Best Large Grants for Nonprofit Organizations

The Community Opportunity Fund, managed by Boreal Waters Community Foundation, empowers local organizations to enhance economic stability and independence in northern communities. The fund supports projects focused on affordable housing, job creation, and access to education. By fostering collaborative efforts, it aims to create lasting change in northeastern Minnesota and northwestern Wisconsin. Organizations led by marginalized communities are especially encouraged to apply, ensuring equitable opportunities for all.

The Dr. Eric W. Bond “Kickstart” Scholarship, initiated by the Community Foundation of the Central Blue Ridge, honors Dr. Bond's dedication to education. It supports three graduating seniors from each Augusta County public high school, focusing on those entering the workforce directly. The scholarship emphasizes financial need, community service, and extracurricular involvement, reflecting Dr. Bond's values. The inaugural scholarships will be awarded in 2026, ensuring a lasting legacy that enriches students' lives and promotes their successful transition into adulthood.

The Private Forest Accord Grant aims to fund projects that benefit various species covered under the anticipated Habitat Conservation Plan (HCP). This program prioritizes initiatives that restore habitats, eliminate threats, and enhance overall ecosystem health. Eligible projects can span multiple types, including implementation and stakeholder engagement, with funding requests typically starting at $50,000. The program emphasizes collaboration and effective strategies for the recovery of native salmon and trout species and other targeted wildlife.

The Watershed Council Grant Program, managed by the Michigan Department of Environment, Great Lakes, and Energy (EGLE), invites proposals from watershed-based organizations to enhance organizational administration, conservation, and educational initiatives. With a total funding of $600,000 available, individual grants are capped at $40,000 for a 12-month period. Projects should focus on capacity building, water quality improvement, and community engagement to foster sustainable water resource management.

The Wetlands and Mountain Meadows Restoration program, funded by the California Department of Fish and Wildlife, aims to restore wetlands and watershed ecosystems with a budget of up to $54 million. This initiative supports biodiversity, climate resilience, and public access while enhancing habitats as per the Natural and Working Lands Climate Smart Strategy. Projects are accepted on a rolling basis, emphasizing sustainable practices and cohabitation with wildlife, particularly beavers.

The Friends of the Island Fox Research Grant offers $7,000 to support research aimed at enhancing scientific understanding of island fox biology, health, behavior, and ecology. This funding is part of the Friends of the Island Fox's mission to ensure the long-term survival of this unique species. Applications are welcomed from researchers dedicated to advancing knowledge in these critical areas.

The MMUF Dissertation Grant, funded by the Mellon Foundation, supports doctoral candidates who are alumni of the Mellon Mays Undergraduate Fellowship. This grant aids scholars in completing their dissertations, ensuring diverse perspectives are represented in academia. With up to $30,000 for a 12-month period, the program encourages candidates to secure additional funding from their institutions. The initiative aims to bolster access to education and foster understanding among varied backgrounds, ultimately enhancing the academic landscape.

The NIDA Mentored Clinical Scientist Development Program Award aims to foster research independence in clinician scientists by providing intensive supervised research training and career development in the field of substance use and substance use disorder. Applications are due by 5:00 PM local time of the applicant organization, ensuring timely submission for this essential funding opportunity.

The Norm Winn Memorial Conservation Grant, managed by the Keta Legacy Foundation, supports conservation, preservation, and restoration projects in Alaska, Montana, Oregon, Idaho, and Eastern Washington. This competitive grant encourages non-profit organizations to apply for up to $25,000 to implement innovative environmental initiatives. Applicants must demonstrate project feasibility and significant community impact, while ensuring their proposals align with the Foundation's commitment to supporting diverse conservation efforts.

The Desert Tortoise Council invites proposals for conservation projects aimed at enhancing desert tortoise populations and habitats. With a funding opportunity of $9,000, the RFP emphasizes the importance of in situ conservation efforts such as habitat restoration and predator control. Projects must be completed within the current year in the Mojave Desert region. Applicants are required to submit detailed proposals, including budgets and project descriptions, and must report outcomes post-completion.

The Northern Arizona Community Health Grant aims to enhance the health and well-being of adolescents in northern Arizona. By focusing on health access, behavioral health, and chronic conditions, the grant supports initiatives for youth aged 0-19. With a funding preference of $50,000 or more, projects promoting equitable healthcare access and healthy behaviors are encouraged. The Health First Foundation seeks innovative collaborations that address community health needs, fostering a comprehensive approach to improve outcomes for young people.

The Community Development Block Grant (CDBG) program provides federal funding to non-entitlement cities and counties to improve infrastructure, support community facilities, and strengthen local economies in ways that primarily help low-to-moderate income people while addressing local health and safety concerns. Project awards are available in several categories for a wide range of community development initiatives.

The Water/Wastewater category provides funding for communities to make improvements to drinking water and wastewater systems, in partnership with the Missouri Department of Natural Resources and the US Department of Agriculture, Rural Development. Proposals can be obtained from the main funding partner at the time a gap in financing is identified. The Missouri Water and Wastewater Review Committee will help determine financing structures available among the participating agencies. If a need for CDBG funding is identified, the community will be invited to make full application.

Grants may be used for construction that is related to water treatment and distribution, and sewer treatment and collection for publicly owned systems. Operation and maintenance activities and not eligible. 

The State of South Carolina is an entitlement state, as designated by the U.S. Department of Housing and Urban Development HUD, and receives federal formula funding to address housing and community development needs statewide. 

The Emergency Solutions Grant (ESG) Program addresses the need for emergency shelter by funding shelters who provide services outlined by HUD to those who are currently homeless. The State Office of Economic Opportunity works closely with all four regional CoCs to identify needs and direct funds for emergency shelter services. 

The ESG program is a competitive grant issued each year to community-based shelters and traditional housing facilities, non-profit organizations that provide housing and counseling assistance to the state's homeless population and to those at-risk of becoming homeless.

The Emergency Solutions Grants (ESG) Program provides funding to:

engage homeless individuals and families living on the street;

improve the number and quality of emergency shelters for homeless individuals and families;

help operate these shelters;

provide essential services to shelter residents;

rapidly re-house homeless individuals and families; and

prevent families and individuals from becoming homeless.

Agricultural Enterprise Fund

The Agricultural Enterprise Fund (AEF) is an incentive program that supports Governor Lee’s priority of job creation and economic development by facilitating agricultural development in Tennessee. It is administered by the Department of Agriculture in conjunction with the Department of Economic and Community Development.

The AEF awards grants to starting or expanding agricultural, food, and forestry businesses; nonprofits, local governments, and other entities in Tennessee, or those whose project will be located in Tennessee. The program focuses on value-added and processing projects that benefit other producers or forest landowners.

Successful grant recipients must demonstrate a strong potential for impact on local farm income, access to markets, increased capacity or agricultural innovation.

Project Categories

Projects funded by the Agricultural Enterprise Fund must match the description of at least one of the following four categories. Many projects will potentially match the description of more than one category and applicants should indicate so on their application.

NC DEQ 319 Grant Program

Through Section 319(h) of the Clean Water Act, the U.S. Environmental Protection Agency provides states with funding to reduce nonpoint source pollution. North Carolina typically receives around $1 million for competitive funding of watershed restoration projects. Funds may be used to conduct watershed restoration projects such as stormwater and agricultural best management practices and restoration of impaired streams. Section 319 grant projects must be used to help restore waterbodies currently impaired by nonpoint source pollution in areas with approved watershed restoration plans. (map) (list)

State and local governments, interstate and intrastate agencies, public and private nonprofit organizations, and educational institutions are all eligible to apply for 319 funding. An interagency workgroup reviews the proposals and selects those of merit to be funded. 

The Melanoma Research Resident and Fellowship Grant offers $10,000 to support early-career residents and fellows in conducting clinical or laboratory research focused on melanoma. This grant encourages innovative approaches to understanding prevention, detection, and treatment of melanoma, including special emphasis on ocular melanoma. Eligible candidates must have a qualified mentor and conduct research at a U.S. institution. This initiative aims to enhance the landscape of melanoma research and foster the next generation of researchers.

The Horton PhD Research Grant supports up to three Ph.D. students annually in hydrology and related fields, funded by the Robert E. Horton Fund. It provides a maximum of $10,000 for research and travel, along with $500 for U.S. and Canadian applicants participating in AGU's annual meeting. Eligible students must be active AGU members, enrolled for the award's duration, and meet all application requirements. This grant promotes excellence in hydrological sciences.

The ASTR Targeted Research Area Grant supports projects by scholars focusing on under-represented areas in theatre, dance, and performance studies. This includes research on Asian, African, Latin American, and Middle Eastern disciplines, as well as pre-1900 studies and essential translations. The grant, offering up to $3000, encourages recipients to publish their findings and collaborate with Theatre Survey editors. Eligibility extends to scholars with terminal degrees and graduate students, provided they are ASTR members.

The AmeriCorps Formula Programs in New Hampshire, administered by Volunteer NH, aim to enhance community strength through service and volunteerism. These programs engage dedicated individuals to tackle pressing societal challenges such as affordable housing, mental health access, and food security. By connecting volunteers with local organizations, AmeriCorps fosters civic engagement and empowers communities to thrive. Participants receive support, including living allowances and educational awards, promoting a culture of service and community improvement.

The Global Raptor Research & Conservation Grant, offered by HawkWatch International, supports crucial projects focused on raptor conservation in high-priority regions such as Latin America, Sub-Saharan Africa, and Southeast Asia. With funding available up to $2,500, the grant encourages applications from local citizens associated with NGOs or universities. Preference is given to projects that address knowledge gaps and have a significant impact on conservation efforts, particularly those led by early-career researchers in low-income countries.

The Center for Diabetes & Metabolic Diseases offers a Pilot & Feasibility Grant aimed at fostering new diabetes-related researchers and supporting innovative, high-risk projects. This grant, up to $50,000 for one year, is directed to new investigators without prior NIH support. It promotes interdisciplinary collaboration among Indiana University campuses and encourages applications that may lead to significant extramural funding. Eligible applicants must be independent investigators with necessary resources for proposed research.

 The Texas Department of Housing and Community Affairs (the Department or TDHCA) announces an annual Notice of Funding Availability for Emergency Solutions Grants (ESG) funds for street outreach, emergency shelter, homeless prevention, rapid re-housing, Homeless Management Information System (HMIS), and Administration.

The Center for Diabetes & Metabolic Diseases Pilot & Feasibility Grant aims to support innovative diabetes research by established investigators with no prior work in the field. The program offers funding of up to $50,000 for one year, encouraging applications from faculty at various Indiana institutions. This initiative seeks to promote interdisciplinary collaborations and aims to advance research that leads to major extramural grant submissions, fostering new insights into diabetes and metabolic diseases.

Thomas R. Nickoloff Family Foundation 

Promoting Excellence in Educational Outcomes

The Nickoloff Family Foundation was founded in 2017 with the singular mission of “Promoting Excellence in Educational Outcomes,” primarily focused on New Mexico.

It is our core belief that a quality education provides a gateway to personal fulfillment, achievement, self-respect and rewarding work, for the betterment of the individual, families and society as a whole. Building stronger individuals, families and community is central to our mission of funding and “Promoting Excellence in Educational Outcomes.”

Grants

Grant support is provided by the Thomas R. Nickoloff Family Foundation (the “Foundation”) at the sole discretion and determination of the Foundation Trustee to non-profit, tax-exempt organizations as defined under section 501(c)(3) of the United States Internal Revenue Code. 

Categories of Support

The following categories may serve as a guideline to applicants in determining whether their programs are consistent with the Foundation’s core mission of “Promoting Excellence in Educational Outcomes”.

1) Proven and Effective Educational Programming/Initiatives

• School Based Programs
• After School Programs

2) Academic and Foundation Research Focused on:

• Policy, Programming and Initiatives to Improve Educational Outcomes
• School Safety Initiatives

3) Arts Education Outreach Programs

Organizations may apply once yearly for grant support. Multi-year grants may also be considered but would be structured as one-year grants renewable annually at the sole discretion of the Foundation. Any and all grant funds, if any, awarded by the Foundation to an Organization shall be used solely for the explicit purposes noted in a grant application as use of funds.

The Strengthening Families and Communities Grant by Telligen Community Initiative focuses on enhancing the resilience of youth and families through community-based funding. This initiative is transitioning to two-year funding periods, with applications due in March and October for different states. The grant aims to address social determinants of health, providing targeted support based on extensive applicant feedback. The program emphasizes a narrowed applicant pool to ensure more consistent funding for impactful projects.

The Nonprofit Resource Training Grant offers up to $1,000 for tax-exempt organizations to send employees to essential training and conferences. This initiative supports community-based groups that serve low- to moderate-income populations and align with The Ready Commitment. By enhancing employee skills, the grant aims to strengthen nonprofits and their impact in the community, ensuring they provide valuable services effectively.

The First United Church of Christ Mission Fund provides vital support to various organizations and initiatives in Berks County, focusing on children's activities, senior citizen benefits, and hunger reduction. Grants totaling up to $65,000 will be awarded, with individual grants generally under $10,000. Preference is given to religious organizations within close proximity to the church, ensuring that the fund effectively supports community needs and outreach efforts.