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Best Operating Grants for Nonprofits

Get operating grants for nonprofits covering essential expenses, staffing, program delivery, and organizational sustainability.

32,000+

Available grants

$8.25B

Total funding

$6K

Median grant

32,000+ grants
$8.25B total
$6K median

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32,483 Results based on applied filters

Regenerative Medicine Minnesota Grant

Regenerative Medicine Minnesota
State/Local Government
Minnesota
Up to US $400,000

Regenerative Medicine Minnesota

The mission of Regenerative Medicine Minnesota (RMM) is to bring breakthrough regenerative medicine therapies to Minnesotans and patients worldwide. Achieving this vision requires not only advancing novel therapies, but also the innovations, capabilities, collaborations and pathways that enable them to ultimately reach patients. Recognizing the need for a multi-pronged innovation strategy, RMM is calling for proposals that align with this vision through the 2027 Request for Proposals (RFP). By strategically investing across these areas, RMM aims to accelerate transformative regenerative medicine therapies, strengthen Minnesota's leadership in regenerative medicine and generate lasting health and economic benefits for Minnesotans.   

Regenerative Medicine Minnesota (RMM) RFP

This RFP is designed to solicit projects that are aligned with one or more of the following objectives:

  • Advance novel regenerative medicine therapies and products towards clinical application. Proposed therapies or products should have a clearly defined target use, indication or disease area.
  • Develop enabling innovations and platforms that improve the ability to discover, develop, manufacture, or deliver regenerative medicine therapies across multiple applications.
  • Build sustainable capabilities and infrastructure that accelerate clinical translation and commercialization in Minnesota.
  • Foster collaborations across institutions and sectors that strengthen Minnesota’s regenerative medicine ecosystem.
  • Expand patient access to regenerative medicine therapies to benefit patients across Minnesota, including greater Minnesota.

Particular areas of interest for funding under this RFP include, but are not limited to:

  • Platform-based approaches that can be applied to many diseases, particularly rare diseases, such as gene editing/replacement strategies, therapeutic approaches, delivery methods, manufacturing models, regulatory strategies, clinical trial designs, etc.
  • Device-enabled regenerative medicine innovations such as biologic/cell-device combination therapeutics, biomanufacturing devices or tools, therapeutic delivery, etc.
  • Strategies to improve immune compatibility and therapeutic durability, including promoting immune tolerance or reducing immune rejection.

Developmental Biology / Embryology Stem Cell Research & Clinical Use Health & Medicine

Strategic Investment Grants (SIG): Organizations

Montana Arts Council
State/Local Government
Montana
Up to US $1,000

About the Montana Arts Council

The Montana Arts Council is the agency of state government established to develop the creative potential of all Montanans, advance education, spur economic vibrancy, and revitalize communities through involvement in the arts. The Montana Arts Council is governed by 15 individuals appointed by the Governor. It is funded by the state and federal government.

Strategic Investment Grants

Strategic Investment Grants (SIG) provide up to $1000 for expenses related to opportunities for professional development, market expansion, and art events. SIG enables artists and teachers to advance their professional careers and supports nonprofit organizations in the advancement of arts-related programs.

SIG supports a wide variety of arts-related activities and opportunities:

  • Attendance at workshops, trainings, residencies, or conferences
  • Exhibiting at trade shows, gallery showings conferences, festivals, or other art events
  • Public outreach and marketing for events or publications
  • Expansion of online presence or entry into new online marketplaces
  • Performances, public art installations, demonstrations, or exhibitions
  • Investments in technology or tools that represent a clear step forward professionally

Application Type: Artist or Organization

Both individual artists--or groups of artists--and Montana 501(c)(3) organizations are eligible to apply for Strategic Investment Grants. Artists and organizations will be directed to separate applications and will be evaluated according to different criteria.

Organizations

The SIG program supports organizations (arts organizations or organizations with demonstrated arts programming) by enabling them to take advantage of opportunities to enhance their mission or better serve their communities. Example expenses the grant will reimburse include:

  • Travel or entry fees associated with professional development for staff including workshops, conferences, or trainings
  • Preparation, freight and shipping costs for materials
  • Materials to complete work scheduled for public art, gallery exhibition, performance or publication
  • Professional fees and services for marketing, outreach, event production, or documenting an event
  • Fees for equipment, instruments or facility that are integral to the opportunity

Arts / Culture Access & Participation Art & Culture

Van Metre Companies Foundation Grants

Van Metre Companies Foundation Inc
Private
District of Columbia, Florida +4 more
Unspecified amount
The Van Metre Companies Foundation Grants support 501(c)(3) charitable organizations in education, medical, and human welfare services. With a legacy of nearly 70 years, Van Metre prioritizes innovation and community involvement, ensuring financial stability while delivering exceptional value through technology. Recognized as a Best Place to Work, their culture empowers employees and fosters a collaborative environment, reflecting a commitment to excellence and strategic growth in the Northern Virginia market.
Emerging Technology Development Community Services Poverty Alleviation & Services

Artist Fellowship Grant - Artist Fellowship Grants

Connecticut Department of Economic and Community Development
State/Local Government
Connecticut
Up to US $3,000
The Artist Fellowship Grant offers $3,000 to Connecticut artists across all disciplines to support new work and enhance their careers. Eligible applicants must be at least 18 years old, full-time residents of Connecticut, and able to provide a Social Security Number. Recent recipients must wait five years before reapplying. This program aims to recognize and nurture artistic talent, ensuring that funds are directed towards artists with a professional body of work.
Art & Culture Artist Training & Development

Group Violence Reduction Strategy Grant

DC Office of Neighborhood Safety and Engagement
State/Local Government
District of Columbia
Approximately US $750,000
The Group Violence Reduction Strategy Grant, administered by the DC Office of Neighborhood Safety and Engagement, aims to reduce gun violence in Washington, D.C. This initiative seeks applications from organizations providing violence intervention services to engage high-risk individuals aged 18-35. By fostering community partnerships and implementing effective intervention strategies, the grant supports efforts to prevent violence and offer alternatives to crime, ultimately enhancing safety and well-being in local neighborhoods.
Violence Prevention Community / Public Safety

Beveridge Family Prize in American History

American Historical Association
Association/Society
United States
US $1,000
The Beveridge Family Prize in American History, awarded annually by the American Historical Association since 1945, recognizes exceptional historical writing. Eligible works include biographies, monographs, and interpretations published in 2024. This prestigious award honors Senator Albert J. Beveridge and aims to promote outstanding scholarship on American, Latin American, and Canadian history. Recipients will be announced in October 2025 and celebrated at the 2026 AHA annual meeting in Chicago.
History American History Hispanic and Latino Culture & Heritage

Kent Community Foundation: Cultural, Arts, and Education Grant Program

Kent Community Foundation
Private
King County, Washington
Up to US $1,000
The Kent Community Foundation, a 501(c)3 nonprofit established in 1986, supports cultural arts and education in Kent, Washington. Its Cultural, Arts, and Education Grant Program invites proposals from community groups and schools each year. The program aims to promote educational activities that enhance learning and foster cultural arts within the community, offering funding up to $1,000 to eligible organizations serving the greater Kent/Covington area.
Art & Culture Art Education

The Excelsior Foundation Grant

Robison Excelsior Foundation
Private
Brown County, Texas, Callahan County, Texas +5 more
Unspecified amount
The Excelsior Foundation Grant, offered by the Robison Excelsior Foundation, supports organizations focused on assisting at-risk youth in the Big Country area of Texas. This private foundation aims to provide hope and resources to those in need, ensuring that eligible 501(c)(3) organizations can apply for funding. Key requirements include a current IRS Form W9 and a commitment to working directly with at-risk youth to foster positive outcomes.
Youth Services Human & Social Services

SUNY Open Educational Resources (OER) Impact Grants

State University of New York (SUNY)
State/Local Government
New York
Unspecified amount
The SUNY Open Educational Resources (OER) Impact Grants aim to enhance accessibility and affordability in education by promoting the use of OER across the State University of New York system. These grants support initiatives that reduce textbook costs and foster innovative teaching methods using openly licensed materials. By facilitating the adoption of OER, SUNY is committed to improving academic success and ensuring equitable access to high-quality educational resources for all students.
Education Literacy

North Idaho Grants- Bonner County Human Rights Task Force Fund

Idaho Community Foundation (ICF)
Private
Bonner County, Idaho
Up to US $8,000
The Bonner County Human Rights Task Force Fund, established in 1992, promotes equality and human rights through community education and advocacy. Grants of up to $8,000 support projects that celebrate diversity and enhance human rights. Eligible applicants include local organizations, educational institutions, and government entities committed to these ideals. Projects should engage the community and focus on non-discrimination and cultural diversity, contributing to the rich fabric of Bonner County.
Social Justice / Human Rights Diversity, Equity & Inclusion

Arthur F. and Alice E. Adams Charitable Foundation Grant

Arthur F And Alice E Adams Supporting Foundation
Private
Florida, New York +1 more
Up to US $50,000
The Arthur F. and Alice E. Adams Charitable Foundation, established in 1985, supports various charitable initiatives focusing on arts, culture, humanities, and education. It primarily benefits organizations in Memphis, Miami, and New York City. Eligible applicants must be 501(c)(3) exempt organizations and seek project sponsorships. The foundation does not fund general operating costs or capital campaigns, and requests over $50,000 are generally discouraged. Proposals must be for projects commencing at least a year after submission.
Art & Culture Human & Social Services Education

Research Interests of the Air Force Office of Scientific Research (362681)

US DOD: Dept. of the Air Force, Materiel Command
Federal Government
American Samoa, Guam +4 more
Up to US $10,000,000
The Air Force Office of Scientific Research (AFOSR) orchestrates the basic research program for the Air Force Research Laboratory, aligning with technical guidance and Air Force needs. It promotes collaboration among Air Force, universities, and industry, ensuring that research effectively transitions to support military capabilities. AFOSR's focus encompasses significant areas of research organized under two scientific departments, enhancing national defense and peacekeeping operations.
Aviation Engineering Aerospace Engineering

Frank King Fund Grant

The Kentucky Annual Conference of The United Methodist Church
Association/Society
Kentucky
Up to US $3,000
The Frank King Fund Grant provides matching funds of up to $3,000 to support churches within the Kentucky Annual Conference for improvements and additions. Eligible churches must have fewer than 200 members or 100 in worship and must submit a project accounting upon completion. A letter of support from the district superintendent is also required. This grant honors the legacy of Rev. Frank C. King, a dedicated United Methodist Pastor.
Community Development & Revitalization Christianity

ACS Bridge Travel & Professional Development Award

American Chemical Society
Association/Society
San Diego County, California
Up to US $1,000
The ACS Bridge Travel & Professional Development Award supports undergraduate and graduate students from diverse backgrounds in the chemical sciences to attend ACS meetings. This funding, up to $1,000, helps cover essential expenses such as registration, transportation, and lodging. By enhancing participation in conferences, the award aims to foster mentorship and opportunity for students from historically marginalized groups, ultimately contributing to a more inclusive scientific community.
Chemistry Diversity, Equity & Inclusion

WMU Department of Chemistry: Craig B. Peot Memorial Endowed Scholarship

Western Michigan University
Private
Kalamazoo County, Michigan
Unspecified amount
The WMU Department of Chemistry offers the Craig B. Peot Memorial Endowed Scholarship to support junior or senior chemistry majors at Western Michigan University. This scholarship recognizes students with a minimum GPA of 3.0 and emphasizes documented service, volunteerism, and financial need. Applications for the scholarship will open on December 15, 2025, and close on February 28, 2026, providing critical financial assistance for students pursuing careers in chemistry and related fields.
Chemistry Academic Scholarship Programs

John G. Duncan Charitable Trust Grant

John G. Duncan Charitable Trust
Private
Colorado
US $10,000 - US $20,000
The John G. Duncan Charitable Trust Grant supports educational, human services, and health initiatives in Colorado, particularly focusing on the state's most impoverished areas. Organizations can apply once a year, with specific eligibility criteria in place. Founded in honor of philanthropist John G. Duncan, the trust aims to perpetuate his generosity by funding various charitable causes across the state. Applications are accepted in designated periods throughout the year, ensuring a broad reach for potential grantees.
Education Health & Medicine Human & Social Services

WMU Department of Chemistry: Dr. Hashem and SuzAnne Akhavan-Tafti Chemistry Scholarship

Western Michigan University
Private
Kalamazoo County, Michigan
Unspecified amount
The Dr. Hashem and SuzAnne Akhavan-Tafti Chemistry Scholarship at Western Michigan University supports chemistry majors pursuing careers in various fields such as industry, teaching, and research. Established in 2014, the scholarship aids students from historically underrepresented populations, enhancing their educational experience through financial assistance. Applications for the fall 2026/spring 2027 cycle open on December 15, 2025, and close on February 28, 2026, via ScholarshipUniverse.
Chemistry Academic Scholarship Programs

WMU Department of Chemistry: Edward Sweet Chemistry Scholarship Endowment

Western Michigan University
Private
Kalamazoo County, Michigan
Unspecified amount
The Edward Sweet Chemistry Scholarship Endowment at Western Michigan University supports chemistry majors pursuing careers in various fields, including industry and academia. Established in honor of Edward Sweet, a dedicated alumnus, the scholarship emphasizes the importance of education and aims to assist deserving students in their academic journeys. Applications open on December 15, 2025, for the fall 2026/spring 2027 academic year, with a focus on outstanding achievement and financial need.
Chemistry Academic Scholarship Programs

WMU Department of Chemistry: Frederick W. Stanley Memorial Chemistry Scholarship for Graduate Students

Western Michigan University
Private
Kalamazoo County, Michigan
Unspecified amount
The WMU Department of Chemistry offers the Frederick W. Stanley Memorial Chemistry Scholarship for Graduate Students, aimed at supporting declared chemistry majors with outstanding academic records. Eligible candidates must have a GPA between 2.5 and 3.5. This scholarship not only provides financial assistance but also recognizes the hard work of students preparing for diverse careers in chemistry, biochemistry, medicine, and related fields. Applications for the fall 2026/spring 2027 term will be accepted from December 15, 2025, to February 28, 2026.
Academic Scholarship Programs Chemistry

Exhibition Grants

Artis
Private
Afghanistan, Africa +54 more
Up to US $10,000
Artis offers exhibition grants to support contemporary artists from Israel, aiming to promote critical dialogue and cultural exchange in international settings. These grants facilitate presentations at renowned organizations globally, focusing on innovative and impactful projects that engage with pressing social and environmental issues. The program prioritizes proposals that demonstrate curatorial ambition and artistic experimentation, fostering collaboration across diverse disciplines. Artis is committed to shaping a sustainable art world while addressing urgent global challenges through artistic practice.
Art & Culture Visual Arts

Access Grants

Bigglesworth Family Foundation
Private
United States
US $1,000 - US $3,500
The Bigglesworth Family Foundation's Access Grants aim to strengthen nonprofit organizations in delivering essential legal services to underserved communities. Ranging from $1,000 to $3,500, these grants provide access to critical tools and resources. The application process is streamlined, ensuring a review within 30 days, with a limit of two applications per organization annually. Eligible organizations must be 501(c)(3) nonprofits focused on legal services, as applications outside this area will not be considered.
Legal Services Computer Science & Engineering

City of Chico City Arts Grant

North Valley Community Foundation
Private
Butte County, California
US $2,000 - US $5,000
The City of Chico Arts Grant Program aims to enhance cultural engagement by supporting local artists and arts organizations. Funded by a portion of the Transient Occupancy Tax, the grant promotes diverse projects that include community participation and artistic excellence. Eligible applicants must demonstrate a 1:1 cash match and a commitment to serving underserved populations. This initiative fosters inclusivity and access to quality arts experiences, ensuring a vibrant cultural landscape for Chico's residents.
Art & Culture Arts / Culture Access & Participation

Zyne Family Foundation Grant

Zyne Family Foundation Inc
Private
United States
Unspecified amount
The Zyne Family Foundation Grant aims to enhance and support Catholic faith-based organizations and other 501(c)(3) nonprofits dedicated to education, medical research, and family values. The foundation's mission focuses on making a direct impact on individuals' daily lives, ensuring that these initiatives can thrive both now and in the future, promoting community well-being and development.
Education Family Services

ESC Texas Tutoring Support Grant

Texas Education Agency
State/Local Government
Texas
US $350,000
The ESC Texas Tutoring Support Grant, managed by the Texas Education Agency, aims to establish a central tutoring hub to enhance educational outcomes. This initiative includes hosting an annual summit focused on best practices, providing technical assistance, and developing resources to ensure sustainable implementation across Texas school systems. By fostering collaboration and sharing effective strategies, the grant seeks to build capacity and improve tutoring services statewide, ultimately benefiting students and educational institutions.
Education Academic Success & Enrichment

Harbor Freight Tools Gift Card Donation Requests

Smidt Foundation
Private
United States
Unspecified amount

About Us

Harbor Freight is America’s #1 Tool Store with more than 1600 locations nationwide. Founded in 1977 by Eric Smidt, the company began as a small mail-order tool business in North Hollywood, California. Over 75 million customers have come to Harbor Freight for our unmatched assortment of quality tools at an unbeatable value, including automotive, air and power tools, storage, outdoor power equipment, generators, welding supplies, shop equipment, hand tools, and much more.

Harbor Freight Tools Gift Card Donation Requests

If you are a Harbor Freight Associate and have been affected by an unexpected, unavoidable crisis and are in financial need, please apply to our Employee Emergency Relief Fund (EERF). To apply, go to www.myHFT.com to review our FAQs, guidelines, eligibility requirements and application form.

For all other donation requests, please note that we have recently updated our criteria. You can find the current eligibility requirements below.

All donations are given in the form of Harbor Freight Store gift cards. We do not provide cash donations, event sponsorships or support for individuals.

Harbor Freight Tools proudly supports the following:

Skilled Trades Education

  • Skilled trades classes that emphasize the expert use of tools and materials to build, repair and maintain products and structures. Fields include Agricultural Mechanics, Carpentry, Construction, Electrical, HVAC, Advanced Manufacturing, Plumbing, Transportation Mechanics and Repair, and Welding
  • Donation requests must be submitted by a K-12 public-school teacher for their own school/classroom. Harbor Freight store gift cards are given directly to the school/teacher requesting one. We do not provide donations to outside organizations, clubs or third parties.
Economic Services & Development Community Development & Revitalization

Chula Vista Community Foundation Grant: Student Learning

The San Diego Foundation
Private
San Diego County, California
US $10,000 - US $30,000
The Chula Vista Community Foundation Grant Cycle aims to enhance the quality of life in Chula Vista through effective philanthropy and community support. For the 2025-2026 cycle, proposals focusing on animal welfare, particularly adoption initiatives and spay-neuter programs, are encouraged. Grants range from $10,000 to $30,000, providing essential funding for impactful projects that benefit both animals and the community.
Mathematics Education - K through 12 Literacy +1 more

Art Bridges Cohort Program

Art Bridges
Private
United States
Unspecified amount
The Art Bridges Cohort Program aims to enhance access to American art by fostering multi-year partnerships among museums across the U.S. This initiative creates sustainable art-sharing ecosystems that promote collaboration and community engagement. The program supports museums through funding for various phases, including research, small art shares, and large art shares, ensuring resources for travel, exhibition design, and educational opportunities. Eligibility includes a strong commitment to community engagement and existing art collections.
Art & Culture Community Culture & Heritage

Operating Grants for Nonprofits Highlights

Operating grants for nonprofits provide essential funding to support day-to-day operations, staff salaries, and infrastructure. The following grants help organizations build capacity, maintain sustainability, and focus on achieving their mission-driven goals.


Search Instrumentl's Operating Grants Database


Explore 8,000+ funding opportunities for operational support, with $3.43B in resources. Instrumentl helps nonprofits secure essential funding by offering grant discovery tools, deadline tracking, and strategic funder analysis to ensure long-term success.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Operating grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Operating grants for nonprofits over $25K in average grant size

3,000+ Operating grants for nonprofits over $50K in average grant size

1,000+ Operating grants for nonprofits supporting general operating expenses

7,000+ Operating grants for nonprofits supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits of all types can apply for operating grants, but they are especially useful for organizations needing flexible funding to support the core work of their mission. Operating grants are ideal for nonprofits involved in general population well-being. Specific sectors include healthcare, education, social services, and the arts. Unlike project-based grants that fund specific initiatives, operating grants help with essential costs like staff salaries, rent, and general admin costs. Funders often look for groups with a clear mission who serve a meaningful purpose and have potential for long-term impact.

Based on Instrumentl’s live grant database for operating, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Operating grants exist to help nonprofits function smoothly and grow effectively. The goal is to give organizations the financial means they need to focus on their mission, serve their communities, and support long-term stability. These grants allow nonprofits to improve everyday operations, invest in staff development, and expand programs. Funders want to see nonprofits thrive, not just survive, and providing operational support is a key element to making that happen.

Funding for operating grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Operating grants are often funded by private foundations like the popular Ford Foundation. Some government agencies offer grants to strengthen nonprofit infrastructure, especially in sectors like health, education, and social services. Corporate giving programs may also support nonprofits that align with their values and create lasting impact.

To improve the chances of getting operating grants, nonprofits should:

  • Showcase past impact – Use data and real-world examples to prove how your organization has already made a difference.
  • Prove how you align with funder priorities – Research what funders care about and explain how your nonprofit’s mission fits within their goals.
  • Prove financial stability – Funders want to support organizations that can manage funds responsibly and have a solid sustainability plan for the long-term.
  • Emphasize lasting growth – Describe how operating funds will help your nonprofit expand its reach, strengthen programs, and increase its overall impact.

For more advice on finding and winning operating grants, check out our step-by-step guide to general operating grants.

Instrumentl simplifies the process of applying for operating grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

Check out how Habitat for Humanity delivered over 200% ROI within just a few weeks.