Best Large Grants for Nonprofit Organizations in Minnesota

Private Well Protection Grant

The Minnesota Department of Health (MDH) received funding from the Clean Water Fund to provide testing and outreach to private well users. A portion of this funding is available through grants aimed at increasing private drinking water well testing among households that rely on private wells for drinking water. Eligible entities may apply for funding to support activities that promote and provide well water testing within their communities.

Over 1.1 million Minnesotans across Minnesota have fewer safeguards because they use a private well. Unlike their peers connected to public water, private well users are responsible for voluntarily protecting and testing their well and addressing water quality issues. MDH received funding from the Clean Water Fund to ensure safe drinking water for private well users. A portion of this funding is being offered as grants to promote private well testing among private well users. Each entity will have the opportunity to apply for up to a predetermined amount of funds to promote well testing for households that rely on private well water for drinking water that will include testing for five common contaminants (arsenic, coliform bacteria, lead, manganese, and nitrate). This will be an iterative and communicative process in which grantees will work with MDH to carry out the grant goals. Entities can submit a shared proposal that adds each entity’s predetermined amount together.

The Maine Cancer Foundation is seeking proposals for cancer screening initiatives aimed at early detection and prevention. This RFP focuses on screenings for breast, cervical, colorectal, lung, prostate, and skin cancers. Proposals should align with evidence-based practices endorsed by the CDC and U.S. Preventive Services Task Force. Interested applicants are encouraged to consult with MCF prior to submission to discuss project concepts and receive feedback on draft applications.

The Thornton S. Glide, Jr. and Katrina D. Glide Foundation provides grants to qualified 501(c)(3) organizations in California that focus on animal protection, land conservancy, agriculture, and civic endeavors. Established in 1995, the foundation prioritizes grants for specific capital acquisitions and does not support operational costs or direct aid to individuals. Emphasizing local impact, California-based organizations are favored over out-of-state counterparts.

Minnesota Department of Transportation (MnDOT)

Safe Routes to School Infrastructure (SRTS) Program Grant Solicitation

The Minnesota Safe Routes to School (SRTS) Infrastructure Program was established by the Minnesota Legislature in 2012 and is defined in Minnesota Statute 174.40. MnDOT State Aid for Local Transportation (SALT) and the Office of Transit and Active Transportation (OTAT) share responsibilities for the administration and oversight of the SRTS program. SALT administers the SRTS infrastructure funds on local roads (county, city, township, and Tribal owned roadways), and OTAT administers the non-infrastructure SRTS funds. Up to $8,500,000.00 in grant funds are available for this 2024 SRTS infrastructure solicitation.

The Minnesota Department of Transportation (MnDOT) State Aid for Local Transportation (SALT) administers the state SRTS infrastructure program with guidance from the Infrastructure Work Group (IWG) of the Active Transportation Advisory Committee (ATAC). The process, criteria, and prioritization for the solicitation are required by statute to establish a geographic equity-based project evaluation and selection process that is competitive, criteria-based, and objective. Projects are selected and approved by the Infrastructure Work Group of the Active Transportation Advisory Committee to provide financial assistance to eligible recipients to construct capital improvement of transportation infrastructure that improves safety and encourages non-motorized transportation to and from schools.

The Ralph J. Torraco Food Bank/Shelter Fund Grant, offered by the UNICO Foundation Inc., aims to combat hunger and provide shelter for the homeless and indigent. Eligible applicants include registered non-profit food pantries, soup kitchens, and shelters in 13 U.S. states. The grant focuses on direct services, ensuring that all funds are used for food and shelter, not for operating expenses, thereby promoting effective community support for vulnerable populations.

The Westinghouse Charitable Giving Program aims to strengthen community ties by providing financial support in key areas such as education focused on STEM, environmental sustainability, and community safety. This program welcomes applications from eligible organizations that meet specific grant criteria, including being tax-exempt and located within 50 miles of a Westinghouse site. The initiative underscores Westinghouse's commitment to advancing education, promoting environmental stewardship, and enhancing community well-being.

The Thriving Community Impact Fund offers grants ranging from $2,500 to $49,999 to support community health initiatives. Gundersen Health emphasizes collaboration and addressing social needs to foster well-being. Eligible organizations include non-profits, schools, and government agencies. The fund prioritizes projects that align with the Community Health Improvement Plan, focusing on health equity, civic engagement, and neighborhood enhancement. This initiative aims to empower communities and improve health outcomes while fostering corporate social responsibility.

The WKKF Grant, offered by the W.K. Kellogg Foundation, is dedicated to fostering a future where every child and family thrives. With a focus on nurturing early education, accessible healthcare, and equitable food systems, this grant supports initiatives that empower communities across the U.S. and parts of Mexico and Haiti. Organizations meeting IRS regulations and being legal entities, particularly 501(c)(3) nonprofits, are encouraged to apply for funding to create lasting impacts in their communities.

The NACD Technical Assistance Grants program, in partnership with NRCS, has been enhancing conservation district support since 2018. By funding staff hires, it aims to improve service for agricultural producers and address conservation workload challenges. The initiative focuses on outreach, education, and civic engagement to empower local communities, promote sustainability, and support historically underserved producers in implementing conservation practices, thereby fostering both individual and community resilience.

The Securian Foundation focuses on enhancing community well-being through financial stability, youth education, and vibrant communities. They aim to empower families by supporting initiatives that ensure equitable access to basic needs, promote financial literacy, and encourage community engagement in arts and culture. The foundation prioritizes funding for food security, housing, workforce development, educational programs, and civic opportunities, while maintaining a commitment to serving underrepresented populations.

The Rural Primary Care Residency Training Grant Program aims to enhance primary care residency training in rural Minnesota. With funding between $1.5 to $2 million, it supports planning, accreditation, and training. Grants of up to $225,000 per resident per year are available for sustainable projects. To qualify, programs must demonstrate ACGME accreditation and provide evidence of resident training. This initiative is vital for strengthening the rural physician workforce and improving healthcare access in underserved areas.

Lilly Foundation

To extend Lilly’s charitable reach and impact, the Eli Lilly and Company Foundation (Lilly Foundation) was established in 1968 and is supported by donations from Eli Lilly and Company.

The Foundation is a tax-exempt, private foundation supporting programs that align with its philanthropic priorities.

Grantmaking Approach

The Lilly Foundation’s work is guided by a charitable vision of a world where every person has an opportunity to live their healthiest life. Through grantmaking focused on Lilly Foundation’s charitable vision, grants can serve as a catalyst for closing gaps and empowering individuals and communities to thrive.

All proposals should demonstrate clear alignment with at least one focus area and include charitable outcomes that are measurable and consistent with the Foundation’s long-term charitable goals.

Global Health, K-12 STEM Education and Economic Mobility Grant

Focus Areas

Global Health

Lilly Foundation, through its charitable grants, aims to support permissible charitable efforts to improve access to quality healthcare for resource-limited communities in low- and lower-middleincome countries (L/LMICs) and in the United States. Strengthening access to care is essential for enhancing community well-being and supporting economic stability in resource-limited settings.

The Global Health focus area aims to close gaps in quality healthcare by supporting charitable solutions that improve access, bring care closer to where people live, and address the high burden of non-communicable diseases (NCDs) in resource-limited settings. To the extent permissible, the Foundation prioritizes charitable efforts related to cardiometabolic health in resource-limited settings.

K-12 STEM Education

The K-12 STEM Education focus area aims to close the gaps for students from low-income communities by supporting programs that foster new pathways and pipelines to STEM education through focused K-12 efforts, concentrating on the critical middle school years. The Foundation’s K-12 STEM Education grants are focused on initiatives that benefit Marion County, Indiana.

Economic Mobility

The Economic Mobility focus area supports charitable and educational programs that strengthen workforce readiness, postsecondary and skills-based educational pathways, and housing stability to promote long-term prosperity. This support is focused on Marion County, Indiana, with the goal of improving economic opportunity for low-income communities and advancing community well-being.

The Minnesota Department of Human Services, through its Behavioral Health Administration (STATE), is seeking Proposals from qualified Responders to address the opioid overdose crisis in communities and populations that have been historically underserved and disproportionately impacted by opioid-related overdose deaths. 

The Biodiversity Fund Grant, offered by the Boreal Waters Community Foundation, aims to enhance biodiversity in the Duluth-Superior region. It supports projects focused on habitat restoration, species protection, and addressing climate change impacts. Eligible applicants include charitable organizations that serve specific counties in Wisconsin and Minnesota. This initiative seeks to promote ecological health and engage local communities in conservation efforts, ensuring the preservation of vital ecosystems for future generations.

Ecolab Foundation

Ecolab Foundation is a philanthropic arm of Ecolab dedicated to advancing community well-being through programs that promote education, environmental stewardship, and public health. Its mission is to create positive social impact by supporting initiatives that strengthen communities and foster sustainable development.

The foundation’s primary areas of engagement include educational programs that enhance learning and workforce readiness, environmental projects that encourage conservation and sustainability, and health-related initiatives that improve hygiene and safety. It focuses on partnerships that deliver measurable benefits and long-term impact.

Ecolab Foundation operates primarily within the United States while also supporting global initiatives aligned with its corporate responsibility goals. Its geographic scope reflects a commitment to addressing local community needs and contributing to broader sustainability efforts.

The foundation collaborates with nonprofit organizations, educational institutions, and community-based groups. It prioritizes partnerships that demonstrate strong governance, clear objectives, and alignment with its mission of education, health, and environmental responsibility.

Ecolab Match Program

Ecolab established the Volunteer and Community Relations programs to encourage and reward Ecolab employee and alumni involvement in the communities where people live and work. There are three programs including the Board Leadership Volunteer Grant.

Board Leadership Volunteer Grant

Ecolab will donate up to $500 USD annually to a qualifying 501(c)3 organization (some restrictions apply) for which an eligible person serves on the Board of Directors. 

Focus Areas of Giving

• Youth and Education: programs that promote youth development, particularly for programs that ensure all students are successful
• Civic & Community Development: affordable housing, work readiness, crisis assistance and hunger relief
• Environment & Conservation: hands-on environmental learning programs, environment and conservation organizations
• Arts & Culture: arts education for children and youth as well as support for museums and the performing arts

The Make it Minnesota Cost-Share Program, administered by the Minnesota Department of Agriculture, offers financial assistance to Minnesota-based consumer packaged goods companies. By reimbursing 50% of eligible marketing investments, the program supports businesses in enhancing their market presence. Eligible entities can receive up to $4,000 annually for Minnesota-manufactured brands and $3,000 for those made elsewhere. Applications are processed on a first-come, first-served basis until the deadline or funds are exhausted, with the final application date set for July 10, 2026.

Minnesota Department of Health

Mission: Protecting, maintaining and improving the health of all Minnesotans.

Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.

Rural Health Transformation Program Funding 

The federal Rural Health Transformation Program (RHTP) was created by H.R.1 (Section 71401 of Public Law 119-21) on July 4, 2025. It is a federal initiative to help states support rural communities in improving health care access, quality, and outcomes by transforming the health care delivery ecosystem. The RHTP focuses on promoting innovation, strategic partnerships, infrastructure development, and workforce investment in rural communities. Minnesota has outlined their initiatives online (learn more about Minnesota's Rural Health Transformation Program).

Grant recipients will select activities from broad RHTP initiatives designed to advance the overarching goals of improving health outcomes and access to care for rural Minnesotans, sustainably expanding the rural health care workforce, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments. 

Entity Type: Certified Community Behavioral Health Clinics (CCBHCs) and Community Mental Health Centers (CMHCs)

Estimated Number of Awards: 16

Estimated Maximum Award in Budget Period 1: $240,000

Applicants may request up to the maximum award.

About OJP

The Office of Justice Programs provides leadership and resources to reduce crime, improve the functioning of the criminal justice system and assist crime victims.

2027 Tribal Nation-based Crime Victim Services

Request for proposals (RFP)

The purpose of this Request for Proposals (RFP) is to solicit applications for funding to provide crime victim services on Tribal Nation lands in Minnesota. Funded grantees are expected to be a resource for their Tribal community and provide crime victim services as detailed in the Program Standards (see Section 2.1 of RFP) under which they are funded.

The Joseph Durda Foundation, established in 1989, prioritizes charitable giving to alleviate poverty, support orphans, and assist disabled individuals. The Foundation seeks to empower underprivileged youth through education and invest in medical research, particularly cardiovascular health. Grants are directed towards organizations that positively impact communities, especially those where board members reside, while maintaining a focus on military veterans and their families. Note that individual grants and funding outside these priorities are not supported.

The Levin Family Foundation Grant supports nonprofits focused on critical issues in Montgomery County, Ohio, such as the opiate epidemic, human trafficking, anti-bullying, and suicide prevention. Established in 1996, the foundation has invested over $12 million globally, emphasizing projects that align with its mission. Eligible organizations must be IRS 501(c)(3) tax-exempt. Priority is given to initiatives in the Greater Dayton Area, fostering positive community impact.

The Old National Bank Foundation offers grants to nonprofit organizations for community impact initiatives across Indiana, Illinois, Kentucky, Tennessee, Michigan, Minnesota, Iowa, and Wisconsin. Focused on four key areas—Affordable Housing, Workforce Development, Economic Development, and Financial Empowerment—the foundation prioritizes programs that support underrepresented communities. Organizations must have 501(c)(3) status and align with the foundation’s funding priorities to qualify for grants, which can be applied for every two years.

The Looking Out Foundation Grant supports social justice and humanitarian initiatives, having donated nearly $6 million to various causes globally. With an average donation of $25 per campaign, it aids organizations focused on disaster relief, racial justice, and support for marginalized communities. Eligible applicants must be tax-exempt public charities under Section 501(c)(3). The foundation prioritizes diverse funding sources and encourages organizations to adapt to changing needs, with grant allocations ranging from $5,000 to $25,000.

The Ecolab St. Paul, MN Area NPO Grant Program supports 501(c)(3) organizations that focus on youth development, community and civic engagement, environmental conservation, and arts education. Grants are available to current grantees in the St. Paul area, with applications opening on September 8, 2025. This initiative aims to enhance health, sustainability, and operational efficiency in local communities, aligning with Ecolab's mission of protecting people and the planet.

The Drive for 5 - Industry Sector Training Competitive Grant, offered by the Minnesota Department of Employment and Economic Development, aims to enhance workforce training opportunities for adults facing employment barriers. It seeks proposals for programs that provide essential workforce development services and job placement assistance. This initiative focuses on eliminating racial disparities and improving access to high-wage jobs, thereby supporting Minnesotans in achieving long-term career success.

Mission

The Biodiversity Fund supports efforts to maintain and strengthen biodiversity in the Duluth-Superior region through preservation and restoration of habitat, help for particular species and ecosystems, planning for changing conditions, research and education. The purpose is to consider now the value to future generations of the species and ecosystem diversity that will remain when/if human population stabilizes.

Biodiversity Fund

The Biodiversity Fund supports projects that preserve and restore habitats, assist vulnerable species and ecosystems, plan for environmental change, and promote research and education in the Duluth-Superior region.

The fund aims to protect the region's biodiversity through conservation, preservation, and restoration of natural resources for the benefit of future generations.

Biodiversity Fund- Large & Multi-Year Grants

The Fund may also support larger initiatives of up to $50,000 per year for up to three years, for projects that require sustained investment to achieve meaningful, long-term impact. ‍

Multi-year requests should demonstrate:

• A clear long-term vision with defined milestones that allow progress to be assessed prior to subsequent years of funding each year
• How the work will scale, adapt, or deepen impact over time
• Strong partnerships, stewardship plans, or systems-level outcomes
• A plan for sustainability beyond the grant period

What We Mean by Biodiversity

‍Biodiversity is the variety of life on Earth, encompassing the diversity of genes, species, and ecosystems and the complex relationships that sustain them. Biodiversity underpins ecosystem stability, climate resilience, and human well-being by providing essential services such as clean air and water, natural food systems, nature-derived medicines, and climate adaptation and regulation.

This grant recognizes that healthy natural ecosystems and sustainable native plant and animal communities are deeply interconnected — environmental degradation often exacerbates social inequities and instability of communities of habitats and ecosystems. Community-led solutions strengthen ecological outcomes.

Biodiversity Fund Priorities

Funded projects should demonstrate strength in several of the following areas. Not every project must address all principles, but competitive proposals will show clear alignment across multiple dimensions.

• Upstream & Preventative Focus
  • Projects address root causes rather than symptoms.
  • Prioritize prevention, restoration, and long-term solutions
  • Reduce risk and vulnerability for people, species, and ecosystems
  • Anticipate environmental and social change rather than reacting after harm occurs
• Collaboration & Community Voice
  • Projects are grounded in authentic partnership.
  • Build cross-sector collaboration (e.g., nonprofits, Tribal Nations, schools, governments, researchers, community groups)
  • Center the expertise and leadership of people with lived experience, including Indigenous knowledge and local ecological expertise
  • Share power in design, decision-making, and implementation
• Equity-Centered Impact
  • Projects advance equity for both people and place.
  • Prioritize historically marginalized communities and/or vulnerable species and ecosystems
  • Focus resources, decision-making power, or stewardship closer to impacted communities
  • Recognize how environmental harm and social inequity intersect
• Systems, Policy & Practice Change
  • Projects have transferability and relevance beyond a single site or program.
  • Improve institutional practices, policies, land-use decisions, or resource flows
  • Strengthen community-level systems related to housing, food security, climate adaptation, education, or conservation
  • Demonstrate potential for replication, scaling, or broader adoption
• Sustainability & Capacity Building
  • Projects plan for impact that lasts beyond the grant period.
  • Strengthen organizational, community, or ecosystem capacity
  • Build skills, infrastructure, stewardship, or long-term management plans
  • Promote ongoing care, monitoring, or adaptive management of natural systems
• Evidence of Change & Learning
  • Projects contribute to shared learning and understanding.
  • Use data, research, community knowledge, or storytelling to demonstrate impact
  • Measure ecological, social, or systems-level outcomes
  • Share lessons learned to inform future equity-, resilience-, and biodiversity-focused work