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Best Lee County Grants for Nonprofits in South Carolina

Looking for grants for 501(c)(3) nonprofit organizations working in Lee County, South Carolina? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

Available grants

$3.23B

Total funding

$5K

Median grant

9,000+ grants
$3.23B total
$5K median

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9,095 Results based on applied filters

The Role of the Innate Immune System in the Pathogenesis of Type 1 Diabetes

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is advancing Type 1 diabetes research by exploring the innate immune system's role in disease onset. This initiative aims to identify genetic and environmental factors contributing to Type 1 diabetes through multidisciplinary teams. By employing innovative methodologies, the program seeks to determine how immune responses affect pancreatic tissues, potentially leading to early detection and prevention strategies for at-risk individuals.
Genetics & Genomics Diabetes Immune System Diseases

Collaborative Centers in Children’s Environmental Health Research and Translation (P2C Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $750,000
The Collaborative Centers in Children’s Environmental Health Research and Translation program aims to establish a national network of research centers focused on improving children's health through innovative research and public health strategies. By fostering collaboration within the children’s environmental health community, these centers will lead the way in translating scientific findings into actionable practices, ensuring a healthier future for children while addressing emerging environmental threats.
Epidemiology & Public Health Environmental Health Children’s Health & Pediatrics

Immune Drivers of Autoimmune Disease

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Immune Drivers of Autoimmune Disease (IDAD) network, supported by NIAID, aims to uncover early triggers and mechanisms of autoimmunity to prevent disease. Key initiatives include developing predictive tools and biomarkers, fostering preclinical cohorts, and utilizing AI and big data. The network will leverage shared infrastructure for collaborative research, managed by the IDAD Network Coordinating Center, which ensures coordination and resource sharing among awardees. This initiative is crucial for advancing understanding and prevention of autoimmune diseases.
Immune System Diseases Preventative Healthcare Emerging Technology Development

NLM Grants for Scholarly Works in Biomedicine and Health (G13 Clinical Trial Not Allowed) (363939)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $80,000
The NLM Grants for Scholarly Works in Biomedicine and Health (G13) program invites applications to support the creation of book-length manuscripts and scholarly works that are vital for U.S. health professionals and scientists. This initiative aims to foster critical reviews and analytical syntheses that enhance understanding of biomedical and public health challenges, ultimately contributing valuable resources for education, research, and clinical practice.
Health & Medicine Epidemiology & Public Health

BJA FY 2026 Emmett Till Unsolved Civil Rights Crimes Act Program

US DOJ: OJP Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Up to US $645,000
The BJA FY 2026 Emmett Till Unsolved Civil Rights Crimes Act Program aims to assist state, local, and tribal law enforcement agencies in investigating and prosecuting civil rights offenses that resulted in death before December 31, 1979. This funding opportunity is part of the DOJ's broader commitment to enhance public safety, protect civil rights, and ensure justice for victims of violent crime. Applications are due on November 20, 2026.
Social Justice / Human Rights Crime & Justice Community / Public Safety +2 more

F26AS00023 FY2026 Prescott Marine Mammal Rescue and Response Grant Program

US Department of the Interior: Fish and Wildlife Service (FWS)
Federal Government
American Samoa, Guam +4 more
Up to US $150,000
The F26AS00023 FY2026 Prescott Marine Mammal Rescue and Response Grant Program offers crucial financial support for marine mammal rescue efforts. This initiative aims to assist eligible participants in the recovery and treatment of stranded marine mammals, provide emergency response to stranding events, and enhance scientific research on marine mammal health. The program prioritizes applications that effectively address species-specific needs and bolster the capacity of stranding networks, ensuring the welfare of marine wildlife under the management of the U.S. Fish and Wildlife Service.
Marine / Ocean Conservation Wildlife Health

Early to Definitive Clinical Trials (R61/R33 Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH is set to release a Notice of Funding Opportunity for early to definitive clinical trials across various biomedical fields. This initiative focuses on trials evaluating drugs, devices, and interventions that align with NIH's mission. Utilizing the R61/R33 funding mechanism, projects can span up to 7 years, supporting both planning and trial phases. Interested investigators are encouraged to prepare collaborative proposals, although applications are not currently being solicited.
Health & Medicine Health Care Access & Delivery

Visa Foundation U.S. Small Business Growth and Innovation Program

Rockefeller Philanthropy Advisors Inc
Private
U.S. Territories, United States
US $100,000 - US $250,000

Across the United States, small and micro businesses (SMBs) play a critical role in driving economic opportunity, job creation, and community prosperity. Yet many entrepreneurs continue to face challenges accessing the training, resources, and support needed to grow and remain competitive in an evolving economy. To help address these needs, Visa Foundation is committing $2M to launch an open-call grant program that will support nonprofit Entrepreneurial Support Organizations (ESOs) that provide direct services to SMBs. Through this program, Visa Foundation aims to strengthen the capacity of high-impact organizations that help small businesses build greater resilience, expand economic opportunity, and contribute to thriving local economies. 

Business Development Entrepreneurship

Mensa Foundation Prize

Mensa Education And Research Foundation
Private
Countries
US $10,000

About

Founded in 1971, the Mensa Foundation was established by members of American Mensa to extend the organization’s impact. While connected by a shared purpose, the Foundation operates independently, guided by its own Board of Trustees, strategic plan, and initiatives.

Awards

Mensa Foundation Prize

The Mensa Foundation Prize celebrates exceptional achievements that redefine our understanding of intelligence and creativity.

Awarded biennially, this distinguished honor highlights transformative scientific discoveries that elevate the understanding of intelligence.

Details

One of the most prestigious honors in the field, the Mensa Foundation Prize highlights exceptional contributions that elevate the understanding of intelligence.

Award Components

Criteria for Entry

Neuroscience

Mensa Foundation: Lifetime Achievement Award

Mensa Education And Research Foundation
Private
Countries
US $2,500

About

Founded in 1971, the Mensa Foundation was established by members of American Mensa to extend the organization’s impact. While connected by a shared purpose, the Foundation operates independently, guided by its own Board of Trustees, strategic plan, and initiatives.

Awards

Lifetime Achievement Award

The Lifetime Achievement Award recognizes individuals whose lifelong contributions have profoundly advanced the understanding, support, and application of intelligence.

Details

This prestigious honor highlights transformative contributions that have reshaped how intelligence is studied, taught, and applied in real-world settings.

Award Components

Recipients of the Lifetime Achievement Award receive:

  • Permanent recognition as a distinguished leader in the field of intelligence.
  • A $2,500 monetary award in honor of their exceptional achievements.
  • A commemorative trophy celebrating their lasting impact on the field.
Education Neuroscience

Mensa Foundation Gifted Education Fellowship

Mensa Education And Research Foundation
Private
United States
US $5,000

About

Founded in 1971, the Mensa Foundation was established by members of American Mensa to extend the organization’s impact. While connected by a shared purpose, the Foundation operates independently, guided by its own Board of Trustees, strategic plan, and initiatives.

Grants & Fellowships

Fellowships

The Mensa Foundation Fellowship program empowers exceptional individuals committed to advancing the application of intelligence in their respective fields.

Details

Our current fellowship, the Gifted Education Fellowship, is designed to empower educators pursuing graduate studies in gifted education or closely related fields, enabling them to make a transformative impact in their classrooms and communities. The fellowship supports both doctoral and non-doctoral students, with awards and renewal terms tailored to each track.

Neuroscience Teacher Development & Training Education - Higher Education +1 more

Mensa Foundation: Dissertation Mini-Grant

Mensa Education And Research Foundation
Private
Countries
US $2,500

About

Founded in 1971, the Mensa Foundation was established by members of American Mensa to extend the organization’s impact. While connected by a shared purpose, the Foundation operates independently, guided by its own Board of Trustees, strategic plan, and initiatives.

Grants & Fellowships

Dissertation Mini-Grant

The Mensa Foundation empowers the next generation of researchers through its Dissertation Mini-Grant program.

Designed to support advanced doctoral students, this grant funds innovative studies that broaden our understanding of intelligence, creativity, gifted education, and related fields.

Details

The Mensa Foundation Dissertation Mini-Grant provides $2,500 to advanced doctoral students conducting research on intelligence and gifted education. By funding innovative studies, the grant promotes research that addresses the complexities of intelligence, creativity, and related fields.

Grant Components

Education - Higher Education Neuroscience Humanities & Social Science +4 more

Early Career Mini-Grant

Mensa Education And Research Foundation
Private
Countries
US $2,500

About

Founded in 1971, the Mensa Foundation was established by members of American Mensa to extend the organization’s impact. While connected by a shared purpose, the Foundation operates independently, guided by its own Board of Trustees, strategic plan, and initiatives.

Grants & Fellowships

Early Career Mini-Grant

The Mensa Foundation empowers emerging researchers through its Early Career Mini-Grant program.

Designed to support post-doctoral researchers and early career faculty, this grant funds innovative studies that advance our understanding of intelligence, creativity, gifted education, and related fields.

Details

The Early Career Mini-Grant provides $2,500 to support post-doctoral researchers and faculty within five years of completing their doctoral degree. This grant is intended to promote groundbreaking studies that advance our understanding of intelligence and its applications in education and beyond.

Grant Components

Neuroscience Education Academic Success & Enrichment

Mensa Foundation: Copper Black Award

Mensa Education And Research Foundation
Private
Countries
US $1,000

About

Founded in 1971, the Mensa Foundation was established by members of American Mensa to extend the organization’s impact. While connected by a shared purpose, the Foundation operates independently, guided by its own Board of Trustees, strategic plan, and initiatives.

Awards

Cooper Black Award for Creativity

The Copper Black Award for Creative Achievement honors Mensa members whose innovative solutions and practical creativity have brought meaningful benefits to the world.

Details

The Copper Black Award annually recognizes Mensa International members who have demonstrated a specific creative achievement with practical value. This award honors innovations that have been implemented, at least in part, to benefit others.

Award Components

Humanities & Social Science STEM / STEAM Education

FY 2027 Continuation of Solicitation for the Office of Science Financial Assistance Program

United States Department of Energy (DOE)
Federal Government
American Samoa, Guam +4 more
US $5,000 - US $10,000,000
The FY 2027 Continuation of Solicitation invites applications to support various program areas, including Advanced Scientific Computing, Basic Energy Sciences, Fusion Energy Sciences, and more. This annual open solicitation from the Department of Energy (DOE) allows research proposals throughout the fiscal year. Applications must align with SC's mission and can be submitted until September 30, 2027, or until a new solicitation is issued. Detailed submission processes are outlined in 10 C.F.R. part 605.
Energy Science Physics +1 more

Dairy Business Innovation Initiatives Program (DBI) Fiscal Year 2026

USDA: Agricultural Marketing Service (AMS)
Federal Government
United States
US $2,300,000 - US $3,450,000
The Dairy Business Innovation Initiatives Program (DBI) for Fiscal Year 2026, administered by the USDA's Agricultural Marketing Service, invites applications from existing initiatives to support the dairy industry. With approximately $12.65 million available, the program aims to diversify dairy markets, enhance farmer income, and promote regional milk production. Funding will prioritize equipment and infrastructure projects, which are vital for strengthening the capacity of dairy businesses and fostering innovation in processing and marketing.
Agriculture Agricultural Economics Business Development

WATER RESOURCES RESEARCH ACT PROGRAM NATIONAL COMPETITIVE GRANTS FY2026 (104g General)

US Department of the Interior: Geological Survey (USGS)
Federal Government
American Samoa, Guam +5 more
Up to US $120,000
The Water Resources Research Act Program National Competitive Grants FY2026, administered by the U.S. Geological Survey, aims to support innovative research initiatives at Water Resources Research Institutes across the U.S. and its territories. These grants facilitate essential studies on water management, addressing critical water resource challenges while promoting collaboration among states. This program seeks to enhance the understanding of water issues, ultimately contributing to sustainable management practices and informed decision-making in water resource policy.
Hydrology Freshwater Conservation Environmental Policy

Fiscal Year 2026 Wildlife Crossings Pilot Program

DOT Federal Highway Administration
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Fiscal Year 2026 Wildlife Crossings Pilot Program aims to enhance public safety by reducing wildlife-vehicle collisions and improving habitat connectivity for various species. With approximately $80 million available through cost reimbursable grants, this initiative supports eligible projects that address these critical environmental and safety concerns. The program may also distribute leftover funds from previous years, contingent on availability, fostering innovative solutions in wildlife management and transportation safety.
Land / Habitat Conservation Community / Public Safety Wildlife Health +1 more

The Science, Mathematics and Research for Transformation (SMART) Scholarship for Service Program Cooperative Agreement

US DOD: Office of the Secretary of Defense
Federal Government
American Samoa, Guam +4 more
US $1,300,000,000
The SMART Scholarship-for-Service Program, managed by the Department of War, aims to enhance the U.S. military's technical workforce by offering competitive scholarships for STEM degrees. With a funding cap of $1.3 billion over ten years, the program prepares scholars for critical roles in national defense, ensuring a pipeline of skilled professionals. Since its inception in 2005, over 8,000 scholarships have been awarded, fostering a strong connection between education and service in defense-related fields.
Education - Higher Education Workforce Preparation & Job Readiness STEM / STEAM Education

GAP Audit Reimbursement Cost Share

South Carolina Department of Agriculture
State/Local Government
South Carolina
Unspecified amount

South Carolina Department of Agriculture

The South Carolina Department of Agriculture was established in 1879 to oversee and promote agriculture in the Palmetto State. With services as diverse as food safety inspections, entrepreneurship development, and the Certified South Carolina branding program, we help the state’s farmers and agribusinesses grow and prosper.

The mission of the South Carolina Department of Agriculture is to promote and nurture the growth and development of South Carolina’s agriculture industry and its related businesses while assuring the safety and security of the buying public.

GAP Audit Reimbursement Cost Share

Through funding from the USDA AMS Specialty Crop Block Grant Program (#25SCBPSC1280), South Carolina growers can now get reimbursed for 90% of the costs associated with a GAP audit completed while funds are available. To help growers receive reimbursements faster, they may choose to receive two separate payments. A grower may submit Part I of the application as soon as they have paid the SCDA portion of the audit without having to wait on the USDA invoice. Then, once the grower has paid the USDA portion, they may submit Part II of the application to receive 90% of that amount as well. However, a grower may choose instead to submit both parts together to receive one larger payment. See examples below:

Example 1

Smith Farm submits a paid receipt from SCDA Fruit & Vegetable Inspections for $575 with Part I of the application and receives a check for $517.50 approximately four weeks later. ($575 × 90%)

Next, the Smiths receive the USDA invoice, pay $345 to USDA, then submit the paid receipt with Part II of the application to USDA. About four weeks later the Smiths receive a second check for $310.50. ($345 × 90%)

Example 2

Jones Farm is charged the same as the Smiths above but chooses to wait until they have paid both invoices to submit the application. In this case, they may submit both Parts I and II of the application at the same time. The Jones’ will receive one check approximately four weeks later for $828.

($575 + $345 = $920 × 90%)

Applicants must submit a complete application package including all of the following:

  • Completed application with correct information
  • A state vendor registration number
  • Complete, detailed answers to the questionnaire included in the application (Note: This information impacts our ability to seek continued funding for this program).
  • Your agreement to provide follow-up information regarding the impact of GAP certification (Note: This information impacts our ability to seek continued funding for this program).
  • A copy of the paid receipt or other proof of payment for the reimbursement you are requesting. We will not send checks unless we have this.
Agricultural Crops

Rehabilitation Engineering Research Center on Recreational, Sport, and Exercise Technologies for People with Disabilities

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $970,000 - US $975,000
The Rehabilitation Engineering Research Center on Recreational, Sport, and Exercise Technologies for People with Disabilities aims to enhance rehabilitation services through innovative technological solutions. This initiative focuses on promoting health and exercise among individuals with disabilities by addressing unique rehabilitation challenges. Funded by the US HHS Administration for Community Living, the project spans 60 months, involving advanced research and development to create effective support mechanisms and overcome environmental barriers.
Engineering Disability Care & Services Medical Rehabilitation +1 more

Field Initiated Projects Program (Research) (363972)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $245,000 - US $250,000
The Field Initiated Projects Program aims to foster new research and develop solutions that enhance the inclusion and independence of individuals with disabilities. This initiative focuses on generating scientific knowledge and understanding critical issues faced by these populations, particularly those with significant support needs. With a total of 16 grants available over a 36-month period, this program encourages innovative approaches that support employment, living arrangements, and caregiver involvement.
Disability Care & Services Medical Rehabilitation Employment Services

Rehabilitation Research and Training Center (RRTC): National Research Center for Parents with Disabilities (363975)

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $920,000 - US $925,000
The Rehabilitation Research and Training Center (RRTC) focuses on enhancing the lives of parents with disabilities through research, training, and technical assistance. This initiative aims to develop evidence-based services and supports that empower parents in their caregiving roles. Funded by the US HHS: Administration for Community Living (ACL), the project spans 60 months with a commitment to fostering inclusive environments for families. The RRTC will explore innovative interventions and technologies to better support these parents in their daily challenges.
Disability Care & Services Family Services

Rehabilitation Engineering Research Center on Technologies for People Who are Blind or have Low Vision

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $970,000 - US $975,000
The Rehabilitation Engineering Research Center aims to enhance services for individuals who are blind or have low vision through innovative technology development. This initiative focuses on overcoming rehabilitation challenges and environmental barriers, promoting independence and community living. A grant of five years will support ongoing research efforts, ensuring advancements in assistive technologies that empower the target population. The project aligns with the Rehabilitation Act's goals, emphasizing the importance of accessibility and inclusion.
Disability Care & Services Medical Rehabilitation Emerging Technology Development

Center on Knowledge Translation for Disability and Rehabilitation Research

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $795,000 - US $800,000
The Center on Knowledge Translation for Disability and Rehabilitation Research (KTDRR Center) aims to enhance the use of relevant disability and rehabilitation research through effective knowledge translation. Serving as a key resource for NIDILRR grantees and the general public, the KTDRR Center's initiatives will support high-quality research dissemination. The project spans 60 months, including five 12-month budget periods, ensuring ongoing support for researchers and stakeholders in the field.
Disability Care & Services Medical Rehabilitation

Burn Injury Model System Centers

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $560,000 - US $640,000
The Burn Injury Model System Centers aim to enhance burn rehabilitation through innovative research. These centers must create knowledge to improve the health, community engagement, and employment outcomes for individuals affected by burn injuries. Funded by US HHS's Administration for Community Living, grants support site-specific and collaborative research while contributing to a longitudinal database. Each grant has a maximum duration of 60 months, divided into five budget periods, ensuring comprehensive support for ongoing studies.
Disability Care & Services Medical Rehabilitation

Lee County Grants for Nonprofits Highlights

Looking for Lee County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all Lee County grants recommended for your specific programs in South Carolina.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Grant Funding Trends in South Carolina

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Lee County Grants for Nonprofits year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Lee County Grants for Nonprofits given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Lee County Grants for Nonprofits changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081