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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

32,000+

Available grants

$8.25B

Total funding

$6K

Median grant

32,000+ grants
$8.25B total
$6K median

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32,423 Results based on applied filters

Tony Marley Memorial Scholarship for a Teacher Education Major

Ashland County Community Foundation
Private
Ohio
Unspecified amount
The Tony Marley Memorial Scholarship, offered by the Ashland County Community Foundation, supports graduating seniors from Ashland County public high schools who aim to pursue a degree in Teacher Education. This scholarship honors Tony Marley, a dedicated educator and World War II veteran. Eligible candidates must maintain a minimum GPA of 2.5 and be accepted into an accredited four-year college or university in Ohio, ensuring that future educators receive the financial assistance they need to achieve their goals.
Academic Scholarship Programs

PLTW Launch - New Program (John Deere)

Project Lead The Way Inc
Private
Barnes County, North Dakota, Black Hawk County, Iowa +22 more
US $10,000
The PLTW Launch program, in partnership with the John Deere Foundation, aims to enhance STEM education access for underserved communities. This initiative supports schools in implementing PLTW Launch modules, fostering equitable opportunities for students. With a commitment to enroll at least 50% of students from the Free and Reduced Lunch program, the program focuses on real-world skills development to prepare youth for future challenges. The goal is to empower one million students by 2030.
STEM / STEAM Education

PLTW Gateway - New Program (John Deere)

Project Lead The Way Inc
Private
Barnes County, North Dakota, Black Hawk County, Iowa +22 more
US $20,000
The PLTW Gateway program, supported by the John Deere Foundation, aims to enhance STEM education access for underserved communities. By 2030, they intend to assist 1 million youth through inclusive educational opportunities. Schools within 40 miles of John Deere facilities can apply for grants to implement PLTW Gateway units, promoting real-world skill development. Priority is given to schools that demonstrate need and ensure student enrollment in these programs, fostering a strong foundation for future success.
STEM / STEAM Education

Community Based Substance Use Disorders Services Access

North Carolina Department of Health and Human Services (NCDHHS)
State/Local Government
North Carolina
Up to US $500,000
The North Carolina Department of Health and Human Services (NCDHHS) is offering grants for community-based services targeting substance use disorders. This initiative aims to expand access to essential services while addressing gaps in care across the state. Eligible organizations can apply for project budgets up to $500,000 annually, with at least 12 contracts expected to be awarded. The funding supports prevention, treatment, and support services to enhance the health and wellbeing of North Carolinians.
Addiction & Substance Use Disorders

YoungArts National Competition

YoungArts (National Foundation For Advancement In The Arts Inc.)
Association/Society
United States
US $250 - US $10,000
The YoungArts National Competition, established in 1981, supports exceptional young artists aged 15-18 in the U.S. through a competitive application process. Winners receive financial awards up to $10,000, mentorship from renowned artists, and lifelong artistic support. This prestigious program allows participants to affirm their identity as artists while gaining access to a robust network of peers and mentors, exclusive opportunities, and national recognition, making it a vital stepping stone in their creative journeys.
Arts / Culture Access & Participation

Trainee Investigator Award

American Academy Of Sleep Medicine Foundation
Private
United States
US $500 - US $1,000
The Trainee Investigator Award, offered by the AASM Foundation, recognizes outstanding research presented by AASM Student/Resident Members at the SLEEP annual meeting. This prestigious award includes a $1,000 prize for the top candidate, along with three honorable mentions each receiving $500. It aims to promote the professional growth of early-career researchers in sleep medicine, encouraging innovative contributions to the field. Nominations require submitting an abstract for the SLEEP 2026 meeting.
Sleep

IDeA Networks of Biomedical Research Excellence (INBRE)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
Alaska, Arkansas +22 more
Unspecified amount
The IDeA Networks of Biomedical Research Excellence (INBRE) program aims to enhance biomedical research capacity in underfunded states by fostering collaborations among research institutions. By supporting faculty research, mentoring, and student involvement, INBREs create pathways for undergraduate students to enter biomedical careers. This initiative not only promotes institutional partnerships but also strengthens research infrastructure, ultimately contributing to a more robust scientific community in IDeA states.
Biology Health & Medicine

AIAA Foundation Classroom Grant Program

American Institute of Aeronautics and Astronautics
Private
United States
Up to US $500
The AIAA Foundation Classroom Grant Program provides funding of up to $500 for K-12 teachers to enhance student learning in STEM subjects, particularly in Aerospace. The program encourages innovative projects that address unmet educational needs. Schools can apply for a maximum of two grants per year. Eligible projects include STEM demonstration kits and robotics supplies, while funding for items like audio-visual equipment and travel is not permitted.
STEM / STEAM Education

Vernier Science Education Inspiration Grants

Vernier Science Education
Corporate
United States
Approximately US $1,000 in in-kind support
The Vernier Science Education Inspiration Grants support innovative K-12 and college educators in the U.S. who creatively use Vernier technology to engage students in hands-on STEM education. Each grant includes $1,000 in Vernier technology, a one-year license for the Vernier Graphical Analysis™ Pro app, and three hours of virtual professional development. This initiative aims to inspire scientific curiosity and enhance STEM literacy among students.
STEM / STEAM Education

James E. and Clyda J. Montague Scholarship Fund

Boreal Waters Community Foundation
Private
St. Louis County, Minnesota
US $2,000 - US $3,000
The James E. and Clyda J. Montague Scholarship Fund provides financial support ranging from $2,000 to $3,000 for graduating high school seniors from any school within the DSACF service area. Eligible students must be enrolled at the University of Minnesota Duluth, the University of Wisconsin-Superior, or the College of St. Scholastica and demonstrate financial need, ensuring access to higher education opportunities.
Academic Scholarship Programs

Bring Back the Trades Scholarship

Bring Back the Trades
Association/Society
United States
US $1,500
The Bring Back the Trades Scholarship is dedicated to addressing the skilled trades shortage by providing $1,500 monthly scholarships to students enrolled in post-secondary skilled trades programs across the United States. Founded by a seasoned business owner, the initiative aims to raise awareness and reshape perceptions of trade careers, ensuring that students have the resources to succeed in vital roles that contribute to the nation's future.
Vocational & Trade Education

Live Your Dream Awards

Soroptimist International Of The Americas Inc
Private
Argentina, Bolivia +18 more
Up to US $10,000
The Live Your Dream Awards, sponsored by Soroptimist International of the Americas, empower women by providing vital monetary assistance for their education and training. Each year, over $3 million is awarded to more than 2,300 women who are the primary financial support for their families. This initiative supports those overcoming significant challenges like poverty and domestic violence, ensuring they have the resources to achieve their dreams and live fulfilling lives.
Women & Girl Services

Dorothy M. Yothers Second Chances Scholarship

Washington State Elks Association
Association/Society
Washington
Up to US $1,000
The Dorothy M. Yothers Second Chances Scholarship, offered by the Washington State Elks Association, aims to support mature women over 25 in achieving their vocational and technical education goals. Each recipient can receive up to $1,000 per quarter, based on financial need, and the scholarship is renewable contingent upon maintaining a GPA of 3.0. This initiative honors the legacy of Dorothy M. Yothers, promoting empowerment and education for women in Washington State.
Vocational & Trade Education

Mellon Postdoctoral Fellowship in Literatures in English

Cornell University- Society for the Humanities
Association/Society
Tompkins County, New York
Up to US $64,000
The Mellon Postdoctoral Fellowship in Literatures in English, offered by Cornell University's Society for the Humanities, invites applications for a two-year position starting August 1, 2026. This fellowship seeks candidates specializing in African American literature and culture, with a preference for those with expertise in gender, sexuality, or media studies. The fellow will conduct research, teach two courses annually, and engage in departmental events and seminars, contributing to the academic community.
Writing & Literature

Berkshire Woodworkers Guild Scholarship

Berkshire Woodworkers Guild
Association/Society
United States
US $500 - US $4,000
The Berkshire Woodworkers Guild Scholarship offers financial support to aspiring professional woodworkers and designers. Established in 1998, this scholarship is funded through generous donations and proceeds from an annual silent auction. Recipients are encouraged to engage with the Guild and showcase their work at events. Preference is given to applicants pursuing comprehensive woodworking programs that lead to certification or degrees, but other professional development opportunities may also be considered.
Vocational & Trade Education

DTA Foundation: Dental Hygiene Scholarship

Dental Trade Alliance Foundation
Private
United States
Unspecified amount
The DTA Foundation: Dental Hygiene Scholarship, in partnership with the Benco Family Foundation, provides up to $10,000 to dental hygiene students from underrepresented backgrounds. This initiative honors Lawrence and Sally Cohen's contributions to the field. With a generous $1M endowment, the scholarship aims to support aspiring dental hygienists, ensuring increased accessibility to the profession and recognizing those who demonstrate passion and commitment to dental care.
Dental Health

Site-Based Clinical Training Grant Program

Minnesota Department of Health
State/Local Government
Anoka County, Minnesota, Carver County, Minnesota +5 more
Unspecified amount
The Site-Based Clinical Training Grant Program, administered by the Minnesota Department of Health, aims to enhance clinical healthcare training throughout Minnesota. With a funding estimate of $4,657,000 for FY 2026, this grant prioritizes rural primary care and oral health training. Eligible applicants include clinical training sites actively enrolled in the Minnesota Health Care Program, which must demonstrate their commitment to addressing healthcare shortages in underserved areas. This initiative supports the development of a skilled healthcare workforce.
Medical Education & Professional Training

CFEC: Emergency Grants

Community Foundation of Elkhart County
Private
Elkhart County, Indiana
US $250 - US $25,000
The CFEC Emergency Grants provide crucial support for nonprofits in Elkhart County facing unexpected challenges. These grants are designed to assist organizations responding to urgent events like natural disasters, theft, or facility issues that threaten their operations. By offering rapid financial assistance, the program ensures that vital community services can continue even in times of crisis, helping nonprofits maintain stability and fulfill their missions effectively.
Disaster Relief / Humanitarian Aid

Aging Services Leadership Fellowship

United Negro College Fund Inc
Private
United States
US $50,000 - US $80,000
The Aging Services Leadership Fellowship, offered by the United Negro College Fund, is a one-year non-clinical program for recent master's graduates or mid-career professionals with at least five years of experience. The program emphasizes cohort learning, community building, and skill development in aging services. Participants engage in specialized training, networking events, and mentorship opportunities designed to foster leadership and cultural humility, ultimately preparing them to lead in the aging services sector.
Aging / Gerontology

Burke Women's Fund

Community Foundation of Burke County
Private
Burke County, North Carolina
Unspecified amount
The Burke Women's Fund, established in 2009 by 15 women, aims to unite diverse groups around critical issues affecting women and families in Burke County. Operating under the Community Foundation of Burke County, it supports 501(c)(3) organizations with grants for charitable, humanitarian, or educational purposes. The Fund prioritizes programs that enrich the lives of women, target underserved populations, and foster collaboration among different backgrounds, while ensuring a minimum project size of $5,000 for consideration.
Women & Girl Services

TESOL Leadership Mentoring Program

Teachers Of English To Speakers Of Other Languages Inc
Association/Society
Algeria, American Samoa +33 more
US $1,000
The TESOL Leadership Mentoring Program connects TESOL members with experienced leaders for mentorship and professional development. Participants receive free registration to the annual convention, up to $1,000 for lodging, and the opportunity to build lasting relationships within the TESOL community. This program is designed for members in good standing, with a preference for individuals from underrepresented groups, fostering inclusivity and active participation in the association's initiatives.
English for Speakers of Other Languages (ESOL) Education

TESOL Teacher of the Year Award

Teachers Of English To Speakers Of Other Languages Inc
Association/Society
Algeria, American Samoa +33 more
US $1,000
The TESOL Teacher of the Year Award, presented by National Geographic Learning, honors exceptional English language teachers who have demonstrated outstanding dedication in the classroom for at least three consecutive years. The winner receives $1,000, a one-year TESOL membership, and free registration for the TESOL International Convention, including travel accommodations. This recognition not only highlights the importance of teaching excellence but also fosters a community of learning and collaboration among educators around the world.
English for Speakers of Other Languages (ESOL) Education

TESOL Award for Excellence in Research

Teachers Of English To Speakers Of Other Languages Inc
Association/Society
Algeria, American Samoa +33 more
US $3,000
The TESOL Award for Excellence in Research honors outstanding empirical research in language teaching and learning, promoting advancements in English language education. Sponsored by Dr. Deborah Short, this award includes a $1,500 grant, an additional $1,500 for conference expenses, a featured session at the TESOL convention, keynote speaking opportunity at the Graduate Student Forum, a one-year subscription to TESOL Quarterly, and a featured article in TESOL Connections.
English for Speakers of Other Languages (ESOL) Education

The Ron Chang Lee for Excellence in Classroom Technology

Teachers Of English To Speakers Of Other Languages Inc
Association/Society
Algeria, American Samoa +33 more
US $1,000
The Ron Chang Lee for Excellence in Classroom Technology award recognizes three TESOL members for their innovative use of technology in English Language Teaching. Established in 2018, the award offers prizes of $1000 for first place, $750 for second, and $500 for third. Eligible candidates must be TESOL members with at least two years of classroom experience and have designed the materials used for this award. Applications from certain countries may be ineligible due to international regulations.
English for Speakers of Other Languages (ESOL) Education

The Next Generation - Northern Delaware- Early Childhood Development Grant

Delaware Community Foundation
Private
New Castle County, Delaware
US $5,000
The Next Gen North Early Childhood Development Grant, offered by the Delaware Community Foundation, provides $7,500 to support initiatives addressing early childhood development issues in New Castle County. This grant invites nonprofits to apply, focusing on equity and community-based philanthropy. It aims to foster opportunities for vulnerable families in Delaware while ensuring that funded programs do not discriminate based on race, religion, or other factors. Nonprofits are encouraged to submit proposals that align with these goals.
Early Childhood Development

ADEAGies Foundation Grant

ADEAGies Foundation
Association/Society
United States
US $10,000 - US $50,000
The ADEAGies Foundation Grant supports oral health innovations and the development of future leaders in academic dentistry. Funded by the ADEAGies Foundation, the program offers annual grants ranging from $10,000 to $50,000 for various dental programs and initiatives. The Board of Trustees evaluates proposals each March, aiming to fully fund as many projects as possible while reserving the right to offer partial funding. Grants are awarded annually to qualifying organizations.
Dental Health

Perkins Leadership Grant

Illinois Community College Board
State/Local Government
Illinois
US $50,000 - US $150,000
The Perkins Leadership Grant, funded by the Illinois Community College Board, aims to enhance Career and Technical Education (CTE) programming across Illinois community colleges. With approximately $1 million in federal funds, the grant focuses on three key objectives: aligning College and Career Pathway Endorsements with Postsecondary Programs, enhancing student-centered support services for CTE students, and expanding innovative delivery models. This initiative seeks to improve educational outcomes and accessibility for over 500,000 residents annually.
Vocational & Trade Education

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.