Best Large Grants for Nonprofit Organizations

Low Threshold Buprenorphine Induction at Harm Reduction Centers NOFA

To support the State Opioid Response (SOR) by conducting Low Threshold Buprenorphine Induction at Harm Reduction  Centers (HRCs) that provide access to medication-assisted treatment (MAT), reduce unmet treatment need, and reducing  opioid overdose related deaths through the provision of prevention, treatment and recovery activities for opioid use  disorder. 

The AHRQ funding opportunity invites proposals to enhance diagnostic safety in ambulatory care settings. The initiative aims to investigate the incidence and causes of diagnostic errors across diverse ambulatory services. Researchers are encouraged to explore innovative approaches and methodologies to improve diagnostic accuracy and patient outcomes, contributing significantly to healthcare quality and safety. All applications must be submitted by 5:00 PM local time of the applicant's organization.

The TURTLE Program aims to empower Tribal Entities by fostering a skilled workforce in biomedical research. It supports undergraduate and graduate students in health research, ensuring they complete their degrees and transition into impactful careers. With phased awards, the program emphasizes effective training and mentoring, inviting eligible organizations to apply. Applications will undergo NIH's peer-review process, ensuring only the most meritorious proposals are funded, ultimately enhancing Tribal health research capabilities.

The Cabot Family Charitable Trust, established in 1942, provides grants to nonprofit organizations in Boston and surrounding areas, focusing on youth and community development. The Trust supports initiatives in arts, education, environment, and health, prioritizing programs that enhance the growth of young children. While most grants are for one year, multi-year funding may be available for capital campaigns. Eligible organizations must have 501(c)(3) status and align with the Trust's philanthropic interests.

The Walter and Andrée de Nottbeck Foundation offers grants for research on Baltic Sea ecosystems at the Tvärminne Zoological Station, Finland. Funding includes scholarships for MSc and PhD students, postdoctoral support, and project grants, totaling around 700,000 € annually. The foundation emphasizes research collaboration and scientific excellence while prioritizing researchers based at the station. Senior researchers are invited to apply for five-year positions with competitive salaries. Successful candidates are expected to reside at the station during their fellowship.

The Wisconsin Department of ​Administration (DOA) administers WCMP Grants in collaboration with the Wisconsin Coastal Management Council (WCMC) and the Office for Coastal Management (OCM), U.S. Department of Commerce, through funding provided under the Coastal Zone Management Act of 1972. The Wisconsin Coastal Management Program (WCMP) supports the management, protection, and restoration of Wisconsin's coastal resources, and increases public access to the Great Lakes. WCMP Grants are available in five categories:

1. Coastal Wetland Protection and Habitat Restoration

2. Nonpoint Source Pollution Control

3. Coastal Resources and Community Planning

4. Great Lakes Education

5. Public Access and Historic Preservation

Family Centered Treatment-Recovery Implementation

This funding will support parents and caregivers with an opioid use disorder, their children, and their other family members to participate in a model of care known as Family Centered Treatment-Recovery.

FCT-R is an innovative practice and systems-of-care model that weaves together the evidence-based Family Centered Treatment model and best practices in substance use treatment. FCT-R addresses not only substance misuse, but also the underlying family systems and trauma histories that contribute to and maintain the cycle of substance use disorder. 

Distinctive features of FCT-R include substance use disorder specific family system interventions, integrated trauma treatment, a peer professional (certified peer specialist, certified parent peer specialist, or peer recovery coach), contingency management, random drug screens, implementation teams, and participation in a community or treatment group of the family’s choice. 

​Comprehensive Opioid, Stimulant, and Substance Use SiteBased Program (COSSUP) Wisco​nsin Deflection Initiative (WDI) Technology Implementation 2024(2026) 

This competitive grant provides funding to sites participating in the Wisconsin Deflection Initiative (WDI) to modernize deflection program processes through technology implementation. ​

Funds will support software, applications, and equipment to increase the efficiency of deflection screening, mobile case management of participants, and participant engagement and interaction. Technology implementation will improve program effectiveness, enhance data collection, and create operational efficiencies for deflection program staff.

Anticipated Funding Amount

$500,000 is available through this initiative. Individual awards are available for up to $50,000 for an initial project period. Project start dates and periods will vary depending on when applications are submitted and approved. Sites ready to begin immediately may receive funding as early as April 1, 2026, while applications will be accepted through August 31, 2026. Project budgets should reflect the specific project period based on anticipated start date.

Wisconsin Department of Health Services

The Department of Health Services (DHS) is one of the largest state agencies in Wisconsin, with an annual budget of roughly $15 billion and more than 6,700 employees. DHS is committed to protecting and promoting the health and safety of the people of Wisconsin, making sure everyone can live their best life.

Wisconsin’s Site Evaluation Program: Mini-Grants

The Wisconsin Site Evaluation Program (SEP) at the Wisconsin Department of Health Services (DHS) is seeking applications from Tribal health departments and Tribal organizations interested in addressing environmental health hazards and their impact on housing in their communities. We are offering mini-grants of up to $30,000 each to help Tribal health departments and Tribal organizations implement new, innovative, expanded, or enhanced interventions to increase tenant and homeowner environmental health literacy. The awarded Tribal health departments and Tribal organizations will build upon existing relationships they have with communities and will use or adapt strategies to meet the unique identified needs of each community.

These grant funds are intended to be used for education, community engagement, collaboration, or other forms of outreach that increase the knowledge of tenants and homeowners to identify and protect themselves from environmental hazards. Hazards addressed under this grant must relate to one or more of the following:

• Indoor air quality
• Water quality
• Soil contamination

The Public Education, Participation, and Outreach Grant Program, established by the Colorado Water Conservation Board (CWCB), is designed to fund statewide education and outreach initiatives. It supports financial backing for coordinators who facilitate basin-specific outreach. The program aims to advance education campaigns, awareness surveys, and initiatives that align with CWCB priorities, promoting water conservation and management across Colorado's diverse water basins.

The Public Education, Participation, and Outreach Grant Program, initiated by the Colorado Water Conservation Board, supports education and outreach initiatives for water conservation. This grant enables coordinators to work closely with basin roundtables, facilitating community engagement on water issues. With funding up to $25,000, the program aims to enhance public awareness and education about water resources, ensuring sustainable management for future generations. Eligible entities include governments and individuals, fostering collaboration across Colorado's nine river basins.

The Holsworth Wildlife Research Endowment Grant, offered by the Ecological Society of Australia, supports Australian PhD students with research funding up to $22,500 for wildlife studies. The grant focuses on ecological interactions, conservation biology, and wildlife management. Eligible applicants include those conducting fieldwork on native species, with specific funding for communication of research outcomes. This grant encourages early-stage doctoral students to apply and emphasizes adherence to ethical research practices.

The Edward Byrne Memorial Justice Assistance Grant (JAG) Program provides vital federal funding to support criminal justice initiatives in North Carolina. It addresses law enforcement, courts, and community programs, promoting equitable public safety solutions. Established by the Governor's Crime Commission, the program adapts to evolving needs, ensuring resources are allocated effectively to enhance safety for over 10 million residents. This initiative empowers local agencies to implement innovative strategies in law enforcement, mental health, and crisis intervention.

Virginia Tree Stewards

Tree Stewards are trained community volunteers committed to promoting healthy urban and rural forests in Virginia. Tree Stewards provide training classes, educational programs, and projects in their communities intended to increase public awareness of the value of trees while teaching about trees and tree care. With classroom training and hands-on practice, Tree Stewards are equipped to identify trees, counsel on tree selection, demonstrate proper tree planting and follow-up care, and guide removal of invasive plants that threaten trees.

Each person taking the Tree Steward training makes a commitment to return a specific number of volunteer hours contributing to local Tree Steward projects. Each community determines the number of hours, sets the standards for volunteer work, and decides the Tree Steward projects its volunteers will undertake. Tree Steward volunteers are a positive force for change in their communities. All Tree Steward projects are tailored to meet the needs of their communities.

Mini Grants

Trees Virginia Mini-Grants are intended to assist the work of Tree Stewards in their communities. These funds may be used to support the training of Tree Stewards, purchase tools and equipment, acquire trees to plant, or develop educational materials or events. The purpose of the Mini-Grants is to provide equitable appropriation to Tree Steward Groups rather than awarding funds to groups on a first-come, first-served basis.

New York State Energy Research and Development Authority

The New York State Energy Research and Development Authority (NYSERDA) offers objective information and analysis, innovative programs, technical expertise, and support to help New Yorkers increase energy efficiency, save money, use renewable energy, and reduce reliance on fossil fuels. A public benefit corporation, NYSERDA has been advancing energy solutions and working to protect the environment since 1975.

On-the-Job Training for Energy Efficiency and Clean Technology

Description

NYSERDA’s On-The-Job Training for Energy Efficiency and Clean Technology program will provide wage subsidies to eligible employers to reduce the financial risk of hiring and training new workers, incentivize and track the retention of the new workers during their first year of employment, and offer compensation for industry certifications earned. This program helps New York State to meet its energy goals and prioritizes the creation of employment opportunities for individuals from disadvantaged communities and priority populations.

NYSERDA is working closely with the New York State Department of Labor (NYSDOL) to deliver the OJT program.

The primary purpose of OJT funding is to train new hires for clean energy work.

Employers must provide services in one or more the following technology areas to be eligible for program funding:

• High efficiency heating, ventilation, and air conditioning (HVAC) / Heat Pumps
• High efficiency water heating
• Insulation / weatherization
• High efficiency lighting and controls
• Building automation and controls
• Smart grid
• Energy storage
• Building operations and maintenance
• Grid-tied solar electric photovoltaics, solar thermal, and related areas
• Offshore and land-based wind and related areas
• Electric vehicle charging stations
• Electric vehicles (manufacturing only)

The CDC is offering funding to enhance collaboration among tuberculosis control programs and various partners in the U.S. This initiative aims to strengthen relationships with national TB control entities, federal agencies, academia, and community organizations. The goal is to promote health and quality of life by preventing, controlling, and eventually eliminating tuberculosis in the United States, building on previous funding opportunities.

Disease Prevention and Chronic Disease Management

Hospital Disease Prevention

• Support critical access hospitals (CAHs) and rural hospitals as designated by CMS in the development, implementation, and monitoring of chronic disease management programs coordinated by or located in the relevant CAHs and rural hospitals as a means to improve patient outcomes and promote population health initiatives in rural communities.
• Participating hospitals are expected to identify local health priorities using resources such as Community Health Needs Assessments (CHNA) or county I-PLANs, which contain data on chronic disease prevalence and high-risk populations.
• Partnership with the facility’s local health department is expected.

Overall Goals of Disease Prevention Grant

Improve patient health outcomes and quality of life through better disease control

Reduce healthcare costs via decreased utilization of high-cost services

Increase access to preventive services in community settings

Empower patients through education and self-management support

Establish sustainable healthcare delivery models aligned with national benchmarks such as Healthy People 2030

Support the identified needs of each region/identified populations

Reduce redundancy

Disease Prevention and Chronic Disease Management

Hospital Disease Prevention

• Support critical access hospitals (CAHs) and rural hospitals as designated by CMS in the development, implementation, and monitoring of chronic disease management programs coordinated by or located in the relevant CAHs and rural hospitals as a means to improve patient outcomes and promote population health initiatives in rural communities.
• Participating hospitals are expected to identify local health priorities using resources such as Community Health Needs Assessments (CHNA) or county I-PLANs, which contain data on chronic disease prevalence and high-risk populations.
• Partnership with the facility’s local health department is expected.

Overall Goals of Disease Prevention Grant

Improve patient health outcomes and quality of life through better disease control

Reduce healthcare costs via decreased utilization of high-cost services

Increase access to preventive services in community settings

Empower patients through education and self-management support

Establish sustainable healthcare delivery models aligned with national benchmarks such as Healthy People 2030

Support the identified needs of each region/identified populations

Reduce redundancy

Disease Prevention and Chronic Disease Management

Hospital Disease Prevention

• Support critical access hospitals (CAHs) and rural hospitals as designated by CMS in the development, implementation, and monitoring of chronic disease management programs coordinated by or located in the relevant CAHs and rural hospitals as a means to improve patient outcomes and promote population health initiatives in rural communities.
• Participating hospitals are expected to identify local health priorities using resources such as Community Health Needs Assessments (CHNA) or county I-PLANs, which contain data on chronic disease prevalence and high-risk populations.
• Partnership with the facility’s local health department is expected.

Overall Goals of Disease Prevention Grant

Improve patient health outcomes and quality of life through better disease control

Reduce healthcare costs via decreased utilization of high-cost services

Increase access to preventive services in community settings

Empower patients through education and self-management support

Establish sustainable healthcare delivery models aligned with national benchmarks such as Healthy People 2030

Support the identified needs of each region/identified populations

Reduce redundancy

The Menke Scholarship, offered by the Webster Groves Nature Study Society, aims to enhance wildlife habitats in Missouri. This initiative honors the legacy of the Menke family, emphasizing sustainability through various conservation practices. It welcomes applicants from diverse fields, prioritizing the project’s impact over academic background. Recipients may engage in internships with conservation programs, fostering hands-on experiences. The scholarship supports efforts to improve habitats for various species, contributing to ecological preservation and education.

Disease Prevention and Chronic Disease Management

Hospital Disease Prevention

• Support critical access hospitals (CAHs) and rural hospitals as designated by CMS in the development, implementation, and monitoring of chronic disease management programs coordinated by or located in the relevant CAHs and rural hospitals as a means to improve patient outcomes and promote population health initiatives in rural communities.
• Participating hospitals are expected to identify local health priorities using resources such as Community Health Needs Assessments (CHNA) or county I-PLANs, which contain data on chronic disease prevalence and high-risk populations.
• Partnership with the facility’s local health department is expected.

Overall Goals of Disease Prevention Grant

Improve patient health outcomes and quality of life through better disease control

Reduce healthcare costs via decreased utilization of high-cost services

Increase access to preventive services in community settings

Empower patients through education and self-management support

Establish sustainable healthcare delivery models aligned with national benchmarks such as Healthy People 2030

Support the identified needs of each region/identified populations

Reduce redundancy

Tennessee Department of Health

Mission: Protect, promote, and improve the health and well-being of all people in Tennessee.

The Tennessee Department of Health's highly talented and dedicated professionals reflect a standard of performance in its effective and engaging public health efforts and collaborative commitment to providing compassionate service to people in all 95 counties of the state. TDH provides health care and wellness services daily to Tennesseans through a statewide network of 89 rural and six metropolitan county health departments at 117 physical locations.

Rural Healthcare Access Modernization Program (RAMP)

Description

The Rural Healthcare Access Modernization Program (RAMP) is intended to strengthen healthcare access in rural Tennessee by funding targeted capital improvements at rural hospitals and supporting the establishment or expansion of rural primary care practices. The opportunity seeks to increase service capacity, improve operational efficiency and quality of care, modernize healthcare facilities, and address critical provider shortages, particularly in pediatrics and obstetrics.

Funding is allocated to the Tennessee Department of Health (TDH) to support three investment goals through RAMP.

Goal 1: Rural Capital Investment

Goal 2: Rural Health Transformation Program (RHTP) Competitive Grant Extension Subsidiary of Goal 1

Goal 3: Rural Primary Care Seed Grants

Rural Health Transformation Program Competitive Grant Extension

Support for eligible projects aligned with Rural Health Transformation priorities that require additional funding to continue or complete implementation.

This investment goal is intended to build upon and extend successful models emerging from Tennessee's Rural Health Transformation Program (RHTP).

Through this approach, TennCare Shared Savings funding may provide additional support for high-quality projects that align with RHTP priorities and demonstrate the potential to improve healthcare access and outcomes in rural communities. This strategy helps maximize the impact of innovative projects and supports continued progress toward rural healthcare transformation goals..

Grants for Relocation Outreach Work (GROW) Program

The Think Vermont Grants for Relocation Outreach Work (GROW) Program provides grant funding to enable local, regional, county-wide, or state-wide organizations to conduct relocation, recruitment, and retention activities. To be eligible for this funding, grantees must provide relocation services on behalf of their region or affinity group and collaborate with other organizations to optimize the success of relocation and retention efforts. These efforts reach and serve a broad audience, including underrepresented communities and new and diverse residents.

There are two tracks within the GROW program, the Relocation Track and the Retention Track. Some awardees will receive grants for both tracks. A description of each track is below along with a list of grant recipients:

Relocation Track: Grantees will complement and support the State’s relocation lead generation and distribution system on ThinkVermont.com. Grantees are required to connect with and follow up on generated leads of potential residents interested in moving to their area. Grantees activities can also include the creation of regional marketing assets to assist with out-of-state advertising campaigns.

Retention Track: Grantees will organize events and/or conduct activities that help new residents feel welcome in their new community. Outreach to recently relocated families and individuals will include invitations to participate in events such as mixers, young professionals’ groups and/or the Vermont Welcome Wagon programming.

This project aims to combat the rapid spread of invasive climbing plants in the southeastern U.S. and Caribbean by creating a comprehensive database on species traits and disturbance locations. The database will enhance understanding of vine expansion and provide predictive maps for future spread, assisting managers in identifying vulnerable areas. This initiative aligns with federal priorities for natural resource stewardship and aims to strengthen community resilience against biological threats.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5429 - Bioavailability and Transformation of Dissolved Organic Nitrogen and Phosphorus Across WRRFs

Project Objectives

• Survey and characterize dissolved organic nitrogen and phosphorus (DON/DOP) concentrations and speciation across North American wastewater facilities, including but not limited to influent, secondary effluent, tertiary effluent, digester supernatant, thermal hydrolysis process (THP) centrate, autothermal thermophilic digestion (ATAD) sidestreams, and dewatering recycle streams.
• Understand the dynamics of DON/DOP in effluent, including quantifying the bioavailable fraction of DON/DOP in different relevant process streams, evaluating their transformation into nitrogenous disinfection by-product (N-DBP) precursors, determining bio-uptake rates representative of receiving water conditions, and measuring the timescale for biodegradation in receiving waters.

The Governor's Workforce Board

The Governor's Workforce Board (GWB) is the primary policy-making body on workforce development matters for the State of Rhode Island and has statutory responsibility and authority to plan, coordinate, fund, and evaluate education, employment, and training programs that increase the skills of the RI workers and address the workforce needs of RI businesses. The Board is housed at the Rhode Island Department of Labor and Training.

Real Skills for Youth

The goal of Real Skills for Youth is to prepare youth for success in college and/or career through meaningful career exposure and exploration of potential career paths and their on-ramps, skill-building with an emphasis on essential and professional skills and supported work-based learning experiences that allow participants to apply learning in a real-world setting. 

Real Skills for Youth programs often provide youth with initial exposure to the world of work, whether through a paid work experience, hands-on exposure to new careers, and practicing essential skills.

In FY26, the GWB allocated $2.8 million to the program to support partnerships consisting of schools, youth-serving organizations, employers, and others to develop and implement high-quality work-based learning and career exploration activities. This program is part of Rhode Island’s larger effort called Prepare RI.

Real Skills for Youth Partners and Programs: Rhode Island Office of the Post Secondary Commissioner

What To Expect

• Explore healthcare careers you may not know about;
• Hands-on activities that show what healthcare jobs are really like
• Learn from professionals who work in hospitals, clinics, and other healthcare settings
• Discover different career paths and what education or training they require
• Build knowledge and confidence about your future in healthcare
• Get inspired to see how you could be part of Rhode Island’s healthcare workforce

Career Pathways to Choose From

• Healthcare Field: Nursing, Pharmacists, Surgical Tech, Medical Assistant, and more.
• Experiential Learning
• Prepare next generation of the Healthcare Workforce

Youth Participants will be participating in a series of career exploration activities: professional spotlights, career skills development days, disaster simulations, career and education fair, research symposiums, and a final career exhibition.

Communities Served: Providence and North Providence Public Schools, Central Falls School District, East Providence School District