Best Operating Grants for Nonprofits

The WA Agricultural Conservation Easement Program (ACEP) focuses on preserving agricultural land through Agricultural Land Easements (ALE) and Wetland Reserve Easements (WRE). This program helps landowners protect their land's agricultural viability and conservation values by limiting non-agricultural uses. To participate, landowners must collaborate with eligible partners and adhere to specific compliance requirements. The USDA's NRCS plays a key role in funding and supporting these conservation efforts, ensuring sustainable agricultural practices in Washington.

The Farmland Retirement Program, funded by the Vermont Housing and Conservation Board, aims to buy out farms that negatively impact water quality. Established to preserve Vermont’s rural character, the program facilitates the transition of agricultural land to conservation uses, ensuring long-term environmental benefits. Eligible applicants include nonprofit organizations and municipalities that demonstrate lasting impacts on the community. Funding may cover acquisition costs and associated expenses, supporting restoration efforts that contribute to Vermont's ecological health.

The VT Agricultural Conservation Easement Program (ACEP) aims to protect the agricultural viability of eligible lands by limiting nonagricultural uses and enhancing conservation values. It includes Agricultural Land Easements (ALE) to help landowners safeguard croplands and grasslands, and Wetland Reserve Easements (WRE) to restore degraded wetlands. Additionally, the program offers the Wetland Reserve Enhancement Partnership (WREP) to leverage resources for high-priority wetland protection and improvement of wildlife habitat.

The UT Agricultural Conservation Easement Program (ACEP) aims to protect agricultural viability and conservation values by limiting nonagricultural land use. It includes two components: Agricultural Land Easements (ALE) which help protect croplands, and Wetland Reserve Easements (WRE) that restore degraded wetlands. USDA collaborates with partners through the Wetland Reserve Enhancement Partnership (WREP) to enhance wetland protection and improve wildlife habitat. Applications are accepted year-round, with automatic considerations for future funding cycles.

The Texas Agricultural Conservation Easement Program (ACEP) aims to protect agricultural viability by limiting non-agricultural land uses. It offers two components: Agricultural Land Easements (ALE) to conserve working farms and ranches, and Wetland Reserve Easements (WRE) to restore degraded wetlands. Additionally, the Wetland Reserve Enhancement Partnership (WREP) supports collaborative efforts for wetland protection and enhancement, ensuring sustainable agriculture and conservation of natural resources.

The Gilead Asia Grants support innovative, community-driven healthcare initiatives across Asia, focusing on HIV, liver diseases, hematology, oncology, and inflammatory diseases. Emphasizing health equity, the program funds projects that improve patient access and education for vulnerable populations. Applications are welcome year-round, with no set funding limit, encouraging organizations to request necessary amounts for impactful projects. Gilead prioritizes direct programmatic support to enhance healthcare infrastructures in communities facing barriers to care.

The IA AmeriCorps Formula Grant, offered by Volunteer Iowa, aims to enhance community service and volunteering in underserved areas. This grant prioritizes projects that serve communities facing poverty, improve youth mental health access, support veterans, and promote environmental stewardship. Organizations that engage AmeriCorps members in these critical areas can receive funding to foster civic engagement and build resilient communities, ultimately contributing to national service efforts across the state.

The Berwick Health and Wellness Fund aims to enhance community well-being by supporting diverse health and wellness initiatives. Eligible projects focus on children's health, oral care access, cardiovascular disease prevention, and mental health improvement. Grants can support program activities, capital projects, and general operating expenses. Organizations must possess 501(c)(3) nonprofit status. Notably, sectarian or religious activities are not funded. This initiative represents a commitment to fostering a healthier community through targeted investments.

SSUS State Opioid Grant shall be used to fund direct services for Core Harm Reduction, Harm Reduction Health, Overdose Prevention & Response Innovation, and planning activities for Capital Improvements to clients with behaviors that make them vulnerable to HIV/STD transmission as a result of injection drug use and support harm reduction and overdose prevention services at syringe access locations, harm reduction centers and county health departments.  This opportunity is limited to entities who were funded under DHSTS Opioid 2026 & DHSTS Opioid Expansion 2026. 

New Jersey Department of Health

The scope of work for the public health system is ever-expanding, and the Department is on the frontlines in leading the response to public health challenges. The Department has three primary branches – Public Health Services, Health Systems, and Integrated Health. All work collaboratively toward improving health by strengthening New Jersey’s health system.

Our Mission: Protect the public’s health, promote healthy communities, and continue to improve the quality of health care in New Jersey

TB Prevention and Control Regional TB Specialty Clinic Services

Purpose for Which the Grant Program Funds Shall be Used

To provide clinical care, treatment, nurse case management and/or outreach services to TB cases and suspects, their associated contacts and Class B1/B2 immigrants and refugees for a defined group of local health jurisdictions.

The Pinellas Community Foundation's PCF Operating Grants provide essential two-year funding to nonprofits, enabling them to address core operational costs such as staffing, infrastructure, and outreach. These flexible, unrestricted grants empower organizations to prioritize their unique needs, ensuring that vital community services continue uninterrupted. With a focus on improving health, enhancing quality of life, advancing education, and promoting arts and culture, these grants align with the foundation's commitment to supporting diverse community initiatives.

The FL Agricultural Conservation Easement Program (ACEP) focuses on protecting agricultural viability and conservation values by limiting nonagricultural uses of eligible lands. It includes Agricultural Land Easements (ALE) to safeguard working farms and Wetland Reserve Easements (WRE) for restoring degraded wetlands. Additionally, ACEP collaborates with partners through the Wetland Reserve Enhancement Partnership (WREP) to enhance wetland conservation and wildlife habitats, ensuring sustainable agricultural practices across Florida.

Pincus Family Foundation

PFF is driven by the values that our founders David and Gerry Pincus lived by: “to get involved, not just think about your own life, you are supposed to do things for other people.” Today, the second and third generation of Pincus Family members have added their ethos, while keeping the founders’ legacy alive.

Pincus Family Foundation Grant

Mission Alignment: We support our non-profit partners to develop and enhance programs that improve the lives of children, their families, and their communities.

PFF Funds Projects, Programs, & General Operating Support in Four Priority Areas

Creative & Performing Arts

The Pincus Family Foundation’s Creative and Performing Arts portfolio supports programs where young people use art as a tool to address the structural inequities they face. Five strategic priorities:

• Arts for Social Change Focus – Integrating artistic practice with community organizing, policy advocacy, and/or systemic change efforts
• Hyperlocal Community Integration – Deep community embedment with extensive local partnerships
• Teaching Artist Investment – Commitment to the professional development and well-being of teaching artists
• Cultural Responsiveness – Programming that incorporates community cultural wealth with community input
• Environmental Justice Integration – Authentic integration of environmental themes from community-identified priorities

Target Constituency: Organizations serving preK-12 youth from marginalized communities with arts for social change programming that connects them to the power of art to question and transform systems.

Education

High school readiness for many low-income students, largely is a result of poor preparation in middle school. PFF is funding programs/projects that support middle school engagement and focus on achievement filling a funding gap. 

Target Constituency: We support non-profit organizations serving middle school students who face gaps in comprehensive high school readiness. These organizations implement innovative programming that creates challenging yet nurturing environments—preparing students for achievement while inspiring them to become engaged, confident citizens ready to contribute to their communities.

Health & Wellness

Goal: Advance children’s health and well-being by supporting nonprofits that strengthen social conditions, empower youth, and build healthier environments in marginalized communities.

Target Constituency: Nonprofits whose work strengthens social determinants of health for children in marginalized communities.

Play & Recreation

Goal: Advance children’s social-emotional development and physical well-being by supporting nonprofits that create inclusive play-based programming, competitive sports opportunities, and outdoor recreational experiences in under-resourced communities.

Target Constituency: Non-profits whose work promotes access to quality recreational programming for children ages 6-18 in under-resourced communities.

For all grants, the organization’s mission and scope must align with the Foundation’s mission. For the latter, these grants can be either unrestricted or restricted to a particular program or project. The type of grant and what it is used for will dictate the goals and objectives to be met.

The Jack and Anne Glenn Foundation, established in 2004, aims to support disadvantaged youth and their families through program and project grants. With a grant range of $5,000 to $25,000, the foundation focuses on organizations that are 501(c)(3) exempt. The foundation prioritizes applicants providing guidance to those at risk of poor educational and social outcomes in communities including Metro Atlanta, GA, and Charleston, SC.

The Daniel and Susan Pfau Foundation, established in 1994, focuses on enhancing education, health, cultural experiences, and social welfare for youth with disabilities and economic challenges in the Greater Cincinnati area. It supports arts organizations and recreation initiatives, prioritizing programs that help young individuals realize their potential. Eligible applicants must be recognized 501(c)(3) nonprofits and demonstrate benefits to specific counties in Ohio, Kentucky, and Indiana. The Foundation encourages collaboration with other donors for project funding.

The H-E-B Tournament of Champions Grant, established in 1986, supports organizations benefiting Special Olympics Texas and educational initiatives. Over 37 years, it has raised over $145 million, promoting health, arts, and social services in Texas. Eligible applicants must be valid 501(c)3 non-profits, focusing on specific areas like disaster relief and education, and located near H-E-B regions. This grant fosters community engagement and enhances the quality of life for many Texans.

The Agricultural Management Assistance (AMA) program, administered by USDA's Natural Resources Conservation Service, aims to assist agricultural producers in managing financial risks through practices such as resource conservation and marketing. Participants can receive up to 75% financial assistance for conservation practices, with a cap of $50,000 per fiscal year. Eligibility includes being engaged in agricultural production and having control of the land for the contract term.

The New Hampshire Nita M. Lowey 21st Century Community Learning Centers (21st CCLC) Grant provides federal funding for academic enrichment and support services for students in high poverty schools. It aims to enhance student learning through tutoring, mentoring, and a range of extracurricular activities. Families also benefit from educational development opportunities. This initiative is part of the broader effort to meet educational standards and improve outcomes for youth in the state.

The Mayor's Matching Grant Program, initiated in 1994, supports Orange County Public Schools and nonprofit organizations by funding projects that enhance community engagement, education, and youth development. Grants ranging from $1,000 to $10,000 are available, requiring a dollar-for-dollar match from applicants. This initiative fosters collaboration among community members and organizations, aiming to create safe environments and improve academic outcomes for youth in Orlando.

The Katharine C. Pierce Trust Grant aims to enhance the lives of women in Massachusetts facing challenging circumstances. Focusing on health and human services, it supports nonprofit organizations providing essential services, including homecare and emergency assistance. The grant prioritizes program or capital requests, with a typical award of $10,000 for one year. Applications for direct service grants are due by May 1. Special consideration is given to initiatives benefiting elderly women.

The L.B. Research and Education Foundation Grant Program supports U.S.-based nonprofits focusing on innovative education and health solutions for underserved populations. Eligible organizations can apply by submitting a 400-word concept paper, and selected applicants may receive funding ranging from $10,000 to $75,000. The Foundation prioritizes projects that foster critical thinking and creativity, address health disparities, and encourage collaboration. There are no application deadlines, promoting year-round engagement.

The Agricultural Conservation Easement Program (ACEP) supports the protection of agricultural land by limiting non-agricultural use, ensuring the conservation of vital resources. It offers Agricultural Land Easements (ALE) and Wetland Reserve Easements (WRE) to safeguard croplands, grasslands, and wetlands. Through financial assistance, the program enhances agricultural viability, promotes environmental quality, and fosters local partnerships for sustainable land management. Eligible partners include tribes, governments, and organizations dedicated to farmland preservation.

The NRP Young Investigator Award is designed to support research on optimizing newborn care during delivery using Neonatal Resuscitation Program (NRP) techniques. This grant encourages innovative projects addressing gaps in transitional physiology and resuscitation practices. Eligible applicants include researchers from Canadian and US institutions, particularly those in training or within four years of completing medical training. Awardees may receive up to $15,000 to enhance their skills and knowledge, ultimately improving neonatal outcomes.

The Bridge Association of REALTORS Community Foundation Grants aims to financially support vital community programs that promote housing, youth opportunities, and diversity. The foundation focuses on Youth Arts and Education, Senior Services, and Workforce Housing, providing grants to non-profits in Albany, Berkeley, Emeryville, Kensington, Oakland, and Piedmont. With an emphasis on specific projects, eligible organizations must have tax-exempt status and demonstrate a commitment to addressing pressing community needs.

The WACF Community Impact Grant aims to empower local organizations in Kandiyohi County, Minnesota, by providing funding between $5,000 and $20,000 for initiatives that address community needs. This grant supports projects focusing on youth development, enhancing community connections, and promoting productive aging. Organizations that demonstrate a commitment to diversity, innovation, and sustainable community impact are encouraged to apply. The foundation prioritizes grants that foster collaboration and improve the quality of life for residents.

The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.

The Alexander and Margaret Stewart Trust Grant supports innovative cancer research and enhances the quality of life for children and cancer patients in Washington, D.C. It funds non-profit organizations focused on pediatric care and cancer treatment, particularly for those in disadvantaged communities. The Trust prioritizes programs that provide compassionate care and support early-career scientists through its Pew-Stewart Scholars program, fostering breakthroughs in cancer research and treatment.