Best Large Grants for Nonprofit Organizations

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Medication Therapy Management (MTM) Initiative

The Medication Therapy Management (MTM) Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to improve medication access, adherence, and patient understanding among uninsured and medically underserved populations. Individuals without health insurance often face significant barriers to obtaining prescription medications and receiving the counseling necessary to manage chronic conditions effectively. Through this initiative, NAFC will provide $30,000 grants to member free and charitable clinics and pharmacies to establish or expand Medication Therapy Management programs aligned with recommendations from the American Pharmacists Association. Funding will support activities such as staff certification in MTM, development of standardized protocols, and patient education to help individuals better understand their medications, manage side effects, and support overall treatment plans. By strengthening pharmacist-led care and improving communication between providers and patients, this initiative seeks to enhance medication adherence, improve chronic disease management, and advance better health outcomes for vulnerable patient populations.

The Nesting Bird Habitat Incentive Program (NBHIP) supports the restoration and maintenance of habitats for nesting waterfowl and game birds on public lands. Established in 2018, it is funded through hunting validation fees, generating approximately $2 million annually. For FY 2025-26, up to $850,000 is allocated for habitat projects, divided into maintenance of existing perennial grass ($150,000) and restoration/enhancement of habitats ($700,000), promoting biodiversity and ecological health.

The New Hampshire Department of Environmental Services has launched the Large PWS Lead Service Line Inventory Grant program to assist water systems with over 1,000 service connections in identifying service lines marked as 'unknown'. This initiative is part of compliance with the EPA Lead Copper Rule Improvements, requiring annual service line inventories. Grants of up to $60,000 are available, with no community match required, to facilitate the identification and replacement planning of lead service lines.

The Rhode Island Department of Health is offering a Short-Term Project Funding Opportunity aimed at promoting hypertension management and diabetes prevention in Providence communities. Eligible organizations can apply for up to $4,999 to create culturally relevant outreach events and materials that encourage the use of preventive health services. This initiative emphasizes community engagement, aiming to address social determinants of health through effective messaging and resource navigation, with project activities expected to run from April to August 2025.

The Knowles-Nelson Stewardship Local Assistance and Federal Recreation Grants, managed by the Wisconsin Department of Natural Resources, aim to enhance outdoor recreation opportunities across the state. These grants support various programs, including local parks development, acquisition of development rights, and urban green spaces. They also encompass federal initiatives such as the Land and Water Conservation Fund and Recreational Trails Program. This funding fosters community engagement and promotes sustainable recreational access.

The Michigan College Access Network (MCAN) offers Innovative Program Grants to enhance college readiness and completion among low-income and first-generation students across Michigan. Grants of up to $10,000 are available to support innovative initiatives that align with MCAN's goal of increasing postsecondary attainment to 60% by 2030. Applicants are encouraged to partner with Local College Access Networks, ensuring a comprehensive approach to community-based educational support.

The JRCT: Peace and Security Grant Programme, from the Joseph Rowntree Charitable Trust, focuses on funding initiatives that address the root causes of conflict and injustice. The Trust emphasizes values of equality, human rights, and environmental sustainability, advocating for non-violent approaches and participatory governance. Its funding priorities include challenging militarism, promoting transparency in counter-terrorism, and supporting innovative solutions to the dual impacts of the Covid-19 pandemic and systemic racism, primarily aimed at creating lasting societal change.

The Ornis Birding x Lost Birds Expedition Grant aims to inspire skilled young birders, aged 18-30, to explore remote regions and rediscover species that have evaded scientific detection for over a decade. Funded by Ornis Birding Expeditions, this grant offers up to $5,000 for innovative expeditions, encouraging participants to submit detailed observations and engage with local communities. The initiative seeks to fill critical gaps in ornithological knowledge while promoting conservation and ecotourism.

The Robert and Joan Dircks Foundation Grant Program supports non-profit organizations in New Jersey that provide opportunities for disadvantaged individuals. With grants ranging from $1,000 to $15,000, the foundation focuses on innovative programs that solve critical issues rather than operational needs. Eligible organizations must be tax-exempt under section 501(c)(3) of the Internal Revenue Code. The foundation does not fund political activities, cultural projects, or operating budgets, ensuring resources directly benefit those in need.

Department of Health and Human Services

DHHS is the largest agency in New Hampshire state government, responsible for the health, safety and well-being of the citizens of New Hampshire. DHHS provides services for individuals, children, families and seniors, and administers programs and services such as mental health, developmental disability, substance misuse, and public health. This is accomplished through partnerships with families, community groups, private providers, other state and local government entities, and many citizens throughout the State who help make New Hampshire a special place in which to live.

RFP-2027-DPH-03-INSUR (DoIT #2026-047): Insurance Benefit and Medical Claims Management for Clients Living With Human Immunodeficiency Virus

The New Hampshire Department of Health and Human Services, Division of Public Health is seeking responses to this Request for Proposals (RFP) from qualified Vendors to provide insurance benefit and medical claim management services on behalf of individuals living with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) who are enrolled in the New Hampshire CARE Program (NH CARE). 

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement invites applications for multi-center observational studies targeting high-risk diseases relevant to NIDDK's mission. The program encourages hypothesis-driven research involving multiple clinical centers. Key deadlines for application submissions are set for February, June, and October of 2025 and 2026. It is advised to consult with NIDDK staff prior to application submission to ensure alignment with grant expectations.

Iowa Department of Health and Human Services

Iowa HHS provides high quality programs and services that protect and improve the health and resiliency of individuals, families, and communities.

Maternal Health Hub and Spoke

The Iowa Department of Health and Human Services (the Agency) is providing this notice of intent to release a request for proposal (RFP) on or around July 2026, for Maternal Health Hub and Spoke networks. This procurement is for establishing the framework for hub and spoke networks of care for the delivery of maternal health care in Iowa. The Agency anticipates successful applicants will be required to complete some activities related to behavioral health care for the maternal health population.

The Agency anticipates that this work may include forming rural provider strategic partnerships, advancing telehealth, establishing referral networks and agreements (particularly among non-affiliated provider organizations), provider recruitment, equipment purchases and associated minor renovations, and other funds needed to establish or advance the provision of maternal health care at hub and spoke sites. Please see the Agency’s Rural Health Transformation Grant website (Rural Health Transformation (RHT) | Health & Human Services) for additional information about the Healthy Hometowns initiative.

The Department of Hawaiian Home Lands (DHHL) offers a grant program to improve facilities on existing homesteads, supporting Native Hawaiian communities. This initiative enhances infrastructure, health services, and cultural facilities, fostering sustainable development. Nonprofits and community associations can apply for funding to strengthen homestead communities and increase access to vital services. Grants are awarded based on project readiness, organizational capacity, and community involvement, aiming to improve the quality of life for Native Hawaiian beneficiaries.

The Limited Competition Small Grant Program for NIDDK K01/K08/K23/K25 recipients offers funding opportunities for pilot studies and feasibility research. This program aims to support researchers transitioning to independent investigator roles by providing resources for small projects that can yield preliminary data for future R01 applications. Key deadlines for applications range from February 2025 through January 2028, with specific dates for standard, renewal, and AIDS-related applications.

Bureau of Behavioral Health FY27 Notice of Funding Opportunities

The Mississippi Department of Mental Health is now accepting applications for a series of competitive grants made available through funding appropriated to the agency.

Family (Parent/Caregiver) Peer Support Development and Program Maintenance Notice of Funding Opportunity FY 2027: Request for Proposals

The Parent/Caregiver Peer Support Program will need to be developed and maintained by the selected agency in alignment with national best practices and standards and approved by the MS Department of Mental Health.

(Certified) Peer Support Specialist Professional- Parent/Caregiver is a biological parent, adoptive parent, or relative caregiver with permanent legal custody who is raising or has raised a child with an emotional, social, behavioral, and /or substance use disability. The Specialist Professional provides support and guidance to parents/caregivers in navigating the child serving systems and advocating with them to help their child/youth.

Bureau of Behavioral Health FY27 Notice of Funding Opportunities

The Mississippi Department of Mental Health is now accepting applications for a series of competitive grants made available through funding appropriated to the agency.

Consumer Education Program

This funding is to provide state-wide evidence-based support and educational programs free of charge to those living with mental illness, their caregivers, and their family members.

Educational programs are to include but are not limited to:

The Family-to-Family Education Program is a free, 12-class course for family caregivers of individuals with severe mental illnesses. The course is taught by trained family members and provides current information on major mental illnesses such as schizophrenia, major depression, bipolar disorder, obsessive compulsive disorder, and others; information about medications; strategies for handling crises and relapse; and most of all, how to cope successfully with a major challenge in your life, which will in turn allow you to best support your mentally ill loved one to work toward recovery.

In Our Own Voice (IOOV) unmasks mental illness using speaker stories to illustrate the individual realities of living with mental illness. Participants gain a better understanding of what it is like to live with mental illness and stay in recovery. In Our Own Voice can change attitudes, preconceived notions and stereotypes regarding mental illness.

Peer-to-Peer is a recovery-focused educational program for adults who wish to establish and maintain wellness in response to mental health challenges. The course provides critical information and strategies related to living with mental illness.

The Provider Education program helps people who work with individuals living with mental illness understand the experience of mental illness from individual and family perspectives. Through exposure to personal stories, participants may gain tools that increase their empathy and professional skills thereby improving patient care.

Patagonia’s Corporate Grant supports grassroots organizations focused on bold, direct-action campaigns that address the root causes of environmental issues. The program emphasizes equity, inclusivity, and long-term change, targeting communities affected by environmental exploitation. Grants are awarded to innovative groups within the US and Canada, fostering civic engagement and measurable objectives. Patagonia prioritizes funding for initiatives that confront systemic bias and promote environmental justice, ensuring that diverse voices are represented in the environmental movement.

The Senior Citizen Services Grants, established by Senior Citizens Services, Inc. at the Pinellas Community Foundation, aim to support wellness programs for residents aged 55 and older in Pinellas County. Eligible organizations can request funding for services such as mental health counseling, adult day care, and caregiver support. Emphasizing competitive funding, these grants prioritize projects that directly benefit the senior population, enhancing their quality of life through various wellness initiatives.

The Altrusa International Grant, managed by the Madison Community Foundation, supports projects that empower children and youth in education, aid workforce reintegration, and encourage lifelong learning. Established in 1942, the foundation has a mission to foster a generous community through impactful charitable giving. Grants range from $1,000 to $5,000, with an average of $1,200, aimed at making a meaningful difference in the lives of individuals in Madison and Dane County.

The Illinois Habitat Fund offers competitive grants for preserving and maintaining high-quality habitat lands, aimed at not-for-profit organizations and governmental entities. This initiative, part of the Special Wildlife Funds Grant Program, supports projects aligned with the Illinois Wildlife Action Plan. Successful proposals typically demonstrate reasonable costs, feasible methods, and public access, contributing to targeted ecological goals across Forest, Farmland, and Wetland Campaigns.

About MNRCP

The Maine Natural Resource Conservation Program (MNRCP) awards competitive grants to projects that restore, enhance, and protect high priority aquatic resources throughout Maine. MNRCP is administered by The Nature Conservancy on behalf of the Maine Department of Environmental Protection (DEP) and the U.S. Army Corps of Engineers. Since its launch in 2008, MNRCP has awarded over $36 million to non-profit groups, municipalities, and public agencies to help restore, enhance, or preserve wetlands and other important habitats at over 180 project sites across the state.

MNRCP was created to manage the allocation of funds collected through Maine’s In Lieu Fee Compensation Program. This voluntary program provides flexibility for regulators as well as for those seeking natural resource permits to choose a fee in lieu of more traditional permittee-responsible mitigation options. These so-called In Lieu Fees are collected by the Maine DEP and then transferred to the Natural Resource Conservation Fund administered by The Nature Conservancy.

Funds are awarded through an annual competitive grants process. Proposals are solicited each year and evaluated by a Review Committee, convened by the Maine DEP, and made up of public and nonprofit entities. Final award decisions are made in November or December of each year by the Interagency Review Team (Approval Committee) comprised of state and federal agencies. The Nature Conservancy administers the process but does not decide which proposals receive funding.

Apply

MNRCP awards competitive grants each year to projects that restore, enhance, and protect high priority aquatic resources in Maine. MNRCP funding rounds are usually announced in April or May. Public agencies, non-profit conservation organizations, tribes, and municipalities are encouraged to submit a Letter of Intent for eligible projects.

Green Partners Grant

Engage, educate, act and collaborate for the environment

Hennepin County provides funding and support to organizations to actively educate, engage and motivate residents to become environmental stewards and make positive behavior changes.

Through the Green Partners program, Hennepin County contracts with organizations to implement projects that engage youth and adults in becoming environmental stewards. Projects engage youth in learning about environmental topics and taking leadership on environmental issues as they get older. Green Partners also supports projects to engage our adult residents in helping the county reach it’s zero waste and climate goals by preventing waste, composting organic waste, reducing, reusing, recycling, and repairing and caring for our natural resources by improving water quality, caring for trees, and creating habitat to protect birds, bats, and pollinators.

Types of Grants

Hennepin County has three Green Partners programs.

• Environmental Action Program
• Youth Environmental Leadership Program
• Youth Environmental Education Program

Youth Environmental Education Grants

Youth environmental education projects engage youth in elementary and middle school in environmental education and outdoor nature experiences. Project activities engage youth in learning about the environment to develop their awareness and increase their knowledge of environmental issues and solutions. Strong projects are inquiry driven, incorporate hands-on and experiential environmental learning, provide outdoor nature experiences, and promote environmental stewardship. Preferred projects incorporate county identified project ideas.

Levels of Funding

• If you have received a Green Partners award before, you can apply for up to $25,000 for a one-year project or, if you meet the criteria, up to $50,000 for a two-year project.
• If you have never received a Green Partners award before, you can apply for up to $12,000 for a one-year project. 

The Friends of Reservoirs: Mossback Grant offers three grants of $1,000 in Mossback products to eligible members of Friends of Reservoirs organizations. Sponsored by Mossback Fish Habitat, these grants aim to enhance structural habitat in public waters. The total retail value is approximately $1,500. Applicants must cover freight costs, and a $25 application fee applies to each submission. This initiative supports habitat restoration efforts across member organizations.

The Friends of Reservoirs: Large Grant supports fish habitat enhancement projects in manmade reservoirs, promoting conservation and partnerships. With approximately $250,000 in Federal funding and $500,000 from Bass Pro Shops, grants up to $75,000 are available. Projects must match funding and can be multi-year, with specific caps on subsequent funding. This initiative aims to address habitat impairments and enrich community quality of life through improved fishing opportunities.

The Martin Luther King/César Chavez/Rosa Parks Future Faculty Fellowship at Western Michigan University aims to support academically or economically disadvantaged doctoral candidates in their final dissertation stage. Established in 1986, this fellowship provides financial aid averaging around $33,000 to help students complete their degrees. Recipients must fulfill a three-year teaching or administrative obligation at a postsecondary institution in Michigan, ensuring a commitment to education and community service.

The Alice M. Ditson Fund provides organizational support for professional performing ensembles and institutions committed to advancing the work of younger and relatively unknown living American composers. Grants are available for general operating or project support, emphasizing contemporary American classical concert music. Eligibility includes organizations without non-profit status if sponsored by a 501(c)(3) entity, while projects featuring American music are prioritized. This funding opportunity encourages innovative performances and fosters greater recognition of emerging talents in the classical music sphere.

The Environment Fund, launched in 2018 by The Community Foundation for Northern Virginia, aims to protect and enhance the natural environment of Northern Virginia. It fosters collaboration among nonprofits, businesses, and educational institutions to promote awareness and citizen engagement in environmental protection. In 2025, funding will support nonprofit organizations providing educational programs in conservation, energy efficiency, sustainability, watershed management, and workforce climate initiatives, specifically targeting areas within Arlington, Fairfax, Loudoun, and Prince William Counties.