,000
The State Biomonitoring Cooperative Agreement aims to enhance public health laboratories' ability to conduct biomonitoring and assess human exposure to environmental chemicals. This funding opportunity emphasizes community investigations, state-level studies, and emerging chemicals not covered in the National Exposure Report. By improving laboratory capacity and fostering collaboration, the initiative seeks to identify harmful exposures and evaluate intervention effectiveness over a three-year period.
Epidemiology & Public Health Environmental Contamination & Pollution Environmental Health

Research to Improve Rigor, Replicability, and Reproducibility in Biomedical and Behavioral Sciences

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Neurological Disorders and Stroke (NINDS) is collaborating with other NIH institutes to enhance rigor and replicability in biomedical and behavioral research. This initiative aims to support projects focused on assessing the impact of improved research practices, developing frameworks for study selection, and measuring the generalizability of findings. Currently, applications are not being solicited, allowing researchers time to prepare collaborative proposals.
Neurological Diseases & Disorders

John H. Prescott Marine Mammal Rescue Assistance Grant (363929)

DOC NOAA - ERA Production
Federal Government
American Samoa, Guam +4 more
Up to US $150,000
The John H. Prescott Marine Mammal Rescue Assistance Grant supports the recovery and care of sick or injured marine mammals through federal assistance to the U.S. National Marine Mammal Stranding and Entanglement Response Networks. Eligible applicants must provide a Prescott Letter of Eligibility, confirming their participation in the network. This program aims to enhance marine mammal health monitoring and response capabilities across the country, ensuring timely and effective interventions for stranded marine life.
Wildlife Management Marine / Ocean Conservation Environmental Health

BJA FY26 DNA Capacity Enhancement for Backlog Reduction (CEBR)—Competitive Grants Program

US DOJ: OJP Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The BJA FY 2026 DNA Capacity Enhancement for Backlog Reduction (CEBR) Competitive Grants Program aims to enhance the capacity of state and local government crime laboratories for processing DNA samples. This program focuses on using DNA technology to improve forensic efficiency and implement Rapid DNA in booking stations. It targets jurisdictions with operational challenges, ensuring fair access to funding. Eligible agencies can apply for both competitive and formula CEBR funding.
Crime & Justice Community / Public Safety Emerging Technology Development

Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required) (363926)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Neurological Disorders and Stroke (NINDS) aims to enhance research on Amyotrophic Lateral Sclerosis (ALS) through intermediate patient population expanded access protocols. These protocols will provide investigational drugs to ALS patients while collecting vital data to inform future treatments and care strategies. This initiative seeks to better understand the disease's biomarkers, patient experiences, and the overall impact of investigational therapies, fostering advancements in ALS research and care.
Neurological Diseases & Disorders Stroke Amyotrophic Lateral Sclerosis (ALS)

Research Scholar Grants (RSG) Summer Cycle

American Cancer Society
Association/Society
American Samoa, Guam +4 more
Up to US $215,000

American Cancer Society

The mission of the American Cancer Society is to improve the lives of people with cancer and their families through advocacy, research, and patient support, to ensure everyone has an opportunity to prevent, detect, treat, and survive cancer.

ACS Research Priority Areas

The American Cancer Society (ACS) has identified these 6 areas to categorize and track the research we fund to help advance our mission. Applicants (except Institutional Research Grants and Professor grants) are asked to select at least 1 of these research areas that aligns with their proposal:

  • Etiology (causes of cancer)
  • Obesity/Healthy Eating and Active Living (HEAL)
  • Screening and Diagnosis
  • Treatment
  • Survivorship
  • Health Equity Across the Cancer Continuum

Research Scholar Grants

Research Scholar Grants (RSG) provide support for independent, self-directed researchers.

Applicants' institutions must provide space and other resources customary for independent investigators.

Grant proposals are investigator-initiated and may pursue questions across the cancer research continuum, as long as they fit within an American Cancer Society (ACS) priority research area.

These grants typically contribute to the cost of salaries, consumable supplies, and other miscellaneous items required in the research. 

Research Scholar Grants are funded up to $215,000 per year (direct costs), plus 10% allowable indirect costs, with a project period up to four years.

Cancer / Oncology

Broad Street Children's Foundation Grant

Broad Street Childrens Foundation
Private
United States
Unspecified amount

Who We Are

Broad Street Children's Foundation is committed to providing financial support to privately funded children's homes caring for the orphaned, abandoned and broken children right here in the United States.

Grant Seekers

Broad Street Children's Foundation supports self-sustaining children's homes across the United States that actively foster the development of strong, well-rounded children in their care.

Since the start of the Foundation, over $1,000,000.00 in grants have been donated to children's homes across the country. Additionally, through the Bill and Jackie Hazelgrove Scholarship Program, we have been able to assist a number of young people to continue their education and work towards a college or vocational degree.

Today, the Broad Street Children's Foundation is continuing the dream of it's original founders through the second generation. Equally as dedicated to changing the lives of children in need across America and striving to break the cycle of abuse and neglect for other children and their families.

Child Welfare Services Vocational & Trade Education Child Abuse & Neglect +2 more

Easement Restoration and Stewardship

USDA: Natural Resources Conservation Service (NRCS)
Federal Government
American Samoa, Guam +4 more
US $250,000 - US $5,000,000
The Easement Restoration and Stewardship program, funded by the USDA NRCS, focuses on restoring and managing Wetland and Floodplain Easements. It includes developing restoration plans, conducting assessments, and implementing stewardship activities to enhance ecological health. Awardees will collaborate with NRCS personnel to ensure effective restoration design and maintenance strategies, fostering sustainable landscapes. This initiative addresses critical habitat conditions and promotes long-term environmental benefits for protected lands.
Habitat & Ecosystem Restoration Freshwater Conservation Land / Habitat Conservation +1 more

Deployed Warfighter Protection FY27

US DOD: Office of the Secretary of Defense
Federal Government
American Samoa, Guam +4 more
US $20,000 - US $1,100,000
The Deployed Warfighter Protection FY27 program aims to safeguard military personnel from disease-carrying arthropods, including ticks and mosquitoes. It seeks innovative research to develop new insecticides, improve existing formulations, and enhance personal protection technologies. The initiative also focuses on effective pesticide application equipment, addressing both current and emerging arthropod threats. This program is crucial for maintaining the health and safety of deployed military forces.
Infectious & Parasitic Diseases Occupational Health & Safety Preventative Healthcare +1 more

Lee County Grants for Nonprofits Highlights

Looking for Lee County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all Lee County grants recommended for your specific programs in South Carolina.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Grant Funding Trends in South Carolina

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Lee County Grants for Nonprofits year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Lee County Grants for Nonprofits given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Lee County Grants for Nonprofits changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081