Upcoming Webinar
Instrumentl Fall Launch: Grant Work, Leveled Up.
Thu, Oct 29 or Wed, Nov 4 @ 2PM ET

Skip to main content
Main content

Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

32,000+

Available grants

$8.25B

Total funding

$6K

Median grant

32,000+ grants
$8.25B total
$6K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

32,423 Results based on applied filters

OREF Mentored Clinician Scientist Grant

Orthopaedic Research and Education Foundation
Private
United States
US $20,000
The Mentored Clinician Scientist Grant, funded by the Orthopaedic Research and Education Foundation, supports the career development of clinician scientists by providing dedicated research time for up to five years. Eligible applicants must have a proven track record in research, evidenced by receiving NIH K08 or K23 funding. This grant is renewable annually based on scientific progress and available funding, fostering a strong future in academic surgery.
Orthopedics

Friend of Education Award

Maine Education Association
Private
Maine
Unspecified amount in in-kind support
The Friend of Education Award honors individuals in elected or appointed positions who significantly contribute to public education in Maine. It is presented by the Maine Education Association, which advocates for educators' rights and aims to ensure equitable education for all students. Nominations are open to any Maine resident holding such a position, recognizing their advocacy at local, state, or national levels. This award highlights the importance of supporting educators and improving educational standards.
Education System Policy & Reform

Koch Family Foundation Grants

Koch Family Foundation
Private
Kansas
Unspecified amount
The Koch Family Foundation supports individuals in Kansas by promoting arts and education initiatives. With over $60 million awarded in scholarships and grants, the foundation encourages personal growth and community contribution. Established by Fred and Mary Koch in 1932, it continues their legacy of fostering creative talents. The foundation aims to create opportunities for all individuals to reach their potential and make a meaningful impact in society.
Art & Culture Education

Clayton Jackson McGhie Memorial Scholarship Fund

Boreal Waters Community Foundation
Private
United States
US $3,000
The Clayton Jackson McGhie Memorial Scholarship Fund, established in 2005, supports students from the Duluth-Superior area. Applicants are encouraged to submit essays or creative works that reflect their understanding of race relations and community service. The fund, initiated by local residents to honor the memory of three African American men lynched in 1920, awards $3,000 for one year, with school selections occurring in the spring.
Academic Scholarship Programs

Physician and Advanced Practice Clinician Fellowship Program

Aspirus Wausau Hospital Inc
Private
Alger County, Michigan, Baraga County, Michigan +14 more
Up to US $90,000
The Physician and Advanced Practice Clinician Fellowship Program at Aspirus Wausau Hospital offers a 12-month, full-time opportunity for recent family medicine graduates and practicing physicians. This program aims to enhance skills in hospital medicine, with flexible start dates and two fellowship spots available annually. Aspirus Health, a nonprofit health system in Wisconsin, operates multiple facilities and employs a large team of healthcare professionals, ensuring comprehensive training and support for fellows.
Medical Education & Professional Training

Advanced Practice Clinician (NP or PA) Fellowship Program

Aspirus Wausau Hospital Inc
Private
Alger County, Michigan, Baraga County, Michigan +14 more
Up to US $30,000
The Advanced Practice Clinician (NP or PA) Fellowship Program at Aspirus Health offers a unique 6-month rotation designed for new graduates to excel in hospital medicine. Aspirus Health, a nonprofit system located in Wisconsin and serving parts of Minnesota and Michigan, operates 18 hospitals and numerous outpatient locations. With a dedicated team of nearly 14,000, including 1,300 employed physicians and advanced practice clinicians, this fellowship is also open to experienced APCs transitioning between departments.
Medical Education & Professional Training

Aspirus Scholars Program

Aspirus Health Foundation Inc
Private
Alger County, Michigan, Baraga County, Michigan +14 more
Up to US $175,000
The Aspirus Scholars Program, developed by Aspirus and community partners, addresses healthcare needs in Wisconsin, Minnesota, and Michigan. This initiative offers scholarships up to $175,000 to medical students at the MCW-CW Campus in exchange for a service commitment with Aspirus. The program aims to alleviate the debt burden of future medical providers while fostering a commitment to primary care and community connection, ensuring quality healthcare for generations to come.
Medical Education & Professional Training

Student Travel Award

AASP - The Palynological Society
Association/Society
France
Unspecified amount
The AASP – The Palynological Society offers a Student Travel Award to support student members presenting at the annual meeting. Applicants must submit a detailed budget covering all travel-related expenses, such as visas, transportation, lodging, and meals. This program encourages students to engage in scientific discussions and showcases the importance of palynology in various fields, including climate research and conservation management. Funding amounts vary based on individual needs, promoting accessibility for all students.
Palynology

Kappa Kappa Gamma Foundation Grant

Kappa Kappa Gamma Foundation
Private
Harris County, Texas
Unspecified amount
The Kappa Kappa Gamma Foundation Grant aims to support charitable organizations that meet established philanthropic guidelines, primarily in the greater Houston area. Since its inception in 1980, the foundation has awarded over $4.3 million to various local charities, focusing on early childhood education and development. Funding is raised through events like the Kappa Holiday Pilgrimage Home Tour and Luncheon. Grants are awarded in the spring of odd-numbered years, ensuring substantial impact on the community.
Early Childhood Development

Together We Thrive: Del Mar Grants for Older Adults

The Dayton Foundation
Private
Greene County, Ohio, Miami County, Ohio +2 more
US $5,000 - US $20,000
The Together We Thrive: Del Mar Grants for Older Adults, provided by The Dayton Foundation, aim to support 501(c)(3) nonprofit organizations addressing the needs of older adults in Greater Dayton. Since 1921, The Dayton Foundation has invested in community well-being through various charitable initiatives, including competitive grants, scholarships, and collaborative efforts to enhance local support systems. The funding amounts and number of grants depend on available resources, emphasizing a commitment to impactful community assistance.
Senior Services

Frank C. Fischer Veterans Fund

Eastern West Virginia Community Foundation
Private
Berkeley County, West Virginia, Hampshire County, West Virginia +3 more
Up to US $2,000
The Frank C. Fischer Veterans Fund, managed by the Eastern West Virginia Community Foundation, aims to support organizations serving veterans in Berkeley, Hampshire, Hardy, Jefferson, and Morgan Counties. Grants of up to $2,000 are available to eligible nonprofits, government agencies, and civic groups focused on improving the quality of life for veterans. This initiative highlights the foundation's commitment to philanthropy and community well-being in the Eastern Panhandle of West Virginia.
Military & Veterans Services

Georgia Trust Callahan Incentive Grant

Georgia Department of Community Affairs
State/Local Government
Georgia (US state)
Up to US $5,000
The Georgia Trust Callahan Incentive Grant, administered by the Georgia Department of Community Affairs, provides funding for historic preservation projects in Georgia. With 1:1 matching grants of up to $5,000, it supports non-profit or governmental organizations working on sites eligible for the National Register of Historic Places. Projects must demonstrate significant community impact and sustainability, ensuring long-term use and maintenance. Applications are due by December 8, 2025, for letters of interest.
Historic Preservation

Portland Arts Project Grant Program

Regional Arts & Culture Council
Private
Clackamas County, Oregon, Columbia County, Oregon +3 more
US $1,000 - US $10,000
The Portland Arts Project Grant Program, administered by the Regional Arts & Culture Council, aims to enhance artistic development and community engagement in Portland, Oregon. This program supports individual artists and organizations with funding ranging from $1,000 to $5,000 for projects that foster public participation in the arts. Eligible applicants must reside or operate within Portland city limits. The program prioritizes investment in under-represented communities, ensuring equitable access to the arts.
Arts / Culture Access & Participation

UMN Graduate School: Professional Development Funding Request

University of Minnesota
Private
Minnesota
Up to US $500
The UMN Graduate School offers Professional Development Funding to support graduate students engaged in opportunities that enhance their academic pursuits. Eligible activities include attending workshops, conferences, or learning new techniques. Funding amounts vary based on travel distance, with a maximum of $500 available. Applicants must be enrolled in research-based graduate programs and in good standing. This funding is available from September 1, 2025, to August 31, 2026, with applications accepted monthly.
Education - Higher Education

UMN Graduate School: Research Travel Requests (RTR)

University of Minnesota
Private
Minnesota
US $500 - US $3,000
The UMN Graduate School offers Research Travel Requests (RTR) for graduate students aiming to enhance their thesis or dissertation through research travel. Award amounts vary: up to $3,000 for doctoral candidates, $1,500 for pre-candidates, and $500 for master’s students. Applications are reviewed monthly from October to April, with a lottery system if demand exceeds funding. Eligible applicants must be enrolled in a research-based graduate program and meet specific travel criteria.
Education - Higher Education

Immigration Legal Access Grant Program

City of Boston Office of Immigrant Advancement
State/Local Government
Suffolk County, Massachusetts
US $20,000 - US $100,000
The Immigration Legal Access Grant Program, initiated by the City of Boston Office of Immigrant Advancement, aims to provide essential legal assistance to immigrants navigating the complex U.S. immigration system. With a total funding of $900,000, this program supports nonprofit organizations that offer services such as legal orientation, consultations, and representation. By prioritizing organizations with licensed attorneys, the program seeks to enhance access to justice for Boston’s immigrant communities, especially in light of recent policy changes.
Immigrant Services

CJP Funding: Small Grants

Center for Jewish Philanthropy of Greater Phoenix
Private
Gila County, Arizona, Maricopa County, Arizona +1 more
Up to US $3,000
The Center for Jewish Philanthropy of Greater Phoenix offers the Small Grants Program to support initiatives that strengthen the local Jewish community. With funding up to $3,000, eligible organizations can apply for projects that address urgent needs or leverage matching grants. Since 2017, this streamlined process prioritizes projects that directly impact the Greater Phoenix Jewish community, reinforcing CJP's commitment to innovation, emergency response, and sustainable local Jewish life.
Judaism

Next Generation Giving Circle

Gaston Community Foundation
Private
Gaston County, North Carolina
Unspecified amount
The CFGC: Next Generation Fund Grant, established by the Gaston Community Foundation, supports charitable initiatives primarily in Gaston County. Since 2000, it has awarded over $193,000 to local nonprofits focused on children's welfare, environmental improvements, and crisis relief. In 2023, the fund emphasizes Health and Wellness, encouraging collaboration among organizations to maximize community impact. This grant fosters grassroots support and sustainable projects, ensuring that resources are used effectively to benefit the county's residents.
Wellness & Healthy Living

Loft Mentor Series

The Loft
Private
Minnesota
US $2,800
The Loft Mentor Series supports twelve early career writers in Minnesota to collaborate with eight acclaimed mentors in poetry and prose. This prestigious program, established in 1979, offers a year of intensive workshops and individual guidance, culminating in public readings. Funded by the Jerome Foundation and NEA, fellows receive $2,800 to assist with program costs, ensuring they can focus on refining their craft and connecting with the literary community.
Poetry

Dream Endowment

Community Foundation of North Central Massachusetts
Private
Massachusetts
Unspecified amount
The Dream Endowment, offered by the Community Foundation of North Central Massachusetts, aims to support underprivileged immigrant students in their pursuit of higher education. This initiative is part of a larger effort to provide over 40 scholarship opportunities that cater to various educational needs in the region. By creating pathways to college, the Dream Endowment helps foster a brighter future for deserving students and reinforces the foundation's commitment to education and community growth.
Education - Higher Education

Jim O'Leary Scholarship Fund

Community Foundation of North Central Massachusetts
Private
Massachusetts
Unspecified amount
The Jim O'Leary Scholarship Fund, managed by the Community Foundation of North Central Massachusetts, provides financial support to high school seniors passionate about golf. This fund is part of a larger initiative that offers over 40 scholarships aimed at fostering educational opportunities in the region. With specific selection criteria set by the donors, the scholarship aims to empower students to achieve their academic goals and promote community involvement.
Academic Scholarship Programs

Rotary Club of Fitchburg Scholarship Fund

Community Foundation of North Central Massachusetts
Private
Worcester County, Massachusetts
Unspecified amount
The Rotary Club of Fitchburg Scholarship Fund, managed by the Community Foundation of North Central Massachusetts, provides financial support to graduating seniors in Fitchburg, MA, who have been recognized as Student of the Month. This initiative aims to encourage educational pursuits among local students and is part of a broader effort to foster community development through scholarship opportunities.
Academic Scholarship Programs

Women's Fund Success Grants

Community Foundation of Central Illinois
Private
Bureau County, Illinois, De Witt County, Illinois +15 more
Unspecified amount
The Women's Fund Success Grants, established by the Community Foundation of Central Illinois, aim to empower women and children in central Illinois. Since 1993, these grants have supported organizations that create impactful programs benefiting women and girls. Eligible applicants include 501(c)(3) organizations and local government units, with a focus on initiatives that address community needs and promote equality. The fund does not support capital campaigns or sectarian purposes, ensuring resources are directed towards community service.
Women & Girl Services

Samaritan Hospital Medical Staff/Ashland County Physicians Medical School Scholarship

Ashland County Community Foundation
Private
United States
Unspecified amount
The Samaritan Hospital Medical Staff/Ashland County Physicians Medical School Scholarship, established in 1996, offers two $1,500 scholarships to Ashland County residents pursuing MD or DO degrees at accredited medical schools in Ohio. This initiative reflects gratitude for past medical education and aims to encourage recipients to return to their community for practice. Eligible applicants can reapply for a maximum of four years, fostering a commitment to local healthcare.
Academic Scholarship Programs

Shelby County Commissioners Tindall Farm Fund Grant

Blue River Community Foundation of Shelby County
Private
Shelby County, Indiana
Up to US $7,500
The Shelby County Commissioners Tindall Farm Fund Grant aims to provide essential support for organizations meeting the basic needs of residents in Shelby County, including food, shelter, and clothing. With a maximum grant of $7,500 per request and up to $15,000 per organization annually, this fund is designed to assist those facing poverty and homelessness. Eligible applicants must be operating within Shelby County to qualify for funding.
Basic Human Needs

Canine Healthcare Fund Grant

National Disaster Search Dog Foundation
Private
United States
Up to US $1,000
The Canine Healthcare Fund Grant provides vital medical coverage for SDF-trained canines throughout their lives, ensuring they receive top-notch veterinary care at no expense to their handlers or agencies. Additionally, it extends support to non-SDF-trained handlers of active and retired disaster search canines, covering veterinary costs for wellness, illness, and injury not funded by their organizations. Each handler may receive up to $1,000 annually to help manage these essential healthcare expenses.
Animal Welfare - Domestic Animals & Pets

Houston Affiliate Grantmaking Program

Community Foundation of the Ozarks Inc.
Private
Texas County, Missouri
Up to US $750
The Houston Affiliate Grantmaking Program, supported by the Community Foundation of the Ozarks, aims to enhance the quality of life for Houston residents through impactful grantmaking. Eligible applicants include 501(c)(3) organizations and other IRS-approved entities serving the city. Organizations can apply for funding up to $1,300 to support their initiatives and community projects. This program emphasizes collaboration and leadership to foster community growth and development.
Economic Services & Development

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.