Best Grants for 501(c)(3) in South Carolina

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. 

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. 

The Express Health Information Outreach Awards aim to enhance public health by increasing access to biomedical information for U.S. health professionals and the general public. These awards support projects that improve health information literacy among consumers and caregivers, ensuring they can effectively find and utilize health information. Focused on partnerships and outreach to underrepresented communities, the initiative seeks to promote healthy behaviors, prevent illness, and improve health outcomes through informed decision-making.

The Watson-Brown Foundation Grant supports organizations dedicated to preserving the history and culture of the South. It offers various types of grants, including for educational programming and historic preservation, with a focus on southern studies. Eligible recipients include public charities in the southeastern United States. The Foundation's Junior Board of Trustees also awards grants to preservation projects in east central Georgia, emphasizing youth engagement in cultural heritage.

The Sidney B. Meadows Scholarship, established in 1989, offers financial support to students pursuing degrees in horticulture across 16 southeastern states. Administered by the Sidney B. Meadows Scholarship Endowment Fund, this scholarship honors the legacy of Sidney B. Meadows, a dedicated advocate for education in the horticultural industry. Applicants must meet specific eligibility criteria related to academic standing and residency, with preference given to those intending to work in the field after graduation.

The Marvin R. and Pearl E. Patterson Family Fund Scholarship, offered by the Grand Haven Area Community Foundation, supports students aspiring to study graphic or fine arts, as well as those interested in environmental sciences. Open to high school graduates from the Tri-Cities area, this scholarship considers leadership, community involvement, and academic achievements, although financial need is not a requirement. Applicants must provide transcripts and relevant documents to qualify for this opportunity.

The Southern Partners Fund's Discretionary Fund Grant aims to support grassroots community organizing for social, economic, and environmental justice in the Southeastern United States. It provides financial resources and technical assistance to rural organizations and leaders focused on transformative change. Eligible applicants include self-governed rural groups engaging in advocacy and community development. The fund prioritizes education reform, immigration rights, and voter engagement, allowing up to two requests per year, with a maximum award of $3,500.

New Leaf Fund - Spring Cycle

The New Leaf Fund was established in 2025 by a Greenville native with a passion for conservation.

The Foundation encourages grant requests that include the protection of land and waterfront areas, increased tree cover and access to green spaces, and the protection and restoration of historical properties, in the City of Greenville, in Greenville County, and, to a lesser degree, in the Upstate.

Additional Information

• Awards typically range from $20,000 to $100,000
• Applicants may apply for more than one grant annually

Funding opportunities may include

Funding opportunities may include

• Projects including acquisition, development, preservation, or restoration of land
• Projects including acquisition, development, preservation, or restoration of historical and cultural assets
• Planning, survey, appraisal or design fees for implementing such projects

The Abelard Foundation, established in 1958, supports progressive social change projects located east of the Mississippi River. With an average grant size of $12,000, they prioritize new initiatives with budgets under $350,000. The foundation emphasizes community organizing, civil rights, and empowering marginalized groups. Eligible applicants must be associated with a nonprofit organization and demonstrate a commitment to local leadership and broader policy connections. The board meets biannually to decide on approximately 15 grants per year, focusing mainly on general support.

The Westinghouse CFFF Charitable Giving Program

Westinghouse believes in giving back to surrounding communities.

The enables our company to provide financial support to the areas around our facility, including Hopkins, Gadsden and Eastover. Grants will be provided in one or more of our strategic areas of giving. This is just one way Westinghouse gives back to its community.

Westinghouse strategic areas of giving:

If your organization meets the criteria of one or more of our strategic areas of giving, we welcome you to apply for a grant.

The Connections to Care initiative aims to modernize and expand digital infrastructure across South Carolina’s rural healthcare ecosystem. This grant opportunity seeks proposals from eligible organizations to implement or enhance electronic health records (EHRs) and remote patient monitoring (RPM).

The NRP Research Grant Program offers up to $50,000 for healthcare professionals to explore optimal neonatal resuscitation methods. It encourages innovative research addressing gaps in transitional physiology and effective teaching of resuscitation skills. Applications must focus on evidence-based practices and demonstrate potential for meaningful impact in delivery room care. Researchers from Canadian and US institutions are eligible, though applications primarily focused on quality improvement without a research emphasis will not be considered.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Benny and Eleanor Clark Scholarship ($2,200)

This renewable scholarship is available to the following (1) residents of South Carolina attending a Historically Black College or University that is located in South Carolina. 

Watersheds Program

SCDES’s Watersheds Program supports the goals of the Clean Water Act in the state’s eight major river basins: Savannah, Saluda, Edisto, Salkehatchie, Broad, Catawba, Santee, and Pee Dee. Through a non-regulatory approach, the program serves as a water quality information and watershed planning resource to stakeholders, provides technical support to the Section 319 Nonpoint Source (NPS) Grants program, and manages the SC Watershed Atlas.

The South Carolina Nonpoint Source (NPS) Program strives to address nonpoint sources of pollution to help restore and maintain water quality throughout the state. To achieve this goal, the objectives of the program are to focus on voluntary measures to reduce and prevent NPS; promote locally driven NPS reduction and prevention; develop collaboration and partnerships; carry out statewide programs and on-the-ground projects to achieve measurable water quality improvements; and provide NPS project and program funding.

Watershed Plan Development Grant

The Drinking Water State Revolving Fund provides set-aside funds for the development of watershed plans to address surface water pollutants impacting source water for drinking water systems. A watershed plan can enhance or augment a source water protection (SWP) plan in that it encompasses the entire watershed that impacts the supply source, as well as the delineated source water protection area. Once a watershed plan is in place, it becomes the guidance and framework for any water quality improvement activities in that watershed. Having a watershed plan in place opens up additional funding opportunities for Section 319 grants to implement nonpoint source-reduction projects identified in the watershed plan.

Selected projects will be funded 100% by monies provided to SCDES by USEPA’s Drinking Water State Revolving Fund set-aside for Source Water Protection. However, additional consideration will be given to proposals which show supplementary funds leveraged for watershed plan development.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Dinkins Family Scholarship ($2,000)

This renewable scholarship is available for graduating high school seniors whose permanent address is in the Community Foundation’s 11-county service area (Calhoun, Clarendon, Fairfield, Kershaw, Lee, Lexington, Newberry, Orangeburg, Richland, Saluda, and Sumter). 

The ReFED Catalytic Grant Fund, managed by Refed Inc., supports innovative solutions to minimize food waste and reduce methane emissions, a cost-effective strategy for climate action. This fund prioritizes initiatives that enhance food recycling and improve supply chain efficiency in the beef and dairy sectors. By focusing on proven methods, the grant aims to accelerate impactful changes in the food system, ultimately fostering sustainable practices and collaborative efforts to combat food waste.

The Leveling Up initiative aims to expand and integrate proven chronic disease management programs statewide, ensuring rural communities have access to comprehensive, coordinated care for serious and chronic conditions such as diabetes, hypertension, and sickle cell disease. Historically, these programs have been implemented in limited regions due to resource constraints, leaving rural areas underserved and often last to benefit from advancements in chronic care. This grant opportunity seeks proposals from eligible organizations to expand chronic disease programs.

The Food Lion Feeds Charitable Foundation, established in 2001, has awarded over $17.5 million to combat hunger in its operating areas. This foundation focuses on supporting children at risk of hunger and enhancing the capacity of feeding agencies to provide nutritious meals. They also emphasize nutrition education to mitigate health risks associated with hunger. Eligible organizations include 501(c)(3) nonprofits located within 20 miles of a Food Lion store, with applications accepted annually.

The Kroger Foundation is dedicated to uplifting communities through significant charitable contributions, having donated over $1.9 billion in the past six years. Their focus on combating hunger through the Zero Hunger | Zero Waste initiative exemplifies their commitment to social impact. Annually, they provide over $300 million to nonprofit organizations aligned with their mission, promoting health, education, and disaster relief while fostering diversity and inclusion. This initiative reflects Kroger's belief that strong communities are a shared responsibility.

Vizo Financial Empowerment Grant

Through the generosity of Vizo Financial Corporate Credit Union, credit unions of all asset sizes can apply for grants that will fund financial education projects or programs to empower members to reach financial goals and establish a better quality of life. Up to $50,000 annually will be allocated to each of the state’s Foundations each year. 

Credit unions are encouraged to submit grant applications to implement programs or undertake projects in collaboration with other credit unions and/or community organizations, enriching financial literacy offerings for members and the communities credit unions serve. Greater consideration will be applied to grant applications when budget limitations act as a barrier to community outreach initiatives. Grants can be requested for up to a maximum of $10,000.

The Foundation will review grant requests for credit union initiatives that offer:

• Affordable options to costly financial products and services
• Lesser dependency on predatory financial providers
• Expanded financial education and literacy
• Enhanced personal financial management and planning for the future
• Increased individual savings and wealth-building
• Strengthened credit worthiness
• Improved financial wellbeing of local people and communities

The SPC Cares Foundation

The SPC Cares Foundation was established in 2024 as a way for SPC Credit Union to strategically support four key development issues identified within our community: Hunger, Housing, Employment, & Education. The Foundation supports our local communities through monetary donations, in-kind donation drives, and volunteerism.

Community Impact Fund

Community Impact funds are available to support nonprofit organizations that are strengthening and improving communities where SPC Members live, work, or attend school. Preference is given to organizations that address our four funding areas (hunger, housing, employment, & education). Education-related projects or initiatives must promote finance, employment, workforce readiness, or leadership.

Applications for funding are reviewed quarterly by the SPC Cares Foundation Advisory Board.

The Gridiron Veterans Scholarship, provided by the Bob Woodruff Foundation, offers essential financial support for military veterans and first responders. This initiative focuses on wellness, rehabilitation, and recovery programs, ensuring participants can access mental health services, physical therapy, and holistic resources. The foundation prioritizes those facing emotional and physical challenges, empowering them to overcome barriers and improve their quality of life through customized, evidence-based support.

Entergy’s Open Grants Program aims to enhance community well-being through funding initiatives in arts, education, social services, and community improvement. The program prioritizes support for organizations that serve diverse populations, including children and low-income communities. Eligible entities must have 501(c)(3) status or equivalent nonprofit recognition. Applications should be submitted three months in advance, allowing ample time for review. Entergy focuses on projects that foster self-sufficiency and enrich local neighborhoods.

The Grand Haven Offshore Challenge Scholarship, offered by the Grand Haven Area Community Foundation, supports students pursuing studies in natural resources, including fisheries and wildlife. This scholarship is available for applicants attending any public or private college or university. The fund was established to honor community contributions towards environmental preservation and is awarded based on academic merit and financial need. Apply once for all scholarships you may qualify for to streamline your application process.

The Growing Tribal Economies Through Forest Market Innovations grant program, initiated by First Nations Development Institute, aims to empower Tribes and Alaska Native Villages to engage in emerging markets that enhance forest health and resilience. With funding of $200,000 to $500,000 per grant, this initiative supports projects focusing on sustainability, innovation, and traditional knowledge. Eligible applicants are encouraged to develop forest products, certifications, and practices that contribute positively to biodiversity and ecosystem management.

About

The Costume Society of America (CSA) is a 501(c)(3) non-profit organization founded on March 23, 1973, and incorporated in the state of New York on September 12, 1973. CSA serves it members, and promotes its goals with national symposia and publications including the journal Dress and its monthly electronic newsletter CSA e-News.

The organization began forming regional groups in 1978. There are six regional groups in the United States and Canada, and one international group. Individual regions hold annual meetings, sponsor programs and publish newsletters.

Our Mission

The Costume Society of America fosters an understanding of appearance and dress practices of people across the globe through research, education, preservation, and design. Our network of members studies the past, examines the present, and anticipates the future of clothing and fashion.

Colleen Callahan Professional Development Award

Members are invited to apply for the Professional Development Grant offered by Southeastern Region of the Costume Society of America. Awards will be made at a minimum of $250 with the total award not to exceed $1000. Your project may be on any aspect of costume, any technical skill, or any administrative expertise which will further the mission and purposes of the Costume Society of America. The grant money may be applied to research, a course, workshop fees, or travel.

About

The Costume Society of America (CSA) is a 501(c)(3) non-profit organization founded on March 23, 1973, and incorporated in the state of New York on September 12, 1973. CSA serves it members, and promotes its goals with national symposia and publications including the journal Dress and its monthly electronic newsletter CSA e-News.

The organization began forming regional groups in 1978. There are six regional groups in the United States and Canada, and one international group. Individual regions hold annual meetings, sponsor programs and publish newsletters.

Our Mission

The Costume Society of America fosters an understanding of appearance and dress practices of people across the globe through research, education, preservation, and design. Our network of members studies the past, examines the present, and anticipates the future of clothing and fashion.

Jim Liles Student Award

 The Jim Liles Student Award is intended to assist students who want to make presentations at a CSA Southeastern Region symposium. These presentations may be on any costume-related topic. The work should be well researched and may or may not be thesis, dissertation, course research project, independent study research, or senior project related. Up to TWO students whose papers are accepted will receive up to $1,000 each to cover travel and other related expenses. The Registration fee will be waived for all student presenters, regardless of whether they receive this award.

The Hickory Fund Grant aims to enhance the quality of life for individuals with disabilities in Wisconsin and South Carolina. Funding supports capital campaigns, new programs, general operating support, and social entrepreneurship. Grants under $5,000 require a Letter of Inquiry, while larger grants require both a Letter of Inquiry and a full application. Notably, funds are not allocated for endowments, individual grants, lobbying, scholarships, or medical research.