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Best Operating Grants for Nonprofits

Get operating grants for nonprofits covering essential expenses, staffing, program delivery, and organizational sustainability.

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$8.25B

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$6K

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32,000+ grants
$8.25B total
$6K median

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32,499 Results based on applied filters

Provident Health Foundation Sponsorships

Provident Health Foundation of Marinette-Menominee Inc.
Private
Marinette County, Wisconsin, Menominee County, Michigan
Up to US $250

Provident Health Foundation of Marinette-Menominee Inc.

The Provident Health Foundation was created in 2019 as part of the final agreement between Advocate Aurora Health and Bay Area Medical Center that made the hospital a wholly-owned member of the Advocate Aurora system with a big vision for community health.

How we fund is evolving as we become more established and as we listen and respond to the needs of our community, both the residents of these counties and the nonprofits with which we partner. Our philosophy of operating is born from the vision of health for Marinette and Menominee Counties that we have written into our bylaws and evidence-based best practices for private foundations on how to achieve that vision. The Provident Health Foundation Board of Directors codifies that in a Strategic Plan for Provident every three years.

Provident Health Foundation Sponsorships

The purpose of the Provident Health Foundation is to improve and sustain the health and well being of the people who live in Marinette and Menominee Counties and ensure them access to affordable quality acute hospital care. Provident Health Foundation's mission is to serve those in Marinette and Menominee counties.  

Provident awards a limited number of event and program sponsorships each year. These sponsorships will consist of either a monetary donation of up to $250 or a raffle item/fabulous prize for your event. 

Wellness & Healthy Living Primary Health Care Hospital Care

Mary S. and David C. Corbin Foundation Grants

Mary S. and David C. Corbin Foundation
Private
Ohio
Unspecified amount
The Mary S. and David C. Corbin Foundation Grants aim to enhance the lives of residents in Akron and Summit County, Ohio, by supporting diverse and inclusive charitable initiatives. Founded by the Corbins, the foundation focuses on local organizations in areas such as arts, education, healthcare, and social services. Grants are exclusively for 501(c)(3) organizations, ensuring funds are allocated to promote equal opportunity and community enrichment. The foundation prioritizes local chapters of national charities to maximize its impact.
Art & Culture Environment Education +7 more

Emergency Citrus Disease Research and Extension Pre-Applications

USDA: National Institute of Food and Agriculture (NIFA)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $15,000,000
The Emergency Citrus Disease Research and Extension Pre-Applications program, funded by the USDA's National Institute of Food and Agriculture, seeks innovative proposals to combat Huanglongbing (HLB) and its associated diseases. This initiative aims to ensure sustainable citrus production in the U.S. through collaborative strategies that leverage existing knowledge. Funded projects will focus on developing actionable solutions for growers to effectively manage and prevent HLB infections, ensuring the health of citrus crops in the near future.
Agriculture Agricultural Crops Sustainable Agriculture & Agroecology +1 more

Lakers Youth Foundation Quarterly Grants

Los Angeles Lakers Youth Foundation
Corporate
Los Angeles County, California, Orange County, California +3 more
US $1,000 - US $20,000
The Lakers Youth Foundation offers quarterly grants aimed at empowering underserved youth through education, health, wellness, and sports programs. Grants range from $1,000 to $20,000, and applicants must detail how funds will be utilized. Eligible organizations must have operated for at least two years and cannot exceed 50% of the project's budget in requested funding. The Foundation excludes funding for individuals, private foundations, and new programs.
Youth Services Youth Development & Leadership Educational Access & Equity +2 more

Veterans Food Assistance Program

Disabled Veterans National Foundation
Private
United States
Unspecified amount

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Veterans Food Assistance Program

It is our goal to ensure that no veteran goes hungry by providing essential food assistance and household support, fostering stability and well-being in the lives of our veterans and their families.

The Veterans Food Assistance Program (VFAP) is designed to provide a one-time grant of essential food and household support to veterans and their families, ensuring no veteran goes hungry. With the rising cost of living, especially food prices due to inflation, this program offers a much-needed lifeline to those who have served our country. Once approved, the DVNF program team will handle the shopping for you.

The Veterans Food Assistance Program provides a one-time grant per household to support different family sizes, given the rising cost of food:

  • Married Veterans Grant Allowance
    • Married - No Children up to $250
    • Married - 1 Child up to $300
    • Married - 2 Children up to $450
    • Married - 3+ Children up to $500
  • Single Veterans Grant Allowance
    • Single - No Children up to $200
    • Single - 1 Child up to $300
    • Single - 2 Children up to $350
    • Single - 3+ Children up to $450
Military & Veterans Services Food Access & Hunger Food Security

CFOV: Women's Giving Circle Grant

Community Foundation for the Ohio Valley
Private
Belmont County, Ohio, Brooke County, West Virginia +6 more
Up to US $10,000
The Women’s Giving Circle, part of the Community Foundation for the Ohio Valley, offers grants to enhance the lives of women and girls in specific counties in West Virginia and Ohio. The focus is on increasing life skills, promoting young girls' development, and addressing gender disparities. Grants support innovative and proven programs aimed at systemic change, sustainability, and measurable impact, ultimately fostering empowerment and community growth.
Women & Girl Services Women's Rights & Equality Reproductive Education +2 more

Poweshiek County Alliance Grants

Greater Poweshiek Community Foundation
Private
Poweshiek County, Iowa
Up to US $10,000
The Poweshiek County Alliance Grants aim to support local nonprofit organizations and public entities in enhancing the community's safety, beauty, and economic vitality. Grants are available for projects that provide cultural, educational, recreational, and wellness opportunities, specifically targeting the needs of Poweshiek County residents. Applications that demonstrate collaborative funding sources are prioritized, ensuring a more robust initiative for community betterment.
Recreation Education Art & Culture +6 more

National Community Care Corps Grant

US HHS: Administration for Community Living (ACL)
Federal Government
United States
US $30,000 - US $200,000

National Community Care Corps Grant

Community Care Corps encourages organizations across the country to apply for 18-month grants ($30,000–$200,000) to develop and scale innovative volunteer programs that provide nonmedical assistance to older adults, adults age 18 and older with disabilities and family caregivers.

Projects funded through this initiative will increase the number of community-based volunteer programs available to provide nonmedical assistance while decreasing the number of older adults, adults with disabilities, and family caregivers who need assistance in maintaining independence in the community but are unable to obtain help. In doing so, the initiative will strengthen community-based supports that help people maintain independence, reduce unmet needs, and improve overall well-being.

Focus Areas

Proposals must include one or more of the following focus areas:

  • Integrate principles of the National Strategy to Support Family Caregivers
  • Support grandparent/kinship-led households
  • Use off-the-shelf materials. Off-the-shelf materials are products, components, or resources that are readily available for purchase and immediate use, without the need for custom development, modification, or special ordering
  • Engage college students/interns for intergenerational connections
  • Expand virtual or low-tech access
  • Provide volunteer chaperone programs for non-emergency medical appointments
  • Increase access to respite programs
  • Build opportunities for volunteer skill-building
Caregiver Support / Respite Care Senior Services Volunteerism & Philanthropy

Native Voices Rising Grants

Common Counsel Foundation
Private
United States
Unspecified amount
Native Voices Rising (NVR) offers grants to empower Native-led grassroots organizations in the U.S. With over $16 million awarded since inception, NVR focuses on enhancing lives through collective action and advocacy. Eligible organizations must be Native-led and engage community members in policy improvement efforts. NVR supports initiatives addressing environmental justice, health, and youth involvement, with a commitment to fostering leadership and social change within Native communities.
Indigenous Sovereignty & Rights Native American Culture & Heritage Native American Services +1 more

Native Hawaiian Health Care Improvement Act Program

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
United States
US $2,530,712 - US $10,000,000
The Native Hawaiian Health Care Improvement Act Program provides funding to enhance the health status of Native Hawaiians through comprehensive health care services. This initiative supports one administrative award to Papa Ola Lokahi and five awards to certified Native Hawaiian Health Care Systems. The program aims to ensure tailored health promotion and disease prevention services within island communities, addressing specific regional health needs from fiscal years 2027 to 2031.
Epidemiology & Public Health Health Care Access & Delivery Wellness & Healthy Living +2 more

Oscar Rennebohm Foundation Grant

Oscar Rennebohm Foundation
Private
Dane County, Wisconsin
Unspecified amount
The Oscar Rennebohm Foundation Grant aims to enhance education, health care, research, and human services in the Madison area. This foundation supports innovative projects and initiatives that positively impact the community, particularly focusing on senior support services and K-12 mental health programs. Organizations eligible for funding must be recognized as public charities under IRS regulations. The foundation encourages applicants to verify their proposals with the President before submission, ensuring alignment with grant requirements.
Education Health & Medicine Human & Social Services +8 more

Native American/Native Hawaiian Museum Services (2027)

Institute of Museum and Library Services (IMLS)
Federal Government
United States
US $5,000 - US $250,000
The Native American/Native Hawaiian Museum Services (NANH) program, funded by the Institute of Museum and Library Services (IMLS), aims to support Native American Tribes, Alaska Native Villages, and organizations serving Native Hawaiians. It focuses on preserving heritage and culture through educational services, workforce development, capacity building, community engagement, and effective collections stewardship. This initiative is crucial for sustaining the rich cultural heritage of Native communities.
Community Culture & Heritage Native American Services Museums & Cultural Institutions +1 more

Executive Committee Discretionary Fund Grant

Ohio Developmental Disabilities Council
State/Local Government
Ohio
Up to US $5,000

Notice of Funds Available (RFP): Ohio Developmental Disabilities Council

12EC06QU26: Executive Committee Discretionary Fund

The Ohio Developmental Disabilities Council wishes to support one-time initiatives, not otherwise included in the state plan. These grants are intended to address the needs of people with intellectual or other developmental disabilities and their families – specifically those traditionally un/underserved and are limited to $5000 dollars or less.

Activities must include programming targeting at least one DD Council State Plan goal. These goals are:

  • People with intellectual and developmental disabilities are provided services and supports by direct support professionals that are knowledgeable, trained and supported.
  • All children, youth, and students with intellectual/developmental disabilities, aged birth to 21 years, will receive individualized, evidence-based supports and services in inclusive settings that will help them attain their maximum potential, including extra-curricular activities.
  • Provide a broad range of leadership development opportunities for people with developmental disabilities, their family members and allies. Offer a variety of opportunities to develop the skills needed to become leaders in the disability movement.
  • People with disabilities and their families will have increased access to services that promote leadership, accessibility, safety, independence, outreach, equality, inclusion, health, work opportunities, and community.

*Un/Underserved means people with developmental disabilities from:

  • Racial and ethnic minority backgrounds
  • Disadvantaged people (those living in poverty)
  • People who use English as a second language
  • Individuals in underserved geographic areas (rural areas and urban areas)
  • Other groups within the population of people with DD
  • People who required technology to participate in and contribute to community life
Disability Care & Services Intellectual / Developmental Disabilities Children’s Mental Health

Washington County 4-H Dairy Scholarship

Community Foundation of Washington County Maryland
Private
United States
Unspecified amount

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

Washington County 4-H Dairy Scholarship

Established to support post-secondary scholarships to participants in Washington County 4-H dairy programs.

Education - Higher Education Livestock & Ranching Agricultural Economics +1 more

Quik Trip Charitable Grants

Quik Trip
Corporate
Alabama, Arizona +21 more
Unspecified amount

About QuikTripQuikTrip believes in investing in the communities in which our employees live and work. Every year, QuikTrip donates 5% of our annual net profit to qualified 501c3 non-profit agencies, which includes our United Way campaign match, support for National Safe Place agencies, Folds of Honor scholarships and many other agencies that support at-risk youth and early childhood education.Mission: To wisely invest dollars in community efforts that will help impact (in measurable terms) individuals in our society who are dependent on the charitable support of others. We believe the most effective way to do that is to invest our contribution dollars and volunteers in strategic efforts that help those at risk reach their functional capacity as successful, independent citizens.About QuikTrip Charitable GrantsQuikTrip funds 501c3 agencies located in the cities in which we have stores and our employees live and work. Funding can include: “in-kind” products (coupons, gift cards or product donation), formal grants, fundraiser/event sponsorships and employee volunteer time.Focus Areas:

  • Creating Safe Communities
    • First Responders: QuikTrip is proud to partner with law enforcement and first responders in every market we serve, making sure that they have the tools, training and support they need to keep our communities safe and to return home safely to their families after each shift.
    • Homeless Outreach & Alternatives to Police Response: To significantly reduce non-emergency calls and help people in crisis get back on their feet, QuikTrip funds dedicated homeless outreach teams across our communities. These teams engage individuals experiencing homelessness and living in encampments – connecting people to services, shelter, detox and long-term care.

    • Creating Strong Communities
      • Ending Homelessness: We support emergency, transitional and permanent supportive housing, diversion and prevention programs, and more.
      • Mental Health & Substance Abuse : We know that healthy communities are safe communities, which is why we invest in detox and substance abuse treatment centers, and behavioral health centers and services to end the perpetuation of cycles of trauma and addiction.
      • At-Risk Youth: We especially prioritize services for at-risk youth – those aging out of foster care, justice-involved or without stable support systems.
    • Additional Community Commitments
      • United Way: Employee donation matching in all markets.
      • Folds of Honor: Scholarships for families of fallen or wounded service members and first responders.
      • National Safe Place: QT stores serve as Safe Place locations for youth in crisis, with trained staff ready to assist.
    Homelessness Services Mental Health & Psychiatric Diseases Youth Services +2 more

    Washington County 4-H Livestock/Market Sale Scholarship

    Community Foundation of Washington County Maryland
    Private
    United States
    Unspecified amount

    This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

    Washington County 4-H Livestock/Market Sale Scholarship

    Established to support post-secondary scholarships to participants in Washington County 4-H Livestock and Market Sale programs.

    Education - Higher Education Livestock & Ranching Agricultural Economics +1 more

    Focus Grants

    Outer Banks Community Foundation
    Private
    Carteret County, North Carolina, Currituck County, North Carolina +2 more
    Unspecified amount
    Focus Grants provide funding requests up to $50,000 aimed at addressing critical needs, particularly in healthcare access, affordable housing, and childcare solutions. These grants are available to qualifying 501c3 charities and government agencies, with a preference for projects that may require multi-year support. The Outer Banks Community Foundation, a private funder, supports these initiatives to enhance community welfare and improve lives.
    Equitable & Affordable Housing Child Care Services Health Care Access & Delivery

    SHIFT 3.2: Rural Health Provider Networks

    Utah Department of Health and Human Services
    State/Local Government
    Utah
    Unspecified amount

    SHIFT 3.2: Rural Health Provider NetworksThis opportunity supports the establishment and/or expansion of integrated rural health provider networks, including but not limited to: rural health clinics, pediatric trauma, or maternal health networks. Awardees will develop a comprehensive resource directory of physical and behavioral healthcare services across rural Utah to detail the capacity, access, and availability of local services to efficiently support both patients and providers. These networks will pool resources, expand local services, reduce duplication of efforts, and lower administrative costs across rural Utah.

    Rural Health Care Children’s Health & Pediatrics Maternal And Perinatal Health

    Mental Health Services Grant

    Patterson Family Foundation
    Private
    Allen County, Kansas, Anderson County, Kansas +116 more
    Unspecified amount

    Rooted in rural.

    Committed to your community

    The Patterson Family Foundation, based in Kansas City, Missouri, is a family-led foundation that extends the legacy of Neal and Jeanne Patterson. The Foundation’s mission, “Working together to help rural communities thrive,” is carried forward through strategic grantmaking and other collaborative initiatives that serve rural counties across Kansas and western Missouri. 

    Our Mission

    Working together to help rural communities thrive.

    Grant Types

    Open Call Grants

    Patterson Family Foundation’s Open Call Grants are publicly announced and submitted through the Grants Portal. Applications are reviewed using criteria aligned with the Foundation’s priorities, including community impact, feasibility, sustainability, and readiness to implement the proposed work in the Kansas or western Missouri rural community. 

    This opportunity increases access to mental health support by expanding services, strengthening local care networks, and promoting prevention, harm reduction, and behavioral health education. Projects should create supportive environments that reduce stigma, increase awareness, and help residents access appropriate care. Applicants should plan to report on services delivered, residents served, improvements in access or awareness, and partnerships that enhance local mental health support.

    Rural Health Care Mental Health & Psychiatric Diseases Community Health Education +1 more

    Behavioral Health FY27 - System of Care Enhancement Program NOFO

    Mississippi Department of Mental Health
    State/Local Government
    Mississippi
    Unspecified amount

    About Us

    The governing board of the Mississippi Department of Mental Health is composed of nine members appointed by the Governor of Mississippi and confirmed by the State Senate. Members’ terms are staggered to ensure continuity of quality care and professional oversight of services. By statute, the nine-member board is composed of a physician, a psychiatrist, a clinical psychologist, a social worker with experience in the field of mental health, and one citizen representative from each of Mississippi’s five congressional districts (as existed in 1974).

    Behavioral Health FY27 - System of Care Enhancement Program NOFO

    The goal of the System of Care Enhancement grant is to improve behavioral health outcomes for children/youth with SED and their families. The three (3) core values of SOC are that services should be child-centered and family focused; community-based, and culturally competent. The Enhancement grant funds will focus on families, parents and caregivers being full participants in all aspects of the planning and delivery of services. Family-focused care provides parents/caregivers of children/youth with SED

    the support and education needed to improve their child’s emotional or behavioral symptoms. This includes, but is not limited to the following:

    • Providing linkages and resources to other community agencies
    • Multi-family group counseling
    • Positive parenting support
    • Behavioral management planning
    • Conducting a Community Needs and Resources Assessment
    • Developing a parent resource center

    The target population includes parents/caregivers of youth involved in the juvenile justice system, child protection services, special education, alternative school, system of care programs, wraparound facilitation, and youth at-risk of out-of-home placement.

    Addiction & Substance Use Disorders Child Welfare Services Mental Health & Psychiatric Diseases +2 more

    RISE 2.1, 2.A: GME Strategic Plan

    Utah Department of Health and Human Services
    State/Local Government
    Utah
    Up to US $1,600,000

    Utah Department of Health and Human Services

    The current health and human services model and accompanying policies have led to a fragmented system of services creating unnecessary barriers and challenges to accessing care for those most in need. These systemic challenges contribute to inequities in health outcomes and determinants of health. A consolidated department will reduce these challenges and improve outcomes for all Utahns, particularly those within communities where disparities are greatest.

    The Utah Department of Health and Human Services will support and serve all individuals and communities throughout Utah. It will do so through effective policy and the operations of an effective and efficient seamless system of services and programs that is centered around the individuals and communities the department serves.

    RISE 2.1, 2.A: GME Strategic Plan

    This opportunity comprises the initial phase of Utah’s rural Graduate Medical Education (GME) expansion. The awardee will develop a comprehensive 10-year strategic plan to expand GME opportunities within rural Utah facilities, in partnership with local medical schools, health care systems, and facilities. Utilizing a collaborative stakeholder framework, the awardee will design a sustainable model for rural GME that ensures a reliable healthcare workforce pipeline.

    Rural Health Care Workforce Preparation & Job Readiness Medical Education & Professional Training

    15 Forever Fund Grant

    The Community Foundation Boulder County
    Private
    Boulder County, Colorado
    Unspecified amount
    The 15 Forever Fund Grant, established by the Community Foundation Boulder County, empowers youth by promoting civic engagement and leadership among Boulder County residents aged 0-18. Since 2006, over $225,000 has been granted through this program, which encourages students to manage their own grant cycles, raising funds for community issues they prioritize. The fund emphasizes diversity, equity, and inclusion in its review process, ensuring that all initiatives align with the needs of local youth.
    Children’s Mental Health Disaster Relief / Humanitarian Aid Firefighting & Fire Prevention

    Women's Fund of Greater Green Bay

    Greater Green Bay Community Foundation
    Private
    Brown County, Wisconsin, Kewaunee County, Wisconsin +1 more
    Up to US $20,000
    The Women's Fund of Greater Green Bay empowers women and girls by providing grants to programs that promote health, safety, education, and leadership. Since 1995, over $1.5 million has been awarded to support initiatives addressing the unique challenges faced by women and girls in Northeast Wisconsin. The Fund seeks proposals that demonstrate measurable community impact and involve participants in their design and execution, fostering self-esteem and collaboration.
    Women & Girl Services Women's Health Domestic Violence +1 more

    Duke Endowment: Child and Family Well-Being Grant

    The Duke Endowment
    Private
    North Carolina, South Carolina
    Unspecified amount
    The Duke Endowment's Child and Family Well-Being Grant provides implementation support to public and private agencies in North and South Carolina. This funding aims to adopt and sustain evidence-based programs that prevent and treat child maltreatment. Eligible organizations must have two years of audited financial statements and work with accredited groups. The grant prioritizes innovative solutions and advocacy to improve child welfare systems, ensuring effective support for children and families at risk.
    Child Welfare Services Child Care Services Parenting Counseling & Education +1 more

    Nestle Foundation: Re-Entry Grants (REG)

    Nestle Foundation -Switzerland
    Corporate
    Afghanistan, Albania +126 more
    Up to US $50,000
    The Nestlé Foundation offers Re-Entry Grants to support post-graduate students from developing countries as they return to their careers. By facilitating research in human nutrition, the Foundation aims to foster sustainable development and capacity building in low-income regions. Eligible projects should address critical public health issues, focusing on maternal and child nutrition, and must demonstrate collaboration between local and international researchers. Grants are non-renewable and may last up to three years.
    Epidemiology & Public Health Maternal And Perinatal Health Nutrition & Healthy Eating

    Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease Grant (Optimistic Scope)

    Gates Foundation
    Private
    Countries
    Up to US $800,000

    Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

    The Challenge

    Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

    The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

    This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

    Epidemiology & Public Health Biochemistry Infectious & Parasitic Diseases +2 more

    Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease Grant (Minimum Scope)

    Gates Foundation
    Private
    Countries
    Up to US $200,000

    Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

    The Challenge

    Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

    The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

    This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

    Epidemiology & Public Health Biochemistry Infectious & Parasitic Diseases +2 more

    Operating Grants for Nonprofits Highlights

    Operating grants for nonprofits provide essential funding to support day-to-day operations, staff salaries, and infrastructure. The following grants help organizations build capacity, maintain sustainability, and focus on achieving their mission-driven goals.


    Search Instrumentl's Operating Grants Database


    Explore 8,000+ funding opportunities for operational support, with $3.43B in resources. Instrumentl helps nonprofits secure essential funding by offering grant discovery tools, deadline tracking, and strategic funder analysis to ensure long-term success.

    Last updated: October 5, 2026. Next update: November 1, 2026.

    Grant Insights : Operating Grants for Nonprofits

    Grant Availability

    How common are grants in this category?

    Quite common — grants in this category are more prevalent than in others.

    8,000+ Operating grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

    3,000+ Operating grants for nonprofits over $25K in average grant size

    3,000+ Operating grants for nonprofits over $50K in average grant size

    1,000+ Operating grants for nonprofits supporting general operating expenses

    7,000+ Operating grants for nonprofits supporting programs / projects

    600+ Grants on Instrumentl focused on Food Access & Hunger

    3,000+ Grants on Instrumentl focused on Education

    Grant Deadline Distribution

    Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits?

    Most grants are due in the first quarter.

    Q1
    29.8%
    Q2
    23.8%
    Q3
    23.9%
    Q4
    22.6%

    Typical Funding Amounts

    What's the typical grant amount funded for Operating Grants for Nonprofits?

    Grants are most commonly $34,887.

    $0 $0 Min.
    $34,887 $34.9 K Median
    $655,609 $655.6 K Average
    $188,250,000 $188.3 M Max.

    Frequently asked questions

    Nonprofits of all types can apply for operating grants, but they are especially useful for organizations needing flexible funding to support the core work of their mission. Operating grants are ideal for nonprofits involved in general population well-being. Specific sectors include healthcare, education, social services, and the arts. Unlike project-based grants that fund specific initiatives, operating grants help with essential costs like staff salaries, rent, and general admin costs. Funders often look for groups with a clear mission who serve a meaningful purpose and have potential for long-term impact.

    Based on Instrumentl’s live grant database for operating, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

    Operating grants exist to help nonprofits function smoothly and grow effectively. The goal is to give organizations the financial means they need to focus on their mission, serve their communities, and support long-term stability. These grants allow nonprofits to improve everyday operations, invest in staff development, and expand programs. Funders want to see nonprofits thrive, not just survive, and providing operational support is a key element to making that happen.

    Funding for operating grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

    Operating grants are often funded by private foundations like the popular Ford Foundation. Some government agencies offer grants to strengthen nonprofit infrastructure, especially in sectors like health, education, and social services. Corporate giving programs may also support nonprofits that align with their values and create lasting impact.

    To improve the chances of getting operating grants, nonprofits should:

    • Showcase past impact – Use data and real-world examples to prove how your organization has already made a difference.
    • Prove how you align with funder priorities – Research what funders care about and explain how your nonprofit’s mission fits within their goals.
    • Prove financial stability – Funders want to support organizations that can manage funds responsibly and have a solid sustainability plan for the long-term.
    • Emphasize lasting growth – Describe how operating funds will help your nonprofit expand its reach, strengthen programs, and increase its overall impact.

    For more advice on finding and winning operating grants, check out our step-by-step guide to general operating grants.

    Instrumentl simplifies the process of applying for operating grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

    Check out how Habitat for Humanity delivered over 200% ROI within just a few weeks.