Best Jefferson County Grants for Nonprofits in Missouri

Nestlé Purina Animal Welfare Grants focus on enhancing the well-being of pets and their owners through monetary donations to 501(c)(3) tax-exempt pet welfare organizations in the U.S. These grants support capacity building, capital improvements, and spay/neuter funding. The program aims to strengthen relationships between pets and people, particularly in communities near Nestlé Purina facilities, ensuring that both pets and their owners thrive together.

Nestlé Purina

Unspecified amount

Tilles Fund Grant

The Tilles Fund Grant focuses on innovative charitable investments in the Greater St. Louis Area, aiming to support children with developmental, intellectual, and physical disabilities. The foundation seeks to partner with effective non-profit organizations that demonstrate measurable outcomes in education and community impact. Since 1926, the Tilles Foundation has been committed to providing essential services and educational opportunities, ensuring disadvantaged children have the tools they need for a brighter future.

Rosalie Tilles Nonsectarian Charity Fund 313743

Up to US $100,000

Gateway Regional Environment Fund Grant Program

Letter of inquiry due Mar 9, 2027

The Gateway Regional Environment Fund Grant Program, managed by the St. Louis Community Foundation, aims to support initiatives in the St. Louis metro area that reduce the carbon footprint. By funding projects that address greenhouse gas emissions, GREF plays a crucial role in combating climate change locally. This program encourages community engagement and innovation to create a sustainable future for the region.

St Louis Community Foundation

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Up to US $25,000

Episcopal Presbyterian Health Trust Grant

Applications due Jul 7, 2027

The Episcopal Presbyterian Health Trust Grant, managed by the St. Louis Community Foundation, focuses on enhancing health care access and addressing chronic diseases. Grants are awarded biannually, prioritizing maternal and infant health in the second cycle. Organizations are encouraged to submit one Letter of Intent (LOI) annually, ensuring their proposals align with the funding priorities to foster sustainable health solutions in the community.

St Louis Community Foundation

Up to US $1,000

Firefighter Grant Program

Applications due Aug 31, 2027

The Firefighter Grant Program by Missouri American Water aims to support local fire departments with financial assistance up to $1,200. This initiative is part of the company's commitment to enhancing community safety and well-being. Eligible applicants include both professional and volunteer fire departments within designated service areas. Funds can be used for essential items such as protective gear, communication equipment, firefighting tools, and training materials, ensuring that fire services are well-equipped to respond effectively.

Missouri American Water

Unspecified amount

Section 5310 – Enhanced Mobility of Seniors and Individuals with Disabilities Grant

Applications due Feb 20, 2027

The Section 5310 – Enhanced Mobility of Seniors and Individuals with Disabilities Grant, administered by the East-West Gateway Council of Governments, aims to enhance transportation access for seniors and individuals with disabilities in the St. Louis region. This federal funding supports projects that improve mobility, including vehicle acquisition, travel training, and barrier removal at bus stops. Eligible applicants include non-profits and government entities focused on serving these communities.

East-West Gateway Council of Governments

Unspecified amount

Lutheran Foundation of St. Louis Grants

Applications due Dec 1, 2026

The Lutheran Foundation of St. Louis provides grants aimed at improving the lives of individuals in the greater St. Louis area. With a focus on strategic priorities such as community engagement and support for vulnerable populations, the foundation encourages organizations to apply for funding that aligns with its mission. Grants are available to 501(c)(3) organizations serving specific counties, and applicants are encouraged to demonstrate measurable impact through their proposed programs.

Lutheran Foundation of St. Louis

Unspecified amount

PNC Foundation: Foundation Grant

The PNC Foundation aims to enhance the lives of individuals in local communities through partnerships with nonprofit organizations. Their focus includes promoting educational opportunities, particularly for early childhood education, and supporting economic development initiatives. Grants are available for organizations that benefit low- to moderate-income families and enhance community growth. The foundation prioritizes programs that foster sustainability and diversity, ensuring a lasting impact on the communities they serve.

PNC Foundation

Up to US $100,000

United Way of Greater St. Louis: Targeted Fund

Applications due Oct 12, 2027

The United Way of Greater St. Louis Targeted Funding aims to provide flexible, one-year grants to nonprofits addressing urgent community needs through emergency, emergent, or innovative approaches. Funding will focus on basic needs, health and wellness, crisis response, and more across 16 counties. Priority will be given to areas identified as having the greatest needs based on recent assessments, ensuring that support is directed where it is most needed.

United Way Of Greater St Louis Inc

Up to US $10,000

Congregation Mini Grants

Lutheran Foundation of St. Louis

Lutheran School Mini Grants

The Foundation continues to encourage congregations to reach out to their surrounding communities through organized, effective social service outreach ministry efforts. We also recognize congregations are looking for innovative ways, outside the traditional social service outreach model, to build relationships and engage their communities.

We look to accomplish this in two ways:

Supporting congregations as they work to engage and serve their neighbors and community through planning and program implementation grants.
Strengthening the ability of congregations to engage in community engagement efforts through coaching assistance, mentoring, and training (through Send Me St. Louis).Examples of Possible Ministry Projects

Congregation Community Engagement is defined for this Funding Focus Area as activities, services, or efforts designed to reach out to others on a local level (St. Louis metropolitan region). Examples include both serving the immediate needs of people and efforts to engage and build relationships with the community. The focus is on bringing the care of Jesus Christ into the lives of hurting people in the community, rather than serving the congregation’s own members. This funding focus area is not meant to support “Word and Sacrament” activities.

Health care/mental health services
Fitness/healthy living programs
English as a second language
After-school mentoring/tutoring
Social activities for seniors
Community revitalization
Recreation activities
Home repair/beautification
Partnerships with local schools/other institutions
Social enterprise/business that benefits the community and/or creates space for relationships
One-time events (run by the congregation) to meet a need in the community

Idea Exploration

Congregations should know what they want to do and have an idea of how to get started. If you are not at this point, coaching services to assist your congregation are offered through Lutheran Foundation’s relationship with Send Me St. Louis. Services include coaching and guidance on:

mapping the congregation’s and community’s assets,
researching opportunities for social service outreach ministry, and/or
planning for a social service outreach ministry.

There are no grant deadlines for the Congregation Mini Grants. Application can be made at any time of the year.

Unspecified amount

Brinker International Charitable Giving Program

The Brinker International Charitable Giving Program focuses on giving back to communities through support for kids, hunger, and education. Organizations eligible for funding must be 501c(3) non-profits and submit requests at least six weeks prior to events. The program does not support individuals, political or religious organizations, or explicit discrimination policies. Funding is provided through monetary donations or in-kind contributions like dining certificates.

Brinker International

US $5,000

PLTW Launch - Program Expansion (Burns and McDonnell)

The PLTW Launch program, in collaboration with Burns and McDonnell, aims to enhance STEM education by expanding access to innovative educational modules in eligible schools. This initiative supports public and charter schools in targeted counties, focusing on increasing student engagement in STEM fields. Through grant funding, participating schools can introduce new PLTW Launch modules and provide essential training for teachers, fostering a richer learning environment to prepare students for future careers in science, technology, engineering, and mathematics.

Applications due Jun 30, 2027

Unspecified amount

ECF of The Boeing Company: St. Louis Missouri Chapter Grant Program

The Employees Community Fund (ECF) of The Boeing Company supports charitable organizations in the St. Louis area through grants focused on Health and Human Services, Education, Arts & Culture, and Civic Engagement. Applications for 2024 will be accepted from April 1 to June 30, with odd-numbered years prioritizing health initiatives. ECF has invested over $165 million in the community, empowering employees to make a significant impact through collaborative giving.

Employees Community Fund Of The Boeing Company

Up to US $20,000

PLTW Launch - New Program (Burns and McDonnell)

The PLTW Launch program, supported by Burns and McDonnell, aims to enhance student engagement in STEM education within eligible communities. This initiative will provide grants to schools that implement at least one PLTW Launch module in the 2025-2026 academic year, followed by another module in subsequent years. The program is designed to empower students with hands-on learning experiences that connect real-world challenges to essential skills, fostering a stronger future in STEM fields.

US $10,000

PLTW Gateway - Program Expansion (Burns and McDonnell)

The PLTW Gateway program, in collaboration with Burns & McDonnell, aims to enhance STEM education by expanding access to Project Lead The Way initiatives in eligible communities. By providing grants for program expansion, the initiative encourages schools to implement new PLTW units and train teachers, empowering students with essential skills for future careers. This partnership seeks to inspire a new generation of learners through hands-on, real-world challenges, thereby fostering greater participation in STEM fields across various regions.

Applications due Aug 26, 2027

Up to US $50,000

Food Insecure Urban Agriculture Matching Grant Program

The Food Insecure Urban Agriculture Matching Grant Program aims to alleviate food insecurity in urban areas by funding projects that enhance food production and accessibility. Grants cover up to 75% of project costs, with a maximum of $50,000. Eligible applicants include individuals and organizations in designated urban areas of Missouri. The program supports initiatives like community gardens and farmers markets, fostering local economic growth and sustainable agricultural practices. This initiative is vital for improving food availability in underserved communities.

Missouri Department of Agriculture

Up to US $200,000

Nonprofit Security Grant Program (NSGP - MO)

Applications due Jul 8, 2027

The FY 2025 Nonprofit Security Grant Program (NSGP) aims to enhance the physical and cybersecurity of nonprofit organizations at risk of extremist attacks. This initiative focuses on improving security postures, addressing capability gaps, and fostering collaboration among organizations and local agencies. By providing essential funding for planning, equipment, and training, the NSGP seeks to protect vulnerable facilities and ensure a coordinated community response to security challenges.

Missouri Department of Public Safety (DPS)

Unspecified amount

PNC Foundation: Grow Up Great Grant

The PNC Foundation's Grow Up Great Grant is a significant initiative aimed at enhancing educational opportunities for children from birth to age 5. With a commitment of $500 million, this program focuses on improving school readiness through support in vocabulary development, social-emotional learning, and the arts. By partnering with community-based nonprofits, PNC aims to foster stronger, smarter, and healthier communities, ensuring a brighter future for the next generation.

PNC Foundation

Approximately US $500

Specialty Grants: Lennie Cloud Fund for the Hearing Impaired

Applications due May 15, 2027

The Lennie Cloud Fund for the Hearing Impaired, managed by the Community Foundation of the Ozarks, aims to improve the lives of hearing-impaired individuals in the Ozarks. This grant will provide $500 to nonprofit agencies that offer essential equipment, programming, or training. Eligible applicants include 501(c)3 organizations, government entities, school districts, and faith-based organizations. The fund emphasizes non-discrimination in its practices and supports community grantmaking across central and southern Missouri.

Community Foundation of the Ozarks Inc.

US $50,000 - US $1,500,000

Safety Net Funding

Applications due Apr 17, 2027

United Way of Greater St. Louis

Our Mission: The United Way of Greater St. Louis mission is to mobilize the community with one goal in mind – helping people live their best possible lives. We unite people, resources and funding to help build strong and equitable communities where everyone can thrive.

Safety Net

United Way’s Safety Net is a collaborative network of agencies that deliver an array of essential direct services to address the region’s most pressing needs, helping families and individuals remain and work toward stability. Safety Net agencies provide direct services that address basic, urgent needs – such as access to food and housing— as well as supports that help move individuals and families toward stability, including education, health and well-being, workforce access, and financial mobility.

Safety Net Funding

United Way of Greater St. Louis is now accepting applications for its Safety Net Funding cycle and invites all eligible agencies across its 16-county region in Missouri and Illinois, including those not currently receiving United Way funding, to apply. United Way equips 160 local nonprofits with vital funding and training resources to support measurable impact across its five impact areas. Organizations selected will receive a three-year contract and become part of the UWGSL member agency network.

United Way’s Impact Areas

Basic Needs 
Community Stability and Crisis Response 
Early Childhood and Youth Success 
Health and Wellbeing 
Jobs and Financial Mobility

While needs are great across the five impact areas, United Way will use data derived from its landscape analysis of community needs to inform how service areas will be prioritized to ensure the region has access to a strong and resilient network as needs arise.

United Way Of Greater St Louis Inc

US $10,000

PLTW Engineering - Program Expansion (Burns and McDonnell)

The PLTW Engineering Program Expansion by Burns and McDonnell aims to enhance STEM education in eligible communities. This initiative supports schools in expanding their existing PLTW Engineering programs, providing students with hands-on experiences and essential skills. The program focuses on empowering students through new courses and teacher training, ensuring access for underrepresented populations. By fostering excitement around STEM, Burns and McDonnell is committed to shaping the future workforce and enhancing educational opportunities in critical areas.

Applications due Mar 31, 2027

Unspecified amount

Charles L. and Dorothy Weaver Memorial Orthodontic Grant

The Charles L. and Dorothy Weaver Memorial Orthodontic Grant offers three scholarships annually for full orthodontic treatment to individuals aged 10 to 30 within the CFO Region. Applicants must demonstrate financial need, have a complete set of permanent teeth, and reside in the southern Missouri Ozarks. Successful candidates must also have reliable transportation to orthodontic appointments and access to ongoing dental care during their treatment. This initiative aims to enhance dental health and quality of life for eligible youth.

Community Foundation of the Ozarks Inc.

US $20,000

PLTW Gateway - New Program (Burns and McDonnell)

The PLTW Gateway program, in partnership with Burns and McDonnell, aims to enhance STEM education by supporting schools in eligible counties to implement PLTW Gateway units. With a total grant of $20,000, schools are encouraged to offer at least one unit per academic year, fostering real-world skills and engagement in STEM fields. This initiative seeks to increase access and participation in high-quality STEM learning experiences, ultimately preparing students for future careers.

Applications due Sep 1, 2027

US $500 - US $2,000

Jean Griswold Foundation Scholarship Program ( Winter )

The Jean Griswold Foundation

The Jean Griswold Foundation (JGF) is a non-profit organization dedicated to supporting Caregivers through educational opportunities and scholarships.

Our Mission

The mission of the Jean Griswold Foundation is to support Caregivers by providing educational scholarships* to enable them to further their training, enhance their careers, and better assist the clients they serve.

By offering educational scholarships*, our Foundation will not only make a positive impact on the Caregivers themselves, but also the clients they assist and the home healthcare agencies where they are employed, as well as help advance the overarching home-care industry.

Scholarships will be paid directly to the federally accredited educational institutions of the winning Scholars’ choosing.

Empowering Caregivers Through Education

The Jean Griswold Foundation Scholarship Program awards scholarships to deserving Caregivers who wish to further their education in a care-related field. Applicants do not have to be associated with Griswold in any way, and the funds will be paid directly to the institution where the caregiver will be receiving education.

Our Winter 2026 Scholarship Application period is now open! Applications will be accepted until 11:59pm ET August 31, 2026. Join our email list to get the first notice of all Scholarship happenings.

Where would we be without Caregivers?

Their selflessness is astounding, yet they are often overlooked and underappreciated.

The Jean Griswold Foundation is dedicated to supporting Caregivers, the backbone of the care industry. We provide educational scholarships so Care Professionals can further their training, enhance their skills, elevate their careers, and better assist the people they serve.

Jean Griswold Foundation (Griswold Cares Foundation)

Unspecified amount

QuikTrip Donations: At-Risk Youth and Early Childhood Education

QuikTrip is dedicated to supporting at-risk youth and early childhood education through strategic community investments. By donating 5% of annual net profits to qualified non-profits, QuikTrip aims to empower individuals and break the cycle of poverty. The company partners with organizations providing educational opportunities, ensuring that all youth, regardless of their backgrounds, can thrive as independent citizens. This initiative highlights QuikTrip's commitment to making a measurable impact in the communities where its employees live and work.

QuikTrip

US $30,000

PLTW Gateway - New Program (Ardagh Group)

The PLTW Gateway program, backed by Ardagh Group, aims to enhance educational opportunities in local communities. Over the next decade, this initiative will support over 500,000 PreK-12 students and provide exceptional training for more than 5,000 teachers across 2,000 schools in the U.S. The program focuses on fostering innovation and creativity through engaging STEM curricula, ensuring that educational resources are accessible and effective for all students.

US $10,000

PLTW Computer Science - Program Expansion (Burns and McDonnell)

Burns and McDonnell, a 100% employee-owned firm, partners with Project Lead The Way (PLTW) to enhance access to STEM education. By expanding PLTW Computer Science programs in local schools, they aim to engage students in real-world challenges and equip them with essential skills. Eligible schools must be located in specific counties and serve a majority of students from low-income backgrounds. This initiative supports the growth of STEM education, fostering a brighter future for communities through enhanced learning opportunities.