Best McCormick County Grants for Nonprofits in South Carolina

The McKnight Endowment Fund for Neuroscience offers Scholar Awards to early-career neuroscientists focusing on learning and memory disorders. The awards provide up to $225,000 over three years, emphasizing research that could lead to significant clinical advancements. Eligible candidates must work as independent investigators at U.S. non-profit institutions, hold an Assistant Professor position for less than four years, and demonstrate their research program's potential. The program aims to foster innovative solutions in neuroscience.

The JA Community Foundation focuses on funding solutions that address the needs of the Japanese American and broader Asian American communities. They prioritize programs that enhance senior health, promote history, arts, culture, and support youth. Eligible applicants must be registered 501c3 organizations and can apply from all 50 states. However, organizations with open grants cannot submit new applications until their current grants are closed.

The Christopher & Dana Reeve Foundation's Expanded Impact Grants Program aims to support previously awarded Quality of Life grantees in expanding successful initiatives for individuals living with paralysis. Offering up to $100,000 for each of the four grants, this program seeks to enhance evidence-based practices that improve the quality of life for both patients and their caregivers. Eligible organizations must demonstrate previous success and be capable of scaling their impactful projects within 24 months.

Grants

Through our grantmaking, we support nonprofits that serve South Carolina at local, regional and state levels to address root causes of poverty while honoring the dignity of every South Carolinian.

Starting in 2026, our grants focus primarily on systems change in the areas of

• economic mobility,
• housing security and
• health care (with health care systems change grants by invitation only).

By focusing our efforts and going deeper on these three issues, we aim to have an even greater impact on the nonprofits and communities we serve.

Systems Change Grants

Systems Change Grants fund organizations and coalitions that are working to change the policies, power structures and mindsets that cause and reinforce poverty in South Carolina. These grants specifically fund systems change that supports economic mobility and housing security.

Through these grants, we aim to generate a larger impact through more intentional funding, highly focused work and alignment across our Foundation’s activities.

What Systems Change Grants Support

• Organizations that are actively working on systems change that impacts people experiencing poverty and addresses economic mobility or housing security. To see how the Foundation defines these terms, visit our Strategic Plan webpage.
• Organizations that are seeking to change systems at the local, regional or state level. Systems Change Grants provide up to $75,000 annually for local or regional work.
  • State-level grants have a $100,000 maximum each year. 
• Organizations addressing systems change in at least one of the following ways:
  • Participating in advocacy and lobbying
    • Focus on changing policies, practices, processes, rules or laws
    • Impacting resource flows (i.e., reallocated and/or new funding streams)
    • Holding systems accountable to their intended purpose through the above as well as through litigation
  • Addressing unequal power
    • Focus on changing the distribution and dynamics of privilege, relationships and tradition
    • Organizing and building connections and coalitions that center community voices and perspectives
    • Civic engagement
  • Affirming the dignity of people experiencing poverty
    • Focus on changing the narrative around poverty
    • Focus on changing attitudes, mindsets, values, belief systems, norms, mental models and paradigms
  • Implementing big impact, scalable, or innovative solutions
    • Focus on changing results, especially for groups experiencing inequitable outcomes as a result of historic and current marginalization

All grants are for one year, with the possibility of renewal up to three years based on meeting reporting requirements and the availability of funding.

The Delta Dental of Missouri Grant Program aims to improve oral health in Missouri by funding initiatives that reduce oral disease, enhance access to quality dental care, and raise awareness, particularly among underserved populations. Grants range from over $5,000 to $100,000 and are awarded for one year, focusing on projects that increase access to care and demonstrate matching funds from other sources.

Delta Dental of Missouri's Community Donation Program aims to enhance community health through charitable contributions, focusing on organizations that serve Missouri and South Carolina. Preference is given to those with an oral health component. Eligible organizations must be 501(c)(3) registered, address the needs of at-risk populations, and be represented by an authorized member for support requests. This initiative underlines Delta Dental's commitment to community well-being and support.

Charlie's Heart Foundation Annual Grant Program supports small nonprofits focusing on mental well-being for families in underserved communities. Grants between $5,000-$30,000 are available, prioritizing organizations based in North Carolina. Eligible applicants must be 501(c)(3) tax-exempt and demonstrate alignment with the Foundation's mission, organizational need, and program sustainability. The Foundation does not fund individuals, private foundations, or religious organizations, ensuring a strong focus on impactful community programs.

The Craig Newmark Philanthropies Grants, established in partnership with the Bob Woodruff Foundation, aim to support military and veteran communities through funding initiatives that enhance health and well-being. Since 2020, this program has positively impacted over 1.6 million veterans, service members, and their families. The grants focus on improving health determinants, increasing access to healthcare, and facilitating veterans' successful transitions to civilian life.

The Analysis Program, funded by the National Science Foundation (NSF), offers support for research in various fields of analysis, including complex and harmonic analysis, dynamical systems, and mathematical physics. Proposals for conferences and workshops must adhere to specific submission timelines, with deadlines between September 16-30 for events starting between March 1 and September 30. This program emphasizes timely submissions and may require external reviews for larger budget requests.

The Rauschenberg Medical Emergency Grants, administered by the New York Foundation for the Arts, provide one-time funding up to $5,000 for artists facing unexpected medical emergencies. This program aims to alleviate financial burdens caused by medical costs, ensuring that artists can receive necessary care without delay. Eligible applicants must be practicing artists in visual arts, film, or choreography, and demonstrate financial need. This initiative supports artists of color, LGBTQ+ individuals, and those outside major coastal cities.

The Petco Foundation offers disaster relief support for animal welfare organizations affected by disasters. Eligible applicants include authorized members of IRS-designated 501c3 nonprofits, government agency representatives with operational insight, and invited for-profit entities focused on animal welfare. However, the foundation does not fund individuals, organizations outside the U.S., or those whose primary mission does not relate to animal welfare. This initiative aims to provide critical assistance during times of crisis.

We are living in a time of intensified state violence and mass criminalization. The current political climate has doubled down on surveillance, policing, incarceration, and the criminalization of protest, migration, and mutual aid. For directly impacted communities, the trauma is relentless — and those of us committed to resistance are feeling the weight of outrage fatigue.

But we know: the antidote to outrage fatigue is movement response. The expansion of state violence and mass incarceration often forces organizations to respond quickly to unanticipated events despite lacking the necessary resources or capacity.

The Strategic Opportunities Support (SOS) Fund-CJI’s rapid-response fund-is designed to support bold, strategic, and immediate actions by grassroots organizations on the front lines of resistance. The Fund awards grants up to $7,500 and enables organizations to move quickly and collaboratively in response to emerging threats and seize opportunities to advance justice, healing, and systemic transformation.

The Disability Inclusion Fund Grant, managed by Borealis Philanthropy, aims to support organizations advocating for disability inclusion, rights, and justice. As a partner in philanthropy, Borealis facilitates donor collaboratives to maximize impact across various communities and movements. Organizations interested in applying for this grant are encouraged to review the detailed FAQ for further information. This initiative is a vital step towards fostering inclusivity and promoting the rights of individuals with disabilities.

The Cameron Award supports field research on native rodents across the Americas, encouraging studies in ecology, behavior, physiology, and conservation. It is available to students in MS or PhD programs and postdoctoral researchers in the U.S. Applicants must be ASM members. Funds cover supplies, equipment, and travel, but not salaries or meeting travel. The award aims to enhance understanding of rodent ecology and their impact on ecosystems.

The Republic Services Community Grant Program supports local nonprofit organizations focused on neighborhood revitalization, safety, disaster relief, and social services. Eligible 501(c)(3) organizations can apply once annually through an online application process. The program emphasizes a non-discrimination policy, ensuring services are provided without bias. However, funding is not available for individuals, government entities, schools, or religious organizations. This initiative reflects Republic Services' commitment to community engagement and support.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

The Chisholm Foundation offers grants to support arts, education, and religion projects across the United States. Applications for May and November grants should be submitted by March 1st and September 1st, respectively. The Foundation evaluates each application individually and encourages innovative projects that can attract additional funding. Grants may be awarded as lump sums or in installments, and applicants are advised to seek matching gifts to enhance their proposals.

Takeda's Corporate Giving program focuses on enhancing community well-being in the U.S. by supporting initiatives in two key areas: Food is Health and Building STEM Foundations. Through employee engagement and partnerships, Takeda aims to provide access to nutritious food and foster STEM education, addressing social disparities and empowering future innovators. This commitment reflects Takeda's mission of better health and a brighter future for all.

The Regenerative Agriculture Foundation Grant supports organizations that promote regenerative practices, emphasizing the value of people, plants, animals, and the planet. With a focus on BIPOC-led initiatives, the foundation encourages systemic change in agricultural systems through collaborative funding. Grants are available to U.S.-based organizations that align with RAF's vision and engage in transformative efforts. The competitive grantmaking process is by invitation only, ensuring targeted support for impactful projects.

The Kids to Parks Day School Grants Program offers funding up to $1,000 for Title I schools in the U.S. to enhance student engagement with parks and public lands. This initiative encourages hands-on learning experiences through outdoor activities and stewardship projects, promoting environmental education and healthy lifestyles. Eligible classrooms can apply, emphasizing student involvement in the application process. The program aims to empower students and teachers to foster a deeper connection with nature and their communities.

The National Fund for Sacred Places Grant Program supports historic houses of worship in the U.S. through matching grants ranging from $50,000 to $250,000. This initiative, in collaboration with the National Trust for Historic Preservation, aims to enhance community engagement and preserve culturally significant buildings. Applicants are encouraged to demonstrate their historical relevance and community service, particularly those representing underrepresented groups. The program prioritizes urgent repair needs and projects that foster inclusivity and accessibility.

Casey's Cash for Classrooms Grants support K-12 public and nonprofit private schools through funding for physical improvements, material needs, teacher support, and community engagement. In 2025, $900,000 was awarded across 80 grants, allowing schools to enhance their learning environments. With a commitment to community engagement, Casey's has donated $15 million since 2019, emphasizing their dedication to making life better for communities and guests. Grants range from $3,000 to $50,000, with funds required to be used within 12 months.

The Lemelson Foundation Grant supports initiatives in invention education and entrepreneurship, aiming to empower young inventors and foster innovation. With over $300 million provided since its inception, the Foundation focuses on strengthening ecosystems for invention in the U.S. and developing countries. Organizations interested in aligning with their mission are encouraged to take an eligibility quiz and submit inquiries through their contact form. This commitment is crucial for driving impactful solutions to global challenges.

The Philanthropic Impact Fund (PIF) by Vanguard Charitable aims to strengthen nonprofit organizations and philanthropic infrastructure. It focuses on integrating AI, educating donors, and enhancing the narrative around the nonprofit sector. Grants typically range from $50,000 to $100,000, with larger requests considered. Organizations must be 501(c)(3) registered nonprofits to apply. This funding is a strategic investment in resilience and sustainability, addressing critical needs in the sector.

The Awards for Advancing Minority Mental Health, established by the American Psychiatric Association Foundation in 2003, aim to honor community organizations that promote mental health awareness in underserved minority communities. These awards recognize efforts to improve access to quality mental health services, enhance treatment quality, and address cultural barriers. Organizations must have been operational for at least two years and demonstrate innovative approaches to mental health challenges.

The U.S. Embassy in Tokyo is launching a competition to promote study abroad programs for Japanese students seeking graduate education in the United States. This initiative invites proposals from American and Japanese non-profit organizations to create innovative programs aimed at increasing enrollment of Japanese students in U.S. graduate schools across various fields, enhancing cross-cultural exchange and educational opportunities.

The Hemophilia Alliance Foundation's Impact Grants aim to support organizations enhancing services for individuals with inherited bleeding disorders. Since its inception in 2009, the foundation has awarded over $6.6 million, enabling innovative projects that expand capacity and collaboration. Eligible applicants include local organizations and federally-funded treatment centers, emphasizing creativity in project proposals. Priority will be given to initiatives that address unserved populations and foster educational advancements in the community.