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Best Oconee County Grants for Nonprofits in South Carolina

Looking for grants for 501(c)(3) nonprofit organizations working in Oconee County, South Carolina? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

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$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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9,262 Results based on applied filters

The Kelley Foundation Grant

The Kelley Foundation
Private
United States
Unspecified amount

The Kelley Foundation

The Kelley Foundation was established by Robert and Judy Kelley and their daughter Marla. The Kelleys are native Oklahomans and longtime residents of Southern Oklahoma.

The foundation is primarily focused on humanitarian projects in Oklahoma, with an emphasis on Southern Oklahoma. Our mission is to develop and strengthen our community, state, and nation by providing essential resources to those in need.

The Kelley Foundation Grant

The Kelley Foundation is a private, charitable foundation, incorporated under the laws of the State of Oklahoma and operated exclusively for providing support through its gifts and grants to religious, charitable, scientific, and educational institutions which are qualified under section 501(c)(3) and which are not private foundations within the meaning of section 509(a) of the Internal Revenue Service Code.

Basic Human Needs Human & Social Services Community Services

Connecting Champions for Diversity, Equity, Inclusion, and Belonging in the Health Professions

Robert Wood Johnson Foundation
Private
United States
Up to US $2,000,000

About RWJF

At the Robert Wood Johnson Foundation, we take bold leaps to transform health in our lifetime and pave the way, together, to a future where health is no longer a privilege, but a right. We take our responsibilities seriously, and pledge to work in ways that reflect our values.

Connecting Champions for Diversity, Equity, Inclusion, and Belonging in the Health Professions

RWJF seeks to fund one lead organization or consortium to serve as a national network-weaver for diversity, equity, inclusion, and belonging (DEIB) in the health professions. The selected grantee will connect and support leaders, organizations, and institutions across the ecosystem, strengthening relationships, aligning strategy and communications, and facilitating shared learning and collective action. By building the connections and infrastructure needed for collaboration, the grantee will help advance belonging, accountability, and systems change across health professions education and healthcare institutions.

Achieving a healthcare system grounded in equity requires both a diverse health professions workforce and institutions committed to advancing diversity, equity, inclusion, and belonging (DEIB). While diverse teams improve quality of care and health outcomes, RWJF has learned that increasing representation alone is insufficient without addressing structural and institutional barriers that shape belonging, leadership, advancement, and accountability. Structural racism and other forms of systemic inequity continue to limit opportunity across the health professions education and healthcare institutions.

Lasting change requires not only supporting diverse leaders, but also strengthening connections among educational institutions, healthcare organizations, professional associations, accrediting and credentialing bodies, students, advocates, community actors, and others within the health professions ecosystem, whose relationships, actions, practices, and mindsets shape health outcomes for the communities they serve. These relationships create the support, trust, shared learning, and coordinated action necessary to advance DEIB and build a more equitable healthcare system. 

Economic Services & Development Community Development & Revitalization Diversity, Equity & Inclusion +1 more

State Recreational Boating Safety (RBS) Grant Program (363847)

US Department of Homeland Security: U.S. Coast Guard
Federal Government
American Samoa, Guam +4 more
US $400,000 - US $12,000,000
The State Recreational Boating Safety (RBS) Grant Program, administered by the US Department of Homeland Security's U.S. Coast Guard, aims to enhance safety and enjoyment on America's waterways. This federal program provides grants to designated state agencies to reduce boating accidents, injuries, and fatalities. Although not open to the public, it plays a critical role in ensuring safe recreational boating experiences by implementing effective safety measures, thereby promoting public welfare and environmental protection.
Recreation Wounds & Injuries Community / Public Safety +2 more

Hispanic-Serving Institutions Education Grants Program (363846)

USDA: National Institute of Food and Agriculture (NIFA)
Federal Government
American Samoa, Guam +4 more
US $100,000 - US $1,200,000
The Hispanic-Serving Institutions Education Grants Program aims to enhance the educational capabilities of HSIs through innovative teaching and community development initiatives. Funded projects will not only serve the Hispanic population but will benefit the entire student body, promoting inclusivity. This program encourages applications that integrate applied research with community outreach, fostering experiential learning opportunities for students. The initiative aspires to set benchmarks for educational excellence at regional and national levels.
Education - Higher Education Agriculture Community Development & Revitalization +2 more

Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT) Infrastructure – Clinical Coordinating Center (CCC) & Data Coordinating Center (DCC)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institutes of Health (NIH) is continuing support for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT), which focuses on clinical trials and biomarker validation studies for neurological disorders. This initiative aims to foster innovation in neurotherapeutics by providing essential infrastructure and expertise. The program encourages the establishment of Clinical Coordinating Centers (CCC) and Data Coordinating Centers (DCC) to enhance collaborative efforts. Note that applications are not currently being solicited.
Health & Medicine Neurological Diseases & Disorders

Undiagnosed Diseases Network (UDN) Clinical and Data Coordinating Center

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Undiagnosed Diseases Network (UDN) Clinical and Data Coordinating Center aims to enhance diagnosis and research for individuals with undiagnosed diseases. This initiative focuses on engagement, education, and innovative diagnostic approaches. The center will oversee recruitment, participant support, and data management while fostering collaboration among various stakeholders. NINDS seeks proposals demonstrating the necessary infrastructure and partnerships to ensure effective implementation of the UDN's mission and transfer successful diagnostic methods into mainstream healthcare.
Neurological Diseases & Disorders Rare Diseases Health Care Access & Delivery +1 more

Undiagnosed Diseases Network (UDN) Diagnostic Research Innovation Center

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Undiagnosed Diseases Network (UDN) Diagnostic Research Innovation Center (DRIC), supported by NINDS, aims to enhance diagnostic capabilities for UDN participants. This initiative will foster collaboration among clinical networks and stakeholders to develop innovative diagnostic tools and strategies. The DRIC will also focus on the systematic evaluation of unresolved UDN cases, advancing genomic and non-genomic diagnostics, and discovering novel disease-associated genes. This forecast allows potential applicants to prepare and collaborate effectively for future projects.
Genetics & Genomics Neurological Diseases & Disorders Rare Diseases +1 more

NIH Stroke Clinical Trials Network (StrokeNet) Infrastructure – Regional Coordinating Stroke Centers (RCCs)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Stroke Clinical Trials Network (StrokeNet) aims to enhance stroke treatment through regional clinical enrollment coordinating centers (RCCs). Supported by the National Institute of Neurological Disorders and Stroke (NINDS), this initiative promotes collaboration for clinical trials that focus on acute stroke treatment, prevention, and rehabilitation. While applications are not currently being solicited, this notice serves to prepare potential applicants for future opportunities in advancing stroke care.
Neurological Diseases & Disorders Medical Rehabilitation

Undiagnosed Diseases Network (UDN) Clinical Networks of Diagnostic Excellence

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Undiagnosed Diseases Network (UDN) aims to enhance diagnostic excellence through multiple clinical Networks of Diagnostic Excellence (NODEs). These NODEs will operate as regional networks, leveraging partnerships with various healthcare facilities to provide participant-centered evaluations for complex conditions. They will also engage in research and training to improve diagnostic tools and strategies. This initiative encourages collaboration and aims to improve the overall experience and access for participants in need of specialized care.
Genetics & Genomics Rare Diseases Health Care Access & Delivery

Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT) Infrastructure – Clinical Research Sites (U24 Clinical Trial Not Allowed)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institutes of Health (NIH) is continuing its support for the NeuroNEXT initiative, which focuses on conducting clinical trials and biomarker validation studies for neurological disorders. This infrastructure aims to foster innovation and enhance the development of effective neurotherapeutics for both adult and pediatric populations. While applications for network clinical research sites are not currently being solicited, this notice allows potential applicants to prepare collaborative and responsive applications.
Neurological Diseases & Disorders Health Care Access & Delivery Emerging Technology Development

Homeless Veterans’ Reintegration Program (HVRP), Incarcerated Veterans’ Transition Program (IVTP), and the Homeless Women Veterans' and Homeless Veterans' with Children Reintegration Grant Program (HWVHVWC) (referred to collectively as HVRP)

US Department of Labor: Veterans' Employment and Training Service (VETS)
Federal Government
Guam, Puerto Rico +2 more
US $150,000 - US $500,000
The Homeless Veterans' Reintegration Program (HVRP) aims to assist veterans experiencing homelessness by providing tailored employment services. This federal initiative focuses on helping veterans transition to stable employment through job training, case management, and connections to local supportive services. HVRP aligns with national priorities to enhance career outcomes for veterans, ensuring they receive the necessary tools and resources for sustainable employment and integration into the workforce.
Military & Veterans Services Homelessness Services Workforce Preparation & Job Readiness +1 more

Native Public Health Resilience

Indian Health Service
Federal Government
United States
Unspecified amount
The Native Public Health Resilience (NPHR) program is a new funding opportunity aimed at supporting Tribes and Tribal Organizations in delivering essential public health services. Sponsored by the Indian Health Service, this initiative seeks to bolster public health infrastructure and resilience within tribal communities, ensuring they have the necessary resources to address health challenges effectively. Eligible applicants will receive financial assistance to enhance their public health capabilities and improve community health outcomes.
Epidemiology & Public Health Health Care Access & Delivery Native American Services +2 more

NIH Stroke Clinical Trials Network (StrokeNet) Infrastructure – National Coordinating Center (NCC) and National Data Management Center (NDMC)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Stroke Clinical Trials Network (StrokeNet) aims to enhance stroke treatment and recovery through a robust national infrastructure. Funded by the National Institutes of Health, this initiative focuses on clinical trials that evaluate innovative therapies for stroke patients and those at risk. The program is currently not soliciting applications but encourages the development of collaborations to support the national coordinating center and data management efforts, ultimately improving outcomes for individuals affected by stroke.
Neurological Diseases & Disorders Medical Rehabilitation Preventative Healthcare

NIDA Avenir Program: Fundamental Mechanistic Research in Addiction Science

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $375,000
The NIDA Avenir Program aims to cultivate innovative leaders in addiction science by funding exceptional early stage investigators (ESIs) embarking on pioneering research. Launched in 2015, this initiative encourages high-risk, high-reward mechanistic studies related to Substance Use Disorders (SUDs) across diverse scientific domains. Applications from new investigators and those outside addiction research are welcomed, fostering interdisciplinary approaches that enhance understanding of SUD mechanisms. The program supports ESIs who may lack preliminary data but demonstrate potential for impactful contributions.
Genetics & Genomics Addiction & Substance Use Disorders Emerging Technology Development

BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The BRAIN Initiative aims to advance innovative neurotechnologies by funding early-stage clinical studies for devices that record or stimulate the human central nervous system. This initiative encourages collaborations between clinical researchers and device manufacturers to facilitate groundbreaking studies. By addressing the challenges of obtaining safety and utility data, this program supports both non-invasive and significant risk devices, providing essential insights into their functionality and design. Applications are currently not being solicited, allowing time for meaningful project development.
Engineering Neurological Diseases & Disorders Emerging Technology Development

Limited Competition: BRAIN Initiative: Promoting Health for All Through BRAIN Technology Partnerships

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The BRAIN Initiative, led by the NIH, aims to advance neurotechnologies at institutions with limited NIH funding. This funding opportunity encourages collaboration and knowledge transfer to integrate innovative neurotechnologies into research and training programs. While applications are currently not being solicited, potential applicants should start developing partnerships and projects in preparation for future submissions. This initiative will enhance the dissemination of BRAIN technologies and support novel research practices.
Education - Higher Education Neurological Diseases & Disorders Emerging Technology Development

RRF Pilot Study Grants

Retina Research Foundation
Private
United States
Unspecified amount

Retina Research Foundation

Across the nation, there were only a handful of voluntary groups with the will and the means to tackle retinal disdorders. Retina Research Foundation, established in 1969, was one of those organizations. By the 1980s, RRF had become a voice for retina research in an effort to reduce the incidence of retinal disease, which was fast becoming the leading cause of blindness in developing countries.

Undaunted, the Foundation steadily raised funds each year for vision scientists who were nationally recognized for their work in retina research. Government funding for eye research increased dramatically, and the field of retina research matured. As this body of knowledge grew, RRF programs were expanded to include major awards that recognize established retina scientists and contribute to their ongoing research. The Foundation also developed scientific exchange programs to disseminate knowledge of the dramatic advances that were being made in the laboratory.

RRF Pilot Study Grants

The mission of the Retina Research Foundation is to reduce retinal blindness worldwide by funding programs in research and education. As a public charity, RRF raises funds from the private sector and the investment of its endowment funds.

RRF is currently welcoming pilot study grant applications for the 2027 grant period. Each grant application must be signed by the principal investigator and either their Department Chair or Dean of Research.

Eye Diseases & Disorders Vision Impairment Care & Services

Dick's Foundation Sports Matter Grant

Dick's Sporting Goods Foundation
Corporate
United States
Unspecified amount

Sports Matter Mission

We believe that sports change lives. In addition to physical and mental health benefits, sports have the power to change our perspectives, our character and our communities for the better. This core belief has guided DICK’S Sporting Goods and The DICK’S Sporting Goods Foundation since the beginning – but not everyone has the same access to play. Through grants and other support, The DICK’S Foundation Sports Matter Program helps under-resourced 501c3 organizations, schools and community teams across all 50 states provide opportunities for youth to play sports.

Why It Counts

  • Low-Income Kids Play at Half the Rate of Wealthier Peers
  • Participation in Team Sports has Declined 4% Since 2017
  • One in Three Kids Can't Participate in the Sports They Want 
  • Number of Kids Playing Multiple Sports Has Declined

Sports Matter Program

We Believe Every Kid Deserves a Chance to Play

The Sports Matter Program focuses on supporting youth sports in under-resourced communities.

All grant applications are made subject to review of the applying organization’s reputation and activities, and its agreement to comply with applicable terms and conditions. 

Sports & Athletics Youth Development & Leadership

Emergency Citrus Disease Research and Extension Pre-Applications

USDA: National Institute of Food and Agriculture (NIFA)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $15,000,000
The Emergency Citrus Disease Research and Extension Pre-Applications program, funded by the USDA's National Institute of Food and Agriculture, seeks innovative proposals to combat Huanglongbing (HLB) and its associated diseases. This initiative aims to ensure sustainable citrus production in the U.S. through collaborative strategies that leverage existing knowledge. Funded projects will focus on developing actionable solutions for growers to effectively manage and prevent HLB infections, ensuring the health of citrus crops in the near future.
Agriculture Agricultural Crops Sustainable Agriculture & Agroecology +1 more

Tribal Colleges Extension Program Special Emphasis

USDA: National Institute of Food and Agriculture (NIFA)
Federal Government
United States
US $50,000 - US $200,000
The Tribal Colleges Extension Program Special Emphasis (TCEP-SE) aims to enhance community engagement through pilot projects at 1994 Institutions, targeting issues like agricultural productivity, food systems, and public health. This program is open to a wide range of Tribal colleges and universities, promoting workforce development and youth involvement in agriculture. By addressing local needs, TCEP-SE fosters community vitality and prepares the next generation of Tribal agriculture leaders.
Agriculture Workforce Preparation & Job Readiness Youth Development & Leadership +2 more

ROSES 2025: A.17 Hydrosphere

National Aeronautics and Space Administration (NASA)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The ROSES 2025: A.17 Hydrosphere program by NASA aims to enhance our understanding of Earth's water systems, focusing on Ocean Physics, Precipitation Science, and Terrestrial Hydrology. This initiative invites proposals targeting specific priorities within these disciplines to advance knowledge on water distribution and movement across the Earth. Proposals will undergo rigorous peer review to ensure transparency and scientific integrity, aligning with NASA's commitment to reproducible and collaborative research.
Earth Science Atmospheric Sciences Oceanography +1 more

Head Start/Early Head Grants in Multiple States

US Dept. of Health & Human Services: Administration for Children & Families
Federal Government
Alabama, Arizona +34 more
US $1,005,287 - US $79,657,340
The US Department of Health & Human Services announces a competitive funding opportunity for the Head Start/Early Head Start programs across various states. This initiative aims to enhance services for low-income families and children, promoting their social and economic well-being. With approximately $818.3 million available, the program seeks to expand access to quality early childhood education, thereby strengthening community stability and prosperity. Interested applicants can seek further information through the OHS Operations Center.
Education - Preschool / Early Learning Youth Services Family Services +2 more

Residential Services for Unaccompanied Alien Children

US Dept. of Health & Human Services: Administration for Children & Families
Federal Government
American Samoa, Guam +4 more
US $2,000,000 - US $5,600,000
The Residential Services for Unaccompanied Alien Children program, funded by the US Department of Health & Human Services, aims to provide safe and child-centered care for unaccompanied minors. This initiative supports organizations that can offer 24/7 services and are licensed to provide necessary care, including group homes and transitional foster care, particularly in areas near the U.S. southern border, ensuring the well-being of vulnerable children.
Basic Human Needs Homelessness Services Youth Services +2 more

Early Head Start Expansion and Early Head Start - Child Care Partnership Grants in Multiple States

US Dept. of Health & Human Services: Administration for Children & Families
Federal Government
American Samoa, Guam +4 more
US $1,232,123 - US $4,964,843
The Early Head Start Expansion and Child Care Partnership Grants aim to enhance early childhood services for low-income families across GA, NC, and VA. With approximately $7.7 million in federal funding, this initiative will provide comprehensive support to pregnant women, infants, and toddlers, fostering family stability and community prosperity. The program reflects the Administration for Children and Families' commitment to improving economic and social well-being through accessible, high-quality early education services.
Education - Preschool / Early Learning Youth Services Family Services +2 more

CIF ; Impact awards

Endeavor Health
Private
United States
US $1,000,000

About

Being deeply connected to the community means more than providing access to excellent healthcare. It means understanding, and investing in, the health needs of our community.

Through our Community Investment Fund (CIF), Endeavor Health has awarded more than $38.5 million to 59 local partnerships dedicated to enhancing community health and wellbeing, advancing health equity and supporting local economic growth. Together, we’re committed to helping everyone in our communities be their best.

Award categories

Through the CIF, we will make meaningful and intentional investments through impact awards and capacity builder awards. These awards are intended to meaningfully advance the health of our community over time towards three bold aspirations through investments in five areas of focus.

We aspire to a future where:

  • A person’s zip code does not determine how long they will live
  • Hunger and homelessness in our communities are history
  • The healthcare workforce is thriving and representative of the communities we serve

To help advance these aspirations, the CIF will invest in the following areas:

  • Access to healthcare
  • Behavioral health
  • Food insecurity
  • Housing insecurity
  • Workforce development for careers in healthcare

Impact awards

  • Designed for 5-year initiatives where organizations come together to drive measurable impact and longer-term change in the communities we serve by improving existing systems and innovation
  • Emphasize strategic cross-sector and/or intra-sector partnerships between community-based organizations
  • Uplift community members of greatest need
  • Directly align with CIF areas of focus and meaningfully contribute to CIF goals
  • Award amount: $1 million per year, up to 5 years
Workforce Preparation & Job Readiness Food Security Health Care Access & Delivery +5 more

CIF : Capacity builder awards

Endeavor Health
Private
United States
US $100,000 - US $500,000
The CIF Capacity Builder Awards by Endeavor Health focus on enhancing community health through strategic investments. With over $38.5 million allocated to local partnerships, these awards aim to address critical areas like healthcare access, food insecurity, and workforce development. Designed for nonprofit organizations, the awards range from $100,000 to $500,000 annually for 1-2 years, fostering long-term community impact and advancing health equity in the service areas.
Homelessness Services Workforce Preparation & Job Readiness Food Security +5 more

ASF Public Projects Grant

American-Scandinavian Foundation (ASF)
Association/Society
Denmark, Faroe Islands +6 more
Up to US $5,000

About American-Scandinavian Foundation (ASF)The American-Scandinavian Foundation (ASF) promotes firsthand exchange of intellectual and creative influence between the United States and the Nordic countries: Denmark, Finland, Iceland, Norway, and Sweden. ASF offers fellowships, cultural grants, internships/training, publications, exhibitions and other public programs reinforcing the strong relationships between the two regions, honoring their shared values, and appreciating their differences.ASF Public Projects GrantThe American-Scandinavian Foundation promotes the cultures of the Nordic countries in the United States and American culture in the Nordic countries by encouraging programs that will enhance public appreciation of culture, art, and thought. In establishing priorities, the Foundation considers the lasting benefits that may be achieved by any grant and favors projects where its contribution will complement support from other sources. 

Arts / Culture Access & Participation Performing Arts Visual Arts

Oconee County Grants for Nonprofits Highlights

Looking for Oconee County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all Oconee County grants recommended for your specific programs in South Carolina.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grant Funding Trends in South Carolina

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Oconee County Grants for Nonprofits year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Oconee County Grants for Nonprofits given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Oconee County Grants for Nonprofits changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081